Kv3 channel assembly, trafficking and activity are regulated by zinc through different binding sites

Journal of Physiology

Volumn 591, Issue 10, 2013, Pages 2491-2507

  Gu, Yuanzheng ^a   Barry, Joshua ^b   Gu, Chen ^a,b  

^a Department of Neuroscience ^*  (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SHAW POTASSIUM CHANNEL; ZINC;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM; SPIKE WAVE;

ANIMALS; BINDING SITES; CELLS, CULTURED; CEREBELLUM; EMBRYO, MAMMALIAN; HEK293 CELLS; HIPPOCAMPUS; HUMANS; NEURONS; PROTEIN TRANSPORT; RATS; SHAW POTASSIUM CHANNELS; ZINC;

EID: 84877811718     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.251983     Document Type: Article

References (54)

1. 2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia. Eur J Neurosci 30, 2250-2257.
2. Bardoni R & Belluzzi O (1994). Modifications of A-current kinetics in mammalian central neurones induced by extracellular zinc. J Physiol 479, 389-400.
3. Barry J, Gu Y & Gu C (2010). Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro. Eur J Neurosci 32, 1618-1631.
4. Bean BP (2007). The action potential in mammalian central neurons. Nat Rev Neurosci 8, 451-465.
5. + channels. Nat Struct Biol 6, 38-43.
6. Cushman SJ, Nanao MH, Jahng AW, DeRubeis D, Choe S & Pfaffinger PJ (2000). Voltage dependent activation of potassium channels is coupled to T1 domain structure. Nat Struct Biol 7, 403-407.
7. 2+. FEBS Lett 576, 237-244.
8. Frederickson CJ, Koh JY & Bush AI (2005). The neurobiology of zinc in health and disease. Nat Rev Neurosci 6, 449-462.
9. Galasso SL & Dyck RH (2007). The role of zinc in cerebral ischemia. Mol Med 13, 380-387.
10. Grigg JJ, Brew HM & Tempel BL (2000). Differential expression of voltage-gated potassium channel genes in auditory nuclei of the mouse brainstem. Hear Res 140, 77-90.
11. Gu C & Barry J (2011). Function and mechanism of axonal targeting of voltage-sensitive potassium channels. Prog Neurobiol 94, 115-132.
12. Gu C & Gu Y (2011). Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons. J Biol Chem 286, 25835-25847.
13. + channel axonal targeting. Neuron 52, 803-816.
14. Gu Y, Barry J, McDougel R, Terman D & Gu C (2012). Alternative splicing regulates Kv3.1 polarized targeting to adjust maximal spiking frequency. J Biol Chem 287, 1755-1769.
15. Gu Y & Gu C (2010). Dynamics of Kv1 channel transport in axons. PLoS One 5.
16. Harrison NL, Radke HK, Talukder G & Ffrench-Mullen JM (1993). Zinc modulates transient outward current gating in hippocampal neurons. Receptors Channels 1, 153-163.
17. Hershfinkel M, Kandler K, Knoch ME, Dagan-Rabin M, Aras MA, Abramovitch-Dahan C, Sekler I & Aizenman E (2009). Intracellular zinc inhibits KCC2 transporter activity. Nat Neurosci 12, 725-727.
18. Horning MS & Trombley PQ (2001). Zinc and copper influence excitability of rat olfactory bulb neurons by multiple mechanisms. J Neurophysiol 86, 1652-1660.
19. + channel via an intracellular domain. J Biol Chem 285, 6434-6442.
20. Hu H, Bandell M, Petrus MJ, Zhu MX & Patapoutian A (2009). Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol 5, 183-190.
21. Huang EP (1997). Metal ions and synaptic transmission: think zinc. Proc Natl Acad Sci U S A 94, 13386-13387.
22. + channel Kv1.4-Kv1.1/Kvβ1.1. Am J Physiol Cell Physiol 292, C778-C787.
23. Jahng AW, Strang C, Kaiser D, Pollard T, Pfaffinger P & Choe S (2002). Zinc mediates assembly of the T1 domain of the voltage-gated K channel 4.2. J Biol Chem 277, 47885-47890.
24. Jiang Q, Inoue K, Wu X, Papasian CJ, Wang JQ, Xiong ZG & Chu XP (2011). Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition. Neuroscience 193, 89-99.
25. Kay AR & Toth K (2008). Is zinc a neuromodulator Sci Signal 1, re3.
26. 2+. J Physiol 541, 9-24.
27. Kobrinsky E, Stevens L, Kazmi Y, Wray D & Soldatov NM (2006). Molecular rearrangements of the Kv2.1 potassium channel termini associated with voltage gating. J Biol Chem 281, 19233-19240.
28. Kunjilwar K, Strang C, DeRubeis D & Pfaffinger PJ (2004). KChIP3 rescues the functional expression of Shal channel tetramerization mutants. J Biol Chem 279, 54542-54551.
29. + current: fast and selective binding to the deactivated channels. Biophys J 77, 2552-2562.
30. Li M, Jan YN & Jan LY (1992). Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science 257, 1225-1230.
31. Lin DD, Cohen AS & Coulter DA (2001). Zinc-induced augmentation of excitatory synaptic currents and glutamate receptor responses in hippocampal CA3 neurons. J Neurophysiol 85, 1185-1196.
32. B receptors in rat hippocampus. Eur J Pharmacol 211, 337-341.
33. Lvov A, Greitzer D, Berlin S, Chikvashvili D, Tsuk S, Lotan I & Michaelevski I (2009). Rearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gating. J Biol Chem 284, 28276-28291.
34. Mathie A, Sutton GL, Clarke CE & Veale EL (2006). Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther 111, 567-583.
35. 2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. J Neurosci 29, 1105-1114.
36. Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY & Berger JM (2000). The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102, 657-670.
37. Nanao MH, Zhou W, Pfaffinger PJ & Choe S (2003). Determining the basis of channel-tetramerization specificity by x-ray crystallography and a sequence-comparison algorithm: Family Values (FamVal). Proc Natl Acad Sci U S A 100, 8670-8675.
38. + channels. Pflugers Arch 462, 331-347.
39. Pithadia AS & Lim MH (2012). Metal-associated amyloid-β species in Alzheimer's disease. Curr Opin Chem Biol 16, 67-73.
40. + channels: subunit selective antagonism by zinc. Neuropharmacology 35, 969-982.
41. ATP channel function. J Physiol 559, 157-167.
42. Puopolo M & Belluzzi O (1998). Functional heterogeneity of periglomerular cells in the rat olfactory bulb. Eur J Neurosci 10, 1073-1083.
43. + channels designed for high-frequency repetitive firing. Trends Neurosci 24, 517-526.
44. Sensi SL, Paoletti P, Bush AI & Sekler I (2009). Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci 10, 780-791.
45. 2+ ions: modulators of excitatory and inhibitory synaptic activity. Neuroscientist 10, 432-442.
46. Wang G, Shahidullah M, Rocha CA, Strang C, Pfaffinger PJ & Covarrubias M (2005). Functionally active T1-T1 interfaces revealed by the accessibility of intracellular thiolate groups in Kv4 channels. J Gen Physiol 126, 55-69.
47. 2+-dependent redox switch in the intracellular T1-T1 interface of a Kv channel. J Biol Chem 282, 13637-13647.
48. + channels in the rat central nervous system. J Neurosci 14, 949-972.
49. 2+: a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci 21, 395-401.
50. Xu J, Yu W, Jan YN, Jan LY & Li M (1995). Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the α-subunits. J Biol Chem 270, 24761-24768.
51. Xu M, Cao R, Xiao R, Zhu MX & Gu C (2007). The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G. J Neurosci 27, 14158-14170.
52. Xu M, Gu Y, Barry J & Gu C (2010). Kinesin I transports tetramerized Kv3 channels through the axon initial segment via direct binding. J Neurosci 30, 15987-16001.
53. Zhang S, Kehl SJ & Fedida D (2001). Modulation of Kv1.5 potassium channel gating by extracellular zinc. Biophys J 81, 125-136.
54. + channels through direct binding to S4. Biophys J 97, 110-120.