Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 3022-3031

  Basiri, Alireza ^a   Murugaiyah, Vikneswaran ^a   Osman, Hasnah ^b   Kumar, Raju Suresh ^c   Kia, Yalda ^b   Ali, Mohamed Ashraf ^d  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b SCHOOL OF PHYSICS   (Malaysia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

Author keywords

AChE and BChE activity; Microwave assisted synthesis; Molecular docking; Pyridopyrimidines

Indexed keywords

4 (NAPHTHALEN 1 YL) 8 (NAPHTHALEN 1 YLMETHYLENE) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (2 CHLOROBENZYLIDENE) 4 (2 CHLOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (2 CHLOROBENZYLIDENE) 4 (2 CHLOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (2 FLUOROBENZYLIDENE) 4 (2 FLUOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (2 FLUOROBENZYLIDENE) 4 (2 FLUOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (2 METHOXYBENZYLIDENE) 4 (2 METHOXYPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (2 METHOXYBENZYLIDENE) 4 (2 METHOXYPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (2 METHYLBENZYLIDENE) 4 TOLYL 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (2 METHYLBENZYLIDENE) 4 TOLYL 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) THIONE; 8 (2,4 DICHLOROBENZYLIDENE) 4 (2,4 DICHLOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (2,4 DICHLOROBENZYLIDENE) 4 (2,4 DICHLOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (2,4 DICHLOROBENZYLIDENE) 4 (4 FLUOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (3 NITROBENZYLIDENE) 4 (3 NITROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (3 NITROBENZYLIDENE) 4 (3 NITROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (4 BROMOBENZYLIDENE) 4 (4 BROMOPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (4 BROMOBENZYLIDENE) 4 (4 BROMOPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (4 CHLOROBENZYLIDENE) 4 (4 CHLOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (4 CHLOROBENZYLIDENE) 4 (4 CHLOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (4 FLUOROBENZYLIDENE) 4 (4 FLUOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (4 FLUOROBENZYLIDENE) 4 (4 FLUOROPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (4 METHYLBENZYLIDENE) 4 TOLYL 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 (4 METHYLBENZYLIDENE) 4 TOLYL 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 BENZYLIDENE 4 PHENYL 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) ONE; 8 BENZYLIDENE 4 PHENYL 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDIN 2(1H) THIONE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; GALANTAMINE; PYRIDOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HYDROPHOBICITY; MICROWAVE RADIATION; MOLECULAR DOCKING; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY; THREE DIMENSIONAL IMAGING; TORPEDO CALIFORNICA;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; GALANTAMINE; HUMANS; MICROWAVES; MOLECULAR DOCKING SIMULATION; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TORPEDO;

TORPEDO CALIFORNICA;

EID: 84877808336     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.058     Document Type: Article

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