The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: Comparison of the N-in-one and single substrate approaches

Toxicology in Vitro

Volumn 27, Issue 5, 2013, Pages 1584-1588

  Abass, Khaled ^a,b   Pelkonen, Olavi ^a  

^a UNIVERSITY OF OULU   (Finland)

^b MENOUFIA UNIVERSITY   (Egypt)

Author keywords

Cytochrome P450; Human hepatic microsomes; Inhibitory interactions; LC MS MS; N in one assay; Pesticides; Single substrate assay

Indexed keywords

CHLORPYRIFOS; CIPERMETHRIN; CYHALOTHRIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DELTAMETHRIN; FENITROTHION; FENVALERATE; MIDAZOLAM; OMEPRAZOLE; ORGANOPHOSPHATE PESTICIDE; PESTICIDE; PROFENOFOS; PYRETHROID;

ARTICLE; CHEMOSENSITIVITY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; IC 50; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; N IN ONE ASSAY; RELIABILITY; SCREENING; SINGLE SUBSTRATE ASSAY; SULFOXIDATION; TANDEM MASS SPECTROMETRY;

BIOLOGICAL ASSAY; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; MICROSOMES, LIVER; PESTICIDES;

EID: 84877792756     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.05.003     Document Type: Article

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