The perioperative use of nitrous oxide: Renaissance of an old gas or funeral of an ancient relict?

Current Opinion in Anaesthesiology

Volumn 26, Issue 3, 2013, Pages 354-360

  Schallner, Nils ^a   Goebel, Ulrich ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Adverse effects; Analgesia; Nitrous oxide; Perioperative period

Indexed keywords

ANALGESIC AGENT; HOMOCYSTEINE; METHIONINE; NITROUS OXIDE; SEDATIVE AGENT; ANXIOLYTIC AGENT; INHALATION ANESTHETIC AGENT;

ANESTHESIA; ANESTHESIA LEVEL; CARDIOVASCULAR DISEASE; CEREBROVASCULAR DISEASE; DRUG MECHANISM; DRUG METABOLISM; ELECTROENCEPHALOGRAM; FEVER; GENERAL ANESTHESIA; HEALTH HAZARD; HISTORY; HUMAN; IMMUNE SYSTEM; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; INTENSIVE CARE UNIT; LENGTH OF STAY; MEDICAL LITERATURE; NAUSEA; NEUROTOXICITY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; PERIOPERATIVE PERIOD; PEROPERATIVE COMPLICATION; PNEUMONIA; POSTHUMOUS CARE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; THROAT DISEASE; TREATMENT OUTCOME; VOMITING; ANESTHESIOLOGY; DRUG EFFECTS; INTRAOPERATIVE AWARENESS; METABOLISM;

ANALGESICS; ANESTHESIOLOGY; ANESTHETICS, INHALATION; ANTI-ANXIETY AGENTS; HOMOCYSTEINE; HUMANS; IMMUNE SYSTEM; INTRAOPERATIVE AWARENESS; METHIONINE; NITROUS OXIDE; OCCUPATIONAL EXPOSURE; PERIOPERATIVE CARE;

EID: 84877760551     PISSN: 09527907     EISSN: 14736500     Source Type: Journal    
DOI: 10.1097/ACO.0b013e32835f8151     Document Type: Review

References (67)

1. Drummond GB, Fisher L, Pumphrey O, Kennedy RR. Direct Measurement of nitrous Oxide Kinetics. Br J Anaesth 2012; 109:776-781
2. Lee SY, Cheng SL, Ng SB, Lim SL. Single-breath vital capacity high concentration sevoflurane induction in children: With or without nitrous oxide? Br J Anaesth 2013; 110:81-6
3. Peyton PJ, Chao I,Weinberg L, et al. Nitrous oxide diffusion and the second gas effect on emergence from anesthesia. Anesthesiology 2011; 114:596-602
4. Smith I. Nitrous oxide in ambulatory anaesthesia: Does it have a place in day surgical anaesthesia or is it just a threat for personnel and the global environment? Curr Opin Anaesthesiol 2006; 19:592-596
5. Kwak HJ, Kim JY, Min SK, et al. Optimal Bolus dose of alfentanil for successful tracheal intubation during sevoflurane induction with and without nitrous oxide in children. Br J Anaesth 2010; 104:628-632
6. Hennequin M, Collado V, Faulks D, et al. A clinical trial of efficacy and safety of inhalation sedation with a 50% nitrous oxide/oxygen premix (kalinox) in general practice. Clin Oral Investig 2012; 16:633-642
7. Sharma S, Sharma D, Jain A, Jain A. Effect of nitrous oxide on pain due to rocuronium injection: A randomised, double-blind, controlled clinical trial. Indian J Anaesth 2010; 54:142-146
8. Reinoso-Barbero F, Pascual-Pascual SI, de Lucas R, et al. Equimolar nitrous oxide/oxygen versus placebo for procedural pain in children: A randomized trial. Pediatrics 2011; 127:e1464-e1470
9. Zier JL, Liu M. Safety of high-Concentration nitrous Oxide by nasal Mask for pediatric procedural Sedation: Experience with 7802 Cases. Pediatr Emerg Care 2011; 27:1107-1112
10. Ekbom K, Kalman S, Jakobsson J, Marcus C. Efficient intravenous Access without Distress: A double-blind randomized Study of Midazolam and nitrous Oxide in Children and Adolescents. Arch Pediatr Adolesc Med 2011; 165:785-791
11. Pita CP, Pazmino S, Vallejo M, et al. Inhaled intrapartum Analgesia using a 50-50% Mixture of nitrous Oxide-Oxygen in a low-Income Hospital Setting. Arch Gynecol Obstet 2012; 286:627-631
12. Young A, Ismail M, Papatsoris AG, et al. Entonox(R) inhalation to reduce pain in common diagnostic and therapeutic outpatient urological procedures: A review of the evidence. Ann R Coll Surg Engl 2012; 94:8-11
13. Kariman H, Majidi A, Amini A, et al. Nitrous oxide/oxygen compared with fentanyl in reducing pain among adults with isolated extremity trauma: A randomized trial. Emerg Med Australas 2011; 23:761-768
14. Myles PS, Leslie K, Chan MT, et al. Avoidance of nitrous oxide for patients undergoing major surgery: A randomized controlled trial. Anesthesiology 2007; 107:221-231
15. Graham AM, Myles PS, Leslie K, et al. A Cost-Benefit Analysis of the ENIGMA Trial. Anesthesiology 2011; 115:265-272
16. Leslie K, Myles PS, Chan MT, et al. Nitrous oxide and long-Term morbidity and mortality in the ENIGMA trial. Anesth Analg 2011; 112:387-393
17. Sanders RD, Graham C, Lewis SC, et al. Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: A nonrandomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid Surgery (GALA) trial. Br J Anaesth 2012; 109:361-367
18. McGregor DG, Lanier WL, Pasternak JJ, et al. Effect of nitrous oxide on neurologic and neuropsychological function after intracranial aneurysm surgery. Anesthesiology 2008; 108:568-579
19. Pasternak JJ, McGregor DG, Lanier WL, et al. Effect of nitrous oxide use on long-Term neurologic and neuropsychological outcome in patients who received temporary proximal artery occlusion during cerebral aneurysm clipping surgery. Anesthesiology 2009; 110:563-573
20. Turan A, Mascha EJ, You J, et al. The Association between nitrous oxide and postoperative mortality and morbidity after noncardiac surgery. Anesth Analg 2012 [Epub ahead of print]. doi:10.1213/ANE.0b013e31824590a5
21. Myles PS, Leslie K, Peyton P, et al. Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) trial: Rationale and design. Am Heart J 2009; 157:488-494
22. Mraovic B, Simurina T, Sonicki Z, et al. The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: A preliminary study. Anesth Analg 2008; 107:818-823
23. Chung JH, Kim YH, Ko YK, et al. Vomiting after a pediatric adenotonsillectomy: Comparison between propofol induced sevoflurane-nitrous oxide maintained anesthesia and TIVA with propofol-remifentanil. Korean J Anesthesiol 2010; 59:185-189
24. Leslie K, Myles PS, Chan MT, et al. Risk Factors for severe postoperative nausea and vomiting in a randomized trial of nitrous oxide-based vs nitrous oxide-free anaesthesia. Br J Anaesth 2008; 101:498-505
25. Park SK, Cho EJ. A randomized controlled trial of two different interventions for the prevention of postoperative nausea and vomiting: Total intravenous anaesthesia using propofol and remifentanil versus prophylactic palonosetron with inhalational anaesthesia using sevoflurane-nitrous oxide. J Int Med Res 2011; 39:1808-1815
26. Lalwani K, Fox EB, Fu R, et al. The effect of nitrous oxide on intra-ocular pressure in healthy adults. Anaesthesia 2012; 67:256-260
27. Chen BZ, Luo LH, Jiang L, et al. The effect of nitrous oxide on intracuff pressure of the size 2 proseal laryngeal mask airway. J Clin Anesth 2011; 23:214-217
28. Tramer M, Moore A, McQuay H. Omitting nitrous oxide in general anaesthesia: Meta-Analysis of intraoperative awareness and postoperative emesis in randomized controlled trials. Br J Anaesth 1996; 76:186-193
29. Ghoneim MM, Block RI, Haffarnan M, Mathews MJ. Awareness during anesthesia: Risk factors, causes and sequelae: A review of reported cases in the literature. Anesth Analg 2009; 108:527-535
30. Prabhakar H, Ali Z, Bithal PK, et al. EEG entropy values during isoflurane, sevoflurane and halothane anesthesia with and without nitrous oxide. J Neurosurg Anesthesiol 2009; 21:108-111
31. Foster BL, Liley DT. Nitrous oxide paradoxically modulates slow electroencephalogram oscillations: Implications for anesthesia monitoring. Anesth Analg 2011; 113:758-765
32. Hagihira S, Takashina M, Mori T, Mashimo T. The Impact of nitrous oxide on electroencephalographic bicoherence during isoflurane anesthesia. Anesth Analg 2012; 115:572-577
33. Foster BL, Liley DT. Effects of nitrous oxide sedation on resting electroencephalogram topography. Clin Neurophysiol 2013; 124:417-423
34. Schmitt EL, Baum VC. Nitrous oxide in pediatric anesthesia: Friend or foe? Curr Opin Anaesthesiol 2008; 21:356-359
35. Pasternak JJ, Lanier WL. Is nitrous oxide use appropriate in neurosurgical and neurologically at-risk patients? Curr Opin Anaesthesiol 2010; 23:544-550
36. Zhen Y, Dong Y, Wu X, et al. Nitrous oxide plus isoflurane induces apoptosis and increases beta-Amyloid protein levels. Anesthesiology 2009; 111:741-752
37. Cattano D, Valleggi S, Abramo A, et al. Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Minerva Anestesiol 2010; 76:420-424
38. Lehmberg J, Waldner M, Baethmann A, Uhl E. Inflammatory response to nitrous oxide in the central nervous system. Brain Res 2008; 1246: 88-95
39. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med 1998; 4:460-463
40. Ma D, Williamson P, Januszewski A, et al. Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology 2007; 106:746-753
41. Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al. Early Exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 2003; 23:876-882
42. Haelewyn B, David HN, Colloc'h N, et al. Interactions between nitrous oxide and tissue plasminogen activator in a rat model of thromboembolic stroke. Anesthesiology 2011; 115:1044-1053
43. Reinstrup P, Ryding E, Ohlsson T, et al. Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans. Br J Anaesth 2008; 100:66-71
44. Myles PS, Chan MT, Leslie K, et al. Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery. Br J Anaesth 2008; 100:780-786
45. Nagele P, Tallchief D, Blood J, et al. Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesth Analg 2011; 113:843-848
46. Pichardo D, Luginbuehl IA, Shakur Y, et al. Effect of nitrous Oxide Exposure during Surgery on the Homocysteine Concentrations of Children. Anesthesiology 2012; 117:15-21
47. Myles PS, Chan MT, Kaye DM, et al. Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function. Anesthesiology 2008; 109:657-663
48. Rao LK, Francis AM, Wilcox U, et al. Preoperative vitamin B Infusion and prevention of nitrous oxide-induced homocysteine increase. Anaesthesia 2010; 65:710-715
49. Sawamura S, Obara M, Takeda K, et al. Corticotropin-releasing factor mediates the antinociceptive action of nitrous oxide in rats. Anesthesiology 2003; 99:708-715
50. Koyanagi S, Himukashi S, Mukaida K, et al. Dopamine D2-like receptor in the nucleus accumbens is involved in the antinociceptive effect of nitrous oxide. Anesth Analg 2008; 106:1904-1909
51. Ohgami Y, Chung E, Quock RM. Nitrous oxide-induced NO-dependent neuronal release of beta-endorphin from the rat arcuate nucleus and periaqueductal gray. Brain Res 2010; 1366:38-43
52. Cope JL, Chung E, Ohgami Y, Quock RM. Antagonism of the antinociceptive effect of nitrous oxide by inhibition of enzyme activity or expression of neuronal nitric oxide synthase in the mouse brain and spinal cord. Eur J Pharmacol 2010; 626:234-238
53. Zhang Y, Quock LP, Chung E, et al. Involvement of a NO-cyclic GMP-PKG Signaling pathway in nitrous oxide-induced antinociception in mice. Eur J Pharmacol 2011; 654:249-253
54. Chan MT, Wan AC, Gin T, et al. Chronic postsurgical pain after nitrous oxide anesthesia. Pain 2011; 152:2514-2520
55. Stiglitz DK, Amaratunge LN, Konstantatos AH, Lindholm DE. Intraoperative nitrous oxide as a preventive analgesic. Anaesth Intensive Care 2010; 38:890-893
56. Echevarria G, Elgueta F, Fierro C, et al. Nitrous oxide (N(2)O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans. Br J Anaesth 2011; 107:959-965
57. Hierons RJ, Dorman ML, Wilson K, et al. Investigation of inhalational conscious sedation as a tool for reducing anxiety in adults undergoing exodontia.Br Dent J 2012; 213:E9
58. Bessiere B, Laboureyras E, Chateauraynaud J, et al. A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats. J Pain 2010; 11:13-23
59. Bessiere B, Laboureyras E, Ben Boujema M, et al. A high-dose of fentanyl induced delayed anxiety-like behavior in rats. prevention by a NMDA receptor antagonist and nitrous oxide (N(2)O). Pharmacol Biochem Behav 2012; 102:562-568
60. Schneemilch CE, Hachenberg T, Ansorge S, et al. Effects of different anaesthetic agents on immune cell function in vitro. Eur J Anaesthesiol 2005; 22:616-623
61. Nunn JF, O'Morain C. Nitrous oxide decreases motility of human neutrophils in vitro. Anesthesiology 1982; 56:45-48
62. Fleischmann E, Lenhardt R, Kurz A, et al. Nitrous oxide and risk of surgical wound infection: A randomised trial. Lancet 2005; 366:1101-1107
63. Greif R, Akca O, Horn EP, et al. Supplemental perioperative oxygen to reduce the incidence of surgical-wound infection. N Engl J Med 2000; 342:161-167
64. Fleischmann E, Marschalek C, Schlemitz K, et al. Nitrous oxide may not increase the risk of cancer recurrence after colorectal surgery: A follow-up of a randomized controlled trial. BMC Anesthesiol 2009; 9:1
65. Krajewski W, Kucharska M, Pilacik B, et al. Impaired vitamin B12 metabolic status in healthcare workers occupationally exposed to nitrous oxide. Br J Anaesth 2007; 99:812-818
66. Wronska-Nofer T, Palus J, Krajewski W, et al. DNA damage induced by nitrous oxide: Study in medical personnel of operating rooms. Mutat Res 2009; 666:39-43
67. Wronska-Nofer T, Nofer JR, Jajte J, et al. Oxidative DNA damage and oxidative stress in subjects occupationally exposed to nitrous oxide (N(2)O). Mutat Res 2012; 731:58-63