Effects of different anaesthetic agents on immune cell function in vitro

European Journal of Anaesthesiology

Volumn 22, Issue 8, 2005, Pages 616-623

  Schneemilch, Christine E ^a   Hachenberg, T ^a   Ansorge, S ^b   Ittenson, A ^b   Bank, U ^c  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b Institute of Medical Technology   (Germany)

^c Institute of Immunology   (Germany)

Author keywords

Anaesthetics inhalational, sevoflurane, nitrous oxide; Anaesthetics intravenous, propofol, thiopental; Analgesics opioid, fentanyl, sufentanil; Cell proliferation, human mononuclear; Cytokines; Lymphocyte activation

Indexed keywords

ANESTHETIC AGENT; FENTANYL; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; NITROUS OXIDE; PHYTOHEMAGGLUTININ; PROPOFOL; SEVOFLURANE; SUFENTANIL; THIOPENTAL; THYMIDINE;

ADULT; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENZYME IMMUNOASSAY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL;

ADULT; ANESTHETICS; ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; HUMANS; IMMUNITY, CELLULAR; INTERLEUKIN-2; MIDDLE AGED; MONOCYTES; PHYTOHEMAGGLUTININS; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES;

EID: 23244448740     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0265021505001031     Document Type: Article

References (38)

1. Salo M. Effects of anaesthesia and surgery on the immune response. Acta Anaesthesiol Scand 1992; 36: 201-220.
2. McBride WT, Armstrong MA, McBride SJ. Immunomodulation: an important concept in modern anaesthesia. Anaesthesia 1996; 51: 465-473.
3. Correa-Sales C, Tosta CE, Rizzo LV. The effects of anesthesia with thiopental on T lymphocyte responses to antigen and mitogens in vivo and in vitro. Int J Immunopharmacol 1997; 19: 117-128.
4. Hamra JG, Yaksh TL. Halothane inhibits T cell proliferation and interleukin-2 receptor expression in rats. Immunopharmacol Immunotoxicol 1996; 18: 323-336.
5. Mikawa K, Akamatsu H, Nishina K et al. Propofol inhibits human neutrophil functions. Anesth Analg 1998; 87: 695-700.
6. Galley HF, Webster NR. Effects of propofol and thiopentone on the immune response. Anaesthesia 1994; 52: 921-923.
7. Angele MK, Faist E. Clinical review: immunodepression in the surgical patient and increased susceptibility to infections. Crit Care 2002; 6: 298-305.
8. Devlin EG, Clarke RSJ, Mirakhur RK, McNeil TA. Effects of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro. Br J Anaesth 1994; 73: 315-317.
9. Spiers EM, Potts RC, Simpson JR, MacConnachie A, Beck JS. Mechanisms by which barbiturates suppress lymphocyte responses to phytohaemagglutinin stimulation. Int J Pharmacol 1987; 9: 505-512.
10. Devlin EG, Clarke RSJ, Mirakhur RK, McNeill TA. The effects of thiopentone and propofol on delayed hypersensitivity reactions. Anaesthesia 1995; 50: 496-498.
11. Hensler T, Hecker H, Heeg K et al. Distinct mechanisms of immunosuppression as a consequence of major surgery. Infect Immun 1997; 65: 2283-2291.
12. Stover JF, Stocker R. Barbiturate coma may promote reversible bone marrow suppression in patients with severe isolated traumatic brain injury. Eur J Clin Pharmacol 1998; 54: 529-534.
13. Eberhardt KE, Thimm BM, Spring A, Maskos WR. Dose-dependent rate of nosocomial pulmonary infection in mechanically ventilated patients with brain oedema receiving barbiturates: a prospective case study. Infection 1992; 20: 12-18.
14. Briggs WA, Eustace J, Gimenez LF, Choi MJ, Scheel Jr PJ, Burdick JF. Lymphocyte suppression by glucocorticoids with cyclosporine, tacrolimus, pentoxifylline, and mycophenolic acid. J Clin Pharmacol 1999; 39: 125-130.
15. Hanisch UK, Quirion R. Interleukin-2 as a neuroregulatory cytokine. Br Res Rev 1996; 21: 246-284.
16. Yang KD, Liou WY, Lee CS, Chu ML, Shaio MF. Effects of phenobarbital on leukocyte activation: membrane potential, actin polymerization, chemotaxis, respiratory burst, cytokine production, and lymphocyte proliferation. J Leukoc Biol 1992; 52: 151-156.
17. Loop T, Liu Z, Humar M et al. Thiopental inhibits the activation of nuclear factor kappaB. Anesthesiology 2002; 96: 1202-1213.
18. Le Grue SJ, Munn CG. Comparison of the immunosuppressive effects of cyclosporine, lipid-soluble anesthetics, and calmodulin antagonists. Response to exogenous interleukin 2. Transplantation 1986; 42: 679-685.
19. Salo M, Pirttikangas CO, Pulkki K. Effects of propofol emulsion and thiopentone on T helper cell type-1/type-2 balance in vitro. Anaesthesia 1997; 52: 341-344.
20. Pirttikangas CO, Perttila J, Salo M. Propofol emulsion reduces proliferative responses of lymphocytes from intensive care patients. Intens Care Med 1993; 19: 299-302.
21. Galley HF, Nelson LR, Webster NR. Anaesthetic agents decrease the activity of nitric oxidase synthase from human polymorphonuclear leukocytes. Br J Anaesth 1995; 75: 326-329.
22. Humar M, Pischke SE, Loop T et al. Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells. Mol Pharmacol 2004; 65: 350-361.
23. Tian J, Chau C, Hales TG, Kaufmann DL. GABA(A) receptors mediate inhibition of T cell responses. J Neuroimmunol 1999; 96: 21-28.
24. McCarthy L, Wetzel M, Sliker JK, Eisenstein TK, Rogers TJ. Opioids, opioid receptors, and the immune response. Drug Alcohol Depend 2001; 62: 111-123.
25. Welters ID, Menzebach A, Goumon Y et al. Morphine inhibits NF-κB nuclear binding in human neutrophils and monocytes by a nitric oxide dependent mechanism. Anesthesiology 2000; 92: 1677-1684.
26. Bidlack JM. Detection and function of opioid receptors on cells from the immune system. Clin Diagn Lab Immunol 2000; 7: 719-723.
27. Yeager MP, Procopio MA, DeLeo JA, Arruda JL, Hildebrandt L, Howell AL. Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humans. Anesth Analg 2002; 94: 94-99.
28. Jacobs R, Karst M, Scheinichen D et al. Effects of fentanyl on cellular immune functions in man. Int J Immunopharmacol 1999; 21: 445-454.
29. Bruce DL. Halothane inhibition of RNA and protein synthesis of PHA-induced human lymphocytes. Anesthesiology 1975; 42: 11-14.
30. Mitsuhata H, Shimizu R, Yokoyama MM. Suppressive effects of volatile anaesthetics on cytokine release in human peripheral blood mononuclear cells. Int J Immunopharmacol 1995; 17: 529-534.
31. De Hert SG, Ten Broecke PW, Mertens E et al. Sevoflurane but not propofol preserves myocardial function in coronary surgery patients. Anesthesiology 2002; 97: 42-49.
32. Horn NA, de Rossi L, Robitzsch T, Hecker KE, Hutschenreuter G, Rossiant R. The effects of sevoflurane and desflurane in vitro on platelet-leukocyte adhesion in whole blood. Anaesthesia 2003; 58: 312-319.
33. Matsuoka H, Kurosawa S, Horinouchi T, Kato M, Hashimoto Y. Inhalation anesthetics induce apoptosis in normal peripheral lymphocytes in vitro. Anesthesiology 2001; 95: 1467-1472.
34. Loop T, Scheiermann P, Doviakue D et al. Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway. Anesthesiology 2004; 101: 710-721.
35. Stevenson GW, Hall SC, Rudnick S, Seleny FL, Stevenson HC. The effect of anaesthetic agents on the human immune response. Anesthesiology 1990; 72: 542-552.
36. Ferrero E, Ferrero ME, Marni A et al. In vitro effects of halothane on lymphocytes. Eur J Anaesthesiol 1986; 3: 321-330.
37. Tschaikowsky K, Ritter J, Schröppel K, Kühn M. Volatile anesthetics differentially affect immunostimulated expression of inducible nitric oxide synthase: role of intracellular calcium. Anesthesiology 2000; 92: 1093-1102.
38. Nakamura K, Terasako K, Toda H et al. Mechanisms of inhibition of endothelium-dependent relaxation by halothane, isoflurane, and sevoflurane. Can J Anaesth 1994; 41: 340-346.