Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery

British Journal of Anaesthesia

Volumn 100, Issue 6, 2008, Pages 780-786

  Myles, P S ^a   Chan, M T V ^b   Leslie, K ^c   Peyton, P ^d   Paech, M ^e,f   Forbes, A ^a  

^a MONASH UNIVERSITY   (Australia)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d AUSTIN HOSPITAL   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f KING EDWARD MEMORIAL HOSPITAL   (Australia)

Author keywords

Anaesthetic gases, nitrous oxide; Complications, postoperative; Metabolism, folic acid; Metabolism, homocysteine; Surgery, postoperative period

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; NITROUS OXIDE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR RISK; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINAEMIA; MAJOR CLINICAL STUDY; MAJOR SURGERY; MALE; MORBIDITY; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RISK FACTOR;

EID: 44649178695     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aen085     Document Type: Article

References (29)

1. Lumb M, Deacon R, Perry J, et al. The effect of nitrous oxide inactivation of vitamin B12 on rat hepatic folate. Implications for the methylfolate-trap hypothesis. Biochem J 1980; 186: 933-6
2. Lumb M, Perry J, Deacon R, Chanarin I. Recovery of tissue folates after inactivation of cobalamin by nitrous oxide. The significance of dietary folate. Am J Clin Nutr 1981; 34: 2418-22
3. Nunn JF. Clinical aspects of the interaction between nitrous oxide and vitamin B12. Br J Anaesth 1987; 59: 3-13
4. Ermens AA, Refsum H, Rupreht J, et al. Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine. Clin Pharmacol Ther 1991; 49: 385-93
5. Horne DW, Holloway RS. Compartmentation of folate metabolism in rat pancreas: nitrous oxide inactivation of methionine synthase leads to accumulation of 5-methyltetrahydrofolate in cytosol. J Nutr 1997; 127: 1772-5
6. Amos RJ, Amess JA, Hinds CJ, Mollin DL. Incidence and pathogenesis of acute megaloblastic bone marrow change in patients receiving intensive care. Lancet 1982; 2: 835-8
7. Lee P, Smith I, Piesowicz A, Brenton D. Spastic paraparesis after anaesthesia. Lancet 1999; 353: 554
8. Rosener M, Dichgans J. Severe combined degeneration of the spinal cord after nitrous oxide anaesthesia in a vegetarian. J Neurol Neurosurg Psychiatry 1996; 60: 354
9. Ogundipe O, Pearson MW, Slater NG, Adepegba T, Westerdale N. Sickle cell disease and nitrous oxide-induced neuropathy. Clin Lab Haematol 1999; 21: 409-12
10. Marie RM, Le Biez E, Busson P, et al. Nitrous oxide anesthesia-associated myelopathy. Arch Neurol 2000; 57: 380-5
11. Deleu D, Louon A, Sivagnanam S, et al. Long-term effects of nitrous oxide anaesthesia on laboratory and clinical parameters in elderly Omani patients: a randomized double-blind study. J Clin Pharm Ther 2000; 25: 271-7
12. Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: a risk factor for vascular disease. N Engl J Med 1991; 324: 1149-55
13. Quere I, Perneger TV, Zittoun J, et al. Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study. Lancet 2002; 359: 747-52
14. Mayer EL, Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol 1996; 27: 517-27
15. Hankey GJ, Eikelboom JW, Ho WK, van Bockxmeer FM. Clinical usefulness of plasma homocysteine in vascular disease. Med J Aust 2004; 181: 314-8
16. Faraci FM, Lentz SR. Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke 2004; 35: 345-7
17. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br Med J 2002; 325: 1202-6
18. Loscalzo J. Homocysteine and dementias. N Engl J Med 2002; 346: 466-8
19. Badner NH, Drader K, Freeman D, Spence JD. The use of intraoperative nitrous oxide leads to postoperative elevations in plasma homocysteine. Anesth Analg 1998; 87: 711-3
20. Foschi D, Rizzi A, Zighetti ML, et al. Effects of surgical stress and nitrous oxide anaesthesia on peri-operative plasma levels of total homocysteine. A randomised, controlled study in general surgery. Anaesthesia 2001; 56: 676-9
21. Badner NH, Beattie WS, Freeman D, Spence JD. Nitrous oxide-induced elevated homocysteine concentrations are associated with increased myocardial ischemia in patients undergoing carotid endarterectomy. Anesth Analg 2000; 91: 1073-9
22. Myles PS, Leslie K, Chan MTV, et al. Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial. Anesthesiology 2007; 107: 221-31
23. Myles PS, Chan MT, Forbes A, Leslie K, Paech M, Peyton P. Preoperative folate and homocysteine status in patients undergoing major surgery. Clin Nutr 2006; 25: 736-45
24. Chambers JC, McGregor A, Jean-Marie J, et al. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 1999; 99: 1156-60
25. Rosenberg IH, Bowman BB, Cooper BA, Halsted C, Lindenbaum J. Folate nutrition in the elderly. Am J Clin Nutr 1982; 36: 1060-6
26. Badner NH, Freeman D, Spence JD. Preoperative oral B vitamins prevent nitrous oxide-induced postoperative plasma homocysteine increases. Anesth Analg 2001; 93: 1507-10
27. Amos RJ, Amess JA, Nancekievill DG, Rees GM. Prevention of nitrous oxide-induced megaloblastic changes in bone marrow using folinic acid. Br J Anaesth 1984; 56: 103-7
28. Banerjee RV, Matthews RG. Cobalamin-dependent methionine synthase. FASEB J 1990; 4: 1450-9
29. Stenqvist O, Husum B, Dale O. Nitrous oxide: an ageing gentleman. Acta Anaesthesiol Scand 2001; 45: 135-7