PSMs of Hypervirulent Staphylococcus aureus Act as Intracellular Toxins That Kill Infected Osteoblasts

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Rasigade, Jean Philippe ^a,b   Trouillet Assant, Sophie ^a   Ferry, Tristan ^a   Diep, Binh An ^c   Sapin, Anaïs ^b   Lhoste, Yannick ^b   Ranfaing, Jérémy ^a   Badiou, Cédric ^a   Benito, Yvonne ^b   Bes, Michèle ^b   Couzon, Florence ^a   Tigaud, Sylvestre ^b   Lina, Gérard ^a,b   Etienne, Jérôme ^a,b   Vandenesch, François ^a,b   Laurent, Frédéric ^a,b  

^a UNIVERSITÉ DE LYON   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOXIN; BACTERIAL TOXIN; PANTON VALENTINE LEUKOCIDIN; PHENOL SOLUBLE MODULIN DERIVATIVE; UNCLASSIFIED DRUG;

AGR GENE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CELL DAMAGE; CELL KILLING; CONTROLLED STUDY; CYTOTOXICITY; DELETION MUTANT; EX VIVO STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; OSTEOBLAST; QUANTITATIVE ANALYSIS; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAERS GENE; SARA GENE; STRAIN DIFFERENCE; TOXIN ANALYSIS;

BACTERIAL LOAD; BACTERIAL TOXINS; CELL DEATH; COMMUNITY-ACQUIRED INFECTIONS; DELIVERY OF HEALTH CARE; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; INTRACELLULAR SPACE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; OSTEOBLASTS; RNA, MESSENGER; SPECIES SPECIFICITY;

EID: 84877745311     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063176     Document Type: Article

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