The MTHFR C677T variant is associated with responsiveness to disulfiram treatment for cocaine dependency

Frontiers in Psychiatry

Volumn 3, Issue JAN, 2013, Pages

  Spellicy, Catherine J ^a   Kosten, Thomas R ^a   Hamon, Sara C ^b   Harding, Mark J ^a   Nielsen, David A ^a  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Cocaine; Dependence; Disulfiram; Genes; Polymorphism; Treatment

Indexed keywords

DISULFIRAM; METHADONE; PLACEBO;

ADULT; ARTICLE; COCAINE DEPENDENCE; COCAINE URINE LEVEL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENE; GENE FREQUENCY; GENE FUNCTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; TREATMENT RESPONSE; URINE LEVEL;

EID: 84877711551     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2012.00109     Document Type: Article

References (69)

1. Anier, K., Malinovskaja, K., Aonurm-Helm, A., Zharkovsky, A., and Kalda, A. (2010). DNA methy lation regulates cocaine-induced behavioral sensitization in mice. Neuropsychopharmacology, 35, 2450-2461.
2. Axume, J., Smith, S., Pogribny, I., Moriarty, D., and Caudill, M. (2007). The MTHFR 677TT genotype and folate intake interact to lower global leukocyte DNa methylation in young Mexican American women. Nutr. Res. 27, 1365-1317.
3. Berke, J., Paletzki, R., Aronson, G., Hyman, S., and Gerfen, C. (1998). A complex program of striatal gene expression induced by dopamin-ergic stimulation. J. Neurosci. 18, 5301-5310.
4. Berrettini, W., Hoehe, M., Ferraro, T., Demaria, P., and Gottheil, E. (1997). Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse. Addict. Biol. 2, 303-308.
5. Berry, R., Erickson, J., Moore, C., Wang, H., Mulinare, J., Zhao, P., et al. (1999). Prevention of neural-tube defects with folic acid in China.China-U.S. Collaborative project for neural tube defect prevention. N. Engl. J. Med. 341, 1485-1490.
6. Carroll, K. M. (1993). Psychothera-peutic treatment of cocaine abuse: models for its evaluation alone and in combination with pharma-cotherapy. NIDA Res. Monogr. 135, 116-132.
7. Carroll, K. M. (1997). Manual-guided psychosocial treatment. A new virtual requirement for pharmacotherapy trials? Arch. Gen. Psychiatry 54, 923-928.
8. Carroll, K. M., Fenton, L. R., Ball, S. A., Nich, C., Frankforter, T. L., Shi, J., et al. (2004). Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial. Arch. Gen. Psychiatry 61,264-272.
9. Carroll, K. M., Nich, C., Ball, S. A., McCance, E., and Rounsavile, B. J. (1998). Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 93, 713-727.
10. Caudill, M., Wang, J., Melnyk, S., Pogribny, I., Jernigan, S., Collins, M., et al. (2001). Intracellular S-adenosylhomocysteine con-centrations predict global DNA hypomethylation in tissues of methyl-deficie3nt cystathionine beta-synthase heterozygous mice. J. Nutr. 131,2811-2818.
11. Chen, Z., Karaplis, A., Ackerman, S., Pogribny, I., Melnyk, S., Lussier-Cacan, S., et al. (2001). Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocys-teinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum. Mol. Genet. 10, 433-443.
12. Covington, H., Maze, I., Sun, H., Bomze, H.,Demaio,K.,Wu,E.,etal. (2011). A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron 71, 656-670.
13. Crist, R., Ambrose-Lanci, L., Vaswani, M., Clarke, T., Zeng, A., Yuan, C., et al. (2012). Case-control association analysis of polymorphisms in the delta-opioid receptor, OPRD1, with cocaine and opiod addicted populations. Drug Alcohol Depend. [epub ahead of print].
14. Czeizel, A., and Dudas, I. (1992). Prevention of the first occurance of neural-tube defects by periconcep-tional vitamin supplementation. N. Engl. J. Med. 327, 1832-1835.
15. Dahl, J., Kampman, K., Oslin, D., Weller, A., Lohoff, F., Ferraro, T., et al. (2005). Association of a polymorphism in the Homer 1 genewith cocaine dependence in an African American population. Psy-chiatr. Genet. 15,277-283.
16. De Lau, L., Refsum, H., Smith, A., Johnson, C., and Breteler, M. (2007). Plasma folate concentration and cognitive performance: Rotterdam scan study. Am. J. Clin. Nutr. 86, 728-734.
17. De Lau, L., Smith, A., Refsum, H., Johnson, C., and Breteler, M. (2009). Plasma vitamin B12 status and cerebral white-matter lesions. J. Neurol. Neurosurg. Psychiatry 80, 149-157.
18. Food and Drug Administration. (1996). Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Final rule, 21 CFR parts 136,137and 139. The Federal Register 61,8781-8797.
19. Frosst, P., Blom, H., Milos, R., Govette, P., Sheppard, C., Matthews, R., et al. (1995). A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 10, 111-113.
20. George, T. P., Chawarski, M. C., Pakes, J., Carroll, K. M., Kosten, T. R., and Schottenfeld, R. S. (2000). Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial. Biol. Psychiatry 47, 1080-1086.
21. Goldman, D., Oroszi, G., and Ducci, E (2005). The genetics of addictions: uncovering the genes. Nat. Rev. Genet. 6,521-532.
22. Greene, N., Stanier, P., and Copp, A. (2009). Genetics of human neural tube defects. Hum. Mol. Genet. 18, R113-R129.
23. Grimm, J., Lu, L., Hayashi, T., Hope, B., Su, T., and Shaham, Y. (2003). Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J. Neu-rosci. 23, 742-747.
24. Harisha, P., Devi, B., Christopher, R., and Kruthika-Vinod, T. (2010). Impace of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects. J. Neurosurg. Pediatr. 6, 364-367.
25. Harris, M. (2009). Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutants. Birth Defects Res. A Clin. Mol. Teratol. 85, 331-339.
26. Hickie, I., Scott, E., Naismith, S., Ward, P., Turner, K., Parker, G., et al. (2001). Late-onset depression: genetic, vascular and clinicalcontributions. Psychol. Med. 31, 1403-1412.
27. Holmes, M., Newcombe, P., Hubacek, J., Sofat, R., Ricketts, S., Cooper, J., et al. (2011). Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet 378, 584-594.
28. Hubisz, M. J., Falush, D., Stephens, M., and Pritchard, J. K. (2009). Inferring weak population structure with the assistance of sample group information. Mol. Ecol. Resour. 9,1322-1332.
29. Jacques, P., Bostom, A., Williams, R., Ellison, R., Eckfeldt, J., Rosenberg, I., et al. (1996). Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93, 7-9.
30. Kalivas, P., and O'Brien, C. (2008). Drug addiction as a pathology of staged neuroplasticity. Neuropsy-chopharmacology 33, 166-180.
31. Kamdar, D., Krull, K., El-Zein, R., Brouwers, P., Potter, B., Harris, L., et al. (2011). Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy. Pediatr. Blood Cancer 57,454-460.
32. Kendler, D., and Prescott, C. (1998). Cocaine use, abuse and dependence in a population-based sample of female twins. Br. J. Psychiatry 173, 345-350.
33. Kinney,S.,and Pradhan, S. (2011). Regulation of expression and activity of DNA (cytosine-5) methyltrans-ferases in mammalian cells. Prog. Mol. Biol. Transl. Sci. 101, 311-333.
34. Kosten, T., Wu, G., Huang, W., Harding, M., Hamon, S., Lappalainen, J., et al. (2012). Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine beta-hydroxylase. (in press).
35. Kreek, M., Bart, G., Lilly, C., Laforge, K., and Nielsen, D. (2005). Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol. Rev. 57, 1-26.
36. Krull, K., Brouwers, M., Jain, N., Zhang, L., Bomgaars, L., Dreyer, Z., et al. (2008). Folate pathway genetic polymorphisms are related to attention disorders in childhoo d leukemia survivors.J. Pediatr. 152, 101-105.
37. La Merrill, M., Torres-Sanchez, L., Ruiz-Ramos, R., Lopez-Carillo, L., Cebrian, M., and Chen, J. (2012). The association between first trimester micronutrient intake, MTHFR genotypes, and global DNAmethylation in pregnant women. J. Matern. Fetal. Neonatal. Med. 25, 133-137.
38. Lan, W., Yang, A., Hwang, J., Hong, C., Liou, Y., Yeh, H., et al. (2012). Association of MTHFR C677T polymorphism with loneliness but not depression in cognitively normal elderly males. Neurosci. Lett. 521, 88-91.
39. Lao, O., Dujin, K. V., Kersbergen, P., Kni-jff, P. D., and Kayser, M. (2006). Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry. Am. J. Hum. Genet. 78, 680-690.
40. Lin, J., Haffner, M., Zhang, Y., Lee, B., Brennen, W., Britton, J., et al. (2011). Disulfiram is a DNA demethy-lating agent and inhibits prostate cancer cell growth. Prostate 71, 333-343.
41. Malouf, R., and Grimley Evans, J. (2008). Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst. Rev. 8, CD004514.
42. Maze, I., Covington, H., Dietz, D., Laplant, Q., Renthal, W., Russo, S., et al. (2010). Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327,213.
43. Maze, I., Feng, J., Wilkinson, M., Sun, H., Shen, L., and Nestler, E. (2011). Cocaine dynamically regulates hete-rochromatin and repetitive element unsilencing in nucleus accumbens. Proc. Natl. Acad. Sci. U.S.A. 108, 3035-3040.
44. McLellan, A., Kushner, H., Metzger, D., Peters, R., Grissom, G., Pettinati, H., et al. (1992). The fifth edition of the addiction severity index. J. Subst. AbuseTreat. 9, 199-213.
45. Moretti, P., Peters, S., Del Gaudio, D., Sahoo, T., Hyland, K., Bottiglieri, T., et al. (2008). Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and diskinesias in CNS folate deficiency. J. Autism Dev. Disord. 38, 1170-1177.
46. Morris, M., Jacques, P., Rosenberg, I., and Selhub, J. (2001). Hyper-homocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am. J. Clin. Nutr. 73, 927-933.
47. MRC Vitamin Study Research Group. (1991). Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338,131-137.
48. Nestler, E. (2001). Molecular basis of long-term plasticity underlying addiction. Nat. Rev. Neurosci. 2, 119-128.
49. Nielsen, D., Hamon, S., Yuferov, V., Jackson, C., Ho, A., Ott, J., et al. (2010). Ethnic diversity of DNA methyla-tion in the OPRM1 promoter region in lymphocytes of heroin addicts. Hum. Genet. 127, 639-649.
50. Nielsen, D., Yuferov, V., Hamon, S., Jackson, C., Ho, A., Ott, J., et al. (2009). Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharma-cology 34, 867-873.
51. Nielsen, D. A., Harding, M. J., Hamon, S., Huang, W., and Kosten, T. (2012a). Modifying role of seroton-ergic 5-HTTLPR & TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. Gene. Brain Behav. (in press).
52. Nielsen, D. A., Utrankar, A., Reyes, J., Simons, D., and Kosten, T. (2012b). Epigenetics of drug abuse: predisposition or response. Pharmacoge-nomics 13, 1149-1160.
53. Novikova, S., He, F., Bai, J., Cutrufello, N., Lidow, M., and Undieh, A. (2008). Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS ONE 3:e1919. doi:10.1371/journal.pone.0001919
54. Petrakis, I. L., Carroll, K. M., Nich, C., Gordon, L. T., McCance-Katz, E. F., Frankforter, T., et al. (2000). Disulfiram treatment for cocaine dependence inmethadone-maintained opioid addicts. Addiction 95, 219-228.
55. Pritchard, J. K., Stephens, M., and Donnelly, P. (2000). Inference of population structure using multi-locus genotype data. Genetics 155, 945-959.
56. R Development Core Team. (2009). R: A Language and Environment for Statistical Computing, 2.9.1 Edn, Vienna: R Foundation for Statistical Computing.
57. Rozen, R. (1997). Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofo-late reductase (MTHFR). Thromb. Haemost. 78, 523-526.
58. Sen, A., and Kanani, S. (2009). Impact of iron-folic acid supplementation on cognitive abilities of school girls in Vadodara. Indian Pediatr. 46, 849-854.
59. Shaham, Y., and Hope, B. (2005). The role of neuroadaptations in relapse to drug seeking. Nat. Neurosci. 8, 1437-1439.
60. Sheehan, D., Lecrubier, Y., Shee-han, K., Amorim, P., Janavs, J., Weiller, E., et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59,22-33.
61. Substance Abuse and Mental Health Services Administration (SAMHSA). (2011). Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. NSDUH Series H-41, HHS Publication No. (SMA) 11-4658. Rockville: SubstanceAbuse and Mental Health Services Administration.
62. Tangney, C., Tang, Y., Evans, D., and Morris, M. (2009). Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. Neurology 72,361-367.
63. Tsuang, M., Lyons, M., Meyer, M., Doyle, T., Eisen, S., Goldberg, J., et al. (1998). Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch. Gen. Psychiatry 55, 967-972.
64. Van Der Linden, I., Afman, L., Heil, S., and Blom, H. (2006). Genetic variation in genes of folate metabolism and neural-tube defect risk. Proc. Nutr. Soc. 65, 204-215.
65. Whitehead, A., Gallagher, P., Mills, J., Kirke, P., Burke, H., Molloy, A., et al. (1995). A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. QJM 88, 763-766.
66. Wong, C., Mill, J., and Fernandes, C. (2011). Drugs and addiction: an introduction to epigenetics. Addiction 106, 480-489.
67. Yang, Q., Botto, L., Gallagher, M., Friedman, J., Sanders, C., Koontz, D., et al. (2008). Prevalence and effects of gene-gene nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am. J. Clin. Nutr. 88, 232-246.
68. Yao, W., Gainetdinov, R., Arbuckle, M., Sotnikova, T., Cyr, M., Beaulieu, J.,et al. (2004). Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. Neuron 41, 625-638.
69. Yi, P., Melnyk, S., Pogribna, M., Pigribny, I., Hine, R., and James, S. (2000). Increase in plasma homocysteine associated with increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J. Biol. Chem. 275,29318-29323.