4-Hydroxypyridazin-3(2 H)-one derivatives as novel d-amino acid oxidase inhibitors

Journal of Medicinal Chemistry

Volumn 56, Issue 9, 2013, Pages 3582-3592

  Hondo, Takeshi ^a   Warizaya, Masaichi ^a   Niimi, Tatsuya ^a   Namatame, Ichiji ^a   Yamaguchi, Tomohiko ^a   Nakanishi, Keita ^a   Hamajima, Toshihiro ^a   Harada, Katsuya ^a   Sakashita, Hitoshi ^a   Matsumoto, Yuzo ^a   Orita, Masaya ^a   Takeuchi, Makoto ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 5(2 PHENYLETHYLPYRIDIN) 2(1H) ONE; 3 HYDROXY 5(2 PHENYLETHYLPYRIDINE) 2(1H) ONE DERIVATIVE; 3 HYDROXY PYRIDINE 2(1H) ONE DERIVATIVE; 4 HYDROXY 6 (PHENOXYMETHYLPYRIDAZIN) 3(2H) ONE; 4 HYDROXY 6(1 PHENYLETHYLPYRIDAZIN) 3(2H) ONE; 4 HYDROXY 6(2 PHENYLETHYLPYRIDAZIN) 3(2H) ONE; 4 HYDROXY 6(3 PHENYLPROPYLPYRIDAZIN) 3(2H) ONE; 4 HYDROXY 6[2(2 (TRIFLUOROMETHYLPHENYLETHYLPYRIDAZIN))] 3(2H) ONE; 4 HYDROXY 6[2(3 (TRIFLUOROMETHYLPHENYLETHYLPYRIDAZIN))] 3(2H) ONE; 4 HYDROXY 6[2(3 METHOXYPHENYLETHYLPYRIDAZIN)] 3(2H) ONE; 4 HYDROXY 6[2(4 (TRIFLUOROMETHYLPHENYLETHYLPYRIDAZIN))] 3(2H) ONE; 4 HYDROXY 6[2(4 METHOXYPHENYLETHYLPYRIDAZIN)] 3(2H) ONE; 4 HYDROXYPYRIDAZIN 3(2H) ONE DERIVATIVE; 6 ((E) 2(4 CHLOROPHENYLVINYL)) 4 HYDROXYPYRIDAZIN 3(2H) ONE; 6 2(3,5 DIFLUOROPHENYLETHYL) 4 HYDROXYPYRIDAZIN 3(2H) ONE DERIVATIVE; 6 CYCLOHEXYL 4 HYDROXYPYRIDAZIN 3(2H) ONE; 6(2 CYCLOHEXYLETHYL) 4 HYDROXYPYRIDAZIN 3(2H) ONE; 6(3,3 DIMETHYLBUTYL) 4 HYDROXYPYRIDAZIN 3(2H) ONE; 6[2(2 FLUOROPHENYLETHYL)] 4 HYDROXYPYRIDAZIN 3(2H) ONE; 6[2(3 FLUOROPHENYLETHYL)] 4 HYDROXYPYRIDAZIN 3(2H) ONE; 6[2(3,5 DIFLUOROPHENYLETHYL)] 4 HYDROXYPYRIDAZIN 3(2H) ONE; 6[2(4 CHLOROPHENYLETHYL)] 4 HYDROXYPYRIDAZIN 3(2H) ONE; 6[2(4 FLUOROPHENYLETHYL)] 4 HYDROXYPYRIDAZIN 3(2H) ONE; DEXTRO AMINO ACID OXIDASE; DEXTRO AMINO ACID OXIDASE INHIBITOR; DIZOCILPINE; OXIDOREDUCTASE INHIBITOR; PYRIDAZINE DERIVATIVE; QUERCETIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ASSAY; CELL MEMBRANE PERMEABILITY; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING SITE; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PROTEIN DATA BANK; RAT; STRUCTURE ACTIVITY RELATION; WORKING MEMORY; X RAY CRYSTALLOGRAPHY;

ANIMALS; D-AMINO-ACID OXIDASE; DIZOCILPINE MALEATE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; MALE; MAZE LEARNING; MEMORY; MICE; MODELS, MOLECULAR; PERMEABILITY; PROTEIN CONFORMATION; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877704487     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400095b     Document Type: Article

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