Synthesis and SAR of 1-hydroxy-1 H -benzo[ d ]imidazol-2(3 H)-ones as inhibitors of d -amino acid oxidase

ACS Medicinal Chemistry Letters

Volumn 3, Issue 10, 2012, Pages 839-843

  Berry, James F ^a   Ferraris, Dana V ^b   Duvall, Bridget ^b   Hin, Niyada ^b   Rais, Rana ^a   Alt, Jesse ^b   Thomas, Ajit G ^b   Rojas, Camilo ^b   Hashimoto, Kenji ^c   Slusher, Barbara S ^a,b   Tsukamoto, Takashi ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

D amino acid oxidase (DAAO); D serine; glucuronidation; NMDA receptors

Indexed keywords

1 HYDROXY1H BENZO[ DEXTRO]IMIDAZOL 2(3H)ONE; 3 HYDROXYQUINOLIN 2(1H)ONE; 4H FURO[3,2 BETA]PYRROLE 5 CARBOXYLIC ACID; 4H THIENO[3,2BETA]PYRROLE 5 CARBOXYLIC ACID; 5 METHYL 3 PYRAZOLECARBOXYLIC ACID; 6 CHLOROBENZO [DEXTRO]ISOXAZOL 3 OL; BENZENE; CARBOXYLIC ACID DERIVATIVE; DEXTRO AMINO ACID OXIDASE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; HUMAN; HYDROGEN BOND; IC 50; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SWINE;

EID: 84867364338     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300212a     Document Type: Article

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