Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels

Biological Psychiatry

Volumn 57, Issue 12, 2005, Pages 1493-1503

  Yamada, Kazuo ^a   Ohnishi, Tetsuo ^a   Hashimoto, Kenji ^b   Ohba, Hisako ^a   Iwayama Shigeno, Yoshimi ^a   Toyoshima, Manabu ^a   Okuno, Akira ^a   Takao, Hitomi ^a   Toyota, Tomoko ^a   Minabe, Yoshio ^c   Nakamura, Kazuhiko ^c   Shimizu, Eiji ^b   Itokawa, Masanari ^d   Mori, Norio ^c   Iyo, Masaomi ^b   Yoshikawa, Takeo ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Alternative splicing; Genotype phenotype correlation; Glycine site; Mutation screening; N methyl D aspartate receptor; Polymorphism

Indexed keywords

DEXTRO AMINO ACID OXIDASE; MESSENGER RNA; RACEMASE; SERINE; SERINE RACEMASE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA DETERMINATION; ENZYME STRUCTURE; EXON; FEMALE; GENE FREQUENCY; GENE MUTATION; GENE REPLICATION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; GENOME ANALYSIS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; RNA ANALYSIS; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AUTORADIOGRAPHY; BLOTTING, NORTHERN; BRIEF PSYCHIATRIC RATING SCALE; CASE-CONTROL STUDIES; D-AMINO-ACID OXIDASE; DNA MUTATIONAL ANALYSIS; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENOMICS; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RACEMASES AND EPIMERASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCHIZOPHRENIA; SERINE;

EID: 20444406392     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.03.018     Document Type: Article

References (47)

1. O. Andersson, A. Stenqvist, A. Attersand, G. von Euler Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B Genomics 78 2001 178 184
2. J.C. Barrett, B. Fry, J. Maller, M.J. Daly Haploview Analysis and visualization of LD and haplotype maps Bioinformatics 21 2005 263 265
3. H. Bauwe, U. Kolukisaoglu Genetic manipulation of glycine decarboxylation J Exp Bot 54 2003 1523 1535
4. I. Chumakov, M. Blumenfeld, O. Guerassimenko, L. Cavarec, M. Palicio, H. Abderrahim Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia Proc Natl Acad Sci U S A 99 2002 13675 13680
5. D. Clayton A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission Am J Hum Genet 65 1999 1170 1177
6. W. Danysz, A.C. Parsons Glycine and N-methyl-D-aspartate receptors physiological significance and possible therapeutic applications Pharmacol Rev 50 1998 597 664
7. J. De Miranda, A. Santoro, S. Engelender, H. Wolosker Human serine racemase molecular cloning, genomic organization and functional analysis Gene 256 2000 183 188
8. R. Dingledine, K. Borges, D. Bowie, S.F. Traynelis The glutamate receptor ion channels Pharmacol Rev 51 1999 7 61
9. F. Dudbridge Pedigree disequilibrium tests for multilocus haplotypes Genet Epidemiol 25 2003 115 121
10. D.S. Dunlop, A. Neidle The origin and turnover of d-serine in brain Biochem Biophys Res Commun 235 1997 26 30
11. D.C. Goff, J.T. Coyle The emerging role of glutamate in the pathophysiology and treatment of schizophrenia Am J Psychiatry 158 2001 1367 1377
12. I.I. Gottesman Schizophrenia Genetics The Origin of Madness 1991 W.H. Freeman New York
13. P.J. Harrison, M.J. Owen Genes for schizophrenia? Recent findings and their pathophysiological implications Lancet 361 2003 417 419
14. Hashimoto K, Engberg G, Shimizu E, Nordin C, Lindstrom LH, Iyo M (in press): Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients. Prog Neuropharmacol Biol Psychiatry.
15. K. Hashimoto, T. Fukushima, E. Shimizu, N. Komatsu, H. Watanabe, N. Shinoda Decreased serum levels of D-serine in patients with schizophrenia evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia Arch Gen Psychiatry 60 2003 572 576
16. A. Hashimoto, T. Oka Free d-aspartate and d-serine in the mammalian brain and periphery Prog Neurobiol 52 1997 325 353
17. K. Hashimoto, N. Okamura, E. Shimizu, M. Iyo Glutamate hypothesis of schizophrenia and approach for possible therapeutic drugs Curr Med Chem -CNS Agents 4 2004 147 154
18. Hashimoto K, Shimizu E, Iyo M (in press): Dysfunction of glia-neuron communication in pathophysiology of schizophrenia. Curr Psychiatry Rev.
19. M. Itokawa, K. Yamada, K. Yoshitsugu, T. Toyota, T. Suga, H. Ohba A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia Pharmacogenetics 13 2003 271 278
20. D.C. Javitt, S.R. Zukin Recent advances in the phencyclidine model of schizophrenia Am J Psychiatry 148 1991 1301 1308
21. K.S. Kendler Psychiatric genetics A methodologic critique Am J Psychiatry 162 2005 3 11
22. M. Kikuchi, K. Yamada, T. Toyota, M. Itokawa, E. Hattori, K. Yoshitsugu Two-step association analyses of the chromosome 18p11.2 region in schizophrenia detect a locus encompassing C18 orf1 Mol Psychiatry 8 2003 467 469
23. M. Kikuchi, K. Yamada, T. Toyota, T. Yoshikawa C18 orf1 located on chromosome 18p11.2 may confer susceptibility to schizophrenia J Med Dent Sci 50 2003 225 229
24. P.M. Kim, H. Aizawa, P.S. Kim, A.S. Huang, S.R. Wickramasinghe, A.H. Kashani Serine racemase Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neural migration Proc Natl Acad Sci U S A 102 2005 2105 2110
25. J.H. Krystal, D.C. D'Souza, I.L. Petrakis, A. Belger, R. Berman, D.S. Charney NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies for neuropsychiatric disorders Harv Rev Psychiatry 7 1999 125 133
26. P.D. Leeson, L.L. Iversen The glycine site on the NMDA receptor Structure-activity relationships and therapeutic potential J Med Chem 37 1994 4053 4067
27. X. Liu, G. He, X. Wang, Q. Chen, X. Qian, W. Lin Association of DAAO with schizophrenia in the Chinese population Neurosci Lett 369 2004 228 233
28. E.R. Martin, M.P. Bass, N.L. Kaplan Correcting for a potential bias in the pedigree disequilibrium test Am J Hum Genet 68 2001 1065 1067
29. E.R. Martin, S.A. Monks, L.L. Warren, N.L. Kaplan A test for linkage and association in general pedigrees the pedigree disequilibrium test Am J Hum Genet 67 2000 146 154
30. J. Mitoma, S. Furuya, M. Shimizu, Y. Shinoda, K. Yoshida, N. Azuma Mouse 3-phosphoglycerate dehydrogenase gene genomic organization, chromosomal localization, and promoter analysis Gene 334 2004 15 22
31. R. Miyatake, A. Furukawa, H. Suwaki Identification of a novel variant of the human NR2B gene promoter region and its possible association with schizophrenia Mol Psychiatry 7 2002 1101 1106
32. J.W. Muntjewerff, N. van der Put, T. Eskes, B. Ellenbroek, E. Steegers, H. Blom Homocysteine metabolism and B-vitamins in schizophrenic patients low plasma folate as a possible independent risk factor for schizophrenia Psychiatry Res 121 2003 1 9
33. Y. Nagata Involvement of d-amino acid oxidase in elimination of d-serine in mouse brain Experientia 48 1992 753 755
34. J.R. O'Connell, D.E. Weeks PedCheck A program for identification of genotype incompatibilities in linkage analysis Am J Hum Genet 63 1998 259 266
35. S. Purcell, S.S. Cherny, P.C. Sham Genetic Power Calculator Design of linkage and association genetic mapping studies of complex traits Bioinformatics 19 2003 149 150
36. S. Sacchi, S. Lorenzi, G. Molla, M.S. Pilone, C. Rossetti, L. Pollegioni Engineering the substrate specificity of d-amino acid oxidase J Biol Chem 277 2002 27510 27516
37. M.J. Schell The N-methyl d-aspartate receptor glycine site and d-serine metabolism An evolutionary perspective Philos Trans R Soc Lond B Biol Sci 359 2004 943 964
38. J. Schumacher, R. Abon Jamra, J. Freudenberg, T. Becker, S. Ohlraun, A.C.J. Otte Examination of G72 and d-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder Mol Psychiatry 9 2004 203 207
39. P.C. Sham, D. Curtis An extended transmission/disequilibrium test (TDT) for multi-allele marker loci Ann Hum Genet 59 1995 323 336
40. S.H. Snyder, C.D. Ferris Novel neurotransmitters and their neuropsychiatric relevance Am J Psychiatry 157 2000 1738 1751
41. K. Takahashi, F. Hayashi, T. Nishikawa In vivo evidence for the link between l- and d-serine metabolism in rat cerebral cortex J Neurochem 69 1997 1286 1290
42. G. Tsai, P. Yang, L.C. Chung, N. Lange, J.T. Coyle d-Serine added to antipsychotics for the treatment of schizophrenia Biol Psychiatry 44 1998 1081 1089
43. G.E. Tsai, P. Yang, L.C. Chung, I.C. Tsai, C.W. Tsai, J.T. Coyle d-serine added to clozapine for the treatment of schizophrenia Am J Psychiatry 156 1999 1822 1825
44. H. Wolosker, S. Blackshaw, S.H. Snyder Serine racemase A glial enzyme synthesizing d-serine to regulate glutamate N-methy-d-aspartate neurotransmission Proc Natl Acad Sci U S A 96 1999 13409 13414
45. H. Wolosker, K.N. Sheth, M. Takahashi, J.P. Mothet, R.O. Brady Jr, C.D. Ferris Purification of serine racemase biosynthesis of the neuromodulator D-serine Proc Natl Acad Sci U S A 96 1999 721 725
46. T. Yoshikawa, A.R. Sanders, L.E. Esterling, S.D. Detera-Wadleigh Multiple transcriptional variantsand RNA editing in C18orf1, a novel gene with LDLRA and transmembrane domains, on 18p11.2 Genomics 47 1998 246 257
47. J.H. Zhao, P.C. Sham, D. Curtis A program for the Monte Carlo evaluation of significance of the extended transmission/disequilibrium test Am J Hum Genet 64 1999 1484 1485