α-MSH signalling via melanocortin 5 receptor promotes lipolysis and impairs re-esterification in adipocytes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1831, Issue 7, 2013, Pages 1267-1275

  Rodrigues, Adriana R ^a,b   Almeida, Henrique ^a,b   Gouveia, Alexandra M ^a,b,c  

^a Institute of Histology and Embryology   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Adipocyte; Lipolysis; Melanocortin 5 receptor; Melanocortins; Re esterification

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; AFAMELANOTIDE; COMPLEMENTARY DNA; CYCLIC AMP; FATTY ACID; MELANOCORTIN; MELANOCORTIN 5 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SMALL INTERFERING RNA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ESTERIFICATION; FLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE MICROSCOPY; LIPID METABOLISM; LIPOLYSIS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

3T3-L1 CELLS; ACETYL-COA CARBOXYLASE; ADIPOCYTES; ALPHA-MSH; ANIMALS; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ESTERIFICATION; LIPASE; LIPOLYSIS; MAP KINASE SIGNALING SYSTEM; MICE; PHOSPHOPROTEINS; RECEPTORS, MELANOCORTIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEROL ESTERASE;

EID: 84877661657     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.04.008     Document Type: Article

References (42)

1. S.N. Cooray, and A.J. Clark Melanocortin receptors and their accessory proteins Mol. Cell. Endocrinol. 331 2011 215 221
2. O.J. Marston, A.S. Garfield, and L.K. Heisler Role of central serotonin and melanocortin systems in the control of energy balance Eur. J. Pharmacol. 660 2011 70 79
3. R. Pandit, J.W. de Jong, L.J. Vanderschuren, and R.A. Adan Neurobiology of overeating and obesity: the role of melanocortins and beyond Eur. J. Pharmacol. 660 2011 28 42
4. B.C. De Jonghe, M.R. Hayes, and K.K. Bence Melanocortin control of energy balance: evidence from rodent models Cell. Mol. Life Sci. 68 2011 2569 2588
5. D. Huszar, C.A. Lynch, V. Fairchild-Huntress, J.H. Dunmore, Q. Fang, L.R. Berkemeier, W. Gu, R.A. Kesterson, B.A. Boston, R.D. Cone, F.J. Smith, L.A. Campfield, P. Burn, and F. Lee Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell 88 1997 131 141
6. C. Vaisse, K. Clement, E. Durand, S. Hercberg, B. Guy-Grand, and P. Froguel Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity J. Clin. Invest. 106 2000 253 262
7. W.L. Prado, L.M. Oyama, M.C. Lofrano-Prado, A. de Piano, S.G. Stella, C.M. Nascimento, J. Carnier, D.A. Caranti, L. Tock, S. Tufik, M.T. de Mello, and A.R. Damaso Alterations in downstream mediators involved in central control of eating behavior in obese adolescents submitted to a multidisciplinary therapy J. Adolesc. Health 49 2011 300 305
8. C.L. Roth, P.J. Enriori, U. Gebhardt, A. Hinney, H.L. Muller, J. Hebebrand, T. Reinehr, and M.A. Cowley Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity Metabolism 59 2010 186 194
9. D.D. Pierroz, M. Ziotopoulou, L. Ungsunan, S. Moschos, J.S. Flier, and C.S. Mantzoros Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity Diabetes 51 2002 1337 1345
10. A.D. Strader, H. Shi, R. Ogawa, R.J. Seeley, and O. Reizes The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents J. Pharmacol. Exp. Ther. 322 2007 1153 1161
11. L. Yaswen, N. Diehl, M.B. Brennan, and U. Hochgeschwender Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin Nat. Med. 5 1999 1066 1070
12. R. Nogueiras, P. Wiedmer, D. Perez-Tilve, C. Veyrat-Durebex, J.M. Keogh, G.M. Sutton, P.T. Pfluger, T.R. Castaneda, S. Neschen, S.M. Hofmann, P.N. Howles, D.A. Morgan, S.C. Benoit, I. Szanto, B. Schrott, A. Schurmann, H.G. Joost, C. Hammond, D.Y. Hui, S.C. Woods, K. Rahmouni, A.A. Butler, I.S. Farooqi, S. O'Rahilly, F. Rohner-Jeanrenaud, and M.H. Tschop The central melanocortin system directly controls peripheral lipid metabolism J. Clin. Invest. 117 2007 3475 3488
13. V.E. Chaves, D. Frasson, and N.H. Kawashita Several agents and pathways regulate lipolysis in adipocytes Biochimie 93 2011 1631 1640
14. T.J. Bartness, Y.B. Shrestha, C.H. Vaughan, G.J. Schwartz, and C.K. Song Sensory and sympathetic nervous system control of white adipose tissue lipolysis Mol. Cell. Endocrinol. 318 2010 34 43
15. C.K. Song, R.M. Jackson, R.B. Harris, D. Richard, and T.J. Bartness Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 2005 R1467 R1476
16. K.G. Mountjoy Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes Biochem. J. 428 2010 305 324
17. M. Hoch, A.N. Eberle, U. Wagner, C. Bussmann, T. Peters, and R. Peterli Expression and localization of melanocortin-1 receptor in human adipose tissues of severely obese patients Obesity (Silver Spring) 15 2007 40 49
18. V. Chhajlani Distribution of cDNA for melanocortin receptor subtypes in human tissues Biochem. Mol. Biol. Int. 38 1996 73 80
19. Y.C. Chagnon, W.J. Chen, L. Perusse, M. Chagnon, A. Nadeau, W.O. Wilkison, and C. Bouchard Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study Mol. Med. 3 1997 663 673
20. S.R. Smith, B. Gawronska-Kozak, L. Janderova, T. Nguyen, A. Murrell, J.M. Stephens, and R.L. Mynatt Agouti expression in human adipose tissue: functional consequences and increased expression in type 2 diabetes Diabetes 52 2003 2914 2922
21. R.L. Bradley, J.P. Mansfield, and E. Maratos-Flier Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes Obes. Res. 13 2005 653 661
22. N. Hoggard, L. Hunter, J.S. Duncan, and D.V. Rayner Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system J. Mol. Endocrinol. 32 2004 145 153
23. B.A. Boston The role of melanocortins in adipocyte function Ann. N. Y. Acad. Sci. 885 1999 75 84
24. C.L. Moller, K. Raun, M.L. Jacobsen, T.A. Pedersen, B. Holst, K.W. Conde-Frieboes, and B.S. Wulff Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved Mol. Cell. Endocrinol. 341 1-2 2011 9 17
25. M.J. Betz, N. Hatiboglu, B. Mauracher, D. Hadaschik, A. Sauter, H. Demmelmair, B. Koletzko, F. Beuschlein, and M. Slawik Mc2 receptor knockdown modulates differentiation and lipid composition in adipocytes Horm. Metab. Res. 44 9 2012 670 675
26. S.C. Harmer, D.J. Pepper, K. Cooke, H.P. Bennett, and A.B. Bicknell Evidence of a possible role for Lys-gamma3-MSH in the regulation of adipocyte function J. Endocrinol. 196 2008 149 158
27. K.J. Cho, J.H. Shim, M.C. Cho, Y.K. Choe, J.T. Hong, D.C. Moon, J.W. Kim, and D.Y. Yoon Signaling pathways implicated in alpha-melanocyte stimulating hormone-induced lipolysis in 3T3-L1 adipocytes J. Cell. Biochem. 96 2005 869 878
28. A.R. Rodrigues, H. Almeida, and A.M. Gouveia Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and β-arrestins 1/2 Mol. Cell. Endocrinol. 361 2012 69 79
29. A.R. Rodrigues, D. Pignatelli, H. Almeida, and A.M. Gouveia Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism Mol. Cell. Endocrinol. 303 2009 74 81
30. Y.Y. Chia, S.Y. Liong, S.H. Ton, and K.B. Kadir Amelioration of glucose homeostasis by glycyrrhizic acid through gluconeogenesis rate-limiting enzymes Eur. J. Pharmacol. 677 2012 197 202
31. A.D. Lampidonis, E. Rogdakis, G.E. Voutsinas, and D.J. Stravopodis The resurgence of hormone-sensitive lipase (HSL) in mammalian lipolysis Gene 477 2011 1 11
32. D.L. Brasaemle Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis J. Lipid Res. 48 2007 2547 2559
33. D. Norman, A.M. Isidori, V. Frajese, M. Caprio, S.L. Chew, A.B. Grossman, A.J. Clark, G. Michael Besser, and A. Fabbri ACTH and alpha-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central-peripheral melanocortin-leptin pathway Mol. Cell. Endocrinol. 200 2003 99 109
34. L. Reshef, Y. Olswang, H. Cassuto, B. Blum, C.M. Croniger, S.C. Kalhan, S.M. Tilghman, and R.W. Hanson Glyceroneogenesis and the triglyceride/fatty acid cycle J. Biol. Chem. 278 2003 30413 30416
35. C. Nye, J. Kim, S.C. Kalhan, and R.W. Hanson Reassessing triglyceride synthesis in adipose tissue Trends Endocrinol. Metab. 19 2008 356 361
36. B.A. Boston, and R.D. Cone Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line Endocrinology 137 1996 2043 2050
37. M.D. Jensen, K. Ekberg, and B.R. Landau Lipid metabolism during fasting Am. J. Physiol. Endocrinol. Metab. 281 2001 E789 E793
38. L. Zhang, W.H. Li, M. Anthonavage, and M. Eisinger Melanocortin-5 receptor: a marker of human sebocyte differentiation Peptides 27 2006 413 420
39. J.J. An, Y. Rhee, S.H. Kim, D.M. Kim, D.H. Han, J.H. Hwang, Y.J. Jin, B.S. Cha, J.H. Baik, W.T. Lee, and S.K. Lim Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle J. Biol. Chem. 282 2007 2862 2870
40. A.W. Taylor, N. Kitaichi, and D. Biros Melanocortin 5 receptor and ocular immunity Cell. Mol. Biol. (Noisy-le-grand) 52 2006 53 59
41. D.J. Jun, K.Y. Na, W. Kim, D. Kwak, E.J. Kwon, J.H. Yoon, K. Yea, H. Lee, J. Kim, P.G. Suh, S.H. Ryu, and K.T. Kim Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes J. Mol. Endocrinol. 44 2010 225 236
42. W. Chen, M.A. Kelly, X. Opitz-Araya, R.E. Thomas, M.J. Low, and R.D. Cone Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides Cell 91 1997 789 798