Identification of P-glycoprotein inhibitors in contaminated freshwater sediments

Environmental Science and Technology

Volumn 47, Issue 9, 2013, Pages 4813-4821

  Zaja, Roko ^a   Terzić, Senka ^a   Senta, Ivan ^a   Lončar, Jovica ^a   Popović, Marta ^a   Ahel, Marijan ^a   Smital, Tvrtko ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

CONTAMINATED SEDIMENT; EFFECT-DIRECTED ANALYSIS; ENVIRONMENTAL SAMPLE; FLIGHT MASS SPECTROMETRY; PHARMACEUTICAL INDUSTRY; PHARMACEUTICAL WASTEWATER; POLYPROPYLENE GLYCOL; WASTEWATER EFFLUENTS;

BIOCHEMISTRY; EFFLUENTS; GLYCOPROTEINS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONIONIC SURFACTANTS; POLYPROPYLENE OXIDES; POLYPROPYLENES; SEDIMENTOLOGY; TOXICITY;

SEDIMENTS;

ADENOSINE TRIPHOSPHATASE; ALCOHOL; ALCOHOL POLYETHOXYLATE; CALCEIN; COLCHICINE; CYCLOSPORIN A; FRESH WATER; GLYCOPROTEIN P INHIBITOR; NONIONIC SURFACTANT; POLOXAMER; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

AQUATIC ORGANISM; BIOASSAY; EXPERIMENTAL STUDY; FISH; FRESHWATER ECOSYSTEM; GENE EXPRESSION; INDUSTRIAL WASTE; PROTEIN; SAMPLING; SEDIMENT POLLUTION; SUBSTRATE; TOXICITY TEST;

ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CROATIA; DRUG CYTOTOXICITY; DRUG INDUSTRY; DRUG RESISTANCE; EFFLUENT; ENZYME ASSAY; PROTEIN EXPRESSION; SEDIMENT; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WASTE WATER MANAGEMENT; WATER CONTAMINATION; WATER SAMPLING; XENOBIOTIC RESISTANCE;

ANIMALS; CELL LINE, TUMOR; FRESH WATER; GEOLOGIC SEDIMENTS; P-GLYCOPROTEIN; WATER POLLUTANTS, CHEMICAL;

CROATIA; ZAGREB;

EID: 84877634475     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es400334t     Document Type: Article

References (36)

1. Leslie, E. M.; Deeley, R. G.; Cole, S. P. C. Multidrug resistance proteins: Role of Pglycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense Toxicol. Appl. Pharmacol. 2005, 204, 216-237
2. Kurelec, B.; Pivcevic, B. Evidence for a multixenobiotic resistance mechanism in the mussel Mytilus galloprovincialis Aquat. Toxicol. 1991, 19, 291-301
3. Kurelec, B. The multixenobiotic resistance mechanisms in aquatic organisms Crit. Rev. Toxicol. 1992, 22, 23-43
4. Bard, S. M. Multixenobiotic resistance as a cellular defense mechanism in aquatic organisms Aquat. Toxicol. 2000, 48, 357-389
5. Sturm, A.; Segner, H. P-glycoproteins and xenobiotic efflux transport in fish. In Biochemistry and Molecular Biology of Fishes Vol. VI. Environmental Toxicology; Mommsen, T. P.; Moon, T. W., Eds; Elsevier: Amsterdam, 2005; pp 496-533.
6. Epel, D.; Luckenbach, T.; Stevenson, C. N.; Macmanus-Spencer, L. A.; Hamdoun, A.; Smital, T. Efflux transporters: Newly appreciated roles in protection against pollutants Environ. Sci. Technol. 2008, 42, 3914-20
7. Smital, T.; Sauerbor, R.; Hackenberger, B. K. Inducibility of the P-glycoprotein transport activity in the marine mussel Mytilus galloprovincialis and the freshwater mussel Dreissena polymorpha Aquat. Toxicol. 2003, 65, 443-465
8. Tutundjian, R.; Cachot, J.; Leboulenger, F.; Minier, C. Genetic and immunological characterisation of multixenobiotic resistance system in the turbot (Scophthalamus maximus) Comp. Biochem. Physiol., Part B 2002, 132, 463-471
9. Williams, T. D.; Gensberg, K.; Minchin, S. D.; Chipman, J. K. A DNA expression array to detect toxic stress response in European flounder (Platichthys flesus) Aquat. Toxicol. 2003, 65, 141-157
10. Smital, T.; Luckenbach, T.; Sauerborn, R.; Hamdoun, A. M.; Vega, R. L.; Epel, D. Emerging contaminants-Pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms Mutat. Res., Fundam. Mol. Mech. Mutagen. 2004, 552, 101-117
11. Smital, T.; Kurelec, B. The chemosensitizers of multixenobiotic resistance mechanism in aquatic invertebrates: A new class of pollutants Mutat. Res., Fundam. Mol. Mech. Mutagen. 1998, 399, 43-53
12. Keiter, S.; Grund, S.; van Bavel, B.; Hagberg, J.; Engwall, M.; Kammann, U.; Klempt, M.; Manz, W.; Olsman, H.; Braunbeck, T.; Hollert, H. Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river Anal. Bioanal. Chem. 2008, 390, 2009-2019
13. Thomas, K. V.; Langford, K.; Petersen, K.; Smith, A. J.; Tollefsen, K. E. Effect-directed identification of naphthenic acids as important in vitro xeno-estrogens and anti-androgens in North Sea offshore produced water discharges Environ. Sci. Technol. 2008, 43, 8066-8071
14. Brack, W. Effect-directed analysis: A promising tool for the identification of organic toxicants in complex mixtures? Anal. Bioanal. Chem. 2003, 377, 397-407
15. Zaja, R.; Caminada, D.; Loncar, J.; Fent, K.; Smital, T. Development and characterization of P-glycoprotein 1 (P-gp1, ABCB1)-mediated doxorubicin-resistant PLHC-1 hepatoma fish cell line Toxicol. Appl. Pharmacol. 2008, 227, 207-18
16. Zaja, R.; Loncar, J.; Popovic, M.; Smital, T. First characterization of fish P-glycoprotein (abcb1) substrate specificity using determinations of its ATPase activity and calcein-AM assay with PLHC-1/dox cell line Aquat. Toxicol. 2011, 103, 52-63
17. Terzic, S.; Mikac, I.; Senta, I.; Ahel, M. Comprehensive molecular characterization of organic contaminants in freshwater sediments by gas chromatography/mass spectrometry and liquid chromatography/time-of-flight mass spectrometry. In Progress in Environmental Science and Technology; Li, S.; Wang, Y.; Cao, F.; Huang, P.; Zhang, Y., Eds.; Science Press: Beijing, China, 2009; Vol. II, Part A, pp 397-405.
18. Smital, T.; Terzic, S.; Zaja, R.; Senta, I.; Pivcevic, B.; Popovic, M.; Mikac, I.; Tollefsen, K. E.; Thomas, K. V.; Ahel, M. Assessment of toxicological profiles of the municipal wastewater effluents using chemical analyses and bioassays Ecotoxicol. Environ. Saf. 2011, 74, 844-851
19. Smital, T.; Terzić, S.; Lončar, J.; Senta, I.; Žaja, R.; Popović, M.; Mikac, I.; Tollefsen, K. E.; Thomas, K. V.; Ahel, M. Prioritisation of organic contaminants in a river basin using chemical analyses and bioassays Environ. Sci. Pollut. Res. 2012, 10.1007/s11356-012-1059-x
20. Terzic, S.; Ahel, M. Nontarget analysis of polar contaminants in freshwater sediments influenced by pharmaceutical industry using ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry Environ. Pollut. 2011, 159, 557-566
21. Zaja, R.; Klobucar, R. S.; Smital, T. Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line Aquat. Toxicol. 2007, 81, 365-76
22. Cornwell, M. M.; Safa, A. R.; Felsted, R. L.; Gottesman, M. M.; Pastan, I. Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling Proc. Natl. Acad. Sci. U.S.A. 1956, 83, 3847-3850
23. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with folin phenol reagent J. Biol. Chem. 1951, 193, 265-275
24. Henkel, R. D.; VandeBerg, J. L.; Walsh, R. A. A microassay for ATPase Anal. Biochem. 1998, 169, 312-318
25. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays J. Immunol. Methods 1983, 65, 55-63
26. Brack, W.; Segner, H.; Moder, M.; Schuurmann, G. Fixed-effect-level toxicity equivalents-A suitable parameter for assessing ethoxyresorufin-O- deethylase induction potency in complex environmental samples Environ. Toxicol. Chem. 2000, 19, 2493-2501
27. Hollo, Z.; Homolya, L.; Davis, C. W.; Sarkadi, B. Calcein accumulation as a fluorometric functional assay of the multidrug transporter Biochim. Biophys. Acta, Biomembr. 1994, 1191, 384-388
28. Batrakova, E. V.; Li, S.; Alakhov, V. Y.; Miller, D. W.; Kabanov, A. V. Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells J. Pharmacol. Exp. Ther. 2003, 304, 845-854
29. Shono, Y.; Nishihara, H.; Matsuda, Y.; Furukawa, S.; Okada, N.; Fujita, T.; Yamamoto, A. Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes J. Pharm. Sci. 2004, 93, 877-885
30. Seelig, A.; Gerebtzoff, G. Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding Expert Opin. Drug Metab. 2006, 2, 733-752
31. Li-Blatter, X.; Seelig, A. Exploring the P-glycoprotein binding cavity with polyoxyethylene alkyl ethers Biophys. J. 2010, 99, 3589-3598
32. Aller, S. G.; Yu, J.; Ward, A.; Weng, Y.; Chittaboina, S.; Zhuo, R.; Harrell, P. M.; Trinh, Y. T.; Zhang, Q.; Urbatsch, I. L.; Chang, G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Science 2009, 323, 1718-1722
33. Li-Blatter, X.; Seelig, A. P-glycoprotein-ATPase modulation: The molecular mechanisms Biophys. J. 2012, 102, 1383-1393
34. Edser, C. Latest market analysis Focus Surfactants 2006, 5, 1-2
35. Ying, G.-G. Fate, behavior and effects of surfactants and their degradation products in the environment Environ. Pollut. 2005, 32, 417-431
36. Krogh, K. A.; Halling-Sørensen, B.; Mogensen, B. B.; Vejrup, K. V. Environmental properties and effects of nonionic surfactant adjuvants in pesticides: A review Chemosphere 2003, 50, 871-901