Fixed-effect-level toxicity equivalents - A suitable parameter for assessing ethoxyresorufin-O-deethylase induction potency in complex environmental samples

Environmental Toxicology and Chemistry

Volumn 19, Issue 10, 2000, Pages 2493-2501

  Brack, Werner ^a   Segner, Helmut ^a   Möder, Monika ^a   Schüürmann, Gerrit ^a  

^a HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

Author keywords

Bioassay directed fractionation; Confirmation; Ethoxyresorufin O deethylase; Sediment extract; Toxicity equivalent assessment

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON; ETHOXYRESORUFIN DEETHYLASE; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON;

ANIMAL CELL; ARTICLE; BIOASSAY; ENZYME INDUCTION; ENZYME INHIBITION; FRACTIONATION; GERMANY; INDUSTRIAL AREA; NONHUMAN; PARAMETER; PRIORITY JOURNAL; RAINBOW TROUT; SEDIMENT; TOXICITY TESTING;

EID: 0033806721     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1002/etc.5620191015     Document Type: Article

References (48)

1. Tracking the distribution of persistent organic pollutants
2. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
3. Cellular response profile to chemical stress
4. Characterization of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar halogenated hydrocarbons in environmental samples
5. The aryl hydrocarbon receptor: A comparative perspective
6. EROD induction in cultured chick embryo liver: A sensitive bioassay for dioxin-like environmental pollutants
7. Aryl hydrocarbon receptor-mediated toxic potency of dissolved lipophilic organic contaminants collected from Lincoln Creek, Milwaukee, Wisconsin, USA, to PLHC-1 (Poeciliopsis lucida) fish hepatoma cells
8. Comparison of toxic equivalent factors for selected dioxin and furan congeners derived using fish and mammalian liver cell lines
9. Chicken embryo hepatocyte bioassay for measuring cytochrome P4501A-based 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent concentrations in environmental samples
10. Rapid assessment of induced cytochrome P4501A protein and catalytic activity in fish hepatoma cells grown in multiwell plates: Response to TCDD, TCDF, and two planar PCBs
11. Induction of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) liver cells: Concentration-response relationships of four model substances
12. Ability of polycyclic hydrocarbons to induce 7-ethoxyresorufin-O-deethylase activity in a trout liver cell line
13. Bioassay-directed chemical analysis in environmental research
14. Bioassay-directed chemical analysis of genotoxic components in coastal sediments
15. A bleached-kraft mill effluent causing induction of a fish mixed-function oxygenase enzyme
16. Source and identity of compounds in a thermomechanical pulp mill effluent inducing hepatic mixed-function oxygenase activity in fish
17. Extracts from settling particulate matter collected in the Stockholm Archipelago waters: Embryolethality, immunotoxicity and EROD-inducing potency of fractions containing aliphatics/monoaromatics, diaromatics or polyaromatics
18. Halogenated aromatic hydrocarbon-mediated porphyrin accumulation and induction of cytochrome P4501A in chicken embryo hepatocytes
19. Toxic potencies of lipophilic extracts from sediments and settling particulate matter (SPM) collected in a PCB-contaminated river system
20. Toxic equivalency factors for dioxin-like PCBs
21. Derivation of 2,3,7,8-TCDD toxic equivalent factors (TEFs) for selected dioxins, furans and PCBs with rainbow trout and rat liver cell lines and the influence of exposure time
22. Bioassay-directed identification of toxicants in river sediment in the industrial region of Bitterfeld (Germany) - A contribution to hazard assessment
23. The ecotoxicology of coplanar polychlorinated biphenyls
24. Development and characterization of rainbow trout liver cell line expressing cytochrome P450-dependent mono-oxygenase activity
25. Mammalian and teleost cell line bioassay and chemically derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent concentrations in lake trout (Salvenius namaycush) from Lake Superior and Lake Ontario, North America
26. Microassay for rapid measurement of 7-ethoxyresorufin-O-deethylase activity in intact fish hepatocytes
27. Toxic potencies of extracts of sediment and settling particulate matter collected in the recipient of a bleached pulp mill effluent before and after abandoning chlorine bleaching
28. Use of liver cell lines to develop TCDD equivalency factors and to derive TCDD-equivalent concentrations in environmental samples
29. Accumulation and biotransformation of tri-n-butyltin by isolated rainbow trout hepatocytes
30. Reversible and time-dependent inhibition of the hepatic cytochrome P450 steroidal hydroxylases by the proestrogenic pesticide methoxychlor in rat and human
31. Screening assay for dioxin-like compounds based on competitive binding to the murine hepatic Ah receptor. 1. Assay development
32. Induction of cytochrome P4501A by binary mixtures of polychlorinated biphenyls and 2,3,7,8-tetradibenzo-p-dioxin in liver cell lines from rat and trout
33. Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver
34. In vitro activation of the dioxin receptor to a DNA-binding form by food-borne heterocyclic amines
35. Structural requirements for the induction of hepatic microsomal cytochrome P450 by imidazole- and pyridine-containing compounds in rats
36. Interaction with the aromatic hydrocarbon receptor, CYP1A induction and mutagenicity of a series of diaminotoluenes: Implications for their carcinogenicity
37. The cytochrome P-450 system in fish, aquatic toxicology and environmental monitoring
38. Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone
39. A fish hepatoma cell line (PLHC-1) as a tool to study cytotoxicity and CYP1A induction properties of cellulose and wood chip extracts
40. Chronic retene exposure causes sustained induction of cyp1A activity and protein in rainbow trout (Oncorhynchus mykiss)
41. Screening assay for dioxin-like compounds based on competitive binding to the murine hepatic Ah receptor. 2. Application to environmental samples
42. Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan
43. Exposure of northern leopard frogs in the green bay ecosystem to polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofuranes is measured by direct chemistry but not hepatic ethoxyresorufin-O-deethalyse activity
44. Chlorinated trans stilbenes: Competitive binding to the Ah receptor, induction of cytochrome P-450 monooxygenase activity and partial 2,3,7,8-TCDD antagonism
45. In vitro bioassays for polychlorinated diphenyl ethers: Quantitative structure-activity relationships
46. Sulfur analogues of polychlorinated dibenzo-p-dioxins, dibenzofurans and diphenyl ethers as inducers of CYP1A1 in mouse hepatoma cell culture and structure-activity relationships
47. New types of environmental POPs