Cell-free carrier system for localized delivery of peripheral blood cell-derived engineered factor signaling: Towards development of a one-step device for autologous angiogenic therapy

Journal of Controlled Release

Volumn 169, Issue 1-2, 2013, Pages 91-102

  Hadjipanayi, E ^a,b   Bauer, A T ^a   Moog, P ^a   Salgin, B ^c   Kuekrek, H ^a   Fersch, B ^d   Hopfner, U ^a   Meissner, T ^c   Schluter A ^d   Ninkovic, M ^b   MacHens, H G ^a   Schilling, A F ^a,e  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b KLINIKUM BOGENHAUSEN   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d MUNICH UNIVERSITY OF APPLIED SCIENCES   (Germany)

^e Center for Applied New Technologies in Engineering for Regenerative Medicine (CANTER)   (Germany)

Author keywords

Angiogenesis; Blood; Cell free; Device; Factor delivery; Hypoxia

Indexed keywords

ANGIOGENESIS; CELL-FREE; DEVICE; FACTOR DELIVERY; HYPOXIA;

ASSAYS; BLOOD; BLOOD VESSELS; CELL CULTURE; COLLAGEN; ENDOTHELIAL CELLS; MIXTURES; POLYSTYRENES; STIFFNESS MATRIX; TISSUE;

SCAFFOLDS (BIOLOGY);

ANGIOGENIN; COLLAGEN; FIBRIN; MATRIGEL; MICROSPHERE; POLYSTYRENE; THROMBOSPONDIN 1; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL ENGINEERING; CELL FREE SYSTEM; CELL HYPOXIA; CELL THERAPY; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; MALE; MICROVASCULATURE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANGIOGENESIS INDUCING AGENTS; BLOOD CELLS; CELL CULTURE TECHNIQUES; CELL HYPOXIA; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; TISSUE SCAFFOLDS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; YOUNG ADULT;

EID: 84877593805     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.04.008     Document Type: Article

References (60)

1. A.P. Levy A cellular paradigm for the failure to increase vascular endothelial growth factor in chronically hypoxic states Coron. Artery Dis. 10 1999 427 430 (Pubitemid 29419560)
2. E. Hadjipanayi, U. Cheema, U. Hopfner, A. Bauer, H.G. Machens, and A.F. Schilling Injectable system for spatio-temporally controlled delivery of hypoxia-induced angiogenic signalling J. Control. Release 161 2012 852 860
3. P. Pichiule, and J.C. LaManna Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia J. Appl. Physiol. 93 2002 1131 1139 (Pubitemid 34919687)
4. A. Yamamoto, H. Takahashi, Y. Kojima, Y. Tsuda, Y. Morio, M. Muramatsu, and Y. Fukuchi Downregulation of angiopoietin-1 and Tie2 in chronic hypoxic pulmonary hypertension Respiration 75 2008 328 338 (Pubitemid 351450405)
5. K. Park Engineered cell/matrix platform for hypoxia-induced angiogenesis J. Control. Release 153 2011 197
6. E. Hadjipanayi, U. Cheema, V. Mudera, D. Deng, W. Liu, and R.A. Brown First implantable device for hypoxia-mediated angiogenic induction J. Control. Release 153 2011 217 224
7. M.M. Hickey, and M.C. Simon Regulation of angiogenesis by hypoxia and hypoxia-inducible factors Curr. Top. Dev. Biol. 76 2006 217 257 (Pubitemid 44773777)
8. U. Cheema, R.A. Brown, B. Alp, and A.J. MacRobert Spatially defined oxygen gradients and vascular endothelial growth factor expression in an engineered 3D cell model Cell Mol. Life Sci. 65 2008 177 186
9. E. Hadjipanayi, R.A. Brown, V. Mudera, D. Deng, W. Liu, and U. Cheema Controlling physiological angiogenesis by hypoxia-induced signaling J. Control. Release 146 2010 309 317
10. A. Namiki, E. Brogi, M. Kearney, E.A. Kim, T.G. Wu, T. Couffinhal, L. Varticovski, and J.M. Isner Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells J. Biol. Chem. 270 1995 31189 31195 (Pubitemid 26012206)
11. S.S. Di, Z. Yang, B.M. Wyler von, J. Voelzmann, N. Diehm, I. Baumgartner, and C. Kalka Novel cell-free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantation PLoS One 4 2009 e5643
12. M. Kubo, T.S. Li, R. Suzuki, B. Shirasawa, N. Morikage, M. Ohshima, S.L. Qin, and K. Hamano Hypoxic preconditioning increases survival and angiogenic potency of peripheral blood mononuclear cells via oxidative stress resistance Am. J. Physiol. Heart Circ. Physiol. 294 2008 H590 H595
13. S.H. Bhang, S. Lee, J.Y. Shin, T.J. Lee, and B.S. Kim Transplantation of cord blood mesenchymal stem cells as spheroids enhances vascularization Tissue Eng. A 18 2012 2138 2147
14. M. Lichtenauer, M. Mildner, K. Hoetzenecker, M. Zimmermann, B.K. Podesser, W. Sipos, E. Berenyi, M. Dworschak, E. Tschachler, M. Gyongyosi, and H.J. Ankersmit Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study Basic Res. Cardiol. 106 2011 1283 1297
15. B. Burke, A. Giannoudis, K.P. Corke, D. Gill, M. Wells, L. Ziegler-Heitbrock, and C.E. Lewis Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy Am. J. Pathol. 163 2003 1233 1243 (Pubitemid 37175073)
16. D. Panutsopulos, A. Zafiropoulos, E. Krambovitis, G.E. Kochiadakis, N.E. Igoumenidis, and D.A. Spandidos Peripheral monocytes from diabetic patients with coronary artery disease display increased bFGF and VEGF mRNA expression J. Transl. Med. 1 2003 6
17. P. Reher, N. Doan, B. Bradnock, S. Meghji, and M. Harris Effect of ultrasound on the production of IL-8, basic FGF and VEGF Cytokine 11 1999 416 423 (Pubitemid 29259636)
18. T. Griga, A. Gutzeit, C. Sommerkamp, and B. May Increased production of vascular endothelial growth factor by peripheral blood mononuclear cells in patients with inflammatory bowel disease Eur. J. Gastroenterol. Hepatol. 11 1999 175 179 (Pubitemid 29103579)
19. C. Pang, Z. Gao, J. Yin, J. Zhang, W. Jia, and J. Ye Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity Am. J. Physiol. Endocrinol. Metab. 295 2008 E313 E322
20. R. Montesano, A. Mossaz, J.E. Ryser, L. Orci, and P. Vassalli Leukocyte interleukins induce cultured endothelial cells to produce a highly organized, glycosaminoglycan-rich pericellular matrix J. Cell Biol. 99 1984 1706 1715 (Pubitemid 15223607)
21. M. Bouchentouf, P. Paradis, K.A. Forner, J. Cuerquis, M.N. Boivin, J. Zheng, M.R. Boulassel, J.P. Routy, E.L. Schiffrin, and J. Galipeau Monocyte derivatives promote angiogenesis and myocyte survival in a model of myocardial infarction Cell Transplant. 19 2010 369 386
22. T. Kobayashi, K. Hamano, T.S. Li, M. Nishida, S. Ikenaga, K. Hirata, N. Zempo, and K. Esato Angiogenesis induced by the injection of peripheral leukocytes and platelets J. Surg. Res. 103 2002 279 286 (Pubitemid 34948513)
23. H. Kamihata, H. Matsubara, T. Nishiue, S. Fujiyama, K. Amano, O. Iba, T. Imada, and T. Iwasaka Improvement of collateral perfusion and regional function by implantation of peripheral blood mononuclear cells into ischemic hibernating myocardium Arterioscler. Thromb. Vasc. Biol. 22 2002 1804 1810 (Pubitemid 35315765)
24. O. Iba, H. Matsubara, Y. Nozawa, S. Fujiyama, K. Amano, Y. Mori, H. Kojima, and T. Iwasaka Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs Circulation 106 2002 2019 2025 (Pubitemid 35176311)
25. S. Li, B. Zhou, and Z.C. Han Therapeutic neovascularization by transplantation of mobilized peripheral blood mononuclear cells for limb ischemia. A comparison between CD34 + and CD34- mononuclear cells Thromb. Haemost. 95 2006 301 311
26. J. Leor, L. Rozen, A. Zuloff-Shani, M.S. Feinberg, Y. Amsalem, I.M. Barbash, E. Kachel, R. Holbova, Y. Mardor, D. Daniels, A. Ocherashvilli, A. Orenstein, and D. Danon Ex vivo activated human macrophages improve healing, remodeling, and function of the infarcted heart Circulation 114 2006 I94 I100
27. B. Amann, C. Luedemann, R. Ratei, and J.A. Schmidt-Lucke Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease Cell Transplant. 18 2009 371 380
28. A. Ozturk, Y. Kucukardali, F. Tangi, A. Erikci, G. Uzun, C. Bashekim, H. Sen, H. Terekeci, Y. Narin, M. Ozyurt, S. Ozkan, O. Sayan, O. Rodop, S. Nalbant, O. Sildiroglu, F.F. Yalniz, I.V. Senkal, H. Sabuncu, and C. Oktenli Therapeutical potential of autologous peripheral blood mononuclear cell transplantation in patients with type 2 diabetic critical limb ischemia J. Diabetes Complications 26 2012 29 33
29. T. Tatsumi, E. Ashihara, T. Yasui, S. Matsunaga, A. Kido, Y. Sasada, S. Nishikawa, M. Hadase, M. Koide, R. Nakamura, H. Irie, K. Ito, A. Matsui, H. Matsui, M. Katamura, S. Kusuoka, S. Matoba, S. Okayama, M. Horii, S. Uemura, C. Shimazaki, H. Tsuji, Y. Saito, and H. Matsubara Intracoronary transplantation of non-expanded peripheral blood-derived mononuclear cells promotes improvement of cardiac function in patients with acute myocardial infarction Circ. J. 71 2007 1199 1207 (Pubitemid 47201778)
30. C. Holzinger, A. Zuckermann, C. Kopp, A. Schollhammer, M. Imhof, W. Zwolfer, I. Baumgartner, H. Magometschnigg, E. Weissinger, and E. Wolner Treatment of non-healing skin ulcers with autologous activated mononuclear cells Eur. J. Vasc. Surg. 8 1994 351 356 (Pubitemid 24133144)
31. A. Zuloff-Shani, E. Kachel, O. Frenkel, A. Orenstein, E. Shinar, and D. Danon Macrophage suspensions prepared from a blood unit for treatment of refractory human ulcers Transfus. Apher. Sci. 30 2004 163 167 (Pubitemid 38519802)
32. E. Hadjipanayi, V. Mudera, and R.A. Brown Close dependence of fibroblast proliferation on collagen scaffold matrix stiffness J. Tissue Eng. Regen. Med. 3 2009 77 84
33. M. Baker, S.D. Robinson, T. Lechertier, P.R. Barber, B. Tavora, G. D'Amico, D.T. Jones, B. Vojnovic, and K. Hodivala-Dilke Use of the mouse aortic ring assay to study angiogenesis Nat. Protoc. 7 2012 89 104
34. A. Buxboim, K. Rajagopal, A.E. Brown, and D.E. Discher How deeply cells feel: methods for thin gels J. Phys. Condens. Matter 22 2010 194116
35. E. Hadjipanayi, V. Mudera, and R.A. Brown Guiding cell migration in 3D: a collagen matrix with graded directional stiffness Cell Motil. Cytoskeleton 66 2009 121 128
36. L.A. DiPietro, and P.J. Polverini Angiogenic macrophages produce the angiogenic inhibitor thrombospondin 1 Am. J. Pathol. 143 1993 678 684 (Pubitemid 24058225)
37. E.M. Battinelli, B.A. Markens, and J.E. Italiano Jr. Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis Blood 118 2011 1359 1369
38. J.M. Reinke, and H. Sorg Wound repair and regeneration Eur. Surg. Res. 49 2012 35 43
39. M.C. Barsotti, A. Magera, C. Armani, F. Chiellini, F. Felice, D. Dinucci, A.M. Piras, A. Minnocci, R. Solaro, G. Soldani, A. Balbarini, and S.R. Di Fibrin acts as biomimetic niche inducing both differentiation and stem cell marker expression of early human endothelial progenitor cells Cell Prolif. 44 2011 33 48
40. J.P. Maloney, C.C. Silliman, D.R. Ambruso, J. Wang, R.M. Tuder, and N.F. Voelkel In vitro release of vascular endothelial growth factor during platelet aggregation Am. J. Physiol. 275 1998 H1054 H1061
41. R.S. O'Connor, X. Hao, K. Shen, K. Bashour, T. Akimova, W.W. Hancock, L.C. Kam, and M.C. Milone Substrate rigidity regulates human T cell activation and proliferation J. Immunol. 189 2012 1330 1339
42. S. Zhang, A. Sun, H. Ma, K. Yao, N. Zhou, L. Shen, C. Zhang, Y. Zou, and J. Ge Infarcted myocardium-like stiffness contributes to endothelial progenitor lineage commitment of bone marrow mononuclear cells J. Cell Mol. Med. 15 2011 2245 2261
43. M.E. Marketou, J.E. Kontaraki, N.A. Tsakountakis, E.A. Zacharis, G.E. Kochiadakis, D.A. Arfanakis, G. Chlouverakis, and P.E. Vardas Arterial stiffness in hypertensives in relation to expression of angiopoietin-1 and 2 genes in peripheral monocytes J. Hum. Hypertens. 24 2010 306 311
44. P.H. Weigel, G.M. Fuller, and R.D. LeBoeuf A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing J. Theor. Biol. 119 1986 219 234 (Pubitemid 16111665)
45. T.T. Chen, A. Luque, S. Lee, S.M. Anderson, T. Segura, and M.L. Iruela-Arispe Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells J. Cell Biol. 188 2010 595 609
46. J.A. Allan, A.J. Docherty, P.J. Barker, N.S. Huskisson, J.J. Reynolds, and G. Murphy Binding of gelatinases A and B to type-I collagen and other matrix components Biochem. J. 309 1995 299 306 (Pt 1)
47. E. Maquoi, N.E. Sounni, L. Devy, F. Olivier, F. Frankenne, H.W. Krell, F. Grams, J.M. Foidart, and A. Noel Anti-invasive, antitumoral, and antiangiogenic efficacy of a pyrimidine-2,4,6-trione derivative, an orally active and selective matrix metalloproteinases inhibitor Clin. Cancer Res. 10 2004 4038 4047 (Pubitemid 38812479)
48. A.B. Ennett, D. Kaigler, and D.J. Mooney Temporally regulated delivery of VEGF in vitro and in vivo J. Biomed. Mater. Res. A 79 2006 176 184 (Pubitemid 44452868)
49. T. Koyama, F. Hackl, P. Aflaki, J. Bergmann, B. Zuhaili, E. Waisbren, U. Govindarajulu, F. Yao, and E. Eriksson A new technique of ex vivo gene delivery of VEGF to wounds using genetically modified skin particles promotes wound angiogenesis J. Am. Coll. Surg. 212 2011 340 348
50. B.P. Chan, and K.F. So Photochemical crosslinking improves the physicochemical properties of collagen scaffolds J. Biomed. Mater. Res. A 75 2005 689 701 (Pubitemid 47233453)
51. A. Sahni, and C.W. Francis Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation Blood 96 2000 3772 3778
52. S.M. Royce, M. Askari, and K.G. Marra Incorporation of polymer microspheres within fibrin scaffolds for the controlled delivery of FGF-1 J. Biomater. Sci. Polym. Ed. 15 2004 1327 1336 (Pubitemid 39419599)
53. E.A. Silva, and D.J. Mooney Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis J. Thromb. Haemost. 5 2007 590 598 (Pubitemid 46680694)
54. J. Kurita, M. Miyamoto, Y. Ishii, J. Aoyama, G. Takagi, Z. Naito, Y. Tabata, M. Ochi, and K. Shimizu Enhanced vascularization by controlled release of platelet-rich plasma impregnated in biodegradable gelatin hydrogel Ann. Thorac. Surg. 92 2011 837 844
55. R. Gorodetsky, R.A. Clark, J. An, J. Gailit, L. Levdansky, A. Vexler, E. Berman, and G. Marx Fibrin microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing J. Invest. Dermatol. 112 1999 866 872 (Pubitemid 29277985)
56. M.J. Carter, C.P. Fylling, and L.K. Parnell Use of platelet rich plasma gel on wound healing: a systematic review and meta-analysis Eplasty 11 2011 e38
57. P.A. de, N. Prevete, I. Fiorentino, F.W. Rossi, S. Staibano, N. Montuori, P. Ragno, A. Longobardi, B. Liccardo, A. Genovese, D. Ribatti, A.F. Walls, and G. Marone Expression and functions of the vascular endothelial growth factors and their receptors in human basophils J. Immunol. 177 2006 7322 7331 (Pubitemid 44715102)
58. Y.H. Kusumanto, W.A. Dam, G.A. Hospers, C. Meijer, and N.H. Mulder Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor Angiogenesis 6 2003 283 287 (Pubitemid 38987537)
59. M. McCourt, J.H. Wang, S. Sookhai, and H.P. Redmond Proinflammatory mediators stimulate neutrophil-directed angiogenesis Arch. Surg. 134 1999 1325 1331
60. I. Puxeddu, A. Alian, A.M. Piliponsky, D. Ribatti, A. Panet, and F. Levi-Schaffer Human peripheral blood eosinophils induce angiogenesis Int. J. Biochem. Cell Biol. 37 2005 628 636. (Pubitemid 40022939)