Therapeutic neovascularization by transplantation of mobilized peripheral blood mononuclear cells for limb ischemia. A comparison between CD34+ and CD34- mononuclear cells

Thrombosis and Haemostasis

Volumn 95, Issue 2, 2006, Pages 301-311

  Lin, Shu ^a,b   Zhou, Bin ^a,b   Han, Zhong Chao ^a,b  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^b AmCellGene Co Ltd   (China)

Author keywords

CD34; G CSF mobilized PBMNCs; Ischemia; Neovascularization; VEGF

Indexed keywords

ANGIOGENIC FACTOR; CD34 ANTIGEN; FLUORESCENT DYE; GRANULOCYTE COLONY STIMULATING FACTOR; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL WALL; CAPILLARY DENSITY; CELL MIGRATION; CELL TRANSPLANTATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPLETION; HUMAN; HUMAN CELL; LASER DOPPLER FLOWMETRY; LEG BLOOD FLOW; LEG MUSCLE; LIMB ISCHEMIA; MALE; MOUSE; MUSCLE PERFUSION; NONHUMAN; NORMAL HUMAN; NUDE MOUSE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; THERAPY EFFECT;

ANIMALS; ANTIGENS, CD34; CAPILLARIES; CELL SEPARATION; HEMATOPOIETIC STEM CELL MOBILIZATION; HINDLIMB; HUMANS; ISCHEMIA; LEUKOCYTES, MONONUCLEAR; MICE; MICE, NUDE; NEOVASCULARIZATION, PHYSIOLOGIC; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS; TREATMENT OUTCOME;

EID: 33645553164     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH05-06-0442     Document Type: Article

References (32)

1. Schaper W, Ito WD. Molecular mechanisms of coronary collateral vessel growth. Circ Res 1996; 79: 911-9.
2. Arras M, Ito WD. Monocyte activation in angiogenesis and collateral growth in the measured rabbit hindlimb. J Clin Invest 1998; 101: 40-50.
3. Ito WD, Arras M, Winkler B et al. Angiogenesis but not collateral growth is associated with ischemia femoral artery occlusion. Am J Physiol 1997; 273: H1255-H1265.
4. Kern MJ. Angiogenesis, arteriogenesis, and physiological perfusion: Review of natural history and concepts. J Interv Cardiol 1999; 12: 313-8.
5. Asahara T, Murohara T, Sullivan A et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-7.
6. Murohara T, Ikeda H, Duan J et al. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization, J Clin Invest 2000; 105: 1527-36.
7. Kalka C, Masuda H, Taakahashi T et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci U S A 2000; 97: 3422-7.
8. Kawamoto A, Gwon HC, Iwaguro H et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 2001; 103: 634-7.
9. Schatteman GC, Hanlon HD, Jiao C et al. Blood-derived angioblasts accelerate blood flow restoration in diabetic mice. J Clin Invest 2000; 106: 571-8.
10. Kocher AA, Schuster MD, Szabolcs MJ et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7: 430-6.
11. Shintani S, Murohara T, Ikeda H et al. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation 2001; 103: 897-903.
12. Minamino T, Toko H, Tateno K et al. Peripheral-blood or bone-marrow mononuclear cells for therapeutic angiogenesis ? Lancet 2002; 360: 2083-4.
13. Tateishi-Yuyama, E, Matsubara H, Murohara T et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 2002; 360: 427-35.
14. Huang PP, Li SZ, Han MZ et al. Autologous transplantation of peripheral blood stem cells as treatment for arteriosclerosis obliterans of lower extremities. Thromb Haemost 2004; 91: 606-9.
15. Wagers AJ, Sherwood RI, Christensen JL et al. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002; 297: 2256-9.
16. Iba O, Matsubara H, Nozawa Y et al. Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limb. Circulation 2002; 106: 2019-25.
17. Tibor Z, Borja F, Sawa K et al. Bone marrow-derived cells do not Incorporate into the adult growing vasculature. Circ Res 2004; 94: 230-8.
18. Arras M, Ito WD, Scholz D et al. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest 1998; 101: 40-50.
19. Takeshita S, Isshiki T, Mori H et al. Microangiographic assessment of collateral vessel formation following direct gene transfer of vascular endothelial growth factor in rats. Cardiovasc Res 1997; 35: 547-52.
20. Asahara T, Masuda H, Takahashi T et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85: 221-8.
21. Noishiki Y, Tomizawa Y, Yamane Y et al. Autocrine angiogenic vascular prosthesis with bone marrow transplantation. Nature Med 1996; 2: 90-3.
22. Asahara T, Takahashi T, Masuda H et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J 1999; 18: 3964-72.
23. Huang P, Li S, Han M et al. Autologous transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetes. Diabetes Care 2005; 28: 2155-60.
24. Heil M, Ziegelhoeffer T, Pipp F et al. Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol 2002; 283: H2411-H2419.
25. Arras M, Ito WD, Scholz D et al. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest 1997; 101: 40-50.
26. Rehman J, Li J, Orschell C et al. Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003; 107: 1164-9.
27. Fernandez Pujol B, Lucibello FC, Gehling UM et al. Endothelial-like cells derived from human CD14 positive monocytes. Differentiation 2000; 65: 287-300.
28. Schmeisser A, Garlichs CD, Zhang H et al. Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel under angiogenic conditions. Cardiovasc Res 2001; 49: 671-80.
29. Hershey JC, Baskin EP, Glass JD et al. Revascularization in the rabbit hindlimb: dissociation between capillary sprouting and arteriogenesis. Cardiovasc Res 200; 49: 618-25.
30. Bergers G, Brekken R, McMahon G et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000; 2: 737-44.
31. Clauss M, Gerlach M, Gerlach H et al. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med 1990; 172: 1535-45.
32. Barleon B, Sozzani S, Zhou D et al. Migration of human monocytes in response to vascular endothelial growth factor is mediated via the VEGF receptor flt-1 receptor. Blood 1996; 97: 3336-43.