Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 298, Issue 2, 2010, Pages

  Dasgupta, Trisha ^a   Fabry, Mary E ^a   Kaul, Dhananjay K ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Hemolysis; Inflammation; Multiple organ damage; Reperfusion; Sickle cell disease

Indexed keywords

ALPHA GLOBIN; ANTISICKLING AGENT; BETA GLOBIN; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEMOGLOBIN F; LIPID; NITRIC OXIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; GENETIC MANIPULATION; HEMOLYSIS; KIDNEY; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER; METABOLITE; MOUSE; MUSCLE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SICKLE CELL ANEMIA; TRANSGENIC MOUSE;

ANEMIA, SICKLE CELL; ANIMALS; ANTIOXIDANTS; ANTISICKLING AGENTS; CATALASE; CYTOSOL; FETAL HEMOGLOBIN; GLOBINS; GLUTATHIONE PEROXIDASE; HEMOLYSIS; HUMANS; LEUKOCYTE COUNT; LIPID PEROXIDATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSOMES, LIVER; NITRIC OXIDE; OXIDATIVE STRESS;

EID: 75449108995     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00611.2009     Document Type: Article

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