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Lee SP, Ataga KI, Orringer EP, et al. Biologically active CD40 ligand is elevated in sickle cell anemia: potential role for platelet-mediated inflammation. Arterioscler Thromb Vasc Biol 2006; 26:1626-1631. In this work, Lee and colleagues describe for the first time a potential role of a known inflammatory mediator - CD40L - in SCD. They document that the platelet is the origin of the elevated CD40L levels in SCD patients and illustrate the novel inflammatory role for the platelet in SCD.
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