1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): New analogs and binding model

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3338-3341

  Liu, Y ^a   Esteva Font, C ^b   Yao, C ^b   Phuan, P W ^b   Verkman, A S ^b   Anderson, M O ^a  

^a SAN FRANCISCO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Microsomal stability; Molecular docking; Triazolothienopyrimidine; Urea transport protein

Indexed keywords

AMIDINE; CARRIER PROTEIN; DIURETIC AGENT; PROTEIN INHIBITOR; PYRIMIDINE DERIVATIVE; THIOPHENE; TRIAZOLOTHIENOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UREA TRANSPORT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG CONFORMATION; DRUG SYNTHESIS; ENZYME INHIBITION; HEMOLYSIS; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; RAT; STATIC ELECTRICITY;

BINDING SITES; FLUORINE; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICROSOMES; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877583620     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.089     Document Type: Article

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