Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4- yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1- carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3157-3161

  Chaturvedula, Prasad V ^a   Mercer, Stephen E ^a   Pin, Sokhom S ^a   Thalody, George ^a   Xu, Cen ^a   Conway, Charlie M ^a   Keavy, Deborah ^a   Signor, Laura ^a   Cantor, Glenn H ^a   Mathias, Neil ^a   Moench, Paul ^a   Denton, Rex ^a   Macci, Robert ^a   Schartman, Richard ^a   Whiterock, Valerie ^a   Davis, Carl ^a   Macor, John E ^a   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

CGRP receptor antagonist for intranasal delivery

Indexed keywords

ANTIMIGRAINE AGENT; BMS 694153; BMS 742413; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE; SUMATRIPTAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BLOOD FLOW; CALLITRICHINAE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG OXIDATION; DRUG PENETRATION; DRUG POTENCY; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; FACE; HAPLORHINI; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NOSE CAVITY; RAT; RESPIRATORY EPITHELIUM; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICITY TESTING;

ADMINISTRATION, INTRANASAL; AMIDES; ANIMALS; CACO-2 CELLS; CALLITHRIX; CORONARY VESSELS; DRUG EVALUATION, PRECLINICAL; FACE; HUMANS; INDAZOLES; MIGRAINE DISORDERS; QUINOLONES; RABBITS; RATS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RESPIRATORY MUCOSA;

MARMOSETS; ORYCTOLAGUS CUNICULUS;

EID: 84877583073     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.012     Document Type: Article

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