The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4723-4727

  Han, Xiaojun ^a   Civiello, Rita L ^a   Conway, Charles M ^a   Cook, Deborah A ^a   Davis, Carl D ^a   MacCi, Robert ^a   Pin, Sokhom S ^a   Ren, Shelly X ^a   Schartman, Richard ^a   Signor, Laura J ^a   Thalody, George ^a   Widmann, Kimberly A ^a   Xu, Cen ^a   Chaturvedula, Prasad V ^a   MacOr, John E ^a   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Calcitonin gene related peptide (CGRP); CGRP receptor antagonist; CYP3A4 inhibition; Migraine headache; Tyrosine surrogates

Indexed keywords

ALANINE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CYTOCHROME P450 3A4; INDAZOLE DERIVATIVE; SUMATRIPTAN; TYROSINE; ZOLMITRIPTAN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTICLE; BLOOD FLOW; BRAIN ARTERY; CALLITRICHINAE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; FACE; HUMAN; HUMAN TISSUE; HYDROGEN BOND; IC 50; MIGRAINE; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALLITHRIX; CORONARY VESSELS; CYTOCHROME P-450 CYP3A; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

MARMOSETS;

EID: 84863438470     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.074     Document Type: Article

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