Discovery of BMS-846372, a potent and orally active human CGRP receptor antagonist for the treatment of migraine

ACS Medicinal Chemistry Letters

Volumn 3, Issue 4, 2012, Pages 337-341

  Luo, Guanglin ^a   Chen, Ling ^a   Conway, Charles M ^a   Denton, Rex ^a   Keavy, Deborah ^a   Gulianello, Michael ^a   Huang, Yanling ^a   Kostich, Walter ^a   Lentz, Kimberley A ^a   Mercer, Stephen E ^a   Schartman, Richard ^a   Signor, Laura ^a   Browning, Marc ^a   MacOr, John E ^a   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

antagonist; CGRP; CGRP receptor; migraine

Indexed keywords

BMS 846372; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; CALLITRICHINAE; CELL MEMBRANE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIASTEREOISOMER; DIHYDROXYLATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL DOG; EXPERIMENTAL MONKEY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIVER MICROSOME; MIGRAINE; NONHUMAN; PRIORITY JOURNAL; RAT; RING CLOSING METATHESIS;

CANIS FAMILIARIS; MACACA FASCICULARIS; MARMOSETS; RATTUS;

EID: 84859771560     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300021s     Document Type: Article

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