Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2917-2921

  Luo, Guanglin ^a   Chen, Ling ^a   Civiello, Rita ^a   Pin, Sokhom S ^a   Xu, Cen ^a   Kostich, Walter ^a   Kelley, Michelle ^a   Conway, Charles M ^a   MacOr, John E ^a   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

CGRP antagonist; Migraine

Indexed keywords

AMIDE; BMS 694153; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; PYRIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG PENETRATION; HUMAN; HUMAN CELL; MIGRAINE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; CACO-2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MIGRAINE DISORDERS; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIDINES; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE;

EID: 84862777374     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.065     Document Type: Article

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