Autophagy and cancer: Taking the 'toxic' out of cytotoxics

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 6, 2013, Pages 777-789

  Giuliani, Charlett M ^a   Dass, Crispin R ^a  

^a VICTORIA UNIVERSITY   (Australia)

Author keywords

autophagy; bcl 2; beclin 1; cell death; chemotherapy

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALKYLATING AGENT; ANTHRACYCLINE DERIVATIVE; ANTIMETABOLITE; ANTINEOPLASTIC AGENT; BAFILOMYCIN; CANNABINOID; CHLOROQUINE; CISPLATIN; DIGOXIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; FLUOROURACIL; GEMCITABINE; OBATOCLAX; OUABAIN; PEMETREXED; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN BCL 2; PROTEIN P53; PROTON PUMP INHIBITOR; PTDINS 3 KINASE INHIBITOR; RAS PROTEIN; SMALL INTERFERING RNA; SODIUM SELENITE; SORAFENIB; TAMOXIFEN; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCA ALKALOID; WOGONIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; AUTOPHAGY; CANCER CELL; CANCER GROWTH; CANCER THERAPY; CATABOLISM; CELL ORGANELLE; CELL SURVIVAL; CYTOTOXICITY; DRUG POTENTIATION; DRUG TARGETING; ESOPHAGUS CANCER; HUMAN; HYPOXIA; LUNG NON SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; NUTRIENT; ONCOGENE; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL PROLIFERATION; DISEASE PROGRESSION; HUMANS; NEOPLASMS;

EID: 84877576996     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12034     Document Type: Review

References (54)

1. Levine B, et al. Autophagy in immunity and inflammation. Nature 2011; 469: 323-335.
2. Hanahan D, Weinberg RA,. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
3. Goel S, et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 2011; 91: 1071-1121.
4. Zong W, et al. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 2004; 18: 1272-1282.
5. Minotti G, et al. Anthracyclines: molecular advances and pharmacologic developments in antitumour activity and cardiotoxicity. Pharmacol Rev 2004; 56: 185-229.
6. Gligorov J, Lotz JP,. Preclinical pharmacology of the taxanes: implications of the differences. Oncologist 2004; 9: 3-8.
7. Swanton C, et al. Chromosome instability determines taxane response. Proc Natl Acad Sci USA 2009; 106: 8671-8676.
8. Jordan M, et al. Mechanisms of inhibition of cell proliferation by vinca alkaloids. Cancer Res 1991; 51: 2212-2222.
9. Zhang C, et al. DNA damage increases sensitivity to vinca alkaloids and decreases sensitivity to taxanes through p53-dependent repression of microtubule-associated protein 4. Cancer Res 1999; 59: 3663-3670.
10. Kaye S,. New antimetabolites in cancer chemotherapy and their clinical impact. Br J Cancer 1998; 78: S1-S7.
11. Kaushik S, Cuervo AM,. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol 2012; 22: 407-417.
12. Mijaljica D, et al. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy 2011; 7: 673-682.
13. White E,. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12: 401-410.
14. Kimmelman A,. The dynamic nature of autophagy in cancer. Genes Dev 2011; 25: 1999-2010.
15. Maiuri MC, et al. Crosstalk between apoptosis and autophagy with the Beclin 1 interactome. EMBO J 2010; 29: 515-516.
16. Fujita N, et al. The ATG16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell 2008; 19: 2092-2100.
17. Komatsu M,. Potential role of p62 in tumor development. Autophagy 2011; 7: 1088-1090.
18. Kabeya Y, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720-5728.
19. Yu L, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304: 1500-1502.
20. Huang Y, et al. PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy 2011; 7: 1132-1144.
21. Witkiewicz AK, et al. An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am J Pathol 2009; 174: 2023-2034.
22. Lisanti MP, et al. Accelerated aging in the tumor microenvironment: connecting aging, inflammation and cancer metabolism with personalized medicine. Cell Cycle 2011; 10: 2059-2063.
23. Ko YH, et al. Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. Cancer Biol Ther 2011; 12: 1085-1097.
24. Rausch V, et al. Autophagy mediates survival of pancreatic tumour- initiating cells in a hypoxic microenvironment. J Pathol 2012; 227: 325-335.
25. Hatchi E, et al. E4F1 deficiency results in oxidative stress- mediated cell death of leukemic cells. J Exp Med 2011; 208: 1403-1417.
26. Balaburski G, et al. p53 and ARF: unexpected players in autophagy. Trends Cell Biol 2010; 20: 363-369.
27. Lomonosova E, Chinnadurai G,. BH3-only proteins in apoptosis and beyond: an overview. Oncogene 2008; 27: S2-19.
28. Umekawa M, Klionsky DJ,. The Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J Biol Chem 2012; 287: 16300-16310.
29. Hsieh AC, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012; 485: 55-61.
30. Ganley IG, et al. ULK1.ATG13.FIP200 complex mediates mTOR signalling and is essential for autophagy. J Biol Chem 2009; 284: 12297-12305.
31. Donadelli M, et al. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS- mediated mechanism. Cell Death Dis 2011; 2: e152.
32. Bareford D, et al. Sorafenib enhances pemetrexed cytotoxicity through an autophagy- dependent mechanism in cancer cells. Autophagy 2011; 7: 1261-1262.
33. Heidari N, et al. GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy. Cell Death Dis 2010; 1: e76.
34. Marino M, et al. Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells. Cell Death Dis 2010; 1: e87.
35. Kaini R, et al. Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen- sensitive prostate cancer cells. Prostate 2012; 72: 1412-1422.
36. Bhutia S, et al. Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24). Autophagy 2011; 7: 1076-1077.
37. Ling L, et al. The role of reactive oxygen species and autophagy in safingol-induced cell death. Cell Death Dis 2011; 2: e129.
38. Akar U, et al. Silencing of bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells. Autophagy 2008; 4: 669-679.
39. Siegelin MD, et al. Sorafenib exerts anti-glioma activity in vitro and in vivo. Neurosci Lett 2010; 478: 165-170.
40. Cardinal J, et al. Cisplatin prevents high mobility group box 1 release and in protective in a murine model of hepatic ischemia/reperfusion injury. Hepatology 2009; 50: 565-574.
41. Zeybeck ND, et al. Rosuvastatin induces apoptosis in cultured human papillary thyroid cancer cells. J Endocrinol 2011; 210: 105-115.
42. Huang J, et al. Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma. Autophagy 2012; 8: 275-277.
43. Sheen J, et al. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell 2011; 19: 613-628.
44. Han W, et al. EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS ONE 2011; 6: e18691.
45. Viola G, et al. MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol 2012; 83: 16-26.
46. O'Donovan T, et al. Induction of autophagy by drug resistant oesophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. Autophagy 2011; 7: 509-524.
47. Guo X, et al. Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cell. Cancer Lett 2012; 320: 171-179.
48. Park S, et al. Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species. Toxicol Lett 2010; 212: 252-261.
49. Chow S, et al. Wogonin induces cross regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. J Cell Biochem 2012; 113: 3476-3485.
50. Thomas S, et al. Preferential killing of triple negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Lett 2012; 325: 63-71.
51. Wang Y, et al. Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signalling pathways. Int J Biochem Cell Biol 2012; 44: 1813-1824.
52. Yang W, et al. AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells. J Surg Oncol 2012; 106: 680-688.
53. Maiuri M, et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between beclin-1 and Bcl-2/Bcl-xL. Autophagy 2007; 3: 374-376.
54. Kung C, et al. Autophagy in tumour suppression and cancer therapy. Crit Rev Eukaryot Gene Expr 2011; 21: 71-100.