Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells

Prostate

Volumn 72, Issue 13, 2012, Pages 1412-1422

  Kaini, Ramesh R ^a   Sillerud, Laurel O ^a,b   Zhaorigetu, Siqin ^a   Hu, Chien An A ^a,b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

androgen deprivation; autophagy; lipid droplets; lipolysis; NMR; prostate cancer

Indexed keywords

3 METHYLADENINE; ANDROGEN; BAFILOMYCIN A1; BICALUTAMIDE; CHARCOAL; FAT DROPLET; PLASMID VECTOR; SMALL INTERFERING RNA; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

ANDROGEN DEPRIVATION THERAPY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENETIC TRANSFECTION; HOMEOSTASIS; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; LIPID DEGRADATION; LIPOLYSIS; LYSOSOME; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROSTATE CANCER;

ANDROGEN ANTAGONISTS; ANILIDES; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; LIPID METABOLISM; LIPOLYSIS; MALE; NEOPLASMS, HORMONE-DEPENDENT; NITRILES; PROSTATE; PROSTATIC NEOPLASMS; TOSYL COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 84864884124     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.22489     Document Type: Article

References (45)

1. Dehm SM, Tindall DJ,. Molecular regulation of androgen action in prostate cancer. J Cell Biochem 2006; 99: 333-344. (Pubitemid 44435552)
2. Swinnen JV, Esquenet M, Goossens K, Heyns W, Verhoeven G,. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res 1997; 57: 1086-1090. (Pubitemid 27138606)
3. Baron A, Migita T, Tang D, Loda M,. Fatty acid synthase: A metabolic oncogene in prostate cancer? J Cell Biochem 2004; 91: 47-53.
4. Swinnen JV, Van Veldhoven PP, Esquenet M, Heyns W, Verhoeven G,. Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology 1996; 137: 4468-4474. (Pubitemid 26321898)
5. 1H nuclear magnetic resonance spectroscopically determined citrate in human seminal fluid accompanies the development of prostate adenocarcinoma. J Urol 2005; 173: 433-438.
6. Nelson PS, Clegg N, Arnold H, Ferguson C, Bonham M, White J, Hood L, Lin B,. The program of androgen-responsive genes in neoplastic prostate epithelium. Proc Natl Acad Sci USA 2002; 99: 11890-11895. (Pubitemid 34994494)
7. DePrimo SE, Diehn M, Nelson JB, Reiter RE, Matese J, Fero M, Tibshirani R, Brown PO, Brooks JD,. Transcriptional programs activated by exposure of human prostate cancer cells to androgen. Genome Biol 2002; 3: RESEARCH0032.
8. Swinnen JV, Heemers H, van de Sande T, de Schrijver E, Brusselmans K, Heyns W, Verhoeven G,. Androgens, lipogenesis and prostate cancer. J Steroid Biochem Mol Biol 2004; 92: 273-279. (Pubitemid 40128248)
9. Liu Y,. Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer. Prostate Cancer Prostatic Dis 2006; 9: 230-234. (Pubitemid 44317255)
10. Zha S, Ferdinandusse S, Hicks JL, Denis S, Dunn TA, Wanders RJ, Luo J, De Marzo AM, Isaacs WB,. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. Prostate 2005; 63: 316-323. (Pubitemid 40664342)
11. Costello LC, Franklin RB,. The intermediary metabolism of the prostate: A key to understanding the pathogenesis and progression of prostate malignancy. Oncology 2000; 59: 269-282.
12. Swinnen JV, Verhoeven G,. Androgens and the control of lipid metabolism in human prostate cancer cells. J Steroid Biochem Mol Biol 1998; 65: 191-198. (Pubitemid 28335606)
13. Garber K,. Energy deregulation: Licensing tumors to grow. Science 2006; 312: 1158-1159.
14. Szende B, Romics I, Vass L,. Apoptosis in prostate cancer after hormonal treatment. Lancet 1993; 342: 1422.
15. Denmeade SR, Lin XS, Isaacs JT,. Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer. Prostate 1996; 28: 251-265. (Pubitemid 26119117)
16. Feldman BJ, Feldman D,. The development of androgen-independent prostate cancer. Nat Rev Cancer 2001; 1: 34-45. (Pubitemid 33741879)
17. Dutt SS, Gao AC,. Molecular mechanisms of castration-resistant prostate cancer progression. Future Oncol 2009; 5: 1403-1413.
18. Mizushima N, Ohsumi Y, Yoshimori T,. Autophagosome formation in mammalian cells. Cell Struct Funct 2002; 27: 421-429. (Pubitemid 36267711)
19. Wan G, Zhaorigetu S, Liu Z, Kaini R, Jiang Z, Hu CA,. Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. J Biol Chem 2008; 283: 21540-21549.
20. Levine B, Mizushima N, Virgin HW,. Autophagy in immunity and inflammation. Nature 2011; 469: 323-335.
21. Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC,. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010; 90: 1383-1435.
22. Li M, Jiang X, Liu D, Na Y, Gao GF, Xi Z,. Autophagy protects LNCaP cells under androgen deprivation conditions. Autophagy 2008; 4: 54-60.
23. Bennett HL, Fleming JT, O'Prey J, Ryan KM, Leung HY,. Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis 2010; 1: e72.
24. Farese RV Jr, Walther TC,. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell 2009; 139: 855-860.
25. Brasaemle DL,. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis. J Lipid Res 2007; 48: 2547-2559. (Pubitemid 350272839)
26. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ,. Autophagy regulates lipid metabolism. Nature 2009; 458: 1131-1135.
27. Czaja MJ,. Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: Pathophysiological implications. Am J Physiol Cell Physiol 2010; 298: C973-C978.
28. Rodriguez-Navarro JA, Cuervo AM,. Autophagy and lipids: Tightening the knot. Semin Immunopathol 2010; 32: 343-353.
29. Liu Z, Lu H, Shi H, Du Y, Yu J, Gu S, Chen X, Liu KJ, Hu CA,. PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells. Cancer Res 2005; 65: 1647-1654. (Pubitemid 40478588)
30. Thompson TA, Wilding G,. Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol in human prostate carcinoma cells. Mol Cancer Ther 2003; 2: 797-803.
31. Sobel RE, Sadar MD,. Cell lines used in prostate cancer research: A compendium of old and new lines-Part 2. J Urol 2005; 173: 360-372.
32. Folch J, Lees M, Sloane Stanley GH,. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957; 226: 497-509.
33. Kim PK, Hailey DW, Mullen RT, Lippincott-Schwartz J,. Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci USA 2008; 105: 20567-20574.
34. Ichimura Y, Komatsu M,. Selective degradation of p62 by autophagy. Semin Immunopathol 2010; 32: 431-436.
35. Brinkmann AO, Kuiper GG, Ris-Stalpers C, van Rooij HC, Romalo G, Trifiro M, Mulder E, Pinsky L, Schweikert HU, Trapman J,. Androgen receptor abnormalities. J Steroid Biochem Mol Biol 1991; 40: 349-352.
36. Hara T, Miyazaki J, Araki H, Yamaoka M, Kanzaki N, Kusaka M, Miyamoto M,. Novel mutations of androgen receptor: A possible mechanism of casodex withdrawal syndrome. Cancer Res 2003; 63: 149-153. (Pubitemid 36070433)
37. Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y,. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 1998; 23: 33-42. (Pubitemid 28223394)
38. Devlin HL, Mudryj M,. Progression of prostate cancer: Multiple pathways to androgen independence. Cancer Lett 2009; 274: 177-186.
39. Levine B,. Unraveling the role of autophagy in cancer. Autophagy 2006; 2: 65-66.
40. Cao C, Subhawong T, Albert JM, Kim KW, Geng L, Sekhar KR, Gi YJ, Lu B,. Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res 2006; 66: 10040-10047. (Pubitemid 44672057)
41. Botti J, Djavaheri-Mergny M, Pilatte Y, Codogno P,. Autophagy signaling and the cogwheels of cancer. Autophagy 2006; 2: 67-73.
42. Herman-Antosiewicz A, Johnson DE, Singh SV,. Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells. Cancer Res 2006; 66: 5828-5835. (Pubitemid 43927137)
43. Mehrpour M, Esclatine A, Beau I, Codogno P,. Overview of macroautophagy regulation in mammalian cells. Cell Res 2010; 20: 748-762.
44. Warburg O,. On the origin of cancer cells. Science 1956; 123: 309-314.
45. Singh G, Lakkis CL, Laucirica R, Epner DE,. Regulation of prostate cancer cell division by glucose. J Cell Physiol 1999; 180: 431-438. (Pubitemid 29334844)