SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3175-3179

Conformational restriction in a series of GPR119 agonists: Differences in pharmacology between mouse and human

(10) Scott, James S a Brocklehurst, Katy J a Brown, Hayley S a Clarke, David S a Coe, Helen a Groombridge, Sam D a Laber, David a Macfaul, Philip A a McKerrecher, Darren a Schofield, Paul a

a ASTRAZENECA (United Kingdom)

Author keywords

G protein coupled receptors; GPR119 agonists; Partial agonists; Pharmacology

Indexed keywords

G PROTEIN COUPLED RECEPTOR 119 AGONIST; PARTIAL AGONIST; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BINDING ASSAY; CONFORMATIONAL TRANSITION; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SOLUBILITY; HUMAN; IC 50; NONHUMAN; NUCLEOPHILICITY; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BIOLOGICAL AVAILABILITY; CELL MEMBRANE PERMEABILITY; CYCLIC AMP; DOGS; HALF-LIFE; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MICE; PROTEIN BINDING; PYRIMIDINES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877574742 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.04.006 Document Type: Article

Times cited : (15)

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