Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1306-1309

  Mascitti, Vincent ^a   Stevens, Benjamin D ^a   Choi, Chulho ^a   McClure, Kim F ^a   Guimarães, Cristiano R W ^a   Farley, Kathleen A ^a   Munchhof, Michael J ^a   Robinson, Ralph P ^a   Futatsugi, Kentaro ^a   Lavergne, Sophie Y ^a   Lefker, Bruce A ^a   Cornelius, Peter ^a   Bonin, Paul D ^a   Kalgutkar, Amit S ^a   Sharma, Raman ^a   Chen, Yue ^a  

^a PFIZER INC   (United States)

Author keywords

Configurational entropy; Diabetes; Gauche effect; GPR119; Metabolism

Indexed keywords

2 (2,3,6 TRIFLUOROPHENYL)ACETAMIDE; ACETAMIDE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; GPR 119 RECEPTOR; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STABILITY; HUMAN; IN VITRO STUDY; LIPOPHILICITY; LIVER MICROSOME METABOLISM;

ACETAMIDES; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED;

EID: 79951726586     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.088     Document Type: Article

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