Functional proteomic analysis of seminal plasma proteins in men with various semen parameters

Reproductive Biology and Endocrinology

Volumn 11, Issue 1, 2013, Pages

  Sharma, Rakesh ^a   Agarwal, Ashok ^a   Mohanty, Gayatri ^a,c   Jesudasan, Rachel ^b   Gopalan, Banu ^a   Willard, Belinda ^a   Yadav, Satya P ^a   Sabanegh, Edmund ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c RAVENSHAW UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; ALBUMIN PREPROPROTEIN; ARMADILLO REPEAT PROTEIN; BETA 2 MICROGLOBULIN; CARBOXYPEPTIDASE E PREPROPROTEIN; CATHEPSIN B; CATHEPSIN D PREPROPROTEIN; CLUSTERIN ISOFORM 1; CYSTATIN C; CYSTATIN S PRECURSOR; EPIDIDYMAL SECRETORY PROTEIN E1; EXTRACELLULAR MATRIX PROTEIN 1 ISOFORM 1; FIBRONECTIN 1 ISOFORM 3 PREPROPROTEIN; GALECTIN 3 BINDING PROTEIN; LACTOFERRIN; OROSOMUCOID; PROLACTIN INDUCED PROTEIN; PROSAPOSIN ISOFORM A PREPROPROTEIN; PROSTAGLANDIN H2; PROSTATE SPECIFIC ANTIGEN ISOFORM 4 PREPROPROTEIN; SEMENOGELIN 2; SEMINAL PLASMA PROTEIN; STOMACH MUCIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFERRIN; UBIQUITIN AND RIBOSOMAL PROTEIN S27A; UNCLASSIFIED DRUG; ZINC ALPHA 2 GLYCOPROTEIN 1;

ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; FUNCTIONAL PROTEOMICS; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MALE; MALE INFERTILITY; MASS SPECTROMETRY; OLIGOSPERMIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SEMEN ANALYSIS; SPERM; SPERMATOZOON COUNT;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; HUMANS; INFERTILITY, MALE; MALE; OLIGOSPERMIA; PROTEOME; PROTEOMICS; REPRODUCIBILITY OF RESULTS; SEMEN; SEMINAL PLASMA PROTEINS; SENSITIVITY AND SPECIFICITY; SPERM COUNT; TANDEM MASS SPECTROMETRY;

EID: 84877306276     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-11-38     Document Type: Article

References (70)

1. The Practice Committee of the American Society for Reproductive Medicine Diagnostic evaluation of the infertile male: a committee opinion. Fertil Steril 2012, 98:294-301. The Practice Committee of the American Society for Reproductive Medicine.
2. Kruger TF, Menkveld R, Stander FS, Lombard CJ, Van der M, van Zyle JA, Smith K. Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril 1986, 46:1118-1123.
3. Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Veeck LL, Morshedi M, Brugo S. New method of evaluating sperm morphology with predictive value for human in vitro fertilization. Urology 1987, 30:248-251. 10.1016/0090-4295(87)90246-9, 3629768.
4. Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, Carson SA, Cisneros P, Steinkampf MP, Hill JA, Xu D, Vogel DL. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 2001, 345:1388-1393. 10.1056/NEJMoa003005, 11794171.
5. Agarwal A, Sharma RK, Nallella KP, Thomas AJ, Alvarez JG, Sikka SC. Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril 2006, 86:878-885. 10.1016/j.fertnstert.2006.02.111, 17027357.
6. Saleh RA, Agarwal A, Nada EA, El-Tonsy MH, Sharma RK, Meyer A, Nelson DR, Thomas AJ. Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Fertil Steril 2003, 79:1597-1605.
7. Sharma R, Agarwal A. Spermatogenesis: an overview. Human sperm chromatin: structure and function. Sperm chromatin. Biological and clinical applications in male infertility and assisted reproduction 2012, 19-44. Springer Science + Business Media, LLC, Zini A, Agarwal A.
8. Batruch I, Lecker I, Kagedan D, Smith CR, Mullen BJ, Grober E, Lo KC, Diamandis EP, Jarvi KA. Proteomic analysis of seminal plasma from normal volunteers and post-vasectomy patients identifies over 2000 proteins and candidate biomarkers of the urogenital system. J Proteome Res 2011, 10:941-953. 10.1021/pr100745u, 21142078.
9. Pilch B, Mann M. Large-scale and high-confidence proteomic analysis of human seminal plasma. Genome Biol 2006, 7(5):R40. 10.1186/gb-2006-7-5-r40, 1779515, 16709260.
10. Davalieva K, Kiprijanovska S, Noveski P, Plaseski T, Kocevska B, Broussard C, Plaseska-Karanfilska D. Proteomic analysis of seminal plasma in men with different spermatogenic impairment. Andrologia 2012, 44:256-264. 10.1111/j.1439-0272.2012.01275.x, 22288839.
11. Primakoff P, Myles DG. Penetration, adhesion, and fusion in mammalian sperm-egg interaction. Science 2002, 296:2183-2185. 10.1126/science.1072029, 12077404.
12. Varilová T, Seménková H, Horák P, Madera M, Pacáková V, Tichá M, Stulík K. Affinity liquid chromatography and capillary electrophoresis of seminal plasma proteins. J Sep Sci 2006, 29:1110-1115. 10.1002/jssc.200500405, 16830725.
13. Kelly RW. Immunosuppressive mechanisms in semen: implications for contraception. Hum Reprod 1995, 10:1686-1693.
14. Nishimune Y, Tanaka H. Infertility caused by polymorphisms or mutations in spermatogenesis-specific genes. J Androl 2006, 27:326-334. 10.2164/jandrol.05162, 16474012.
15. Mengual L, Ballescá JL, Ascaso C, Oliva R. Marked differences in protamine content and P1/P2 ratios in sperm cells from percoll fractions between patients and controls. J Androl 2003, 24:438-447.
16. Aoki VW, Moskovtsev SI, Willis J, Liu L, Mullen JB, Carrell DT. DNA integrity is compromised in protamine-deficient human sperm. J Androl 2005, 26:741-748. 10.2164/jandrol.05063, 16291969.
17. Fung KY, Glode LM, Green S, Duncan MW. A comprehensive characterization of the peptide and protein constituents of human seminal fluid. Prostate 2004, 61:171-181. 10.1002/pros.20089, 15305340.
18. Milardi D, Grande G, Vincenzoni F, Messana I, Pontecorvi A, De Marinis L, Castagnola M, Marana R. Proteomic approach in the identification of fertility pattern in seminal plasma of fertile men. Fertil Steril 2012, 97:67-73. 10.1016/j.fertnstert.2011.10.013, 22088208.
19. Starita-Geribaldi M, Poggioli S, Zucchini M, Garin J, Chevallier D, Fenichel P, Pointis G. Mapping of seminal plasma proteins by two dimensional gel electrophoresis in men with normal and impaired spermatogenesis. Mol Hum Reprod 2001, 7:715-722. 10.1093/molehr/7.8.715, 11470858.
20. Yamakawa K, Yoshida K, Nishikawa H, Kato T, Iwamoto T. Comparative analysis of interindividual variations in the seminal plasma proteome of fertile men with identification of potential markers for azoospermia in infertile patients. J Androl 2007, 28:858-865. 10.2164/jandrol.107.002824, 17554110.
21. Wang J, Wang J, Zhang HR, Shi HJ, Ma D, Zhao HX, Lin B, Li RS. Proteomic analysis of seminal plasma from asthenozoospermia patients reveals proteins that affect oxidative stress responses and semen quality. Asian J Androl 2009, 11:484-491. 10.1038/aja.2009.26, 19448646.
22. World Health Organization WHO laboratory manual for the examination and processing of human semen 2010, Cambridge: World Health Organization, 5, World Health Organization.
23. Hamada A, Sharma R, du Plessis SS, Willard B, Yadav SP, Sabanegh E, Agarwal A. Two-dimensional differential in-gel electrophoresis-based proteomics of male gametes in relation to oxidative stress. Fertil Steril 2013,
24. Boyle E, Weng S, Gollub J, Jin H, Botstein D, Cherry JM, Sherlock G. GO:TermFinder-open source software for accessing gene ontology information and finding significantly enriched gene ontology terms associated with a list of genes. Bioinformatics 2004, 20:3710-3715. 10.1093/bioinformatics/bth456, 3037731, 15297299.
25. GO term mapper http://go.princeton.edu/cgi-bin/GOTermMapper.
26. The UniProt Consortium Reorganizing the protein space at the universal protein resource (UniProt). Nucleic Acids Res 2012, 40:D71-D75. 3245120, 22102590, The UniProt Consortium.
27. Bhatia VN, Perlman DH, Costello CE, McComb ME. Software tool for researching annotations of proteins: open-source protein annotation software with data visualization. Anal Chem 2009, 81:9819-9823. 10.1021/ac901335x, 2787672, 19839595.
28. Chunlei W, Camilo O, Jason B, Marc L, James G, Serge B, Hodge CL, James H, Jeff J, Huss JW. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol 2009, 10:R130. 10.1186/gb-2009-10-11-r130, 3091323, 19919682.
29. Ingenuity pathway analysis (IPA) from ingenuity® systems Website Title: http://www.ingenuity.com.
30. Metacore™ from GeneGo Inc Website: http://www.genego.com.
31. Frenette G, Girouard J, Sullivan R. Comparison between epididymosomes collected in the intraluminal compartment of the bovine caput and cauda epididymidis. Biol Reprod 2006, 75:885-890. 10.1095/biolreprod.106.054692, 16943362.
32. Mirza SP, Olivier M. Methods and approaches for the comprehensive characterization and quantification of cellular proteomes using mass spectrometry. Physiol Genomics 2008, 33:3-11. 10.1152/physiolgenomics.00292.2007, 2771641, 18162499.
33. Claverol S, Burlet-Schiltz O, Gairin JE, Monsarrat B. Characterization of protein variants and post-translational modifications: ESI-MSn analyses of intact proteins eluted from polyacrylamide gels. Mol Cell Proteomics 2003, 2:483-493.
34. Guthals A, Bandeira N. Peptide identification by tandem mass spectrometry with alternate fragmentation modes. Mol Cell Proteomics 2012, 11:550-557. 10.1074/mcp.R112.018556, 22595789.
35. Liao TT, Xiang Z, Zhu WB, Fan LQ. Proteome analysis of round-headed and normal spermatozoa by 2-D fluorescence difference gel electrophoresis and mass spectrometry. Asian J Androl 2009, 11:683-693. 10.1038/aja.2009.59, 19823175.
36. VerBerkmoes NC, Bundy JL, Hauser L, Asano KG, Razumovskaya J, Larimer F, Hettich RL, Stephenson JL. Integrating " top-down" and " bottom-up" mass spectrometric approaches for proteomic analysis of shewanella oneidensis. J Proteome Res 2002, 1:239-52. 10.1021/pr025508a, 12645901.
37. Rolland AD, Lavigne R, Dauly C, Calvel P, Kervarrec C, Freour T, Evrard B, Rioux-Leclercq N, Auger J, Pineau C. Identification of genital tract markers in the human seminal plasma using an integrative genomics approach. Hum Reprod 2013, 28:199-209. 10.1093/humrep/des360, 23024119.
38. Kagedan D, Lecker I, Batruch I, Smith C, Kaploun I, Lo K, Grober E, Diamandis EP, Jarvi KA. Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry. Clin Proteomics 2012, 9:2. 3305567, 22309592.
39. Utleg AG, Yi EC, Xie T, Shannon P, White JT, Goodlett DR, Hood L, Lin B. Proteomic analysis of human prostasomes. Prostate 2003, 56:150-161. 10.1002/pros.10255, 12746840.
40. Mitra A, Richardson RT, O'Rand MG. Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. Biol Reprod 2010, 82:489-496. 10.1095/biolreprod.109.081331, 2825168, 19889947.
41. Robert M, Gibbs BF, Jacobson E, Gagnon C. Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I. Biochemistry 1997, 36:3811-3819. 10.1021/bi9626158, 9092810.
42. Lilja H, Abrahamsson PA, Lundwall A. Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. J Biol Chem 1989, 264:1894-1900.
43. Thacker S, Yadav SP, Sharma RK, Kashou A, Willard B, Zhang D, Agarwal A. Evaluation of sperm proteins in infertile men: a proteomic approach. Fertil Steril 2011, 95:2745-2748. 10.1016/j.fertnstert.2011.03.112, 21536282.
44. Malm J, Hellman J, Magnusson H, Laurell CB, Lilja H. Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. Eur J Biochem 1996, 238:48-53. 10.1111/j.1432-1033.1996.0048q.x, 8665951.
45. Zhao C, Huo R, Wang FQ, Lin M, Zhou ZM, Sha JH. Identification of several proteins involved in regulation of sperm motility by proteomic analysis. Fertil Steril 2007, 87:436-438. 10.1016/j.fertnstert.2006.06.057, 17074334.
46. Jansen S, Ekhlasi-Hundrieser M, Töpfer-Petersen E. Sperm adhesion molecules: structure and function. Cells Tissues Organs 2001, 168:82-92. 10.1159/000016809, 11114590.
47. Vaubourdolle M, Clavel JP, Gonzales J, Galli A. Evaluation of acid phosphatase isoenzymes in seminal fluid from normozoospermic, oligozoospermic, azoospermic and asthenoteratozoospermic men. Andrologia 1985, 17:598-604.
48. Dave BN, Rindani TH. Acid phosphatase activity in human semen. Int J Fertil 1988, 33:45-47.
49. Ziyyat A, Barraud-Lange V, Sifer C, Ducot B, Wolf JP, Soufir JC. Paradoxical increase of sperm motility and seminal carnitine associated with moderate leukocytospermia in infertile patients. Fertil Steril 2008, 90:2257-2263. 10.1016/j.fertnstert.2007.10.032, 18439589.
50. Singh G, Adaikan PG, Ng YK. Is seminal prostatic acid phosphatase a reliable marker for male infertility?. Singapore Med J 1996, 37:598-599.
51. Ostrowski W. Male accessory Sex glands 1980, pp. 197-213. Amsterdam: Elsevier/North-Holland Biomedical Press, Spring-Mills E, Hafez E.
52. Li R, Guo Y, Han BM, Yan X, Utleg AG, Li W, Tu LC, Wang J, Hood L, Xia S, Lin B. Proteomics cataloging analysis of human expressed prostatic secretions reveals rich source of biomarker candidates. Clin Appl 2008, 2:543-555.
53. Cooper EH, Plesner T. Beta-2-microglobulin review: its relevance in clinical oncology. Med Pediatr Oncol 1980, 8:323-334. 10.1002/mpo.2950080403, 6161299.
54. Di Giovanni S, Valentini G, Carducci P, Giallonardo P. Beta-2-microglobulin is a reliable tumor marker in chronic lymphocytic leukemia. Acta Haematol 1989, 81:181-185. 10.1159/000205558, 2502891.
55. He XH, Xu LH, Liu Y, Zeng YY. Cloning of human beta-microglobulin gene and its high expression in Escherichia coli. Sheng Wu Gong Cheng Xue Bao 2004, 20:99-103.
56. Miyata T, Inagi R, Wada Y, Ueda Y, Iida Y, Takahashi M, Taniguchi N, Maeda K. Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites. Biochemistry 1994, 33:12215-12221. 10.1021/bi00206a026, 7918443.
57. Sire J, Colle A, Pinatel MC, Fellous M, Manuel Y. beta2-Microglobulin in human seminal fluid (author's transl). Pathol Biol (Paris) 1978, 26:392-394.
58. Chard T, Parslow J, Rehmann T, Dawnay A. The concentrations of transferrin, beta 2-microglobulin, and albumin in seminal plasma in relation to sperm count. Fertil Steril 1991, 55:211-213.
59. Pacis RA, Pilat MJ, Pienta KJ, Wojno K, Raz A, Hogan V, Cooper CR. Decreased galectin-3 expression in prostate cancer. Prostate 2000, 4:118-123.
60. Brew K, Dinakarpandian D, Nagase H. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochem Biophys Acta 2000, 1477:267-283. 10.1016/S0167-4838(99)00279-4, 10708863.
61. Bode W, Fernandez-Catalan C, Tschesche H, Grams F, Nagase H, Maskos K. Structural properties of matrix metalloproteinases. Cell Mol Life Sci 1999, 55:639-652. 10.1007/s000180050320, 10357232.
62. Itoh Y, Binner S, Nagase H. Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate. Biochem J 1995, 308:645-651. 1136975, 7772054.
63. Michaely P, Tomchick DR, Machius M, Anderson RG. Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J 2002, 21:6387-6396. 10.1093/emboj/cdf651, 136955, 12456646.
64. Bennett V, Baines AJ. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev 2001, 81:1353-1392.
65. Neilsen PM, Cheney KM, Li CW, Chen JD, Cawrse JE, Schulz RB, Powell JA, Kumar R, Callen DF. Identification of ANKRD11 as a p53 coactivator. J Cell Sci 2008, 121:3541-3552. 10.1242/jcs.026351, 18840648.
66. Wong P, Borst DE, Farber D, Danciger JS, Tenniswood M, Chader GJ, Van Veen T. Increased TRPM-2/clusterin mRNA levels during the time of retinal degeneration in mouse models of retinitis pigmentosa. Biochem Cell Biol 1994, 72:439-446. 10.1139/o94-058, 7605616.
67. Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA. Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem 2003, 278:11590-11600. 10.1074/jbc.M209233200, 12551933.
68. Jain D, Jain R, Eberhard D, Eglinger J, Bugliani M, Piemonti L, Marchetti P, Lammert E. Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. J Mol Cell Biol 2012, 4:221-230. 10.1093/jmcb/mjs025, 22611253.
69. Waanders LF, Chwalek K, Monetti M, Kumar C, Lammert E, Mann M. Quantitative proteomic analysis of single pancreatic islets. Proc Natl Acad Sci USA 2009, 106:18902-18907. 10.1073/pnas.0908351106, 2765458, 19846766.
70. Okada M, Matsumoto K, Niki T, Taira T, Iguchi-Ariga SM, Ariga H. DJ-1, a target protein for an endocrine disrupter, participates in the fertilization in mice. Biol Pharm Bull 2002, 25:853-856. 10.1248/bpb.25.853, 12132656.