Identification of genital tract markers in the human seminal plasma using an integrative genomics approach

Human Reproduction

Volumn 28, Issue 1, 2013, Pages 199-209

  Rolland, A D ^a   Lavigne, R ^a,b   Dauly, C ^c   Calvel, P ^a   Kervarrec, C ^a   Freour, T ^d   Evrard, B ^a   Rioux Leclercq, N ^a,e   Auger, J ^f   Pineau, C ^a,b  

^a UNIVERSITÉ DE RENNES 1   (France)

^b Campus de Beaulieu   (France)

^c Thermo Fisher Scientific   (United States)

^d NANTES UNIVERSITY HOSPITAL   (France)

^e PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^f Hôpital Cochin ^*  (France)

Author keywords

biomarkers; germ cell; integrative genomics; proteome; seminal plasma

Indexed keywords

BIOLOGICAL MARKER; SEMINAL PLASMA PROTEIN; TRYPSIN;

ARTICLE; COMBINATORIAL LIBRARY; EPIDIDYMIS; FEMALE; FEMALE GENITAL SYSTEM; GENE LIBRARY; GENOMICS; GERM CELL; HUMAN; HUMAN TISSUE; INTEGRATIVE MEDICINE; MALE; MALE FERTILITY; MALE GENITAL SYSTEM; MALE INFERTILITY; NORMAL HUMAN; PEPTIDE ANALYSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN METABOLISM; SEMINAL PLASMA; SEMINAL VESICLE; SPECTROMETRY; SPERMATOZOON MATURATION; TESTIS; TISSUE SPECIFICITY; TRANSCRIPTOMICS;

EID: 84871196581     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des360     Document Type: Article

References (46)

1. Anawalt BD, Bebb RA, Matsumoto AM, Groome NP, Illingworth PJ, McNeilly AS, Bremner WJ. Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab 1996;81:3341-3345.
2. Anderson RA, Irvine DS, Balfour C, Groome NP, Riley SC. Inhibin B in seminal plasma: testicular origin and relationship to spermatogenesis. Hum Reprod 1998;13:920-926.
3. Auger J, Eustache F. Second to fourth digit ratios, male genital development and reproductive health: a clinical study among fertile men and testis cancer patients. Int J Androl 2011;34:e49-e58.
4. Batruch I, Lecker I, Kagedan D, Smith CR, Mullen BJ, Grober E, Lo KC, Diamandis EP, Jarvi KA. Proteomic analysis of seminal plasma from normal volunteers and post-vasectomy patients identifies over 2000 proteins and candidate biomarkers of the urogenital system. J Proteome Res 2011;10:941-953.
5. Boschetti E, Righetti PG. The art of observing rare protein species in proteomes with peptide ligand libraries. Proteomics 2009;9:1492-1510.
6. Bruckert E. How frequent is unintentional childlessness in Germany? Andrologia 1991;23:245-250.
7. Brugo-Olmedo S, De Vincentiis S, Calamera JC, Urrutia F, Nodar F, Acosta AA. Serum inhibin B may be a reliable marker of the presence of testicular spermatozoa in patients with nonobstructive azoospermia. Fertil Steril 2001;76:1124-1129.
8. Carpi A, Sabanegh E, Mechanick J. Controversies in the management of nonobstructive azoospermia. Fertil Steril 2009;91:963-970.
9. Castagna A, Cecconi D, Sennels L, Rappsilber J, Guerrier L, Fortis F, Boschetti E, Lomas L, Righetti PG. Exploring the hidden human urinary proteome via ligand library beads. J Proteome Res 2005; 4:1917-1930.
10. Chalmel F, Primig M. The Annotation, Mapping, Expression and Network (AMEN) suite of tools for molecular systems biology. BMC Bioinformatics 2008;9:86.
11. Chalmel F, Rolland AD, Niederhauser-Wiederkehr C, Chung SS, Demougin P, Gattiker A, Moore J, Patard JJ, Wolgemuth DJ, Jegou B et al. The conserved transcriptome in human and rodent male gametogenesis. Proc Natl Acad Sci USA 2007;104:8346-8351.
12. Com E, Rolland AD, Guerrois M, Aubry F, Jegou B, Vallet-Erdtmann V, Pineau C. Identification, molecular cloning, and cellular distribution of the rat homolog of minichromosome maintenance protein 7 (MCM7) in the rat testis. Mol Reprod Dev 2006;73:866-877.
13. Danshina PV, Geyer CB, Dai Q, Goulding EH, Willis WD, Kitto GB, McCarrey JR, Eddy EM, O'brien DA. Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice. Biol Reprod 2010;82:136-145.
14. de Lamirande E. Semenogelin, the main protein of the human semen coagulum, regulates sperm function. Semin Thromb Hemost 2007; 33:60-68.
15. Drabovich AP, Jarvi K, Diamandis EP. Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay. Mol Cell Proteomics 2011;10:M110. 004127.
16. Drake RR, White KY, Fuller TW, Igwe E, Clements MA, Nyalwidhe JO, Given RW, Lance RS, Semmes OJ. Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease. J Proteomics 2009;72:907-917.
17. Duncan MW, Thompson HS. Proteomics of semen and its constituents. Proteomics Clin Appl 2007;1:861-875.
18. El Garem YF, El Arini AF, El Beheiry AH, Zeid SA, Comhaire FH. Possible relationship between seminal plasma inhibin B and spermatogenesis in patients with azoospermia. J Androl 2002;23:825-829.
19. Fenichel P, Rey R, Poggioli S, Donzeau M, Chevallier D, Pointis G. Anti-Mullerian hormone as a seminal marker for spermatogenesis in non-obstructive azoospermia. Hum Reprod 1999;14:2020-2024.
20. Fung KY, Glode LM, Green S, Duncan MW. A comprehensive characterization of the peptide and protein constituents of human seminal fluid. Prostate 2004;61:171-181.
21. Guthauser B, Bailly M, Bergere M, Wainer R, Ville Y, Selva J. Successful pregnancy and delivery after testicular sperm extraction despite an undetectable concentration of serum inhibin B in a patient with nonobstructive azoospermia. Fertil Steril 2002;77:1077-1078.
22. Illingworth PJ, Groome NP, Byrd W, Rainey WE, McNeilly AS, Mather JP, Bremner WJ. Inhibin-B: a likely candidate for the physiologically important form of inhibin in men. J Clin Endocrinol Metab 1996; 81:1321-1325.
23. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4:249-264.
24. Ishikawa T. Surgical recovery of sperm in non-obstructive azoospermia. Asian J Androl 2012;14:109-115.
25. Juul S, Karmaus W, Olsen J. Regional differences in waiting time to pregnancy: pregnancy-based surveys from Denmark, France, Germany, Italy and Sweden. The European infertility and subfecundity study group. Hum Reprod 1999;14:1250-1254.
26. Mann T. The Biochemistry of Semen. London, UK: Menthuen, 1954.
27. Mouton-Barbosa E, Roux-Dalvai F, Bouyssie D, Berger F, Schmidt E, Righetti PG, Guerrier L, Boschetti E, Burlet-Schiltz O, Monsarrat B et al. In-depth exploration of cerebrospinal fluid by combining peptide ligand library treatment and label-free protein quantification. Mol Cell Proteomics 2010;9:1006-1021.
28. Odet F, Duan C, Willis WD, Goulding EH, Kung A, Eddy EM, Goldberg E. Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility. Biol Reprod 2008;79:26-34.
29. Owen DH, Katz DF. A review of the physical and chemical properties of human semen and the formulation of a semen stimulant. J Androl 2005; 26:459-469.
30. Pilch B, Mann M. Large-scale and high-confidence proteomic analysis of human seminal plasma. Genome Biol 2006;7:R40.
31. Poliakov A, Spilman M, Dokland T, Amling CL, Mobley JA. Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen. Prostate 2009;69:159-167.
32. Righetti PG, Boschetti E. The ProteoMiner and the FortyNiners: searching for gold nuggets in the proteomic arena. Mass Spectrom Rev 2008; 27:596-608.
33. Righetti PG, Boschetti E, Lomas L, Citterio A. Protein equalizer technology: the quest for a 'democratic proteome'. Proteomics 2006; 6:3980-3992.
34. Robertson SA. Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res 2005;322:43-52.
35. Rodriguez-Martinez H, Kvist U, Ernerudh J, Sanz L, Calvete JJ. Seminal plasma proteins: what role do they play? Am J Reprod Immunol 2011; 66(Suppl. 1):11-22.
36. Rowe PJ, Comhaire FH, Hargreave TB, Mahmoud AMA. WHO Manual for the Standardized Investigation, Diagnosis and Management of the Infertile Male. Cambridge, UK: Cambridge University Press, 2000.
37. Rudomin EL, Carr SA, Jaffe JD. Directed sample interrogation utilizing an accurate mass exclusion-based data-dependent acquisition strategy (AMEx). J Proteome Res 2009;8:3154-3160.
38. Sennels L, Salek M, Lomas L, Boschetti E, Righetti PG, Rappsilber J. Proteomic analysis of human blood serum using peptide library beads. J Proteome Res 2007;6:4055-4062.
39. Thimon V, Koukoui O, Calvo E, Sullivan R. Region-specific gene expression profiling along the human epididymis. Mol Hum Reprod 2007; 13:691-704.
40. Thimon V, Frenette G, Saez F, Thabet M, Sullivan R. Protein composition of human epididymosomes collected during surgical vasectomy reversal: a proteomic and genomic approach. Hum Reprod 2008;23:1698-1707.
41. Utleg AG, Yi EC, Xie T, Shannon P, White JT, Goodlett DR, Hood L, Lin B. Proteomic analysis of human prostasomes. Prostate 2003; 56:150-161.
42. Varambally S, Yu J, Laxman B, Rhodes DR, Mehra R, Tomlins SA, Shah RB, Chandran U, Monzon FA, Becich MJ et al. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 2005;8:393-406.
43. Vernaeve V, Tournaye H, Schiettecatte J, Verheyen G, Van Steirteghem A, Devroey P. Serum inhibin B cannot predict testicular sperm retrieval in patients with non-obstructive azoospermia. Hum Reprod 2002; 17:971-976.
44. von Eckardstein S, Simoni M, Bergmann M, Weinbauer GF, Gassner P, Schepers AG, Nieschlag E. Serum inhibin B in combination with serum follicle-stimulating hormone (FSH) is a more sensitive marker than serum FSH alone for impaired spermatogenesis in men, but cannot predict the presence of sperm in testicular tissue samples. J Clin Endocrinol Metab 1999;84:2496-2501.
45. Wang J, Zhang HR, Shi HJ, Ma D, Zhao HX, Lin B, Li RS. Proteomic analysis of seminal plasma from asthenozoospermia patients reveals proteins that affect oxidative stress responses and semen quality. Asian J Androl 2009;11:484-491.
46. Wettenhall JM, Smyth GK. limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics 2004;20:3705-3706.