An aqueous extract of Radix Astragali, Angelica sinensis, and Panax notoginseng is effective in preventing diabetic retinopathy

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Gao, Dehong ^a   Guo, Yijuan ^a   Li, Xuejun ^a   Li, Xiumin ^a   Li, Zhipeng ^a   Xue, Mei ^a   Ou, Zhimin ^a   Liu, Ming ^a   Yang, Mingxing ^a   Liu, Suhuan ^a   Yang, Shuyu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGELICA SINENSIS EXTRACT; BIOLOGICAL MARKER; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; PANAX NOTOGINSENG EXTRACT; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANGELICA SINENSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; LEUKOSTASIS; MALE; MEDICINAL PLANT; NONHUMAN; PANAX NOTOGINSENG; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIX ASTRAGALI; RAT; RETINA BLOOD VESSEL; RETINITIS;

EID: 84877300897     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/578165     Document Type: Article

References (53)

1. Liou G. I., Diabetic retinopathy: role of inflammation and potential therapies for anti-inflammation. World Journal of Diabetes 2010 1 1 12 18 10.4239/wjd.v1.i1.12
2. Giacco F., Brownlee M., Oxidative stress and diabetic complications. Circulation Research 2010 107 9 1058 1070 2-s2.0-78349297565 10.1161/CIRCRESAHA.110.223545
3. Joussen A. M., Poulaki V., Le M. L., Koizumi K., Esser C., Janicki H., Schraermeyer U., Kociok N., Fauser S., Kirchhof B., Kern T. S., Adamis A. P., A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB Journal 2004 18 12 1450 1452 2-s2.0-7044228789 10.1096/fj.03-1476fje (Pubitemid 39561611)
4. Joussen A. M., Murata T., Tsujikawa A., Kirchhof B., Bursell S. E., Adamis A. P., Leukocyte-mediated endothelial cell injury and death in the diabetic retina. American Journal of Pathology 2001 158 1 147 152 2-s2.0-0035139461 (Pubitemid 32096479)
5. Schroder S., Palinski W., Schmid-Schonbein G. W., Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. American Journal of Pathology 1991 139 1 81 100 2-s2.0-0025769620
6. Murakami T., Felinski E. A., Antonetti D. A., Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. Journal of Biological Chemistry 2009 284 31 21036 21046 2-s2.0-68949129005 10.1074/jbc.M109.016766
7. Durham J. T., Herman I. M., Microvascular modifications in diabetic retinopathy. Current Diabetes Reports 2011 11 4 253 264 10.1007/s11892-011-0204- 0
8. Kelly L. W., Barden C. A., Tiedeman J. S., Hatchell D. L., Alterations in viscosity and filterability of whole blood and blood cell subpopulations in diabetic cats. Experimental Eye Research 1993 56 3 341 347 2-s2.0-0027411465 10.1006/exer.1993.1044 (Pubitemid 23084999)
9. Kimura K., Toyota T., Kakizaki M., Kudo M., Takebe K., Goto Y., Impaired insulin secretion in the spontaneous diabetes rats. Tohoku Journal of Experimental Medicine 1982 137 4 453 459 2-s2.0-0020173967
10. Abdel-Halim S. M., Guenifi A., Luthman H., Grill V., Efendic S., Ostenson C. G., Impact of diabetic inheritance on glucose tolerance and insulin-secretion in spontaneously diabetic GK-Wistar rats. Diabetes 1994 43 2 281 288 2-s2.0-0028144530
11. Ostenson C. G., Khan A., Abdel-Halim S. M., Guenifi A., Suzuki K., Goto Y., Efendic S., Abnormalin insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 1993 36 1 3 8 2-s2.0-0027339801 (Pubitemid 23018328)
12. Agardh C. D., Agardh E., Zhang H., Östenson C. G., Altered endothelial/pericyte ratio in Goto-Kakizaki rat retina. Journal of Diabetes and its Complications 1997 11 3 158 162 2-s2.0-0031006055 10.1016/S1056-8727(96) 00049-9 (Pubitemid 27243639)
13. Omri S., Behar-Cohen F., de Kozak Y., Sennlaub F., Verissimo L. M., Jonet L., Savoldelli M., Omri B., Crisanti P., Microglia/macrophages migrate through retinal epithelium barrier by a transcellular route in diabetic retinopathy: role of PKC ζ in the Goto Kakizaki rat model. American Journal of Pathology 2011 179 2 942 953 10.1016/j.ajpath.2011.04.018
14. Sone H., Kawakami Y., Okuda Y., Sekine Y., Honmura S., Matsuo K., Segawa T., Suzuki H., Yamashita K., Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes. Diabetologia 1997 40 6 726 730 2-s2.0-0030803023 10.1007/s001250050740 (Pubitemid 27288120)
15. Yatoh S., Mizutani M., Yokoo T., Kozawa T., Sone H., Toyoshima H., Suzuki S., Shimano H., Kawakami Y., Okuda Y., Yamada N., Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy. Diabetes/Metabolism Research and Reviews 2006 22 1 38 45 2-s2.0-31544483294 10.1002/dmrr.562 (Pubitemid 43154460)
16. Zhao P., Su G., Xiao X., Hao E., Zhu X., Ren J., Chinese medicinal herb Radix Astragali suppresses cardiac contractile dysfunction and inflammation in a rat model of autoimmune myocarditis. Toxicology Letters 2008 182 1-3 29 35 2-s2.0-54949093559 10.1016/j.toxlet.2008.08.002
17. Shon Y. H., Nam K. S., Protective effect of Astragali Radix extract on Interleukin 1 β -induced Infammation in human amnion. Phytotherapy Research 2003 17 9 1016 1020 2-s2.0-0012977422 10.1002/ptr.1276 (Pubitemid 37351572)
18. Ryu M., Kim E. H., Chun M., Kang S., Shim B., Yu Y. B., Jeong G., Lee J. S., Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk. Journal of Ethnopharmacology 2008 115 2 184 193 2-s2.0-37249028093 10.1016/j.jep.2007.09.027 (Pubitemid 350266261)
19. Shon Y. H., Kim J. H., Nam K. S., Effect of Astragali radix extract on lipopolysaccharide-induced inflammation in human amnion. Biological & Pharmaceutical Bulletin 2002 25 1 77 80 2-s2.0-0036370801
20. Hoo R. L. C., Wong J. Y. L., Qiao C. F., Xu A., Xu H. X., Lam K. S. L., The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutrition and Metabolism 2010 7 article 67 2-s2.0-77955793729 10.1186/1743-7075-7-67
21. Jiang J. B., Qiu J. D., Yang L. H., He J. P., Smith G. W., Li H. Q., Therapeutic effects of astragalus polysaccharides on inflammation and synovial apoptosis in rats with adjuvant-induced arthritis. International Journal of Rheumatic Diseases 2010 13 4 396 405 2-s2.0-77958104221 10.1111/j.1756-185X. 2010.01555.x
22. Law P. C., Auyeung K. K., Chan L. Y., Ko J. K., Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. BMC Complementary and Alternative Medicine 2012 12 article 160 10.1186/1472-6882-12-160
23. Yang C., Niu S., Yu L., Zhu S., Zhu J., Zhu Q., The aqueous extract of Angelica sinensis, a popular Chinese herb, inhibits wear debris-induced inflammatory osteolysis in mice. Journal of Surgical Research 2012 176 2 476 483 10.1016/j.jss.2011.08.011
24. Han C., Guo J., Antibacterial and anti-inflammatory activity of traditional Chinese herb pairs, Angelica sinensis and Sophora flavescens. Inflammation 2012 35 3 913 919 10.1007/s10753-011-9393-6
25. Chao W. W., Hong Y. H., Chen M. L., Lin B. F., Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF- B trans-activation activity and LPS-induced inflammation. Journal of Ethnopharmacology 2010 129 2 244 249 2-s2.0-77952892183 10.1016/j.jep.2010.03. 022
26. Zhang H., Chen S., Deng X., Yang X., Huang X., Danggui-Buxue-Tang decoction has an anti-inflammatory effect in diabetic atherosclerosis rat model. Diabetes Research and Clinical Practice 2006 74 2 194 196 2-s2.0-33751078340 10.1016/j.diabres.2006.04.003 (Pubitemid 44764906)
27. Lv J., Zhao Z., Chen Y., Wang Q., Tao Y., Yang L., Fan T. P., Liu C., The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evidence-Based Complementary and Alternative Medicine 2012 2012 11 284963 10.1155/2012/284963
28. Fan J. S., Liu D. N., Huang G., Xu Z. Z., Jia Y., Zhang H. G., Li X. H., He F. T., Panax notoginseng saponins attenuate atherosclerosis via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression. Journal of Ethnopharmacology 2012 142 3 732 738 10.1016/j.jep.2012.05.053
29. Ning N., Dang X., Bai C., Zhang C., Wang K., Panax notoginsenoside produces neuroprotective effects in rat model of acute spinal cord ischemia-reperfusion injury. Journal of Ethnopharmacology 2012 139 2 504 512 10.1016/j.jep.2011.11.040
30. Wang N., Wan J. B., Chan S. W., Deng Y. H., Yu N., Zhang Q. W., Wang Y. T., Lee S. M., Comparative study on saponin fractions from Panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion. Chinese Medicine 2011 6 article 37 10.1186/1749-8546-6-37
31. Liu Y., Zhang H. G., Jia Y., Li X. H., Panax notoginseng saponins attenuate atherogenesis accelerated by zymosan in rabbits. Biological and Pharmaceutical Bulletin 2010 33 8 1324 1330 2-s2.0-77956098022 10.1248/bpb.33.1324
32. Wan J. B., Lee S. M. Y., Wang J. D., Wang N., He C. W., Wang Y. T., Kang J. X., Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF- α -induced endothelial adhesion molecule expression and monocyte adhesion. Journal of Agricultural and Food Chemistry 2009 57 15 6692 6697 2-s2.0-68249118235 10.1021/jf900529w
33. Jung H. W., Seo U. K., Kim J. H., Leem K. H., Park Y. K., Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF- B signaling pathway in murine macrophages. Journal of Ethnopharmacology 2009 122 2 313 319 2-s2.0-60849104069 10.1016/j.jep.2008.12. 024
34. Zhang Y. G., Zhang H. G., Zhang G. Y., Fan J. S., Li X. H., Liu Y. H., Li S. H., Lian X. M., Tang Z., Panax notoginseng saponins attenuate atherosclerosis in rats by regulating the blood lipid profile and an anti-inflammatory action. Clinical and Experimental Pharmacology and Physiology 2008 35 10 1238 1244 2-s2.0-50649083057 10.1111/j.1440-1681.2008.04997.x
35. Rhule A., Navarro S., Smith J. R., Shepherd D. M., Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells. Journal of Ethnopharmacology 2006 106 1 121 128 2-s2.0-33646534388 10.1016/j.jep.2005.12. 012
36. Dou L., Lu Y., Shen T., Huang X., Man Y., Wang S., Li J., Panax notogingseng saponins suppress RAGE/MAPK signaling and NF-kappaB activation in apolipoprotein-E-deficient atherosclerosis-prone mice. Cellular Physiology and Biochemistry 2012 29 5-6 875 882
37. Angulo J., Peiro C., Romacho T., Fernandez A., Cuevas B., Gonzalez-Corrochano R., Gimenez-Gallego G., de Tejada I. S., Sanchez-Ferrer C. F., Cuevas P., Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial proliferation, arterial relaxation, vascular permeability and angiogenesis by dobesilate. European Journal of Pharmacology 2011 667 1-3 153 159 10.1016/j.ejphar.2011.06.015
38. Skondra D., Noda K., Almulki L., Tayyari F., Frimmel S., Nakazawa T., Kim I. K., Zandi S., Thomas K. L., Miller J. W., Gragoudas E. S., Hafezi-Moghadam A., Characterization of azurocidin as a permeability factor in the Retina: involvement in VEGF-induced and early diabetic blood-retinal barrier breakdown. Investigative Ophthalmology and Visual Science 2008 49 2 726 731 2-s2.0-40649099152 10.1167/iovs.07-0405
39. Kern T. S., Engerman R. L., Vascular lesions in diabetes are distributed non-uniformly within the retina. Experimental Eye Research 1995 60 5 545 549 2-s2.0-0028998575 10.1016/S0014-4835(05)80069-7
40. Kowluru R. A., Odenbach S., Effect of long-term administration of α -lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes 2004 53 12 3233 3238 2-s2.0-9444224415 10.2337/diabetes.53.12.3233 (Pubitemid 39564500)
41. Miyamoto K., Khosrof S., Bursell S. E., Rohan R., Murata T., Clermont A. C., Aiello L. P., Ogura Y., Adamis A. P., Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proceedings of the National Academy of Sciences of the United States of America 1999 96 19 10836 10841 2-s2.0-0032863021 10.1073/pnas.96.19.10836 (Pubitemid 29442230)
42. Yang C. Y., Wang J., Zhao Y., Shen L., Jiang X., Xie Z. G., Liang N., Zhang L., Chen Z. H., Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components. Journal of Ethnopharmacology 2010 130 2 231 236 2-s2.0-77954956789 10.1016/j.jep.2010.04.039
43. Rangasamy S., McGuire P. G., Das A., Diabetic retinopathy and inflammation: novel therapeutic targets. Middle East African Journal of Ophthalmology 2012 19 1 52 59 10.4103/0974-9233.92116
44. Joussen A. M., Poulaki V., Mitsiades N., Kirchhof B., Koizumi K., Döhmen S., Adamis A. P., Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. The FASEB Journal 2002 16 3 438 440 2-s2.0-0036517850
45. Pakneshan P., Birsner A. E., Adini I., Becker C. M., D'Amato R. J., Differential suppression of vascular permeability and corneal angiogenesis by nonsteroidal anti-inflammatory drugs. Investigative Ophthalmology and Visual Science 2008 49 9 3909 3913 2-s2.0-53149143165 10.1167/iovs.07-1527
46. Van Hecke M. V., Dekker J. M., Nijpels G., Moll A. C., Heine R. J., Bouter L. M., Polak B. C. P., Stehouwer C. D. A., Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study. Diabetologia 2005 48 7 1300 1306 2-s2.0-23944492556 10.1007/s00125-005-1799-y (Pubitemid 41186094)
47. Carmo A., Cunha-Vaz J. G., Carvalho A. P., Lopes M. C., Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability. Nitric Oxide 2000 4 6 590 596 2-s2.0-0034524671 10.1006/niox.2000.0312 (Pubitemid 32053270)
48. Moss S. E., Klein R., Klein B. E. K., The 14-year incidence of visual loss in a diabetic population. Ophthalmology 1998 105 6 998 1003 2-s2.0-0031807908 10.1016/S0161-6420(98)96025-0 (Pubitemid 28268322)
49. Joussen A., Smyth N., Niessen C., Pathophysiology of diabetic macular edema. Developments in Ophthalmology 2007 39 1 12 2-s2.0-33947532777 10.1159/000098495
50. Chan P. S., Kanwar M., Kowluru R. A., Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control: novel mechanism for metabolic memory. Journal of Diabetes and its Complications 2010 24 1 55 63 2-s2.0-70749133081 10.1016/j.jdiacomp.2008.10.002
51. Kowluru R. A., Kanwar M., Kennedy A., Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries. Experimental Diabesity Research 2007 2007 7 2-s2.0-34547858127 10.1155/2007/21976 21976 (Pubitemid 47261554)
52. Vincent J. A., Mohr S., Inhibition of caspase-1/interleukin-1 β signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 2007 56 1 224 230 2-s2.0-33847048626 10.2337/db06-0427
53. Joussen A. M., Doehmen S., Le M. L., Koizumi K., Radetzky S., Krohne T. U., Poulaki V., Semkova I., Kociok N., TNF- α mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations. Molecular Vision 2009 15 1418 1428 2-s2.0-68149131912