Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-α-induced endothelial adhesion molecule expression and monocyte adhesion

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 15, 2009, Pages 6692-6697

  Wan, Jian Bo ^a,b   Lee, Simon Ming Yuen ^b   Wang, Jing Dong ^a   Wang, Nan ^b   He, Cheng Wei ^a   Wang, Yi Tao ^a,b   Kang, Jing X ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b University of Macau   (Macao)

Author keywords

Adhesion molecules; ApoE deficient mice; Atherosclerosis; Inflammation; Panax notoginseng

Indexed keywords

MUS; PANAX NOTOGINSENG;

APOLIPOPROTEIN E; CELL ADHESION MOLECULE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; ATHEROSCLEROSIS; C57BL MOUSE; CELL ADHESION; CELL CULTURE; CHEMISTRY; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; MONOCYTE; MOUSE; MOUSE MUTANT; PANAX NOTOGINSENG;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; PANAX NOTOGINSENG; PLANT EXTRACTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 68249118235     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf900529w     Document Type: Article

References (28)

1. Murray, C. J.; Lopez, A. D. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997, 349, 1436-1442.
2. Libby, P. Inflammation in atherosclerosis. Nature 2002, 420, 868-874.
3. Ross, R. Atherosclerosis-an inflammatory disease. N Engl. J. Med. 1999, 340, 115-126.
4. Ling, S.; Nheu, L.; Dai, A.; Guo, Z.; Komesaroff, P. Effects of four medicinal herbs on human vascular endothelial cells in culture. Int. J. Cardiol. 2008, 128, 350-358.
5. Ji, W.; Gong, B. Q. Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats. J. Ethnopharmacol. 2001, 113, 318-324.
6. Wan, J. B.; Li. S. P.; Chen, J. M.; Wang, Y. T. Chemical characteristics of three medicinal plants of the Panax genus determined by HPLC-ELSD. J. Sep. Sci. 2007, 30, 825-832.
7. Wan, J. B.; Wang, Y. T.; Li. S. P. Sanqi (Panax notoginseng). In Pharmacological Activity-Based Quality Control of Chinese Herbs; Li, S. P., Wang, Y. T., Eds.; Nova Science Publishers: New York, 2008; pp 179-203.
8. Rhule, A.; Navarro, S.; Smith, J. R.; Shepherd, D. M. Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells. J. Ethnopharmacol. 2006, 106, 121-128.
9. Li, S. H.; Chu, Y. Anti-inflammatory effects of total saponins of Panax notoginseng. Zhongguo Yao Li Xue Bao 1999, 20, 551-554.
10. Li, Y. H.; Liu, Y.; Gu, R. Y. Experimental study of the effective fractions of Panax notoginseng in rabbit atherosclerosis. Chin. J. Integr. Med. Cardio/Cerebrovasc. Dis. 2003, 1, 582-584.
11. Li,T.; Qu, D. Y.; Lei, B.; Nong, S.; Huang, Y. Z.; Wang, H. J. Effects of Panax notoginseng powder on atherosclerosis in rabbits. TCM Res. 2006, 19, 17-19.
12. Liu, Y.; Li, X. H. Effect of Pannax notoginseng total saponin on inflammatory immune factors in a therosclerosis. Chin. Tradit. Herbal Drugs 2005, 35, 728-730.
13. Zhang. Y. G.; Zhang, H. G.; Zhang. G. Y.; Fan, J. S.; Li, X. H.; Liu, Y. H.; Li, S. H.; Lian, X. M.; Tang, Z. Panax notoginseng saponins attenuate atherosclerosis in rats by regulating the blood lipid profile and an anti-inflammatory action. Clin. Exp. Pharmacol. Physiol. 2008, 35, 1238-1244.
14. Zhang, S. H.; Reddick, R. L.; Piedrahita, J. A.; Maeda, N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992, 258, 468-471.
15. Azuma, K.; Kawamori, R.; Toyofuku, Y.; Kitahara, Y.; Sato, F.; Shimizu, T.; Miura, K.; Mine, T.; Tanaka, Y.; Mitsumata, M.; Watada, H. Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta. Arterioscler. Thromb. Vase. Biol. 2006, 26, 2275-2280.
16. Tran-Lundmark, K.; Tran, P. K.; Paulsson-Berne, G.; Friden, V.; Soininen, R.; Tryggvason, K.; Wight, T. N.; Kinsella, M. G.; Boren, J.; Hedin. U. Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation. Circ. Res. 2008, 103, 43-52.
17. ( 17) Lebherz, C.; Sanmiguel, J.; Wilson, J. M.; Rader, D. J. Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent. Cardiovasc. Diahetol. 2001, 6, 15.
18. Wan, J. B.; Lai, C. M.; Li, S. P.; Lee, M. Y.; Kong, L. Y.; Wang, Y. T. Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction. J. Pharm. Biomed. Anal. 2006, 41, 274-279.
19. Rothlein, R.; Czajkowski, M.; O'Neill, M. M.; Marlin. S. D.; Mainolfi, E.; Merluzzi, V. J. Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies. J. Immunol. 1988, 141, 1665-1669.
20. Ikonen, E. Mechanisms for cellular cholesterol transport: defects and human disease, Physiol. Rev. 2006, 86, 1237-1261.
21. Piedrahita, J. A.; Zhang, S. H.; Hagaman, J. R.; Oliver, P. M.; Maeda, N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 4471-4475.
22. Nakashima, Y.; Plump, A. S.; Raines, E. W.; Breslow, J. L.; Ross, R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. Vasc. Biol. 1994, 14, 133-140.
23. Ohsuzu. F. The roles of cytokines, inflammation and immunity in vascular diseases. J. Atheroscler. Thromb. 2004, 11, 313-321.
24. Nashed, B.; Yeganeh, B.; HayGlass, K. T.; Moghadasian, M. H. Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in apoE-KO mice. J. Nutr. 2005, 135, 2438-2444.
25. Sukovich, D. A.; Kauser, K.; Shirley, F. D.; DelVecchio, V.; Halks-Miller, M.; Rubanyi, G. M. Expression of interleukin-6 in atherosclerotic lesions of male apoE-knockout mice: inhibition by 17β-estradiol. Arterioscler. Thromb. Vasc. Biol. 1998, 18, 1498-1505.
26. Kluger, M. S. Vascular endothelial cell adhesion and signaling during leukocyte recruitment. Adv. Dermatol. 2004, 20, 163-201.
27. Lin, S. G.; Zheng. X. L.; Chen, Q. Y.; Sun, J. J. Effect of Panax notoginseng saponins on increased proliferation of cultured aortic smooth muscle cells stimulated by hypercholesterolemic serum. Zapngguo Yao Li Xue Bao 1993, 14. 314-316.
28. Liu, Q.; Deng, Y. P. Effect of total saponins from Panax notoginseng on tissue plasminogen activator produced by blood vessel endothelium. Chin. J. Hematol. 1994, 15, 433-434.