Panax notogingseng saponins suppress RAGE/MAPK signaling and NF-kappaB activation in apolipoprotein-E-deficient atherosclerosis-prone mice

Cellular Physiology and Biochemistry

Volumn 29, Issue 5-6, 2012, Pages 875-882

  Dou, Lin ^a,b   Lu, Yonggang ^a,b   Shen, Tao ^b   Huang, Xiuqing ^b   Man, Yong ^b   Wang, Shu ^b   Li, Jian ^a,b  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b BEIJING HOSPITAL   (China)

Author keywords

Adhesion molecules; ApoE deficient mice; Atherosclerosis; Nuclear factor kappa B; Panax notoginseng saponins; Receptor of advanced glycation end products

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; ADVANCED GLYCATION END PRODUCT RECEPTOR; APOLIPOPROTEIN E; CD68 ANTIGEN; CHEMOKINE; GALECTIN 3; GLUCOSE; GLUTATHIONE; I KAPPA B; INTERCELLULAR ADHESION MOLECULE 1; LIPID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PANAX NOTOGINSENG EXTRACT; PHOSPHORUS DERIVATIVE; REACTIVE OXYGEN METABOLITE; SAPONIN; SUPEROXIDE DISMUTASE; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; AORTA ROOT; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; BRACHIOCEPHALIC TRUNK; CELL SIZE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; DRUG BLOOD LEVEL; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; GLUCOSE BLOOD LEVEL; LIPID BLOOD LEVEL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PANAX NOTOGINSENG; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE;

MUS; PANAX; PANAX NOTOGINSENG;

EID: 84861379440     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000315061     Document Type: Article

References (27)

1. Sima AV, Stancu CS, Simionescu M: Vascular endothelium in atherosclerosis. Cell Tissue Res 2009;335:191-203.
2. Karatzis EN: The role of inflammatory agents in endothelial function and their contribution to atherosclerosis. Hellenic J Cardiol 2005;46:232-239. (Pubitemid 41664060)
3. Yung LM, Leung FP, Yao X, Chen ZY, Huang Y: Reactive oxygen species in vascular wall. Cardiovasc Hematol Disord Drug Targets 2006;6:1-19. (Pubitemid 43803123)
4. Li M, Zhang Y, Ren H, Zhu X: Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model. Atherosclerosis 2007;194:348-356. (Pubitemid 47513098)
5. Huo Y, Xia L: P-selectin glycoprotein ligand-1 plays a crucial role in the selective recruitment of leukocytes into the atherosclerotic arterial wall. Trends Cardiovasc Med 2009;19:140-145.
6. Cybulsky MI, Liyama K, Li H, Zhu S, Chen M, Liyama M, Davis V, Gutierrez-Ramos JC, Connelly PW, Milstone DS: A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001;107:1255-1262. (Pubitemid 32494542)
7. Bobryshev YV: Monocyte recruitment and foam cell formation in atherosclerosis. Micron 2006;37:208-222. (Pubitemid 43106595)
8. Sun L, Ishida T, Yasuda T, Kojima Y, Honjo T, Yamamoto Y, Yamamoto H, Ishibashi S, Hirata K, Hayashi Y: RAGE mediates oxidized LDL-induced proinflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice. Cardiovasc Res 2009;82:371-381.
9. -/- mice. J Clin Invest 2008;118:183-194.
10. Hoefen RJ, Berk BC: The role of MAP kinases in endothelial activation. Vascul Pharmacol 2002;38:271-273. (Pubitemid 36398260)
11. Goldin A, Beckman JA, Schmidt AM, Creager MA: Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 2006;114:597-605. (Pubitemid 44199649)
12. Lin SJ, Shyue SK, Hung YY, Chen YH, Ku HH, Chen JW, Tam KB, Chen YL: Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways. Arterioscler Thromb Vasc Biol 2005;25:334-340.
13. Kutuk O, Basaga H: Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis. Trends Mol Med 2003;9:549-557. (Pubitemid 38017194)
14. Wan JB, Lee SM, Wang JD, Wang N, He CW, Wang YT, Kang JX: Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. J Agric Food Chem 2009;57:6692-6697.
15. Liu G, Wang B, Zhang J, Jiang H, Liu F: Total panax notoginsenosides prevent atherosclerosis in apolipoprotein Eknockout mice: Role of downregulation of CD40 and MMP-9 expression. J Ethnopharmacol 2009;126:350-354.
16. -/- mice. J Hypertens 2005;23:1541-1549. (Pubitemid 41104826)
17. Zuckerman SH, Evans GF, Schelm JA, Eacho PI, Sandushy G: Estrogenmediated increases in LDL cholesterol and foam cell-containing lesions in human ApoB100xCETP transgenic mice. Arterioscler Thromb Vasc Biol 1999;19:1476-1483. (Pubitemid 29263017)
18. Basta G, Schmidt AM, De Caterina R: Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res 2004;63:582-592. (Pubitemid 39078671)
19. Li J, Xie ZZ, Tang YB, Zhou JG, Guan YY: Ginsenoside-Rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoE knockout mice. Eur J Pharmacol 2011;652:104-110.
20. Zhang F, Kent KC, Yamanouchi D, Zhang Y, Kato K, Tsai S, Nowygrod R, Schmidt AM, Liu B: Anti-receptor for advanced glycation end products therapies as novel treatment for abdominal aortic aneurysm. Ann Surg 2009;250:416-423.
21. Guo ZJ, Niu HX, Hou FF, Zhang L, Fu N, Nagai R, Lu X, Chen BH, Shan YX, Tian JW, Nagaraj RH, Xie D, Zhang X: Advanced oxidation protein products activate vascular endothelial cells via a RAGE-mediated signaling pathway. Antioxid Redox Signal 2008;10:1699-1712.
22. Baker RG, Hayden MS, Ghosh S: NFkappaB, inflammation, and metabolic disease. Cell Metab 2011;13:11-22.
23. Liu Y, Zhang HG, Jia Y, Li XH: Panax notoginseng saponins attenuate atherogenesis accelerated by zymosan in rabbits. Biol Pharm Bull 2010;33:1324-1330.
24. Jung HW, Seo UK, Kim JH, Leem KH, Park YK: Flower extract of Panax notoginseng attenuates lipopolysaccharideinduced inflammatory response via blocking of NF-kappaB signaling pathway in murine macrophages. J Ethnopharmacol 2009;122:313-319.
25. Zhang F, Kent KC, Yamanouchi D, Zhang Y, Kato K, Tsai S, Nowygrod R, Schmidt AM, Liu B: Anti-receptor for advanced glycation end products therapies as novel treatment for abdominal aortic aneurysm. Ann Surg 2009;250:416-423.
26. Yao D, Brownlee M: Hyperglycemiainduced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 2010;59:249-255.
27. Li J, Schmidt AM: Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products. J Biol Chem 1997;272:16498-165006.