Oily nanosuspension for long-acting intramuscular delivery of curcumin didecanoate prodrug: Preparation, characterization and in vivo evaluation

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 2, 2013, Pages 286-293

  Wei, Xiao Lan ^a   Han, Ying Rui ^a   Quan, Li Hui ^a   Liu, Chun Yu ^a   Liao, Yong Hong ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

Anti depression; Curcumin didecanoate; Long acting; Nanosuspension; Wet ball milling

Indexed keywords

ARACHIS OIL; CURCUMIN; CURCUMIN DIDECANOATE; IMIPRAMINE; LONG ACTING DRUG; NANOCRYSTAL; PRODRUG; RESERPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG RELEASE; DRUG SCREENING; DRUG SYNTHESIS; FREEZE DRYING; HYPOTHERMIA; INJECTION SITE; INTERMETHOD COMPARISON; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OILY MICROSUSPENSION; OILY NANOSUSPENSION; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SUSPENSION; SYNTHESIS; TISSUE DISTRIBUTION; WET BALL MILLING; ZETA POTENTIAL;

ANIMALS; BODY TEMPERATURE; BRAIN; CURCUMIN; DRUG COMPOUNDING; HYPOTHERMIA; INJECTIONS, INTRAMUSCULAR; MALE; MICE; MICE, INBRED ICR; NANOPARTICLES; PLANT OILS; PRODRUGS; RATS; RATS, WISTAR; RESERPINE; SUSPENSIONS; TISSUE DISTRIBUTION;

EID: 84877281314     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.03.010     Document Type: Article

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