A simple RP-HPLC method for the simultaneous determination of curcumin and its prodrug, curcumin didecanoate, in rat plasma and the application to pharmacokinetic study

Biomedical Chromatography

Volumn 25, Issue 10, 2011, Pages 1144-1149

  Han, Ying Rui ^a,b   Zhu, Jin Jin ^a,c   Wang, Yu Rong ^b   Wang, Xing Sheng ^c   Liao, Yong Hong ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Curcumin; Curcumin didecanoate; Pharmacokinetics; Prodrug

Indexed keywords

BODY FLUIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RATS; SODIUM DODECYL SULFATE; SULFUR COMPOUNDS;

CURCUMIN; CURCUMIN DIDECANOATE; DIDECANOATE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS; LOWER LIMITS OF QUANTITATIONS; PRODRUGS; RAT PLASMA; SIMPLE++; SIMULTANEOUS DETERMINATIONS;

PHARMACOKINETICS;

ACETIC ACID ETHYL ESTER; CURCUMIN; CURCUMIN DIDECANOATE; DODECYL SULFATE SODIUM; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STRUCTURE; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; QUALITY CONTROL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRAVIOLET SPECTROSCOPY;

RATTUS;

EID: 80052522676     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1584     Document Type: Article

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