The effects of notoginsenoside R 1 on the intestinal absorption of geniposide by the everted rat gut sac model

Journal of Ethnopharmacology

Volumn 142, Issue 1, 2012, Pages 136-143

  Sa, Chula ^a   Lv, Hang ^a   Ba, Yinying ^a   Sun, Jianning ^a   Shi, Renbing ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Absorption; Everted rat gut sac; Geniposide; Notoginsenoside R 1; P glycoprotein inhibitor

Indexed keywords

GENIPOSIDE; GINSENOSIDE; NOTOGINSENOSIDE R1; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; DRUG ADSORPTION; DRUG EFFECT; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE; INTESTINE ABSORPTION; MALE; NONHUMAN; RAT; TIME; VALIDATION STUDY;

ANIMALS; GINSENOSIDES; INTESTINAL ABSORPTION; INTESTINES; IRIDOIDS; MALE; P-GLYCOPROTEIN; RATS; RATS, WISTAR; RHODAMINE 123; VERAPAMIL;

CANIS FAMILIARIS; GARDENIA ANGUSTA; PANAX NOTOGINSENG; RATTUS; RUBIACEAE;

EID: 84861965996     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.04.027     Document Type: Article

References (20)

1. Balimane, P.V., Chong, S., Morrison, R.A., 2000. Current methodologies used for evaluation of intestinal permeability and absorption. Journal of Pharmacological and Toxicological Methods 44, 301-312.
2. Barthe, L., Bessouet, M., Woodley, J.F., Houin, G.T., 1998. The improved everted gut sac: a simple method to study intestinal P-glycoprotein. International Journal of Pharmaceutics 173, 255-258.
3. Bouer, R., Barthe, L., Philibert, C., Toumaire, C., Woodley, J., Houin, G., 1999. The role of P-glycorprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac. Fundamental Clinical Pharmacology 13, 494-500.
4. Chang, H.M., But, P.P.H., 1987. Pharmacology and Applications of Chinese Materia Medica, 2. World Scientific Publishing, Singapore, p. 1005.
5. 1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion. World Journal of Gastroenterology 14, 29-37.
6. Emi, Y., Tsunashima, D., Ogawara, K., Higaki, K., Kimura, T., 1998. Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine. Journal of Pharmaceutical Sciences 87, 295-299.
7. Fontaine, M., Elmquist, W.F., Miller, D.W., 1996. Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers. Life Sciences 59, 1521.
8. 1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate recep-tors composed of an NR1/NR2B subunit assembly. Journal of Neuroscience Research 87, 2145-2156.
9. Jain, R., Agarwal, S., Mandave, N.K., Sheng, Y., Mitra, A.K., 2008. Interaction of dipeptide prodrugs of saquinavir with multidrug resistance protein-2 (MRP-2): evasion of MRP-2 mediated efflux. International Journal of Pharmaceutics 362, 44-51.
10. Jia, L., Zhao, Y., Liang, X.J., 2009. Current evaluation of the millennium phytomedicine-ginseng (Π): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Current Medicinal Chemistry 16, 2924-2942.
11. Liu, H.T., He, J.L., Li, W.M., Yang, Z., Wang, Y.X., Yin, J., Du, Y.G., Yu, C., 2010. Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways. Inflamm Research 59, 451-461.
12. Moshtaghie, A.A., Sabet-Jahromi, M., 1992. Identification of transferrin in cytosol isolated from rat intestinal mucosal cells. Biochemical Society Transactions 21, 71S.
13. Nam, K.N., Choi, Y.S., Jung, H.J., Park, G.H., Park, J.M., Moon, S.K., Cho, K.H., Kang, C., Kang, I., Oh, M.S., Lee, E.H., 2010. Genipin inhibits the inflammatory response of rat brain microglial cells. International Immunopharmacology 10, 493-499.
14. Sharma, P., Chawla, H.P.S., Panchagnula, R., 2002. LC determination of cephalosporins in in vitro rat intestinal sac absorption model. Journal of Pharmaceutical and Biomedical 27, 39-50.
15. Suzuki, Y., Kondo, I., keda, Y., Umemura, K., 2001. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Medica 67, 807-810.
16. Wang, L., Jiang, X., Xu, W., Li, C., 2007. Complexation of tanshinone IIA with 2-hydroxypropyl-β-cyclodextrin: effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats. International Journal of Pharmaceutics 341, 58-67.
17. Wilson, T.H., Wiseman, G., 1954. The use of sacs everted of small intestine for study of transference of substance from mucosal to serosal surface. The Journal of Physiology 123, 116-125.
18. Zhang, Z.J., Li, P., Wang, Z., Li, P.T., Zhang, W.S., Sun, Z.H., Zhang, X.J., Wag, Y.Y., 2006. A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury. Brain Research 1123, 188-195.
19. Zhang, W., Wojta, J., Binder, B.R., 1994. Effect of notoginsenoside R1 on the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells. Arteriosclerosis, Thrombosis. 14, 1040-1046.
20. Zhou, Y.Q., Li, W.Z., Chen, L.Y., Ma, S.W., Li, P., Yang, Z.L., 2010. Enhancement of intestinal absorption of akebia saponin D by borneol and probenecid in situ and in vitro. Environmental Toxicology and Pharmacology. 29, 229-234.