Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression

Italian Journal of Pediatrics

Volumn 39, Issue 1, 2013, Pages

  Carta, Sonia ^a   Silvestri, Michela ^a   Rossi, Giovanni A ^a  

^a G GASLINI INSTITUTE   (Italy)

Author keywords

ICAM 1; Immunostimulants; Recurrent respiratory infections; Toll like receptor 2

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PIDOTIMOD; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ARTICLE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; WESTERN BLOTTING;

BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRONCHI; CELL LINE; CELL NUCLEUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOLOGIC FACTORS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-8; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; PHOSPHORYLATION; PYRROLIDONECARBOXYLIC ACID; THIAZOLIDINES; TOLL-LIKE RECEPTOR 2; TRANSLOCATION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84877262964     PISSN: 17208424     EISSN: 18247288     Source Type: Journal    
DOI: 10.1186/1824-7288-39-29     Document Type: Article

References (61)

1. Upper respiratory tract infections in young children: duration of and frequency of complications. Wald ER, Guerra N, Byers C, Pediatrics 1991 87 129 133 1987522
2. Acute respiratory-tract infections in children. A 3-year follow-up from birth. Harsten G, Prellner K, Heldrup J, Kalm O, Kornfalt R, Acta Paediatr Scand 1990 79 402 409 10.1111/j.1651-2227.1990.tb11484.x 2349876 (Pubitemid 20134092)
3. Upper airway infections in preschool children- frequency and risk factors. Benediktsdottir B, Scand J Prim Health Care 1993 11 197 201 10.3109/02813439308994830 8272652 (Pubitemid 23307097)
4. Economic evaluation of immunoprophylaxis in children with recurrent ear, nose and throat infections. Banz K, Schwicker D, Thomas AM, PharmacoEconomics 1994 6 464 477 10.2165/00019053-199406050-00008 10155274
5. Recurrent respiratory tract infections: how should we investigate and treat? Cohen R, Just J, Koskas M, Bingen E, Boucherat M, Bourrillon A, Foucaud P, François M, Garnier JM, Guillot M, Ployet MJ, Schlemmer C, Gaudelus J, Arch Pediatr 2005 12 183 190 10.1016/j.arcped.2004.11.013 15694546 (Pubitemid 40247608)
6. The common cold. Heikkinen T, Järvinen A, Lancet 2003 361 51 59 10.1016/S0140-6736(03)12162-9 12517470 (Pubitemid 36050965)
7. Human metapneumovirus in paediatric patients. Principi N, Bosis S, Esposito S, Clin Microbiol Infect 2006 12 301 308 10.1111/j.1469-0691.2005. 01325.x 16524405 (Pubitemid 43337518)
8. Rhinovirus infections in infancy and early childhood. Kieninger E, Fuchs O, Latzin P, Frey U, Regamey N, Eur Respir J 2012 Epub ahead of print
9. Airway epithelial cells: functional roles in airway disease. Rennard SI, Romberger DJ, Sisson JH, Von Essen SG, Rubinstein I, Robbins RA, Spurzem JR, Am J Respir Crit Care Med 1994 150 5 Pt 2 27 S30 7952587
10. Epithelial cells and fibroblasts: structural repair and remodelling in the airways. Sacco O, Silvestri M, Sabatini F, Sale R, Defilippi AC, Rossi GA, Paediatr Respir Rev 2004 5 Suppl A 35 S40 14980241
11. The airway epithelium in asthma. Lambrecht BN, Hammad H, Nat Med 2012 18 684 692 10.1038/nm.2737 22561832
12. Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. Saito T, Deskin RW, Casola A, Häeberle H, Olszewska B, Ernst PB, Alarm R, Ogra PL, Garofalo L, J Infect Dis 1997 175 497 504 10.1093/infdis/175.3.497 9041319 (Pubitemid 27086151)
13. Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis. McNamara PS, Flanagan BF, Hart CA, Smyth RL, J Infect Dis 2005 191 1225 1232 10.1086/428855 15776367
14. Effects of rhinovirus-induced common colds on granulocyte activity in allergic rhinitis. Greiff L, Venge P, Andersson M, Enander I, Linden M, Myint S, Persson CG, J Infect 2002 45 227 232 10.1053/jinf.2002.1063 12423609 (Pubitemid 36104854)
15. The immunology of virus infection in asthma. Message SD, Johnston SL, Eur Respir J 2001 18 1013 1025 10.1183/09031936.01.00228701 11829084 (Pubitemid 34092878)
16. Influence of attendance at day care on the common cold from birth through 13 years of age. Ball TM, Holberg CJ, Aldous MB, Martinez FD, Wright AL, Arch Pediatr Adolesc Med 2002 156 121 126 10.1001/archpedi.156.2.121 11814371 (Pubitemid 34111467)
17. Allergic children have more numerous and severe respiratory infections than non-allergic children. Ciprandi G, Tosca MA, Fasce L, Pediatr Allergy Immunol 2006 17 389 391 10.1111/j.1399-3038.2006.00413.x 16846459 (Pubitemid 43989963)
18. Coexistence of (partial) immune defects and risk of recurrent respiratory infections. Bossuyt X, Moens L, Van Hoeyveld E, Jeurissen A, Bogaert G, Sauer K, Proesmans M, Raes M, De Boeck K, Clin Chem 2007 53 124 130 17110469 (Pubitemid 46047772)
19. Naturally occurring immune response against bacteria commonly involved in upper respiratory tract infections: analysis of the antigen-specific salivary IgA levels. Rossi GA, Peri C, Raynal ME, Defilippi AC, Risso FM, Schenone G, Pallestrini E, Melioli G, Immunol Lett 2003 86 85 91 10.1016/S0165-2478(02) 00290-0 12600750 (Pubitemid 36205042)
20. Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level. Giagulli C, Noerder M, Avolio M, Becker PD, Fiorentini S, Guzman CA, Caruso A, Int Immunopharmacol 2009 9 1366 1373 10.1016/j.intimp.2009.08.010 19712757
21. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-V40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Reddel RR, Ke Y, Gerwin BI, McMenamin MG, Lechner JF, Su RT, Brash DE, Park JB, Rhim JS, Harris CC, Cancer Res 1988 48 1904 1909 2450641
22. Cytokine-activated bronchial epithelial cell pro-inflammatory functions are effectively downregulated in vitro by ciclesonide. Silvestri M, Serpero L, Petecchia L, Sabatini F, Cerasoli F Jr, Rossi GA, Pulm Pharmacol Ther 2006 19 210 217 10.1016/j.pupt.2005.05.006 16084120
23. Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway. Petecchia L, Sabatini F, Usai C, Caci E, Varesio L, Rossi GA, Lab Invest 2012 92 1140 1148 10.1038/labinvest.2012.67 22584669
24. Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts. Donnelly RP, Crofford LJ, Freeman SL, Buras J, Remmers E, Wilder RL, Fenton MJ, J Immunol 1993 151 5603 5612 8228249 (Pubitemid 23332370)
25. Pidotimod: a reappraisal. Riboldi P, Gerosa M, Meroni PL, Int J Immunopathol Pharmacol 2009 22 255 262 19505378
26. Immunostimulants for preventing respiratory tract infection in children. Del-Rio-Navarro BE, Espinosa Rosales F, Flenady V, Sienra-Monge JJ, Cochrane Database Syst Rev 2006 4 D004974 17054227
27. Comparative meta-analysis of immunoestimulant agents used in pediatric patients in Mexico. De la Torre GC, Pacheco Ríos A, Escalante Domínguez AJ, del Río Navarro BE, Rev Alerg Mex 2005 52 25 38 15957470
28. Effects of viral respiratory infections on lung development and childhood asthma. Gern JE, Rosenthal LA, Sorkness RL, Lemanske RF Jr, J Allergy Clin Immunol 2005 115 668 674 10.1016/j.jaci.2005.01.057 15805982 (Pubitemid 40460837)
29. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. Heymann PW, Carper HT, Murphy DD, Platts-Mills TA, Patrie J, Mclaughlin AP, Erwin EA, Shaker MS, Hellems M, Peerzada J, Hayden FG, Hatley TK, Chamberlain R, J Allergy Clin Immunol 2004 114 239 247 10.1016/j.jaci.2004.04.006 15316497 (Pubitemid 39119019)
30. Downregulation of the expression of intercellular adhesion molecule (ICAM)-1 on bronchial epithelial cells by a beta2-adrenoceptor agonist: fenoterol. Oddera S, Silvestri M, Lantero S, Sacco O, Rossi GA, J Asthma 1998 35 401 408 10.3109/02770909809048948 9734347 (Pubitemid 28438359)
31. Reducing agents inhibit rhinovirus-induced up-regulation of the rhinovirus receptor intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells. Papi A, Papadopoulos NG, Stanciu LA, Bellettato CM, Pinamonti S, Degitz K, Holgate ST, Johnston SL, FASEB J 2002 16 1934 1936 12368227
32. Neutrophil transmigration across human airway epithelial monolayers: mechanisms and dependence on electrical resistance. Kidney JC, Proud D, Am J Respir Cell Mol Biol 2000 23 389 395 10.1165/ajrcmb.23.3.4068 10970831
33. Role of leukocyte adhesion molecules in complement-induced lung injury. Mulligan MS, Smith CW, Anderson DC, Todd RF 3rd, Miyasaka M, Tamatani T, Issekutz TB, Ward PA, J Immunol 1993 150 2401 2406 8095513 (Pubitemid 23127486)
34. Acute lung injury: the role of cytokines in the elicitation of neutrophils. Strieter RM, Kunkel SL, J Investig Med 1994 42 640 651 8521027
35. Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection. Everard ML, Swarbrick A, Wrightham M, McIntyre J, Dunkley C, James PD, Sewell HF, Milner AD, Arch Dis Child 1994 71 428 432 10.1136/adc.71.5.428 7826113 (Pubitemid 24349852)
36. Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice. Huang SH, Cao XJ, Liu W, Shi XY, Wei W, J Pineal Res 2010 48 109 116 10.1111/j.1600-079X.2009.00733.x 20070490
37. Nerve growth factor modulates human rhinovirus infection in airway epithelial cells by controlling ICAM-1 expression. Othumpangat S, Regier M, Piedimonte G, Am J Physiol Lung Cell Mol Physiol 2012 302 1057 1066 10.1152/ajplung.00365.2011
38. Differential expression of Toll-like receptor 2 in human cells. Flo TH, Halaas O, Torp S, Ryan L, Lien E, Dybdahl B, Sundan A, Espevik T, J Leukoc Biol 2001 69 474 481 11261796 (Pubitemid 32221453)
39. A novel cyclin-dependent kinase inhibitor down-regulates tumor necrosis factor-alpha (TNF-alpha)-induced expression of cell adhesion molecules by inhibition of NF-kappaB activation in human pulmonary epithelial cells. Oh JH, Park EJ, Park JW, Lee J, Lee SH, Kwon TK, Int Immunopharmacol 2010 10 572 579 10.1016/j.intimp.2010.02.004 20156602
40. Involvement of p42/p44 MAPK, JNK, and NF-kappaB in IL-1beta-induced ICAM-1 expression in human pulmonary epithelial cells. Lin FS, Lin CC, Chien CS, Luo SF, Yang CM, Cell Physiol 2005 202 464 473 10.1002/jcp.20142 (Pubitemid 40041316)
41. Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components. Talreja J, Kabir MH, B Filla M, Stechschulte DJ, Dileepan KN, Immunology 2004 113 224 233 10.1111/j.1365-2567.2004.01946.x 15379983 (Pubitemid 39312450)
42. HLA-DR and ICAM-1 expression and modulation in epithelial cells from nasal polyps. Papon JF, Coste A, Gendron MC, Cordonnier C, Wingerstmann L, Peynègre R, Escudier E, Laryngoscope 2002 112 2067 2075 10.1097/00005537-200211000-00030 12439183 (Pubitemid 35283476)
43. Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children. Gourgiotis D, Papadopoulos NG, Bossios A, Zamanis P, Saxoni-Papageorgiou P, J Asthma 2004 41 285 287 10.1081/JAS-120026085 15260461 (Pubitemid 38823310)
44. Toll-like receptors: critical proteins linking innate and acquired immunity. Akira S, Takeda K, Kaisho T, Nat Immunol 2001 2 675 680 10.1038/90609 11477402 (Pubitemid 32747155)
45. Toll-like receptor signalling. Akira S, Takeda K, Nat Rev Immunol 2004 4 499 511 10.1038/nri1391 15229469 (Pubitemid 38931765)
46. Cystic fibrosis pathogens activate Ca2§ssup§+§esup§ dependent MAPK signaling pathways in airway epithelial cells. Ratner AJ, Bryan R, Weber A, Nguyen S, Barnes D, Pitt A, Gelber SE, Cheung A, Prince A, J Biol Chem 2001 276 19267 19275 10.1074/jbc.M007703200 11278360
47. Regulation of toll-like receptor 2 expression by macrophages following Mycobacterium avium infection. Wang T, Lafuse WP, Zwilling BS, J Immunol 2000 165 6308 6313 11086067
48. NFkappaB and Sp1 elements are necessary for maximal transcription of toll-like receptor 2 induced by Mycobacterium avium. Wang T, Lafuse WP, Zwilling BS, J Immunol 2001 167 6924 6932 11739511 (Pubitemid 33144186)
49. Mammalian MAP kinase signalling cascades. Chang L, Karin M, Nature 2001 410 37 40 10.1038/35065000 11242034 (Pubitemid 32225829)
50. Modulation of the Ras/Raf/MEK/ERK pathway by Ca2§ssup§+§ esup§, and calmodulin. Agell N, Bachs O, Rocamora N, Villalonga P, Cell Signal 2002 14 649 654 10.1016/S0898-6568(02)00007-4 12020764 (Pubitemid 34518618)
51. Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. Profita M, Sala A, Bonanno A, Siena L, Ferraro M, Di Giorgi R, Montalbano AM, D. Albano G, Gagliardo R, Gjomarkaj M, The American Society for Pharmacology and Experimental Therapeutics 2008 325 1024 1030 10.1124/jpet.107.131649 (Pubitemid 351724327)
52. Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. Imasato A, Desbois-Mouthon C, Han J, Kai H, Cato AC, Akira S, Li JD, J Biol Chem 2002 277 47444 47450 10.1074/jbc.M208140200 12356755 (Pubitemid 36159261)
53. Introduction to NF-kB: players, pathways, perspectives. Gilmore TD, Oncogene 2006 25 6680 6684 10.1038/sj.onc.1209954 17072321 (Pubitemid 44657845)
54. The NF-kB regulatory network. Brasier AR, Cardiovasc Toxicol 2006 6 111 130 10.1385/CT:6:2:111 17303919 (Pubitemid 46277550)
55. Integrating cell-signalling pathways with NF-kB and IKK function. Perkins ND, Nat Rev Mol Cell Biol 2007 8 49 62 10.1038/nrm2083 17183360 (Pubitemid 46012014)
56. LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia. Qin H, Wilson CA, Lee SJ, Zhao X, Benveniste EN, Blood 2005 106 3114 3122 10.1182/blood-2005-02-0759 16020513 (Pubitemid 41565908)
57. Pathophysiology of allergic inflammation. Barnes PJ, Immunol Rev 2011 242 31 50 10.1111/j.1600-065X.2011.01020.x 21682737
58. An NF-kB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium. Cormet-Boyaka E, Jolivette K, Bonnegarde-Bernard A, Rennolds J, Hassan F, Mehta P, Tridandapani S, Webster-Marketon J, Boyaka PN, Toxicol Sci 2012 125 418 429 10.1093/toxsci/ kfr310 22094458
59. Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells. Mio T, Romberger DJ, Thompson AB, Robbins RA, Heires A, Rennard SI, Am J Respir Cri Care Med 1997 155 1770 1776 10.1164/ajrccm.155.5. 9154890 (Pubitemid 27216691)
60. Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase. Witherden IR, Vanden Bon EJ, Goldstraw P, Ratcliffe C, Pastorino U, Tetley TD, Am J Respir Cell Mol Biol 2004 30 500 509 10.1165/rcmb.4890 15033639 (Pubitemid 38457183)
61. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Rahman I, MacNee W, Free Radic Biol Med 2000 28 1405 1420 10.1016/S0891-5849(00)00215-X 10924859 (Pubitemid 30621483)