Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway

Laboratory Investigation

Volumn 92, Issue 8, 2012, Pages 1140-1148

  Petecchia, Loredana ^a   Sabatini, Federica ^a   Usai, Cesare ^b   Caci, Emanuela ^a   Varesio, Luigi ^a   Rossi, Giovanni A ^a  

^a G GASLINI INSTITUTE   (Italy)

^b CNR   (Italy)

Author keywords

airway inflammation; IL 4; INF ; occludin; TNF ; zonula occludens family

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 4; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OCCLUDIN; PROTEIN ZO1; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL MEMBRANE CONDUCTANCE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ELECTRIC RESISTANCE; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NICK END LABELING; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TIGHT JUNCTION; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; CYTOKINES; DNA DAMAGE; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; HUMANS; IN SITU NICK-END LABELING; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHOPROTEINS; RABBITS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESPIRATORY MUCOSA; TIGHT JUNCTIONS;

EID: 84864421205     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.67     Document Type: Article

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