Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current

Cardiovascular Research

Volumn 98, Issue 2, 2013, Pages 286-296

  Sikkel, Markus B ^a   Collins, Thomas P ^a   Rowlands, Christina ^a   Shah, Mit ^a   O'Gara, Peter ^a   Williams, Alan J ^b   Harding, Sian E ^a   Lyon, Alexander R ^a   MacLeod, Kenneth T ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Ca2+ sparks; Ca2+ waves; Flecainide; Na+ current

Indexed keywords

CALCIUM ION; FLECAINIDE; LIDOCAINE; PROPAFENONE; SODIUM CALCIUM EXCHANGE PROTEIN; TETRODOTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL ISOLATION; CONTROLLED STUDY; ELECTRIC POTENTIAL; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE; MALE; MOUSE; MUSCLE CELL; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM; SODIUM CURRENT; VOLTAGE CLAMP;

ANIMALS; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; FLECAINIDE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SARCOLEMMA; SARCOPLASMIC RETICULUM; SODIUM-CALCIUM EXCHANGER; TETRODOTOXIN; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84877254146     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt012     Document Type: Article

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