Corneal endothelial regeneration and tissue engineering

Progress in Retinal and Eye Research

Volumn 35, Issue , 2013, Pages 1-17

  Mimura, Tatsuya ^a,b   Yamagami, Satoru ^a,b   Amano, Shiro ^b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Corneal endothelium; Descemet stripping automated endothelial keratoplasty; Review; Tissue engineering; Transplantation; Wound healing

Indexed keywords

AMPHOTERICIN B; ASCORBIC ACID; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; BOVINE INSULIN; CALCIUM CHLORIDE; CHOLERA TOXIN; DOXYCYCLINE; GENTAMICIN; GROWTH FACTOR; HYDROCORTISONE; NERVE GROWTH FACTOR; SELENIUM; SODIUM SELENITE; TELOMERASE; TRANSFERRIN;

ALLOGRAFT; AMNION; CELL CULTURE; CELL FUNCTION; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CORNEA ENDOTHELIUM; CORNEA TRANSPLANTATION; CORNEAL ENDOTHELIAL CELL LOSS; CORNEAL ENDOTHELIAL REGENERATION; DEHYDRATION; DESCEMET STRIPPING ENDOTHELIAL KERATOPLASTY; DONOR; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL KERATOPLASTY; ENZYME ACTIVITY; HUMAN; IMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; RABBIT; REVIEW; STEM CELL; TISSUE ENGINEERING; WOUND HEALING;

DESCEMET STRIPPING ENDOTHELIAL KERATOPLASTY; ENDOTHELIAL CELLS; ENDOTHELIUM, CORNEAL; HUMANS; REGENERATION; TISSUE ENGINEERING; WOUND HEALING;

EID: 84877145074     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2013.01.003     Document Type: Review

References (160)

1. Aboalchamat B., Engelmann K., Bohnke M., Eggli P., Bednarz J. Morphological and functional analysis of immortalized human corneal endothelial cells after transplantation. Exp. Eye Res. 1999, 69:547-553.
2. Akl A., Luo S., Wood K.J. Induction of transplantation tolerance-the potential of regulatory T cells. Transpl. Immunol. 2005, 14:225-230.
3. Allsopp R.C., Vaziri H., Patterson C., Goldstein S., Younglai E.V., Futcher A.B., Greider C.W., Harley C.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:10114-10118.
4. Amann J., Holley G.P., Lee S.B., Edelhauser H.F. Increased endothelial cell density in the paracentral and peripheral regions of the human cornea. Am. J. Ophthalmol. 2003, 135:584-590.
5. Amano S. Transplantation of corneal endothelial cells. Nihon Ganka Gakkai Zasshi 2002, 106:805-835. Discussion 836.
6. Amano S. Transplantation of cultured human corneal endothelial cells. Cornea 2003, 22:S66-S74.
7. Amano S., Yamagami S., Mimura T., Uchida S., Yokoo S. Corneal stromal and endothelial cell precursors. Cornea 2006, 25:S73-S77.
8. Bahn C.F., Falls H.F., Varley G.A., Meyer R.F., Edelhauser H.F., Bourne W.M. Classification of corneal endothelial disorders based on neural crest origin. Ophthalmology 1984, 91:558-563.
9. Bard J.B., Hay E.D., Meller S.M. Formation of the endothelium of the avian cornea: a study of cell movement in vivo. Dev. Biol. 1975, 42:334-361.
10. Baum J.L., Niedra R., Davis C., Yue B.Y. Mass culture of human corneal endothelial cells. Arch. Ophthalmol. 1979, 97:1136-1140.
11. Bednarz J., Rodokanaki-von Schrenck A., Engelmann K. Different characteristics of endothelial cells from central and peripheral human cornea in primary culture and after subculture. In Vitro Cell. Dev. Biol. Anim. 1998, 34:149-153.
12. Binder P.S., Akers P., Zavala E.Y. Endothelial cell density determined by specular microscopy and scanning electron microscopy. Ophthalmology 1979, 86:1831-1847.
13. Blake D.A., Yu H., Young D.L., Caldwell D.R. Matrix stimulates the proliferation of human corneal endothelial cells in culture. Invest. Ophthalmol. Vis. Sci. 1997, 38:1119-1129.
14. Bohnke M., Eggli P., Engelmann K. Transplantation of cultured adult human or porcine corneal endothelial cells onto human recipients in vitro. Part II: evaluation in the scanning electron microscope. Cornea 1999, 18:207-213.
15. Boisjoly H.M., Tourigny R., Bazin R., Laughrea P.A., Dube I., Chamberland G., Bernier J., Roy R. Risk factors of corneal graft failure. Ophthalmology 1993, 100:1728-1735.
16. Bourne W.M., Nelson L.R., Hodge D.O. Central corneal endothelial cell changes over a ten-year period. Invest. Ophthalmol. Vis. Sci. 1997, 38:779-782.
17. Brown S.I., Hedbys B.O. The effect of ouabain on the hydration of the cornea. Invest. Ophthalmol. 1965, 4:216-221.
18. Chen K.H., Azar D., Joyce N.C. Transplantation of adult human corneal endothelium ex vivo: a morphologic study. Cornea 2001, 20:731-737.
19. Chen Q., Fischer A., Reagan J.D., Yan L.J., Ames B.N. Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:4337-4341.
20. Chen W., Ishikawa M., Yamaki K., Sakuragi S. Wistar rat palpebral conjunctiva contains more slow-cycling stem cells that have larger proliferative capacity: implication for conjunctival epithelial homeostasis. Jpn. J. Ophthalmol. 2003, 47:119-128.
21. Chiu C.P., Dragowska W., Kim N.W., Vaziri H., Yui J., Thomas T.E., Harley C.B., Lansdorp P.M. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells 1996, 14:239-248.
22. Choi J.S., Williams J.K., Greven M., Walter K.A., Laber P.W., Khang G., Soker S. Bioengineering endothelialized neo-corneas using donor-derived corneal endothelial cells and decellularized corneal stroma. Biomaterials 2010, 31:6738-6745.
23. Coles B.L., Angenieux B., Inoue T., Del Rio-Tsonis K., Spence J.R., McInnes R.R., Arsenijevic Y., van der Kooy D. Facile isolation and the characterization of human retinal stem cells. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:15772-15777.
24. Cosar C.B., Sridhar M.S., Cohen E.J., Held E.L., Alvim Pde T., Rapuano C.J., Raber I.M., Laibson P.R. Indications for penetrating keratoplasty and associated procedures, 1996-2000. Cornea 2002, 21:148-151.
25. Dapena I., Moutsouris K., Droutsas K., Ham L., van Dijk K., Melles G.R. Standardized "no-touch" technique for descemet membrane endothelial keratoplasty. Arch. Ophthalmol. 2011, 129:88-94.
26. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:9363-9367.
27. Egan C.A., Savre-Train I., Shay J.W., Wilson S.E., Bourne W.M. Analysis of telomere lengths in human corneal endothelial cells from donors of different ages. Invest. Ophthalmol. Vis. Sci. 1998, 39:648-653.
28. Engelmann K., Bohnke M., Friedl P. Isolation and long-term cultivation of human corneal endothelial cells. Invest. Ophthalmol. Vis. Sci. 1988, 29:1656-1662.
29. Engelmann K., Friedl P. Optimization of culture conditions for human corneal endothelial cells. In Vitro Cell. Dev. Biol. 1989, 25:1065-1072.
30. Engelmann K., Friedl P. Growth of human corneal endothelial cells in a serum-reduced medium. Cornea 1995, 14:62-70.
31. Engelmann K., Drexler D., Bohnke M. Transplantation of adult human or porcine corneal endothelial cells onto human recipients in vitro. Part I: cell culturing and transplantation procedure. Cornea 1999, 18:199-206.
32. Enomoto K., Mimura T., Harris D.L., Joyce N.C. Age differences in cyclin-dependent kinase inhibitor expression and rb hyperphosphorylation in human corneal endothelial cells. Invest. Ophthalmol. Vis. Sci. 2006, 47:4330-4340.
33. Fischbarg J., Hernandez J., Liebovitch L.S., Koniarek J.P. The mechanism of fluid and electrolyte transport across corneal endothelium: critical revision and update of a model. Curr. Eye Res. 1985, 4:351-360.
34. Gorovoy M.S. Descemet-stripping automated endothelial keratoplasty. Cornea 2006, 25:886-889.
35. Gospodarowicz D., Greenburg G., Alvarado J. Transplantation of cultured bovine corneal endothelial cells to species with nonregenerative endothelium. The cat as an experimental model. Arch. Ophthalmol. 1979, 97:2163-2169.
36. Gospodarowicz D., Greenburg G., Alvarado J. Transplantation of cultured bovine corneal endothelial cells to rabbit cornea: clinical implications for human studies. Proc. Natl. Acad. Sci. U. S. A. 1979, 76:464-468.
37. Gospodarowicz D., Greenburg G. The coating of bovine and rabbit corneas denuded of their endothelium with bovine corneal endothelial cells. Exp. Eye Res. 1979, 28:249-265.
38. Grueterich M., Espana E.M., Tseng S.C. Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche. Surv. Ophthalmol. 2003, 48:631-646.
39. Guerra F.P., Anshu A., Price M.O., Giebel A.W., Price F.W. Descemet's membrane endothelial keratoplasty: prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology 2011, 118:2368-2373.
40. Hansen J.M., Klass M., Harris C., Csete M. A reducing redox environment promotes C2C12 myogenesis: implications for regeneration in aged muscle. Cell. Biol. Int. 2007, 31:546-553.
41. Hattori S., Adachi E., Ebihara T., Shirai T., Someki I., Irie S. Alkali-treated collagen retained the triple helical conformation and the ligand activity for the cell adhesion via alpha2beta1 integrin. J. Biochem. 1999, 125:676-684.
42. Hayashi T., Yamagami S., Tanaka K., Yokoo S., Usui T., Amano S., Mizuki N. Immunologic mechanisms of corneal allografts reconstituted from cultured allogeneic endothelial cells in an immune-privileged site. Invest. Ophthalmol. Vis. Sci. 2009, 50:3151-3158.
43. Hiyama K., Hirai Y., Kyoizumi S., Akiyama M., Hiyama E., Piatyszek M.A., Shay J.W., Ishioka S., Yamakido M. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol. 1995, 155:3711-3715.
44. Hiyama E., Hiyama K. Telomere and telomerase in stem cells. Br. J. Cancer 2007, 96:1020-1024.
45. Hodson S. Evidence for a bicarbonate-dependent sodium pump in corneal endothelium. Exp. Eye Res. 1971, 11:20-29.
46. Hodson S., Wigham C. The permeability of rabbit and human corneal endothelium. J. Physiol. 1983, 342:409-419.
47. Hollingsworth J., Perez-Gomez I., Mutalib H.A., Efron N. A population study of the normal cornea using an in vivo, slit-scanning confocal microscope. Optom. Vis. Sci. 2001, 78:706-711.
48. Honda N., Mimura T., Usui T., Amano S. Descemet stripping automated endothelial keratoplasty using cultured corneal endothelial cells in a rabbit model. Arch. Ophthalmol. 2009, 127:1321-1326.
49. Horan P.K., Melnicoff M.J., Jensen B.D., Slezak S.E. Fluorescent cell labeling for in vivo and in vitro cell tracking. Methods Cell. Biol. 1990, 33:469-490.
50. Huff J.W., Green K. Demonstration of active sodium transport across the isolated rabbit corneal endothelium. Curr. Eye Res. 1981, 1:113-114.
51. Insler M.S., Lopez J.G. Transplantation of cultured human neonatal corneal endothelium. Curr. Eye Res. 1986, 5:967-972.
52. Insler M.S., Lopez J.G. Extended incubation times improve corneal endothelial cell transplantation success. Invest. Ophthalmol. Vis. Sci. 1991, 32:1828-1836.
53. Insler M.S., Lopez J.G. Heterologous transplantation versus enhancement of human corneal endothelium. Cornea 1991, 10:136-148.
54. Ishino Y., Sano Y., Nakamura T., Connon C.J., Rigby H., Fullwood N.J., Kinoshita S. Amniotic membrane as a carrier for cultivated human corneal endothelial cell transplantation. Invest. Ophthalmol. Vis. Sci. 2004, 45:800-806.
55. Jackel T., Knels L., Valtink M., Funk R.H., Engelmann K. Serum-free corneal organ culture medium (SFM) but not conventional minimal essential organ culture medium (MEM) protects human corneal endothelial cells from apoptotic and necrotic cell death. Br. J. Ophthalmol. 2011, 95:123-130.
56. Johnston M.C., Noden D.M., Hazelton R.D., Coulombre J.L., Coulombre A.J. Origins of avian ocular and periocular tissues. Exp. Eye Res. 1979, 29:27-43.
57. Joo C.K., Green W.R., Pepose J.S., Fleming T.P. Repopulation of denuded murine Descemet's membrane with life-extended murine corneal endothelial cells as a model for corneal cell transplantation. Graefes Arch. Clin. Exp. Ophthalmol. 2000, 238:174-180.
58. Joyce N.C., Matkin E.D., Neufeld A.H. Corneal endothelial wound closure in vitro. Effects of EGF and/or indomethacin. Invest. Ophthalmol. Vis. Sci. 1989, 30:1548-1559.
59. Joyce N.C., Meklir B., Joyce S.J., Zieske J.D. Cell cycle protein expression and proliferative status in human corneal cells. Invest. Ophthalmol. Vis. Sci. 1996, 37:645-655.
60. Joyce N.C., Navon S.E., Roy S., Zieske J.D. Expression of cell cycle-associated proteins in human and rabbit corneal endothelium in situ. Invest. Ophthalmol. Vis. Sci. 1996, 37:1566-1575.
61. Joyce N.C. Proliferative capacity of the corneal endothelium. Prog. Retin. Eye Res. 2003, 22:359-389.
62. Joyce N.C., Zhu C.C. Human corneal endothelial cell proliferation: potential for use in regenerative medicine. Cornea 2004, 23:S8-S19.
63. Joyce N.C., Zhu C.C., Harris D.L. Relationship among oxidative stress, DNA damage, and proliferative capacity in human corneal endothelium. Invest. Ophthalmol. Vis. Sci. 2009, 50:2116-2122.
64. Joyce N.C., Harris D.L., Zhu C.C. Age-related gene response of human corneal endothelium to oxidative stress and DNA damage. Invest. Ophthalmol. Vis. Sci. 2011, 52:1641-1649.
65. Jumblatt M.M., Maurice D.M., McCulley J.P. Transplantation of tissue-cultured corneal endothelium. Invest. Ophthalmol. Vis. Sci. 1978, 17:1135-1141.
66. Jumblatt M.M., Maurice D.M., Schwartz B.D. A gelatin membrane substrate for the transplantation of tissue cultured cells. Transplantation 1980, 29:498-499.
67. Kanai A., Tanaka M., Ishii R., Nakajima A. Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism. Am. J. Ophthalmol. 1982, 93:600-606.
68. Kang S.M., Tang Q., Bluestone J.A. CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am. J. Transplant. 2007, 7:1457-1463.
69. Kawano H., Uesugi Y., Nakayasu K., Kanai A. Long-term follow-up for bullous keratopathy after sato-type anterior-posterior corneal refractive surgery. Am. J. Ophthalmol. 2003, 136:1154-1155.
70. Kawase Y., Yanagi Y., Takato T., Fujimoto M., Okochi H. Characterization of multipotent adult stem cells from the skin: transforming growth factor-beta (TGF-beta) facilitates cell growth. Exp. Cell. Res. 2004, 295:194-203.
71. Kinoshita S., Adachi W., Sotozono C., Nishida K., Yokoi N., Quantock A.J., Okubo K. Characteristics of the human ocular surface epithelium. Prog. Retin. Eye Res. 2001, 20:639-673.
72. Koenig S.B., Covert D.J. Early results of small-incision Descemet's stripping and automated endothelial keratoplasty. Ophthalmology 2007, 114:221-226.
73. Koizumi N., Sakamoto Y., Okumura N., Okahara N., Tsuchiya H., Torii R., Cooper L.J., Ban Y., Tanioka H., Kinoshita S. Cultivated corneal endothelial cell sheet transplantation in a primate model. Invest. Ophthalmol. Vis. Sci. 2007, 48:4519-4526.
74. Koizumi N., Sakamoto Y., Okumura N., Tsuchiya H., Torii R., Cooper L.J., Ban Y., Tanioka H., Kinoshita S. Cultivated corneal endothelial transplantation in a primate: possible future clinical application in corneal endothelial regenerative medicine. Cornea 2008, 27(Suppl. 1):S48-S55.
75. Konomi K., Zhu C., Harris D., Joyce N.C. Comparison of the proliferative capacity of human corneal endothelial cells from the central and peripheral areas. Invest. Ophthalmol. Vis. Sci. 2005, 46:4086-4091.
76. Konomi K., Joyce N.C. Age and topographical comparison of telomere lengths in human corneal endothelial cells. Mol. Vis. 2007, 13:1251-1258.
77. Krabcova I., Studeny P., Jirsova K. Endothelial Quality of Pre-cut Posterior Corneal Lamellae for Descemet Membrane Endothelial Keratoplasty with a Stromal Rim (DMEK-S): Two-year Outcome of Manual Preparation in an Ocular Tissue Bank 2012, Cell Tissue Bank.
78. Krause D.S., Theise N.D., Collector M.I., Henegariu O., Hwang S., Gardner R., Neutzel S., Sharkis S.J. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001, 105:369-377.
79. Lai J.Y., Chen K.H., Hsiue G.H. Tissue-engineered human corneal endothelial cell sheet transplantation in a rabbit model using functional biomaterials. Transplantation 2007, 84:1222-1232.
80. Lange T.M., Wood T.O., McLaughlin B.J. Corneal endothelial cell transplantation using Descemet's membrane as a carrier. J. Cataract Refract. Surg. 1993, 19:232-235.
81. Laaser K., Bachmann B.O., Horn F.K., Cursiefen C., Kruse F.E. Descemet membrane endothelial keratoplasty combined with phacoemulsification and intraocular lens implantation: advanced triple procedure. Am. J. Ophthalmol. 2012, 154:47-55. e42.
82. Lavker R.M., Wei Z.G., Sun T.T. Phorbol ester preferentially stimulates mouse fornical conjunctival and limbal epithelial cells to proliferate in vivo. Invest. Ophthalmol. Vis. Sci. 1998, 39:301-307.
83. Lavker R.M., Tseng S.C., Sun T.T. Corneal epithelial stem cells at the limbus: looking at some old problems from a new angle. Exp. Eye Res. 2004, 78:433-446.
84. Lees S.J., Childs T.E., Booth F.W. p21(Cip1) expression is increased in ambient oxygen, compared to estimated physiological (5%) levels in rat muscle precursor cell culture. Cell. Prolif. 2008, 41:193-207.
85. Li W., Sabater A.L., Chen Y.T., Hayashida Y., Chen S.Y., He H., Tseng S.C. A novel method of isolation, preservation, and expansion of human corneal endothelial cells. Invest. Ophthalmol. Vis. Sci. 2007, 48:614-620.
86. Liang Y., Liu W., Han B., Yang C., Ma Q., Zhao W., Rong M., Li H. Fabrication and characters of a corneal endothelial cells scaffold based on chitosan. J. Mater. Sci. Mater. Med. 2011, 22:175-183.
87. Mannis M.J., Krachmer J.H. Keratoplasty: a historical perspective. Surv. Ophthalmol. 1981, 25:333-338.
88. Matsubara M., Tanishima T. Wound-healing of corneal endothelium in monkey: an autoradiographic study. Jpn. J. Ophthalmol. 1983, 27:444-450.
89. McCulley J.P., Maurice D.M., Schwartz B.D. Corneal endothelial transplantation. Ophthalmology 1980, 87:194-201.
90. McGowan S.L., Edelhauser H.F., Pfister R.R., Whikehart D.R. Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol. Vis. 2007, 13:1984-2000.
91. Meier S. The distribution of cranial neural crest cells during ocular morphogenesis. Prog. Clin. Biol. Res. 1982, 82:1-15.
92. Mimura T., Amano S., Usui T., Araie M., Ono K., Akihiro H., Yokoo S., Yamagami S. Transplantation of corneas reconstructed with cultured adult human corneal endothelial cells in nude rats. Exp. Eye Res. 2004, 79:231-237.
93. Mimura T., Yamagami S., Yokoo S., Usui T., Tanaka K., Hattori S., Irie S., Miyata K., Araie M., Amano S. Cultured human corneal endothelial cell transplantation with a collagen sheet in a rabbit model. Invest. Ophthalmol. Vis. Sci. 2004, 45:2992-2997.
94. Mimura T., Yamagami S., Usui T., Ishii Y., Ono K., Yokoo S., Funatsu H., Araie M., Amano S. Long-term outcome of iron-endocytosing cultured corneal endothelial cell transplantation with magnetic attraction. Exp. Eye Res. 2005, 80:149-157.
95. Mimura T., Yamagami S., Yokoo S., Araie M., Amano S. Comparison of rabbit corneal endothelial cell precursors in the central and peripheral cornea. Invest. Ophthalmol. Vis. Sci. 2005, 46:3645-3648.
96. Mimura T., Yokoo S., Araie M., Amano S., Yamagami S. Treatment of rabbit bullous keratopathy with precursors derived from cultured human corneal endothelium. Invest. Ophthalmol. Vis. Sci. 2005, 46:3637-3644.
97. Mimura T., Joyce N.C. Replication competence and senescence in central and peripheral human corneal endothelium. Invest. Ophthalmol. Vis. Sci. 2006, 47:1387-1396.
98. Mimura T., Yamagami S., Usui T., Seiichi Honda N., Amano S. Necessary prone position time for human corneal endothelial precursor transplantation in a rabbit endothelial deficiency model. Curr. Eye Res. 2007, 32:617-623.
99. Mimura T., Amano S., Yokoo S., Uchida S., Usui T., Yamagami S. Isolation and distribution of rabbit keratocyte precursors. Mol. Vis. 2008, 14:197-203.
100. Mimura T., Amano S., Yokoo S., Uchida S., Yamagami S., Usui T., Kimura Y., Tabata Y. Tissue engineering of corneal stroma with rabbit fibroblast precursors and gelatin hydrogels. Mol. Vis. 2008, 14:1819-1828.
101. Mimura T., Yamagami S., Uchida S., Yokoo S., Ono K., Usui T., Amano S. Isolation of adult progenitor cells with neuronal potential from rabbit corneal epithelial cells in serum- and feeder layer-free culture conditions. Mol. Vis. 2010, 16:1712-1719.
102. Mimura T., Yamagami S., Yokoo S., Usui T., Amano S. Selective isolation of young cells from human corneal endothelium by the sphere-forming assay. Tissue Eng. Part. C Methods 2010, 16:803-812.
103. Miyashita H., Higa K., Kato N., Kawakita T., Yoshida S., Tsubota K., Shimmura S. Hypoxia enhances the expansion of human limbal epithelial progenitor cells in vitro. Invest. Ophthalmol. Vis. Sci. 2007, 48:3586-3593.
104. Miyata K., Drake J., Osakabe Y., Hosokawa Y., Hwang D., Soya K., Oshika T., Amano S. Effect of donor age on morphologic variation of cultured human corneal endothelial cells. Cornea 2001, 20:59-63.
105. Murphy C., Alvarado J., Juster R., Maglio M. Prenatal and postnatal cellularity of the human corneal endothelium. A quantitative histologic study. Invest. Ophthalmol. Vis. Sci. 1984, 25:312-322.
106. Nagasaki T., Zhao J. Uniform distribution of epithelial stem cells in the bulbar conjunctiva. Invest. Ophthalmol. Vis. Sci. 2005, 46:126-132.
107. Naveiras M., Dirisamer M., Parker J., Ham L., van Dijk K., Dapena I., Melles G.R. Causes of glaucoma after descemet membrane endothelial keratoplasty. Am. J. Ophthalmol. 2012, 153:958-966. e951.
108. Niederkorn J.Y., Mellon J. Anterior chamber-associated immune deviation promotes corneal allograft survival. Invest. Ophthalmol. Vis. Sci. 1996, 37:2700-2707.
109. Nunes M.C., Roy N.S., Keyoung H.M., Goodman R.R., McKhann G., Jiang L., Kang J., Nedergaard M., Goldman S.A. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat. Med. 2003, 9:439-447.
110. Parker J., Dirisamer M., Naveiras M., Tse W.H., van Dijk K., Frank L.E., Ham L., Melles G.R. Outcomes of Descemet membrane endothelial keratoplasty in phakic eyes. J. Cataract Refract. Surg. 2012, 38:871-877.
111. Paull A.C., Whikehart D.R. Expression of the p53 family of proteins in central and peripheral human corneal endothelial cells. Mol. Vis. 2005, 11:328-334.
112. Pe'er J., Zajicek G., Greifner H., Kogan M. Streaming conjunctiva. Anat. Rec. 1996, 245:36-40.
113. Peh G.S., Toh K.P., Wu F.Y., Tan D.T., Mehta J.S. Cultivation of human corneal endothelial cells isolated from paired donor corneas. PLoS One 2011, 6:e28310.
114. Pellegrini G., Golisano O., Paterna P., Lambiase A., Bonini S., Rama P., De Luca M. Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. J. Cell. Biol. 1999, 145:769-782.
115. Price M.O., Baig K.M., Brubaker J.W., Price F.W. Randomized, prospective comparison of precut vs surgeon-dissected grafts for descemet stripping automated endothelial keratoplasty. Am. J. Ophthalmol. 2008, 146:36-41.
116. Rapuano C.J., Cohen E.J., Brady S.E., Arentsen J.J., Laibson P.R. Indications for and outcomes of repeat penetrating keratoplasty. Am. J. Ophthalmol. 1990, 109:689-695.
117. Samples J.R., Binder P.S., Nayak S.K. Propagation of human corneal endothelium in vitro effect of growth factors. Exp. Eye Res. 1991, 52:121-128.
118. Schimmelpfennig B.H. Direct and indirect determination of nonuniform cell density distribution in human corneal endothelium. Invest. Ophthalmol. Vis. Sci. 1984, 25:223-229.
119. Schultz G., Cipolla L., Whitehouse A., Eiferman R., Woost P., Jumblatt M. Growth factors and corneal endothelial cells: III. Stimulation of adult human corneal endothelial cell mitosis in vitro by defined mitogenic agents. Cornea 1992, 11:20-27.
120. Senoo T., Joyce N.C. Cell cycle kinetics in corneal endothelium from old and young donors. Invest. Ophthalmol. Vis. Sci. 2000, 41:660-667.
121. Senoo T., Obara Y., Joyce N.C. EDTA: a promoter of proliferation in human corneal endothelium. Invest. Ophthalmol. Vis. Sci. 2000, 41:2930-2935.
122. Shima N., Kimoto M., Yamaguchi M., Yamagami S. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate. Invest. Ophthalmol. Vis. Sci. 2011, 52:8711-8717.
123. Simonsen J.L., Rosada C., Serakinci N., Justesen J., Stenderup K., Rattan S.I., Jensen T.G., Kassem M. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat. Biotechnol. 2002, 20:592-596.
124. Sonoda K.H., Taniguchi M., Stein-Streilein J. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. J. Immunol. 2002, 168:2028-2034.
125. Sonoda Y., Streilein J.W. Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts. J. Immunol. 1993, 150:1727-1734.
126. Stenzel K.H., Dunn M.W., Rubin A.L., Miyata T. Collagen gels: design for a vitreous replace-ment. Science 1969, 164:1282-1283.
127. Streilein J.W., Niederkorn J.Y. Induction of anterior chamber-associated immune deviation requires an intact, functional spleen. J. Exp. Med. 1981, 153:1058-1067.
128. Streilein J.W., Bradley D., Sano Y., Sonoda Y. Immunosuppressive properties of tissues obtained from eyes with experimentally manipulated corneas. Invest. Ophthalmol. Vis. Sci. 1996, 37:413-424.
129. Sumide T., Nishida K., Yamato M., Ide T., Hayashida Y., Watanabe K., Yang J., Kohno C., Kikuchi A., Maeda N., Watanabe H., Okano T., Tano Y. Functional human corneal endothelial cell sheets harvested from temperature-responsive culture surfaces. FASEB J. 2006, 20:392-394.
130. Tao R., Hancock W.W. Regulating regulatory T cells to achieve transplant tolerance. Hepatobiliary Pancreat. Dis. Int. 2007, 6:348-357.
131. Terry M.A., Shamie N., Chen E.S., Hoar K.L., Friend D.J. Endothelial keratoplasty a simplified technique to minimize graft dislocation, iatrogenic graft failure, and pupillary block. Ophthalmology 2008, 115:1179-1186.
132. Terry M.A. Endothelial keratoplasty: why aren't we all doing Descemet membrane endothelial keratoplasty?. Cornea 2012, 31:469-471.
133. Todorov I.T., Attaran A., Kearsey S.E. BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication. J. Cell. Biol. 1995, 129:1433-1445.
134. Todorov I.T., Werness B.A., Wang H.Q., Buddharaju L.N., Todorova P.D., Slocum H.K., Brooks J.S., Huberman J.A. HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues. Lab. Invest. 1998, 78:73-78.
135. Toma J.G., Akhavan M., Fernandes K.J., Barnabe-Heider F., Sadikot A., Kaplan D.R., Miller F.D. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat. Cell. Biol. 2001, 3:778-784.
136. Tropepe V., Coles B.L., Chiasson B.J., Horsford D.J., Elia A.J., McInnes R.R., van der Kooy D. Retinal stem cells in the adult mammalian eye. Science 2000, 287:2032-2036.
137. Uchida S., Yokoo S., Yanagi Y., Usui T., Yokota C., Mimura T., Araie M., Yamagami S., Amano S. Sphere formation and expression of neural proteins by human corneal stromal cells in vitro. Invest. Ophthalmol. Vis. Sci. 2005, 46:1620-1625.
138. Wang J.C., Warner J.K., Erdmann N., Lansdorp P.M., Harrington L., Dick J.E. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:14398-14403.
139. Wang X., Tsao S.W., Wong Y.C., Cheung A.L. Induction of senescent-like growth arrest as a new target in anticancer treatment. Curr. Cancer Drug Targets 2003, 3:153-159.
140. Watanabe R., Hayashi R., Kimura Y., Tanaka Y., Kageyama T., Hara S., Tabata Y., Nishida K. A novel gelatin hydrogel carrier sheet for corneal endothelial transplantation. Tissue Eng. Part. A 2011, 17:2213-2219.
141. Wei Z.G., Wu R.L., Lavker R.M., Sun T.T. In vitro growth and differentiation of rabbit bulbar, fornix, and palpebral conjunctival epithelia. Implications on conjunctival epithelial transdifferentiation and stem cells. Invest. Ophthalmol. Vis. Sci. 1993, 34:1814-1828.
142. Wei Z.G., Cotsarelis G., Sun T.T., Lavker R.M. Label-retaining cells are preferentially located in fornical epithelium: implications on conjunctival epithelial homeostasis. Invest. Ophthalmol. Vis. Sci. 1995, 36:236-246.
143. Wharton S.B., Chan K.K., Anderson J.R., Stoeber K., Williams G.H. Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis. Neuropathol. Appl. Neurobiol. 2001, 27:305-313.
144. Whikehart D.R., Parikh C.H., Vaughn A.V., Mishler K., Edelhauser H.F. Evidence suggesting the existence of stem cells for the human corneal endothelium. Mol. Vis. 2005, 11:816-824.
145. Wigham C., Hodson S. The effect of bicarbonate ion concentration on trans-endothelial short circuit current in ox corneas. Curr. Eye Res. 1981, 1:37-41.
146. Wigham C.G., Turner H.C., Swan J., Hodson S.A. Modulation of corneal endothelial hydration control mechanisms by Rolipram. Pflugers Arch. 2000, 440:866-870.
147. Williams K.A., Roder D., Esterman A., Muehlberg S.M., Coster D.J. Factors predictive of corneal graft survival. Report from the Australian Corneal Graft Registry. Ophthalmology 1992, 99:403-414.
148. Wilson S.E., Lloyd S.A., He Y.G., McCash C.S. Extended life of human corneal endothelial cells transfected with the SV40 large T antigen. Invest. Ophthalmol. Vis. Sci. 1993, 34:2112-2123.
149. Wilson S.E., Weng J., Blair S., He Y.G., Lloyd S. Expression of E6/E7 or SV40 large T antigen-coding oncogenes in human corneal endothelial cells indicates regulated high-proliferative capacity. Invest. Ophthalmol. Vis. Sci. 1995, 36:32-40.
150. Wirtschafter J.D., Ketcham J.M., Weinstock R.J., Tabesh T., McLoon L.K. Mucocutaneous junction as the major source of replacement palpebral conjunctival epithelial cells. Invest. Ophthalmol. Vis. Sci. 1999, 40:3138-3146.
151. Yamada J., Hamuro J., Sano Y., Maruyama K., Kinoshita S. Allogeneic corneal tolerance in rodents with long-term graft survival. Transplantation 2005, 79:1362-1369.
152. Yamagami S., Suzuki Y., Tsuru T. Risk factors for graft failure in penetrating keratoplasty. Acta Ophthalmol. Scand. 1996, 74:584-588.
153. Yamagami S., Mimura T., Yokoo S., Takato T., Amano S. Isolation of human corneal endothelial cell precursors and construction of cell sheets by precursors. Cornea 2006, 25:S90-S92.
154. Yamagami S., Yokoo S., Mimura T., Takato T., Araie M., Amano S. Distribution of precursors in human corneal stromal cells and endothelial cells. Ophthalmology 2007, 114:433-439.
155. Yamaguchi M., Ebihara N., Shima N., Kimoto M., Funaki T., Yokoo S., Murakami A., Yamagami S. Adhesion, migration, and proliferation of cultured human corneal endothelial cells by laminin-5. Invest. Ophthalmol. Vis. Sci. 2011, 52:679-684.
156. Yang X.F. Factors regulating apoptosis and homeostasis of CD4+ CD25(high) FOXP3+ regulatory T cells are new therapeutic targets. Front. Biosci. 2008, 13:1472-1499.
157. Yokoo S., Yamagami S., Yanagi Y., Uchida S., Mimura T., Usui T., Amano S. Human corneal endothelial cell precursors isolated by sphere-forming assay. Invest. Ophthalmol. Vis. Sci. 2005, 46:1626-1631.
158. Yue B.Y., Sugar J., Gilboy J.E., Elvart J.L. Growth of human corneal endothelial cells in culture. Invest. Ophthalmol. Vis. Sci. 1989, 30:248-253.
159. Zhu C., Joyce N.C. Proliferative response of corneal endothelial cells from young and older donors. Invest. Ophthalmol. Vis. Sci. 2004, 45:1743-1751.
160. Zimmermann S., Glaser S., Ketteler R., Waller C.F., Klingmuller U., Martens U.M. Effects of telomerase modulation in human hematopoietic progenitor cells. Stem Cells 2004, 22:741-749.