Sources of technical variability in quantitative LC-MS proteomics: Human brain tissue sample analysis

Journal of Proteome Research

Volumn 12, Issue 5, 2013, Pages 2128-2137

  Piehowski, Paul D ^a   Petyuk, Vladislav A ^a   Orton, Daniel J ^a   Xie, Fang ^a   Moore, Ronald J ^a   Ramirez Restrepo, Manuel ^e   Engel, Anzhelika ^e   Lieberman, Andrew P ^b,c   Albin, Roger L ^b,c,d   Camp, David G ^a   Smith, Richard D ^a   Myers, Amanda J ^e  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d VAAAHS   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

label free quantification; reproducibility; sample preparation; study design; technical variation; tissue analysis

Indexed keywords

AGED; ANALYTIC METHOD; ARTICLE; BRAIN TISSUE; CASE REPORT; CONTROLLED STUDY; DISSECTION; EXTRACTION; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METHODOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DENATURATION; PROTEOMICS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SAMPLE; TISSUE PREPARATION; TISSUE SECTION; ALGORITHM; ALZHEIMER DISEASE; ARTIFACT; BIOLOGICAL MODEL; BRAIN; CASE CONTROL STUDY; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; STANDARD; STANDARDS; TANDEM MASS SPECTROMETRY;

NERVE PROTEIN; PROTEOME;

AGED; ALGORITHMS; ALZHEIMER DISEASE; ARTIFACTS; BRAIN; CASE-CONTROL STUDIES; HUMANS; MALE; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; PROTEOME; PROTEOMICS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84877133620     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr301146m     Document Type: Article

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