Production of biopharmaceutical proteins by yeast: Advances through metabolic engineering

Bioengineered

Volumn 4, Issue 4, 2013, Pages 207-211

  Nielsen, Jens ^a,b,c  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b Chalmers University of Technology   (Denmark)

^c SCIENCE FOR LIFE LABORATORY   (Sweden)

Author keywords

Industrial biotechnology; Insulin; Saccharomyces cerevisiae; Secretory pathway; Systems biology

Indexed keywords

GLUCAGON; HEPATITIS VACCINE; HUMAN SERUM ALBUMIN; PLASMA SUBSTITUTE; PREPROINSULIN; RECOMBINANT HIRUDIN; RECOMBINANT PROTEIN; TRANSFERRIN;

ANEMIA; BLOOD CLOTTING DISORDER; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; GENETIC ENGINEERING; MATHEMATICAL MODEL; METABOLIC ENGINEERING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN SECRETION; REVIEW; SACCHAROMYCES CEREVISIAE; SECRETORY PATHWAY; SYSTEMS BIOLOGY;

INDUSTRIAL BIOTECHNOLOGY; INSULIN; SACCHAROMYCES CEREVISIAE; SECRETORY PATHWAY; SYSTEMS BIOLOGY;

BIOTECHNOLOGY; METABOLIC ENGINEERING; RECOMBINANT PROTEINS; YEASTS;

EID: 84877131240     PISSN: 19491018     EISSN: 19491026     Source Type: Journal    
DOI: 10.4161/bioe.22856     Document Type: Review

References (31)

1. Cohen SN, Chang ACY, Boyer HW, Helling RB. Construction of biologically functional bacterial plasmids in vitro. Proc Natl Acad Sci U S A 1973; 70:3240-4; PMID:4594039; http://dx.doi.org/10.1073/pnas.70.11.3240
2. Walsh G. Biopharmaceutical benchmarks. Nat Biotechnol 2000; 18:831-3; PMID:10932150; http://dx.doi.org/10.1038/78720.
3. Walsh G. Biopharmaceuticals: Biochemistry and Biotechnology. 1998. J. Wiley & Sons, Ltd., Chichester, UK.
4. Chang CN, Rey M, Bochner B, Heyneker H, Gray G. High-level secretion of human growth hormone by Escherichia coli. Gene 1987; 55:189-96; PMID:3311882; http://dx.doi.org/10.1016/0378-1119(87)90279-4.
5. Langer ES. Biomanufacturing outsourcing outlook. BioPharm International. 2012; 25:15-6.
6. Goodman M. Market watch: Sales of biologics to show robust growth through to 2013. Nat Rev Drug Discov 2009; 8:837; PMID:19876035; http://dx.doi.org/10.1038/nrd3040.
7. Aggarwal S. What's fueling the biotech engine-2010 to 2011. Nat Biotechnol 2011; 29:1083-9; PMID:22158359; http://dx.doi.org/10.1038/nbt.2060.
8. Schröder M. Engineering eukaryotic protein factories. Biotechnol Lett 2008; 30:187-96; PMID:17885737; http://dx.doi.org/10.1007/s10529-007-9524-1.
9. Walsh G. Biopharmaceutical benchmarks 2010. Nat Biotechnol 2010; 28:917-24; PMID:20829826; http://dx.doi.org/10.1038/nbt0910-917.
10. Ferrer-Miralles N, Domingo-Espín J, Corchero JL, Vázquez E, Villaverde A. Microbial factories for recombinant pharmaceuticals. Microb Cell Fact 2009; 8:17; PMID:19317892; http://dx.doi.org/10.1186/1475-2859-8-17.
11. Martinez JL, Liu L, Petranovic D, Nielsen J. Pharmaceutical protein production by yeast: towards production of human blood proteins by microbial fermentation. Curr. Opionion Biotechnol. 2012; In press; http://dx.doi.org/10.1016/j.copbio.2012.03.011.
12. Hou J, Tyo KEJ, Liu Z, Petranovic D, Nielsen J. Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae. FEMS Yeast Res 2012; 12:491-510; PMID:22533807; http://dx.doi.org/10.1111/j.1567-1364.2012.00810.x
13. Petranovic D, Nielsen J. Can yeast systems biology contribute to the understanding of human disease? Trends Biotechnol 2008; 26:584-90; PMID:18801589; http://dx.doi.org/10.1016/j.tibtech.2008.07.008.
14. Petranovic D, Tyo K, Vemuri GN, Nielsen J. Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism. FEMS Yeast Res 2010; 10:1046-59; PMID:20977625; http://dx.doi.org/10.1111/j.1567-1364.2010.00689.x.
15. Kim I-K, Roldão A, Siewers V, Nielsen J. A systemslevel approach for metabolic engineering of yeast cell factories. FEMS Yeast Res 2012; 12:228-48; PMID:22188344; http://dx.doi.org/10.1111/j.1567-1364.2011.00779.x.
16. Wildt S, Gerngross TU. The humanization of N-glycosylation pathways in yeast. Nat Rev Microbiol 2005; 3:119-28; PMID:15685223; http://dx.doi.org/10.1038/nrmicro1087.
17. Hamilton SR, Davidson RC, Sethuraman N, Nett JH, Jiang Y, Rios S, et al. Humanization of yeast to produce complex terminally sialylated glycoproteins. Science 2006; 313:1441-3; PMID:16960007; http://dx.doi.org/10.1126/science.1130256.
18. Li H, Sethuraman N, Stadheim TA, Zha D, Prinz B, Ballew N, et al. Optimization of humanized IgGs in glycoengineered Pichia pastoris. Nat Biotechnol 2006; 24:210-5; PMID:16429149; http://dx.doi.org/10.1038/nbt1178.
19. Kjeldsen T, Hach M, Balschmidt P, Havelund S, Pettersson AF, Markussen J. Prepro-leaders lacking N-linked glycosylation for secretory expression in the yeast Saccharomyces cerevisiae. Protein Expr Purif 1998; 14:309-16; PMID:9882564; http://dx.doi.org/10.1006/prep.1998.0977.
20. Tyo KEJ, Liu Z, Petranovic D, Nielsen J. Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress. BMC Biol 2012; 10:16; PMID:22380681; http://dx.doi.org/10.1186/1741-7007-10-16.
21. Patil C, Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol 2001; 13:349-55; PMID:11343907; http://dx.doi.org/10.1016/S0955-0674(00)00219-2.
22. Liu Z, Tyo KEJ, Martínez JL, Petranovic D, Nielsen J. Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae. Biotechnol Bioeng 2012; 109:1259-68; PMID:22179756; http://dx.doi.org/10.1002/bit.24409.
23. Hou J, Tyo KEJ, Liu Z, Petranovic D, Nielsen J. Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae. Metab Eng 2012; 14:120-7; PMID:22265825; http://dx.doi.org/10.1016/j.ymben.2012.01.002.
24. Bro C, Regenberg B, Förster J, Nielsen J. In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production. Metab Eng 2006; 8:102-11; PMID:16289778; http://dx.doi.org/10.1016/j.ymben.2005.09.007.
25. Tyo KEJ, Kocharin K, Nielsen J. Toward designbased engineering of industrial microbes. Curr Opin Microbiol 2010; 13:255-62; PMID:20226723; http://dx.doi.org/10.1016/j.mib.2010.02.001.
26. Nielsen J. Metabolic engineering. Appl Microbiol Biotechnol 2001; 55:263-83; PMID:11341306; http://dx.doi.org/10.1007/s002530000511.
27. Nielsen J, Jewett MC. Impact of systems biology on metabolic engineering of Saccharomyces cerevisiae. FEMS Yeast Res 2008; 8:122-31; PMID:17727659; http://dx.doi.org/10.1111/j.1567-1364.2007.00302.x.
28. Umaña P, Bailey JE. A mathematical model of N-linked glycoform biosynthesis. Biotechnol Bioeng 1997; 55:890-908; PMID:18636599; http://dx.doi.org/10.1002/(SICI)1097-0290(19970920)55:6890::AID-BIT73.0.CO;2-B.
29. Krambeck FJ, Betenbaugh MJ. A mathematical model of N-linked glycosylation. Biotechnol Bioeng 2005; 92:711-28; PMID:16247773; http://dx.doi.org/10.1002/bit.20645
30. Österlund T, Nookaew I, Nielsen J. Fifteen years of large scale metabolic modeling of yeast: developments and impacts. Biotechnol Adv 2012; 30:979-88; PMID:21846501; http://dx.doi.org/10.1016/j.biotechadv.2011.07.021.
31. Patil KR, Nielsen J. Uncovering transcriptional regulation of metabolism by using metabolic network topology. Proc Natl Acad Sci U S A 2005; 102:2685-9; PMID:15710883; http://dx.doi.org/10.1073/pnas.0406811102