Interaction of dihydrofolate reductase and aminoglycoside adenyltransferase enzyme from Klebsiella pneumoniae multidrug resistant strain DF12SA with clindamycin: A molecular modelling and docking study

Journal of Molecular Modeling

Volumn 19, Issue 3, 2013, Pages 973-983

  Shahi, Shailesh K ^a   Singh, Vinay K ^a   Kumar, Ashok ^a   Gupta, Sanjeev K ^b   Singh, Surya K ^b  

^a BANARAS HINDU UNIVERSITY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Aminoglycoside adenyltransferase; Antibiotic resistance; Dihydrofolate reductase; Homology search; Integrons; Klebsiella pneumoniae

Indexed keywords

AMIKACIN; AMINO ACID; AMINOGLYCOSIDE ADENYLTRANSFERASE; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; CARBAPENEM; CEFOPERAZONE; CLINDAMYCIN; COTRIMOXAZOLE; DIHYDROFOLATE REDUCTASE; GENTAMICIN; KANAMYCIN; MEROPENEM; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; SPECTINOMYCIN; STREPTOMYCIN; TETRACYCLINE; TRANSFERASE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME STRUCTURE; GENE AMPLIFICATION; GENE CASSETTE; INTEGRON; KLEBSIELLA PNEUMONIAE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CATALYTIC DOMAIN; CLINDAMYCIN; DIABETIC FOOT; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; INTEGRONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; NUCLEOTIDYLTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; RESTRICTION MAPPING; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; TETRAHYDROFOLATE DEHYDROGENASE;

KLEBSIELLA PNEUMONIAE;

EID: 84877128890     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-012-1635-5     Document Type: Article

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