Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis

Journal of Autoimmunity

Volumn 42, Issue , 2013, Pages 39-49

  Ehser, Janine ^a   Holdener, Martin ^a   Christen, Selina ^a   Bayer, Monika ^a   Pfeilschifter, Josef M ^a   Hintermann, Edith ^a   Bogdanos, Dimitrios ^b   Christen, Urs ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Autoantigen; Autoimmune liver disease; Cross reactivity; Virus infection

Indexed keywords

ANTIGEN; AUTOANTIGEN; CYTOCHROME P450 2D6; EPITOPE; LKM 1 ANTIBODY; UNCLASSIFIED DRUG;

ADENOVIRUS; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE HEPATITIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS REACTION; CYTOTOXICITY; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; LIVER; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; SPLEEN; T LYMPHOCYTE; TRANSGENIC MOUSE;

ADENOVIRIDAE; ANIMALS; AUTOANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOCHROME P-450 CYP2D6; DISEASE MODELS, ANIMAL; GENETIC VECTORS; HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; LIVER; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MOLECULAR MIMICRY; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY;

EID: 84877115410     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.11.001     Document Type: Article

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