Bone formation controlled by biologically relevant inorganic ions: Role and controlled delivery from phosphate-based glasses

Advanced Drug Delivery Reviews

Volumn 65, Issue 4, 2013, Pages 405-420

  Lakhkar, Nilay J ^a   Lee, In Ho ^b   Kim, Hae Won ^b   Salih, Vehid ^a   Wall, Ivan B ^a,b   Knowles, Jonathan C ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Dankook University   (South Korea)

Author keywords

Bone; Boron; Calcium; Controlled release; Copper; Ions; Magnesium; Phosphate; Strontium; Titanium; Zinc

Indexed keywords

BONE FORMATION; CELL CULTURE MEDIUMS; CONTROLLED DELIVERY; CONTROLLED RELEASE; DELIVERY SYSTEMS; PHOSPHATE ANIONS; SUSTAINED RELEASE; TISSUE RESPONSE;

BORON; CALCIUM; CELL CULTURE; COPPER; IONS; MAGNESIUM; METAL IONS; PHOSPHATES; STRONTIUM; TISSUE; TITANIUM; ZINC;

BONE;

ALKALINE PHOSPHATASE; BIOCERAMICS; BIOMATERIAL; BORON; CALCIUM ION; CALCIUM PHOSPHATE; COPPER ION; GLASS; ION; MAGNESIUM ION; PHOSPHATE; PYROPHOSPHATE; STRONTIUM; TITANIUM; ZINC ION;

ANGIOGENESIS; BONE DEVELOPMENT; BONE MINERALIZATION; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; HUMAN; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; REVIEW;

ANIMALS; BORON; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; GLASS; HUMANS; IONS; METALS; OSTEOGENESIS; PHOSPHATES;

EID: 84877082550     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.05.015     Document Type: Review

References (262)

1. Ash C., Stone R. A question of dose - introduction. Science 2003, 300:925-925.
2. Thompson K.H., Orvig C. Boon and bane of metal ions in medicine. Science 2003, 300:936-939.
3. Akao M., Aoki H., Kato K. Mechanical-properties of sintered hydroxyapatite for prosthetic applications. J. Mater. Sci. 1981, 16:809-812.
4. Kato K., Aoki H., Tabata T., Ogiso M. Biocompatibility of apatite ceramics in mandibles. Biomat. Med. Devices Artif. Organs 1979, 7:291-297.
5. Li T.T., Lee J.H., Kobayashi T., Aoki H. Hydroxyapatite coating by dipping method, and bone bonding strength. J. Mat. Sci. Mater. Med. 1996, 7:355-357.
6. Berglundh T., Lindhe J. Healing around implants placed in bone defects treated with BiO-Oss(R) - an experimental study in the dog. Clin. Oral Implants Res. 1997, 8:117-124.
7. Jensen S.S., Aaboe M., Pinholt E.M., Hjorting-Hansen E., Melsen F., Ruyter I.E. Tissue reaction and material characteristics of four bone substitutes. Int. J. Oral Maxillofac. Implants 1996, 11:55-66.
8. Piattelli M., Favero G.A., Scarano A., Orsini G., Piattelli A. Bone reactions to anorganic bovine bone (Bio-Oss) used in sinus augmentation procedures: a histologic long-term report of 20 cases in humans. Int. J. Oral Maxillofac. Implants 1999, 14:835-840.
9. Barralet J., Akao M., Aoki H., Aoki H. Dissolution of dense carbonate apatite subcutaneously implanted in Wistar rats. J. Biomed. Mater. Res. 2000, 49:176-182.
10. Barralet J., Knowles J.C., Best S., Bonfield W. Thermal decomposition of synthesised carbonate hydroxyapatite. J. Mater. Sci. Mater. Med. 2002, 13:529-533.
11. Iwai S.I., Sotome Y., Aoki H., Morikawa H. Reactions of magnesium carbonates by direct X-ray diffraction under hydrothermal conditions. Am. Miner. 1971, 56. (628-&).
12. Rodriguez-Lorenzo L.M., Hart J.N., Gross K.A. Influence of fluorine in the synthesis of apatites, synthesis of solid solutions of hydroxy-fluorapatite. Biomaterials 2003, 24:3777-3785.
13. Wei M., Evans J.H., Bostrom T., Grondahl L. Synthesis and characterization of hydroxyapatite, fluoride-substituted hydroxyapatite and fluorapatite. J. Mater. Sci.-Mater. Med. 2003, 14:311-320.
14. Zhang H.G., Zhu Q.S., Wang Y. Morphologically controlled synthesis of hydroxyapatite with partial substitution of fluorine. Chem. Mater. 2005, 17:5824-5830.
15. Barralet J., Best S., Bonfield W. Carbonate substitution in precipitated hydroxyapatite: an investigation into the effects of reaction temperature and bicarbonate ion concentration. J. Biomed. Mater. Res. 1998, 41:79-86.
16. Barralet J.E., Best S.M., Bonfield W. Effect of sintering parameters on the density and microstructure of carbonate hydroxyapatite. J. Mater. Sci.-Mater. Med. 2000, 11:719-724.
17. Doi Y., Shibutani T., Moriwaki Y., Kajimoto T., Iwayama Y. Sintered carbonate apatites as bioresorbable bone substitutes. J. Biomed. Mater. Res. 1998, 39:603-610.
18. Habibovic P., Barralet J.E. Bioinorganics and biomaterials: bone repair. Acta Biomaterialia 2011, 7:3013-3026.
19. Hench L.L. Glasses to turn on genes. Glas. Sci. Technol. 2004, 77:95-103.
20. Hench L.L. Bioceramics - from concept to clinic. J. Am. Ceram. Soc. 1991, 74:1487-1510.
21. Hench L.L. Bioceramics. J. Am. Ceram. Soc. 1998, 81:1705-1728.
22. Hench L.L., Polak J.M. Third-generation biomedical materials. Science 2002, 295. (1014-+).
23. Hench L.L., Xynos I.D., Polak J.M. Bioactive glasses for in situ tissue regeneration. J. Biomater. Sci. Polym. Ed. 2004, 15:543-562.
24. Xynos I.D., Edgar A.J., Buttery L.D.K., Hench L.L., Polak J.M. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem. Biophys. Res. Commun. 2000, 276:461-465.
25. Xynos I.D., Hukkanen M.V.J., Batten J.J., Buttery L.D., Hench L.L., Polak J.M. Bioglass (R) 45S5 stimulates osteoblast turnover and enhances bone formation in vitro: implications and applications for bone tissue engineering. Calcif. Tissue Int. 2000, 67:321-329.
26. Fernandez E., Tortuero F., Martin L. The effect of different levels of dietary sepioloite on tibial dyschondroplasia in chickens. Archiv Fur Geflugelkunde 1994, 58:171-175.
27. Tortuero F., Fernandez E., Rioperez J. Effects of sepiolite on mineral metabolism and skeletal development in chickens. Archivos de Zootecnia 1993, 42:401-408.
28. Gezen S.S., Eren M., Deniz G. The effect of zeolite on broiler performance. Indian Vet. J. 2004, 81:411-415.
29. Ward T.L., Watkins K.L., Southern L.L. Interactive effects of sodium zeolite a (ethacal) and monensin in uninfected and eimeria-acervulina-infected chicks. Poult. Sci. 1990, 69:276-280.
30. Southern L.L., Ward T.L., Bidner T.D., Hebert L.G. Effect of sodium bentonite or hydrated sodium-calcium aluminosilicate on growth-performance and tibia mineral concentrations in broiler chickens fed nutrient-deficient diets poultry. Science 1994, 73:848-854.
31. Merkley J.W., Miller E.R. The effect of sodium-fluoride and sodium-silicate on growth and bone strength of broilers. Poult. Sci. 1983, 62:798-804.
32. 2-ZnO bioglass. Acta Biomaterialia 2007, 3:255-262.
33. Oki A., Parveen B., Hossain S., Adeniji S., Donahue H. Preparation and in vitro bioactivity of zinc containing sol-gel-derived bioglass materials. J. Biomed. Mater. Res. 2004, 69A:216-221.
34. Vrouwenvelder W.C.A., Groot C.G., Degroot K. Better histology and biochemistry for osteoblasts cultured on titanium doped bioactive glass - Bioglass 45S5 compared with iron-containing, titanium-containing, fluorine containing and boron-containing bioactive glasses. Biomaterials 1994, 15:97-106.
35. Boyd D., Carroll G., Towler M.R., Freeman C., Farthing P., Brook I.M. Preliminary investigation of novel bone graft substitutes based on strontium-calcium-zinc-silicate glasses. J. Mater. Sci.-Mater. Med. 2009, 20:413-420.
36. Hesaraki S., Alizadeh M., Nazarian H., Sharifi D. Physico-chemical and in vitro biological evaluation of strontium/calcium silicophosphate glass. J. Mater. Sci.-Mater. Med. 2010, 21:695-705.
37. Leonelli C., Lusvardi G., Malavasi G., Menabue L., Tonelli M. Synthesis and characterization of cerium-doped glasses and in vitro evaluation of bioactivity. J. Non-Cryst. Solids 2003, 316:198-216.
38. 2O-doped bioactive glass. Antimicrob. Agents Chemother. 2002, 46:1940-1945.
39. Blaker J.J., Nazhat S.N., Boccaccini A.R. Development and characterisation of silver-doped bioactive glasscoated sutures for tissue engineering and wound healing applications. Biomaterials 2004, 25:1319-1329.
40. Hoppe A., Gueldal N.S., Boccaccini A.R. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials 2011, 32:2757-2774.
41. Knowles J.C. Phosphate based glasses for biomedical applications. J. Mater. Chem. 2003, 13:2395-2401.
42. Abou Neel E.A., Pickup D.M., Valappil S.P., Newport R.J., Knowles J.C. Bioactive functional materials: a perspective on phosphate-based glasses. J. Mater. Chem. 2009, 19:690-701.
43. Abou Neel E.A., Chrzanowski W., Valappil S.P., O'Dell L.A., Pickup D.M., Smith M.E., Newport R.J., Knowles J.C. Doping of a high calcium oxide metaphosphate glass with titanium dioxide. J. Non-Cryst. Solids 2009, 355:991-1000.
44. Ahmed I., Abou Neel E.A., Valappil S.P., Nazhat S.N., Pickup D.M., Carta D., Carroll D.L., Newport R.J., Smith M.E., Knowles J.C. The structure and properties of silver-doped phosphate-based glasses. J. Mater. Sci. 2007, 42:9827-9835.
45. Abou Neel E.A., Ahmed I., Blaker J.J., Bismarck A., Boccaccini A.R., Lewis M.P., Nazhat S.N., Knowles J.C. Effect of iron on the surface, degradation and ion release properties of phosphate-based glass fibres. Acta Biomater. 2005, 1:553-563.
46. Abou Neel E.A., Ahmed I., Pratten J., Nazhat S.N., Knowles J.C. Characterisation of antibacterial copper releasing degradable phosphate glass fibres. Biomaterials 2005, 26:2247-2254.
47. Abou Neel E.A., Chrzanowski W., Knowles J.C. Effect of increasing titanium dioxide content on bulk and surface properties of phosphate-based glasses. Acta Biomaterialia 2008, 4:523-534.
48. Abou Neel E.A., Chrzanowski W., Pickup D.M., O'Dell L.A., Mordan N.J., Newport R.J., Smith M.E., Knowles J.C. Structure and properties of strontium-doped phosphate-based glasses. J. R. Soc. Interface 2009, 6:435-446.
49. Abou Neel E.A., Knowles J.C. Physical and biocompatibility studies of novel titanium dioxide doped phosphate-based glasses for bone tissue engineering applications. J. Mater. Sci.-Mater. Med. 2008, 19:377-386.
50. Abou Neel E.A., O'Dell L.A., Chrzanowski W., Smith M.E., Knowles J.C. Control of surface free energy in titanium doped phosphate based glasses by Co-doping with zinc. J. Biomed. Mater. Res. 2009, 89B:392-407.
51. 5. J. Biomater. Appl. 2005, 20:65-80.
52. Ahmed I., Parsons A., Jones A., Walker G., Scotchford C., Rudd C. Cytocompatibility and effect of increasing MgO content in a range of quaternary invert phosphate-based glasses. J. Biomater. Appl. 2010, 24:555-575.
53. Ahmed I., Parsons A.J., Rudd C.D., Nazhat S.N., Knowles J.C., Guerry P., Smith M.E. Comparison of phosphate-based glasses in the range 50P(2)O(5)-(50-x)CaO-xNa(2)O prepared using different precursors, Glass Technology. Eur. J. Glass Sci. Technol., Part A 2008, 49:63-72.
54. Brauer D.S., Russel C., Li W., Habelitz S. Effect of degradation rates of resorbable phosphate invert glasses on in vitro osteoblast proliferation. J. Biomed. Mater. Res. 2006, 77A:213-219.
55. 2-doped phosphate-based bioglasses and glass-ceramics. Mater. Chem. Phys. 2010, 124:312-318.
56. ElBatal H.A., Khalil E.M.A., Hamdy Y.M. In vitro behavior of bioactive phosphate glass-ceramics from the system P2O5-Na2O-CaO containing titania. Ceram. Int. 2009, 35:1195-1204.
57. Franks K., Abrahams I., Knowles J.C. Development of soluble glasses for biomedical use Part I: in vitro solubility measurement. J. Mater. Sci. - Mater. Med. 2000, 11:609-614.
58. Khor S.F., Talib Z.A., Daud W.M., Sidek H.A.A. Degradation study on ternary zinc magnesium phosphate glasses. J. Mater. Sci. 2011, 46:7895-7900.
59. Knowles J.C., Ahmed I., Abou Neel E.A., Valappil S.P., Nazhat S.N., Pickup D.M., Carta D., Carroll D.L., Newport R.J., Smith M.E. The structure and properties of silver-doped phosphate-based glasses. J. Mater. Sci. 2007, 42:9827-9835.
60. Lakhkar N.J., Abou Neel E.A., Salih V., Knowles J.C. Strontium oxide doped quaternary glasses: effect on structure, degradation and cytocompatibility. J. Mater. Sci. - Mater. Med. 2009, 20:1339-1346.
61. Navarro M., Ginebra M.P., Clement J., Martinez S., Avila G., Planell J.A. Physicochemical degradation of titania-stabilized soluble phosphate glasses for medical applications. J. Am. Ceram. Soc. 2003, 86:1345-1352.
62. Ahmed I., Lewis M., Olsen I., Knowles J.C. Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary-based P2O5-CaO-Na2O glass system. Biomaterials 2004, 25:491-499.
63. Salih V., Franks K., James M., Hastings G.W., Knowles J.C., Olsen I. Development of soluble glasses for biomedical use Part II: The biological response of human osteoblast cell lines to phosphate-based soluble glasses. J. Mater. Sci. - Mater. Med. 2000, 11:615-620.
64. Knowles J.C., Franks K., Abrahams I. Investigation of the solubility and ion release in the glass system K2O-Na2O-CaO-P2O5. Biomaterials 2001, 22:3091-3096.
65. Abou Neel E.A., O'Dell L.A., Smith M.E., Knowles J.C. Processing, characterisation, and biocompatibility of zinc modified metaphosphate based glasses for biomedical applications. J. Mater. Sci. - Mater. Med. 2008, 19:1669-1679.
66. Dietrich E., Oudadesse H., Lucas-Girot A., Le Gal Y., Jeanne S., Cathelineau G. Effects of Mg and Zn on the surface of doped melt-derived glass for biomaterials applications. Appl. Surf. Sci. 2008, 255:391-395.
67. Salih V., Patel A., Knowles J.C. Zinc-containing phosphate-based glasses for tissue engineering. Biomed. Mater. 2007, 2:11-20.
68. Blair H.C., Schlesinger P.H., Huang C.L.H., Zaidi M. Calcium signalling and calcium transport in bone disease. Subcellular Biochemistry 2007, 539-562. E.B.M. Carafoli (Ed.).
69. Peacock M. Calcium metabolism in health and disease. Clin. J. Am. Soc. Nephrol. 2010, 5:S23-S30.
70. Calcium and Milk: What's Best for Your Bones and Health?, in, Harvard School of Public Health,. http://www.hsph.harvard.edu/nutritionsource/what-should-you-eat/calcium-full-story/index.html.
71. Feagin F., Koulouri T., Pigman W. Characterization of enamel surface demineralization, remineralization, and associated hardness changes in human and bovine material. Arch. Oral Biol. 1969, 14. (1407-&).
72. Ducy P., Desbois C., Boyce B., Pinero G., Story B., Dunstan C., Smith E., Bonadio J., Goldstein S., Gundberg C., Bradley A., Karsenty G. Increased bone formation in osteocalcin-deficient mice. Nature 1996, 382:448-452.
73. Brindley D., Moorthy K., Lee J.-H., Mason C., Kim H.-W., Wall I. Bioprocess forces and their impact on cell behavior: implications for bone regeneration therapy. J. Tissue Eng. 2011, 2011:620247.
74. Kamioka H., Sugawara Y., Murshid S.A., Ishihara Y., Honjo T., Takano-Yamamoto T. Fluid shear stress induces less calcium response in a single primary osteocyte than in a single osteoblast: implication of different focal adhesion formation. J. Bone Miner. Res. 2006, 21:1012-1021.
75. Sikavitsas V.I., Temenoff J.S., Mikos A.G. Biomaterials and bone mechanotransduction. Biomaterials 2001, 22:2581-2593.
76. Burger E.H., Klein-Nulend J. Mechanotransduction in bone - role of the lacuno-canalicular network. FASEB J. 1999, 13:S101-S112.
77. Liu D.W., Genetos D.C., Shao Y., Geist D.J., Li J.L., Ke H.Z., Turner C.H., Duncan R.L. Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca2+- and ATP-dependent in MC3T3-E1 osteoblasts. Bone 2008, 42:644-652.
78. Riddle R.C., Taylor A.F., Genetos D.C., Donahue H.J. MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am. J. Physiol. Cell Physiol. 2006, 290:C776-C784.
79. Hughes-Fulford M. Signal transduction and mechanical stress. Science's STKE: signal transduction knowledge environment, 2004 2004, RE12.
80. Foreman M.A., Gu Y.C., Howl J.D., Jones S., Publicover S.J. Group III metabotropic glutamate receptor activation inhibits Ca2+ influx and nitric oxide synthase activity in bone marrow stromal cells. J. Cell. Physiol. 2005, 204:704-713.
81. Danciu T.E., Adam R.M., Naruse K., Freeman M.R., Hauschka P.V. Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett. 2003, 536:193-197.
82. Shin M.K., Kim M.K., Bae Y.S., Jo I., Lee S.J., Chung C.P., Park Y.J., Min D.S. A novel collagen-binding peptide promotes osteogenic differentiation via Ca2+/calmodulin-dependent protein kinase II/ERK/AP-1 signaling pathway in human bone marrow-derived mesenchymal stem cells. Cell. Signal. 2008, 20:613-624.
83. Haasper C., Jagodzinski M., Drescher M., Meller R., Wehmeier M., Krettek C., Hesse E. Cyclic strain induces FosB and initiates osteogenic differentiation of mesenchymal cells. Exp. Toxicol. Pathol. 2008, 59:355-363.
84. Iqbal J., Zaidi M. Molecular regulation of mechanotransduction. Biochem. Biophys. Res. Commun. 2005, 328:751-755.
85. Robinson L.J., Blair H.C., Barnett J.B., Zaidi M., Huang C.L.H. Regulation of bone turnover by calcium-regulated calcium channels. Skeletal Biology and Medicine 2010, 351-357. M. Zaidi (Ed.).
86. Mentaverri R., Yano S., Chattopadhyay N., Petit L., Kifor O., Kamel S., Terwilliger E.F., Brazier M., Brown E.M. The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J. 2006, 20. (2562-+).
87. Asagiri M., Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 2007, 40:251-264.
88. Kuroda Y., Hisatsune C., Nakamura T., Matsuo K., Mikoshiba K. Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:8643-8648.
89. Foskett J.K., White C., Cheung K.-H., Mak D.-O.D. Inositol trisphosphate receptor Ca2+ release channels. Physiol. Rev. 2007, 87:593-658.
90. Yaroslavskiy B.B., Sharrow A.C., Wells A., Robinson L.J., Blair H.C. Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility. J. Cell Sci. 2007, 120:2884-2894.
91. Zaidi M., Shankar V.S., Tunwell R., Adebanjo O.A., Mackrill J., Pazianas M., Oconnell D., Simon B.J., Rifkin B.R., Venkitaraman A.R., Huang C.L.H., Lai F.A. A ryanodine receptor-like molecule expressed in the osteoclast plasma-membrane functions in extracellular Ca2+. J. Clin. Invest. 1995, 96:1582-1590.
92. Zaidi M., Shankar V.S., Alam A., Moonga B.S., Pazianas M., Huang C.L.H. Evidence that a ryanodine receptor triggers signal transduction in the osteoclast. Biochem. Biophys. Res. Commun. 1992, 188:1332-1336.
93. Foster B.L., Tompkins K.A., Rutherford R.B., Zhang H., Chu E.Y., Fong H., Somerman M.J. Phosphate: known and potential roles during development and regeneration of teeth and supporting structures. Birth Defects Res. 2008, 84:281-314.
94. Khoshniat S., Bourgine A., Julien M., Weiss P., Guicheux J., Beck L. The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals. Cell Mol. Life Sci. 2011, 68:205-218.
95. Prie D., Torres P.U., Friedlander G. Latest findings in phosphate homeostasis. Kidney Int. 2009, 75:882-889.
96. Mazzaferro S., Pasquali M., Pirro G., Rotondi S., Tartaglione L. The bone and the kidney. Arch. Biochem. Biophys. 2010, 503:95-102.
97. Moochhala S.H., Sayer J.A., Carr G., Simmons N.L. Renal calcium stones: insights from the control of bone mineralization. Exp. Physiol. 2008, 93:43-49.
98. Takeda E., Yamamoto H., Nashiki K., Sato T., Arai H., Taketani Y. Inorganic phosphate homeostasis and the role of dietary phosphorus. J. Cell Mol. Med. 2004, 8:191-200.
99. Ghishan F.K., Kiela P.R. Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases. Am. J. Physiol. Gastroint. Liver 2011, 300:G191-G201.
100. Barber P.J. Disorders of the parathyroid glands. J. Feline Med. Surg. 2004, 6:259-269.
101. Fleisch H., Bisaz S. Isolation from the plasma of pyrophosphate, an inhibitor of calcification. Helv. Physiol. Pharmacol. Acta 1962, 20:C52-C53.
102. Fleisch H., Bisaz S. Isolation from urine of pyrophosphate, a calcification inhibitor. Am. J. Physiol. 1962, 203. (671-&).
103. Fleisch H., Bisaz S. Mechanism of calcification - inhibitory role of pyrophosphate. Nature 1962, 195. (911-&).
104. Meyer J.L. Phase-transformations in the spontaneous precipitation of calcium-phosphate. Croat. Chem. Acta 1983, 56:753-767.
105. Aoba T., Moreno E.C. The enamel fluid in the early secretory stage of porcine amelogenesis - chemical composition and saturation with respect to enamel mineral. Calcif. Tissue Int. 1987, 41:86-94.
106. Hay D.I., Carlson E.R., Schluckebier S.K., Moreno E.C., Schlesinger D.H. Inhibition of calcium-phosphate precipitation by human salivary acidic proline-rich proteins - structure-activity-relationships. Calcif. Tissue Int. 1987, 40:126-132.
107. Terkeltaub R.A. Inorganic pyrophosphate generation and disposition in pathophysiology. Am. J. Physiol. Cell Physiol. 2001, 281:C1-C11.
108. Costello J.C., Rosenthal A.K., Kurup I.V., Masuda I., Medhora M., Ryan L.M. Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. Connect. Tissue Res. 2011, 52:139-146.
109. Cailotto F., Reboul P., Sebillaud S., Netter P., Jouzeau J.-Y., Bianchi A. Calcium input potentiates the transforming Growth Factor (TGF)-beta 1-dependent signaling to promote the export of inorganic pyrophosphate by articular chondrocyte. J. Biol. Chem. 2011, 286:19215-19228.
110. Ho A.M., Johnson M.D., Kingsley D.M. Role of the mouse ank gene in control of tissue calcification and arthritis. Science 2000, 289:265-270.
111. Ryan L.M., Wortmann R.L., Karas B., McCarty D.J. Cartilage nucleoside triphosphate (NTP) pyrophosphohydrolase. 1. Identification as an ecto-enzyme. Arthritis and Rheum. 1984, 27:404-409.
112. Ryan L.M., Wortmann R.L., Karas B., McCarty D.J. Elevated intracellular pyrophopshate PPI and ecto-nucleoside pyrophosphohydrolase activity (NTPPPH) in fibroblasts of patients with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. Clin. Res. 1984, 32:A792-A792.
113. Kim H.J., Delaney J.D., Kirsch T. The role of pyrophosphate/phosphate homeostasis in terminal differentiation and apoptosis of growth plate chondrocytes. Bone 2010, 47:657-665.
114. Addison W.N., Azari F., Sorensen E.S., Kaartinen M.T., McKee M.D. Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity. J. Biol. Chem. 2007, 282:15872-15883.
115. Hessle L., Johnson K.A., Anderson H.C., Terkeltaub R., Millan J.L. TNAP and PC-1 control bone mineral deposition by directly regulating pyrophosphate levels. J. Bone Miner. Res. 2002, 17:S128-S128.
116. Fleisch H. Bisphosphonates: mechanisms of action. Endocr. Rev. 1998, 19:80-100.
117. Drake M.T., Cremers S.C.L.M. Bisphosphonate therapeutics in bone disease: the hard and soft data on osteoclast inhibition. Mol. Interv. 2010, 10:141-152.
118. Adami S., Zamberlan N. Adverse effects of bisphosphonates - a comparative review. Drug Saf. 1996, 14:158-170.
119. Woo S.B., Hellstein J.W., Kalmar J.R. Systematic review: bisphosphonates and osteonecrosis of the jaws (vol 144, pg 753, 2006). Ann. Intern. Med. 2006, 145:235-235.
120. Baluyot E.S., Hartford C.G. Comparison of polyphosphate analysis by ion chromatography and by modified end-group titration. J. Chromatogr. A 1996, 739:217-222.
121. Ahmed I., Lewis M.P., Nazhat S.N., Knowles J.C. Quantification of anion and cation release from a range of ternary phosphate-based glasses with fixed 45 mol% P(2)O(5). J. Biomater. Appl. 2005, 20:65-80.
122. Ahmed I., Lewis M.P., Knowles J.C. Quantification of anions and cations from ternary phosphate based glasses with fixed 50 and 55mol% P2O5 using ion chromatography. Phys. Chem. Glasses 2005, 46:547-552.
123. Bunker B.C., Arnold G.W., Wilder J.A. Phosphate-glass dissolution in aqueous-solutions. J. Non-Cryst. Solids 1984, 64:291-316.
124. Valappil S.P., Ready D., Abou Neel E.A., Pickup D.M., Chrzanowski W., O'Dell L.A., Newport R.J., Smith M.E., Wilson M., Knowles J.C. Antimicrobial gallium-doped phosphate-based glasses. Adv. Funct. Mater. 2008, 18:732-741.
125. Salih V., Patel A., Knowles J.C. Zinc-containing phosphate-based glasses for tissue engineering. Biomed. Mater. 2007, 2:11-20.
126. Abou Neel E.A., Knowles J.C., Chrzanowski W., Pickup D.M., O'Dell L.A., Mordan N.J., Newport R.J., Smith M.E. Structure and properties of strontium-doped phosphate-based glasses. J. R. Soc. Interface 2009, 6:435-446.
127. Diamond I., Hurley L.S. Histopathology of Zinc-Deficient Fetal Rats. J. Nutr. 1970, 100. (325-&).
128. Hall S.L., Dimai H.P., Farley J.R. Effects of zinc on human skeletal alkaline phosphatase activity in vitro. Calcif. Tissue Int. 1999, 64:163-172.
129. Yamaguchi M. Role of nutritional zinc in the prevention of osteoporosis. Mol. Cell. Biochem. 2010, 338:241-254.
130. Fong L., Tan K., Tran C., Cool J., Scherer M.A., Elovaris R., Coyle P., Foster B.K., Rofe A.M., Xian C.J. Interaction of dietary zinc and intracellular binding protein metallothionein in postnatal bone growth. Bone 2009, 44:1151-1162.
131. Haumont S. Distribution of zinc in bone tissue. J. Histochem. Cytochem. 1967, 9:141-145.
132. Hurley L.S., Tao S.H. Alleviation of teratogenic effect of zinc deficiency by simultaneous lack of calcium. Am. J. Physiol. 1972, 222. (322-&).
133. Gomez S., Rizzo R., Pozzi-Mucelli M., Bonucci E., Vittur F. Zinc mapping in bone tissues by histochemistry and synchrotron radiation-induced X-ray emission: correlation with the distribution of alkaline phosphatase. Bone 1999, 25:33-38.
134. Krane S.M., Inada M. Matrix metalloproteinases and bone. Bone 2008, 43:7-18.
135. Litchfield T.M., Ishikawa Y., Wu L.N.Y., Wuthier R.E., Saner G.R. Effect of metal ions on calcifying growth plate cartilage chondrocytes. Calcif. Tissue Int. 1998, 62:341-349.
136. Neame P.J., Choi H.U., Rosenberg L.C. The primary strucutre of the core protein of the small, leucine-rich proteoglycan (Pg I) from bovine articular cartilage. J. Biol. Chem. 1989, 264:8653-8661.
137. Wolf E., Rapp K., Brem G. Expression of metallothionein-human-growth-hormone fusion genes in transgenic mice results in disproportionate skeletal gigantism. Growth Dev. Aging 1991, 55:117-127.
138. Yamaguchi M., Weitzmann M.N. Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-kappa B activation. Mol. Cell. Biochem. 2011, 355:179-186.
139. Moonga B.S., Dempster D.W. Zinc is a potent inhibitor of osteoclastic bone-resorption in-vitro. J. Bone Miner. Res. 1995, 10:453-457.
140. Dimai H.P., Hall S.L., Stilt-Coffing B., Farley J.R. Skeletal response to dietary zinc in adult female mice. Calcif. Tissue Int. 1998, 62:309-315.
141. Seo H.J., Cho Y.E., Kim T., Shin H.I., Kwun I.S. Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells. Nutr. Res. Pract. 2010, 4:356-361.
142. Tanimura A., McGregor D.H., Anderson H.C. Calcification in Atherosclerosis 1. Human Studies. J. Exp. Pathol. 1986, 2:261-274.
143. Tanimura A., McGregor D.H., Anderson H.C. Matrix vesicles in atherosclerotic calcification. Proc. Soc. Exp Biol Med. 1983, 172:173-177.
144. Anderson H.C. Mechanisms of pathologic calcification. Rheum. Dis. Clin. N Am. 1988, 14:303-319.
145. Cotmore J.M., Nichols G., Wurthier R.E. Phospholipid-calcium phosphate complex - enhance calcium migration in the presence of phosphate. Science 1971, 172. (1339-&).
146. Genge B.R., Wu L.N.Y., Wuthier R.E. In vitro modeling of matrix vesicle nucleation - synergistic stimulation of mineral formation by annexin a5 and phosphatidylserine. J. Biol. Chem. 2007, 282:26035-26045.
147. Wu L.N.Y., Genge B.R., Wuthier R.E. Differential effects of zinc and magnesium ions on mineralization activity of phosphatidylserine calcium phosphate complexes. J. Inorg. Biochem. 2009, 103:948-962.
148. Diaz-Arnold A.M., Vargas M.A., Haselton D.R. Current status of luting agents for fixed prosthodontics. J. Prosthet. Dent. 1999, 81:135-141.
149. Khashaba R.M., Lockwood P.E., Lewis J.B., Messer R.L., Chutkan N.B., Borke J.L. Cytotoxicity, calcium release, and pH changes generated by novel calcium phosphate cement formulations. J. Biomed. Mater. Res. B Appl. Biomater. 2010, 93B:297-303.
150. Mayanagi G., Igarashi K., Washio J., Nakajo K., Domon-Tawaraya H., Takahashi N. Evaluation of pH at the bacteria-dental cement interface. J. Dent. Res. 2011, 90:1446-1450.
151. Rosenstiel S.F., Land M.F., Crispin B.J. Dental luting agents: a review of the current literature. J. Prosthet. Dent. 1998, 80:280-301.
152. Geurtsen W. Biocompatibility of root canal filling materials. Aust. Endod. J. 2001, 27:12-21.
153. Leon A.R. Periodontium and restorative procedures - critical review. J. Oral Rehabil. 1977, 4:105-117.
154. Oilo G. Luting cements: a review and comparison. Int. Dent. J. 1991, 41:81-88.
155. Bapna M.S., Mueller H.J. Leaching of glass-ionomer cements. J. Oral Rehabil. 1994, 21:577-583.
156. Murakami H., Matsuya Y., Matsuya S. Dissolution mechanism of zinc phosphate dental cement in acetic and lactic-acid buffers. Biomaterials 1990, 11:435-440.
157. Teisseyre A., Mozrzymas J. Influence of extracellular pH on the modulatory effect of zinc ions on Kv1.3 potassium channels. J. Physiol. Pharmacol. 2006, 57:131-147.
158. Teisseyre A., Mozrzymas J.W. The influence of protons and zinc ions on the steady-state inactivation of Kv1.3 potassium channels. Cell Mol. Biol. Lett. 2007, 12:220-230.
159. Teisseyre A., Mozrzymas J.W. Additive modulatory effects of extracellular pH and zinc ions on potassium channels Kv1.3. Eur. Biophys. J. 2005, 34:655.
160. Kiani A., Cahill L.S., Abou Neel E.A., Hanna J.V., Smith M.E., Knowles J.C. Physical properties and MAS-NMR studies of titanium phosphate-based glasses. Mater. Chem. Phys. 2010, 120:68-74.
161. Kiani A., Hanna J.V., King S.P., Rees G.J., Smith M.E., Roohpour N., Salih V., Knowles J.C. Structural characterization and physical properties of P(2)O(5)-CaO-Na(2)O-TiO(2) glasses by Fourier transform, Raman and solid-state magic angle spinning nuclear magnetic resonance. Acta Biomater. 2012, 8:333-340.
162. Moss R.M., Abou Neel E.A., Pickup D.M., Twyman H.L., Martin R.A., Henson M.D., Barney E.R., Hannon A.C., Knowles J.C., Newport R.J. The effect of zinc and titanium on the structure of calcium-sodium phosphate based glass. J. Non-Cryst. Solids 2010, 356:1319-1324.
163. Pickup D.M., Abou Neel E.A., Moss R.M., Wetherall K.M., Guerry P., Smith M.E., Knowles J.C., Newport R.J. TiK-edge XANES study of the local environment of titanium in bioresorbable TiO2-CaO-Na2O-P2O5 glasses. J. Mater. Sci. - Mater. Med. 2008, 19:1681-1685.
164. Abou Neel E.A., Mizoguchi T., Ito M., Bitar M., Salih V., Knowles J.C. In vitro bioactivity and gene expression by cells cultured on titanium dioxide doped phosphate-based glasses. Biomaterials 2007, 28:2967-2977.
165. Marciano F.R., Wachesk C.C., Lobo A.O., Trava-Airoldi V.J., Pacheco-Soares C., Da-Silva N.S. Thermodynamic aspects of fibroblastic spreading on diamond-like carbon films containing titanium dioxide nanoparticles. Theor. Chem. Acc. 2011, 130:1085-1093.
166. Yang L., Li Y., Sheldon B.W., Webster T.J. Altering surface energy of nanocrystalline diamond to control osteoblast responses. J. Mater. Chem. 2012, 22:205-214.
167. Boskey A.L., Rimnac C.M., Bansal M., Federman M., Lian J., Boyan B.D. Effect of short-term hypomagnesia on the chemical and mechanical properties of rat bone. J. Orthop. Res. 1992, 10:774-783.
168. Dimai H.P., Porta S., Wirnsberger G., Lindschinger M., Pamperl I., Dobnig H., Wilders-Truschnig M., Lau K.H. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J. Clin. Endocrinol. Metab. 1998, 83:2742-2748.
169. Classen H.G., Baier S., Schimatschek H.F., Classen C.U. Clinically relevant interactions between hormones and magnesium-metabolism - a review. Magnesium-B 1995, 17:96-103.
170. Neuman W.F., Mulryan B.J. Synthetic hydroxyapatite crystals. 4. Magnesium incorporation. Calcif. Tissue Res. 1971, 7. (133-&).
171. Wuthier R.E. Electrolytes of isolated epiphyseal chondrocytes, matrix vesicles and extracellular fluid. Calcif. Tissue Res. 1977, 23:125-133.
172. Wuthier R.E. Mechanism of denovo mineral formation by matrix vesicles. Connect. Tissue Res. 1989, 22:653-659.
173. Wuthier R.E., Lipscomb G.F. Matrix vesicles: structure, composition, formation and function in calcification. Front. Biosci. Landmark 2011, 16. (2812-+).
174. Wu L.N.Y., Genge B.R., Wuthier R.E. Analysis and molecular modeling of the formation, structure, and activity of the phosphatidylserine-calcium-phosphate complex associated with biomineralization. J. Biol. Chem. 2008, 283:3827-3838.
175. Boskey A.L., Posner A.S. Magnesium stabilisation of amorphous calcium phosphate - kinetic study. Mater. Res. Bull. 1974, 9:907-916.
176. Lai C.C., Singer L., Armstrong W.D. Bone composition and phosphatase activity in magnesium deficiency in rats. J. Bone Joint Surg. 1975, 57:516-522.
177. Burnell J.M., Liu C., Miller A.G., Teubner E. Effects of dietary alteration of bicarbonate and magnesium on rat bone. Am. J. Physiol. 1986, 250:F302-F307.
178. Bernick S., Hungerford G.F. Effect of dietary magnesium deficiency on bones and teeth of rats. J. Dent. Res. 1965, 44:1317-1324.
179. Walter G., Vogel J., Hoppe U., Hartmann P. The structure of CaO-Na2O-MgO-P2O5 invert glass. J. Non-Cryst. Solids 2001, 296:212-223.
180. Cartmell S.H., Doherty P.J., Rhodes N.P., Hunt J.A., Healy D.M., Gilchrist T. Haemocompatiblity of controlled release glass. J. Mater. Sci. - Mater. Med. 1998, 9:1-7.
181. Meunier P.J., Roux C., Ortolani S., Badurski J., Kaufman J.M., Spector T., Diez-Perez A., Seeman E., Lemmel E., Balogh A., Pors-Nielsen S., Phenekos C., Rizzoli R., Slosman D., Tupinon-Mathieu I., Reginster J.Y. Strontium ranelate reduces the vertebral fracture risk in women with postmenopausal osteoporosis. Osteoporos. Int. 2002, 13:521-522.
182. Meunier P.J., Slosman D.O., Delmas P.D., Sebert J.L., Brandi M.L., Albanese C., Lorenc R., Pors-Nielsen S., de Vernejoul M.C., Roces A., Reginster J.Y. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis - a 2-year randomized placebo controlled trial. J. Clin. Endocr. Metab. 2002, 87:2060-2066.
183. Ammann P., Badoud I., Barraud S., Dayer D., Rizzoli R. Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength (vol 22, pg 1419, 2007). J. Bone Miner. Res. 2007, 22:1828-1828.
184. Ammann P., Badoud I., Barraud S., Dayer R., Rizzoli R. Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength. J. Bone Miner. Res. 2007, 22:1419-1425.
185. Dahl S.G., Allain P., Marie P.J., Mauras Y., Boivin G., Ammann P., Tsouderos Y., Delmas P.D., Christiansen C. Incorporation and distribution of strontium in bone. Bone 2001, 28:446-453.
186. Buehler J., Chappuis P., Saffar J.L., Tsouderos Y., Vignery A. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone 2001, 29:176-179.
187. Boivin G., Deloffre P., Perrat B., Panczer G., Boudeulle M., Mauras Y., Allain P., Tsouderos Y., Meunier P.J. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J. Bone Miner. Res. 1996, 11:1302-1311.
188. Mazzuoli G., Samachson J., Laszlo D. Interrelationship between serum calcium levels - calcium45 and strontium85 metabolism in man. S. Afr. J. Lab. Clin. Med. 1958, 52:522-532.
189. Marie P.J. Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporos. Int. 2005, 16:S7-S10.
190. Takahashi N., Sasaki T., Tsouderos Y., Suda T. S 12911-2 inhibits osteoclastic bone resorption in vitro. J. Bone Miner. Res. 2003, 18:1082-1087.
191. Alkhralsat M.H., Marino F.T., Rodriguez C.R., Jerez L.B., Cabarcos E.L. Combined effect of strontium and pyrophosphate on the properties of brushite cements. Acta Biomaterialia 2008, 4:664-670.
192. Pires R., Abrahams I., Nunes T.G., Hawkes G.E. Non-random cation distribution in sodium-strontium-phosphate glasses. J. Non-Cryst. Solids 2004, 337:1-8.
193. Pires R.A., Abrahams I., Nunes T.G., Hawkes G.E. P-31 nuclear magnetic resonance and X-ray diffraction studies of Na-Sr-phosphate glass-ceramics. Bioceramics 2004, Vol 16:95-98. M.A.M.F.J.C.R.L.B. Barbosa (Ed.).
194. Meyer K., Barz A. Peculiarities of the structure of strontium phosphate glasses studied by vibrational spectroscopy. Phys. Chem. Glasses 2001, 42:371-380.
195. Long M., Rack H.J. Titanium alloys in total joint replacement - a materials science perspective. Biomaterials 1998, 19:1621-1639.
196. Williams D. The golden anniversary of titanium biomaterials. Med. Device Technol. 2001, 12:8-11.
197. Navarro M., Michiardi A., Castano O., Planell J.A. Biomaterials in orthopaedics. J. R. Soc. Interface 2008, 5:1137-1158.
198. Geetha M., Singh A.K., Asokamani R., Gogia A.K. Ti based biomaterials, the ultimate choice for orthopaedic implants - a review. Prog. Mater. Sci. 2009, 54:397-425.
199. Goodman S.B., Gomez Barrena E., Takagi M., Konttinen Y.T. Biocompatibility of total joint replacements: a review. J. Biomed. Mater. Res. 2009, 90:603-618.
200. Ehrenfest D.M.D., Coelho P.G., Kang B.S., Sul Y.T., Albrektsson T. Classification of osseointegrated implant surfaces: materials, chemistry and topography. Trends Biotechnol. 2010, 28:198-206.
201. Kokubo T., Kim H.M., Kawashita M. Novel bioactive materials with different mechanical properties. Biomaterials 2003, 24:2161-2175.
202. Le Guehennec L., Soueidan A., Layrolle P., Amouriq Y. Surface treatments of titanium dental implants for rapid osseointegration. Dent. Mater. 2007, 23:844-854.
203. Sykaras N., Iacopino A.M., Marker V.A., Triplett R.G., Woody R.D. Implant materials, designs, and surface topographies: their effect on osseointegration. A literature review. Int. J. Oral Max Impl. 2000, 15:675-690.
204. Adell R., Lekholm U., Rockler B., Branemark P.I. A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int. J. Oral Surg. 1981, 10:387-416.
205. Albrektsson T., Branemark P.I., Hansson H.A., Lindstrom J. Osseointegrated titanium implants - requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop. Scand. 1981, 52:155-170.
206. Albrektsson T., Zarb G., Worthington P., Eriksson A.R. The long-term efficacy of currently used dental implants: a review and proposed criteria of success. Int. J. Oral Maxillofac. Implants 1986, 1:11-25.
207. Remes A., Williams D.F. Immune-response in biocompatibility. Biomaterials 1992, 13:731-743.
208. Williams D.F. Implants in dental and maxillofacial surgery. Biomaterials 1981, 2:133-146.
209. Marco F., Milena F., Gianluca G., Vittoria O. Peri-implant osteogenesis in health and osteoporosis. Micron 2005, 36:630-644.
210. Bi Y.M., Van de Motter R.R., Ragab A.A., Goldberg V.M., Anderson J.M., Greenfield E.M. Titanium particles stimulate bone resorption by inducing differentiation of murine osteoclasts. J. Bone Joint Surg. 2001, 83A:501-508.
211. Goodacre C.J., Kan J.Y.K., Rungcharassaeng K. Clinical complications of osseointegrated implants. J. Prosthet. Dent. 1999, 81:537-552.
212. Ingham E., Fisher J. Biological reactions to wear debris in total joint replacement. P. I. Mech. Eng. H 2000, 214:21-37.
213. Agins H.J., Alcock N.W., Bansal M., Salvati E.A., Wilson P.D., Pellicci P.M., Bullough P.G. Metallic wear in failed titanium-alloy total hip replacements - a histological and quantitative-analysis. J. Bone Joint Surg. 1988, 70A:347-356.
214. Wang J.Y., Wicklund B.H., Gustilo R.B., Tsukayama D.T. Titanium, chromium and cobalt ions modulate the release of bone-associated cytokines by human monocytes/macrophages in vitro. Biomaterials 1996, 17:2233-2240.
215. Liu H.C., Chang W.H., Lin F.H., Lu K.H., Tsuang Y.H., Sun J.S. Cytokine and prostaglandin E2 release from leukocytes in response to metal ions derived from different prosthetic materials: an in vitro study. Artif. Organs 1999, 23:1099-1106.
216. Chan E.P., Mhawi A., Clode P., Saunders M., Filgueira L. Effects of titanium(iv) ions on human monocyte-derived dendritic cells. Metallomics Integrated Biometal. Sci. 2009, 1:166-174.
217. Sun Z.L., Wataha J.C., Hanks C.T. Effects of metal ions on osteoblast-like cell metabolism and differentiation. J. Biomed. Mater. Res. 1997, 34:29-37.
218. Liao H.H., Wurtz T., Li J.G. Influence of titanium ion on mineral formation and properties of osteoid nodules in rat calvaria cultures. J. Biomed. Mater. Res. 1999, 47:220-227.
219. Matsunaga T., Kojo T., Tsujisawa T., Fukuizumi T., Wada S., Uchida Y., Inoue H. Preferential degradation of osteoclasts by titanium tetrachloride. J. Biomed. Mater. Res. 2001, 55:313-319.
220. Mine Y., Makihira S., Nikawa H., Murata H., Hosokawa R., Hiyama A., Mimura S. Impact of titanium ions on osteoblast-, osteoclast- and gingival epithelial-like cells. J. Prosthodontic Res. 2010, 54:1-6.
221. Wall I., Donos N., Carlqvist K., Jones F., Brett P. Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. Bone 2009, 45:17-26.
222. Rajendran V., Devi A.V.G., Azooz M., El-Batal F.H. Physicochemical studies of phosphate based P2O5-Na2O-CaO-TiO2 glasses for biomedical applications. J. Non-Cryst. Solids 2007, 353:77-84.
223. Abou Neel E.A., O'Dell L.A., Chrzanowski W., Smith M.E., Knowles J.C. Control of surface free energy in titanium doped phosphate based glasses by co-doping with zinc. J. Biomed. Mater. Res. B Appl. Biomater. 2009, 89B:392-407.
224. Lakhkar N., Abou Neel E.A., Salih V., Knowles J.C. Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells. J. Biomater. Appl. 2011, 25:877-893.
225. Devirian T.A., Volpe S.L. The physiological effects of dietary boron. Crit. Rev. Food Sci. Nutr. 2003, 43:219-231.
226. Samman S., Naghii M.R., Wall P.M.L., Verus A.P. The nutritional and metabolic effects of boron in humans and animals. Biol. Trace Elem. Res. 1998, 66:227-235.
227. Moseman R.F. Chemical disposition of boron in animals and humans. Environ. Health Perspect. 1994, 102:113-117.
228. Ying X., Cheng S., Wang W., Lin Z., Chen Q., Zhang W., Kou D., Shen Y., Cheng X., Rompis F.A., Peng L., Lu C.Z. Effect of boron on osteogenic differentiation of human bone marrow stromal cells. Biol. Trace Elem. Res. 2011, 144:306-315.
229. Rowe R.I., Bouzan C., Nabili S., Eckhert C.D. The response of trout and zebrafish embryos to low and high boron concentrations is U-shaped. Biol. Trace Elem. Res. 1998, 66:261-270.
230. Barranco W.T., Kim D.H., Stella S.L., Eckhert C.D. Boric acid inhibits stored Ca(2+) release in DU-145 prostate cancer cells. Cell Biol. Toxicol. 2009, 25:309-320.
231. Cheng J., Peng K., Jin E., Zhang Y., Liu Y., Zhang N., Song H., Liu H., Tang Z. Effect of additional boron on tibias of african ostrich chicks. Biol. Trace Elem. Res. 2011, 144:538-549.
232. Mizrak C., Yenice E., Can M., Yildirim U., Atik Z. Effects of dietary boron on performance, egg production, egg quality and some bone parameters in layer hens. S. Afr. J. Anim. Sci. 2010, 40:257-264.
233. Olgun O., Cufadar Y., Yildiz A.O. Effects of boron supplementation fed with low calcium to diet on performance and egg quality in molted laying hens. J. Anim. Vet. Adv. 2009, 8:650-654.
234. Bozkurt M., Kucukyilmaz K., Cath A.U., Cinar M., Cabuk M., Bintas E. Effects of boron supplementation to diets deficient in calcium and phosphorus on performance with some serum, bone and fecal characteristics of broiler chickens. A. Australas. J. Anim. Sci. 2012, 25:248-255.
235. Haro Durand L.A., Mesones R.V., Nielsen F.H., Gorustovich A.A. Histomorphometric and microchemical characterization of maturing dental enamel in rats fed a boron-deficient diet. Biol. Trace Elem. Res. 2010, 135:242-252.
236. Kim M.-H., Bae Y.-J., Lee Y.-S., Choi M.-K. Estimation of boron intake and its relation with bone mineral density in free-living Korean female subjects. Biol. Trace Elem. Res. 2008, 125:213-222.
237. Naghii M.R., Mofid M., Asgari A.R., Hedayati M., Daneshpour M.-S. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J. Trace Elem. Exp. Med. 2011, 25:54-58.
238. Pan H.B., Zhao X.L., Zhang X., Zhang K.B., Li L.C., Li Z.Y., Lam W.M., Lu W.W., Wang D.P., Huang W.H., Lin K.L., Chang J. Strontium borate glass: potential biomaterial for bone regeneration. J. R. Soc. Interface 2010, 7:1025-1031.
239. Mantsos T., Chatzistavrou X., Roether J.A., Hupa L., Arstila H., Boccaccini A.R. Non-crystalline composite tissue engineering scaffolds using boron-containing bioactive glass and poly(D,L-lactic acid) coatings. Biomed. Mater. 2009, 4.
240. Liu X., Xie Z., Zhang C., Pan H., Rahaman M.N., Zhang X., Fu Q., Huang W. Bioactive borate glass scaffolds: in vitro and in vivo evaluation for use as a drug delivery system in the treatment of bone infection. J. Mater. Sci. - Mater. Med. 2010, 21:575-582.
241. Yao A.H., Wang D.P., Huang W.H., Fu Q., Rahaman M.N., Day D.E. In vitro bioactive characteristics of borate-based glasses with controllable degradation behavior. J. Am. Ceram. Soc. 2007, 90:303-306.
242. Liu X., Pan H., Fu H., Fu Q., Rahaman M.N., Huang W. Conversion of borate-based glass scaffold to hydroxyapatite in a dilute phosphate solution. Biomed. Mater. 2010, 5:15005.
243. Harris E.D. A requirement for copper in angiogenesis. Nutr. Rev. 2004, 62:60-64.
244. Gerard C., Bordeleau L.-J., Barralet J., Doillon C.J. The stimulation of angiogenesis and collagen deposition by copper. Biomaterials 2010, 31:824-831.
245. Hu G.F. Copper stimulates proliferation of human endothelial cells under culture. J. Cell. Biochem. 1998, 69:326-335.
246. Lowndes S.A., Harris A.L. The role of copper in tumour angiogenesis. J. Mammary Gland Biol. Neoplasia 2005, 10:299-310.
247. Camphausen K., Sproull M., Tantama S., Sankineni S., Scott T., Menard C., Coleman C.N., Brechbiel M.W. Evaluation of copper chelation agents as anti-angiogenic therapy. Bioorg. Med. Chem. 2003, 11:4287-4293.
248. Camphausen K., Sproull M., Tantama S., Venditto V., Sankineni S., Scott T., Brechbiel M.W. Evaluation of chelating agents as anti-angiogenic therapy through copper chelation. Bioorg. Med. Chem. 2004, 12:5133-5140.
249. Merajver S.D., Brewer G.J. Preclinical and clinical studies of the anti-angiogenic effect of copper deficiency induced by tetrathiomolybdate. Clin. Exp. Metastasis 1999, 17:747.
250. Merajver S.D., Brewer G.J. Preclinical and clinical studies of the anti-angiogenic effect of copper deficiency induced by tetrathiomolybdate. Clin. Exp. Metastasis 2000, 17:747.
251. Pan Q., Dick R., Brewer G., Merajver S. Inhibition of angiogenesis by copper deficiency with tetrathiomolybdate: Molecular mechanisms and translation to the clinic. Proceedings of the American Association for Cancer Research Annual Meeting 2001, 42:581.
252. Pan Q., Kleer C.G., van Golen K.L., Irani J., Bottema K.M., Bias C., De Carvalho M., Mesri E.A., Robins D.M., Dick R.D., Brewer G.J., Merajver S.D. Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis. Cancer Res. 2002, 62:4854-4859.
253. Chen X., Bading J.R., Conti P.S. Copper-64 labeled RGD peptide for PET imaging of tumor angiogenesis, Abstracts of Papers. Am. Chem. Soc. 2003, 226:45.
254. Yang S.J., Uriu-Adams J.Y., Keen C.L., Rucker R.B., Lanoue L. Effects of copper deficiency on mouse yolk sac vasculature and expression of angiogenic mediators, Birth Defects Research Part B-Developmental and Reproductive. Toxicology 2006, 77:445-454.
255. Yang S.J., Uriu-Adams J.Y., Keen C.L., Rucker R.B., Lanoue L. Copper (Cu) deficiency alters mouse embryonic and yolk sac vasculature and expression of angiogenic mediators. Birth Defects Res. 2004, 70:320.
256. Barralet J., Gbureck U., Habibovic P., Vorndran E., Gerard C., Doillon C.J. Angiogenesis in calcium phosphate scaffolds by inorganic copper ion release. Tissue Eng. 2009, 15:1601-1609.
257. O'Sullivan T.N., Smith J.D., Thomas J.D., Drake C.F. Copper Molluscicides for Control of Schistosomiasis. 1. Effect of Inorganic Complexes on Toxicity. Environ. Sci. Technol. 1989, 23:1102-1106.
258. Allen W.M., Sansom B.F., Gleed P.T., Mallinson C.B., Drake C.F. Boluses of controlled release glass for suplementing ruminants with copper. Vet. Rec. 1984, 115:55-57.
259. Mirzayi M., Hekmatshoar M.H. Optical and IR study of Li(2)O-CuO-P(2)O(5) glasses. Ionics 2009, 15:121-127.
260. Daoudi S., Bejjit L., Haddad M., Archidi M.E., Chahine A., Et-tabirou M., Molinie P. EPR and magnetic susceptibility of Na2O-CuO-P2O5 glasses. Spectrosc. Lett. 2007, 40:785-795.
261. Das S.S., Singh N.P., Srivastava P.K. Ion conducting phosphate glassy materials. Progr. Cryst. Growth Char. Mater. 2009, 55:47-62.
262. Mulligan A.M., Wilson M., Knowles J.C. The effect of increasing copper content in phosphate-based glasses on biofilms of Streptococcus sanguis. Biomaterials 2003, 24:1797-1807.