The role of pyrophosphate/phosphate homeostasis in terminal differentiation and apoptosis of growth plate chondrocytes

Bone

Volumn 47, Issue 3, 2010, Pages 657-665

  Kim, Hyon Jong ^a   Delaney, John D ^a   Kirsch, Thorsten ^a  

^a NYU HOSPITAL FOR JOINT DISEASES   (United States)

Author keywords

Alkaline phosphatase; Apoptosis; Growth plate chondrocytes; Phosphate; Progressive ankylosis protein (ANK); Pyrophosphate

Indexed keywords

ALKALINE PHOSPHATASE; CASPASE 3; COLLAGENASE 3; OSTEOCALCIN; PHOSPHATE; PYROPHOSPHATE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PIT 1; TRANSCRIPTION FACTOR PIT 2; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANKYLOSIS; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CHICK; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GROWTH PLATE; HOMEOSTASIS; HYDROLYSIS; MINERALIZATION; MOUSE; NEWBORN; NONHUMAN; UPREGULATION;

ALKALINE PHOSPHATASE; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; CHICK EMBRYO; CHONDROCYTES; DIPHOSPHATES; GROWTH PLATE; HOMEOSTASIS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PHOSPHATES; RNA, MESSENGER;

EID: 77955843549     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.06.018     Document Type: Article

References (38)

1. Adams C.S., Shapiro I.M. The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Crit Rev Oral Biol Med 2002, 13:465-473.
2. Boyde A., Shapiro I.M. Energy dispersive X-ray elemental analysis of isolated epiphyseal growth plate chondrocyte fragments. Histochemistry 1980, 69:85-94.
3. Shapiro I.M., Boyde A. Microdissection-elemental analysis of the mineralizing growth cartilage of the normal and rachitic chick. Metab Bone Dis Relat Res 1984, 5:317-326.
4. i prior to matrix mineralization. J Cell Biochem 1995, 57:218-237.
5. Sabbagh Y., Carpenter T.O., Demay M.B. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proc Natl Acad Sci USA 2005, 102:9637-9642.
6. Mansfield K., Pucci B., Adams C.S., Shapiro I.M. Induction of apoptosis in skeletal tissues: phosphate-mediated chick chondrocyte apoptosis is calcium dependent. Calcif Tissue Int 2003, 73:161-172.
7. Mansfield K., Rajpurohit R., Shapiro I.M. Extracellular phosphate ions cause apoptosis of terminally differentiated epiphyseal chondrocytes. J Cell Physiol 1999, 179:276-286.
8. Mansfield K., Teixeira C.C., Adams C.S., Shapiro I.M. Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism. Bone 2001, 28:1-8.
9. Magne D., Bluteau G., Faucheux C., Palmer G., Vignes-Colombeix C., Pilet P., et al. Phosphate is a specific signal for ATDC5 chondrocyte maturation and apoptosis-associated mineralization: possible implication of apoptosis in the regulation of endochondral ossification. J Bone Miner Res 2003, 18:1430-1442.
10. Fedde K.N., Blair L., Silverstein J., Coburn S.P., Ryan L.M., Weinstein R.S., et al. Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J Bone Miner Res 1999, 14:2015-2026.
11. Ho A.M., Johnson M.D., Kingsley D.M. Role of the mouse ank gene in control of tissue calcification and arthritis. Science 2000, 289:265-270.
12. Terkeltaub R.A. Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 2001, 281:C1-C11.
13. Takeda E., Taketani Y., Morita K., Tatsumi S., Katai K., Nii T., et al. Molecular mechanisms of mammalian inorganic phosphate homeostasis. Adv Enzyme Regul 2000, 40:285-302.
14. i transport in osteogenic cells for bone metabolism. Kidney Int 1996, 49:975-980.
15. Addison W.N., Azari F., Sorensen E.S., Kaartinen M.T., McKee M.D. Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity. J Biol Chem 2007, 282:15872-15883.
16. Kirsch T., Nah H.D., Shapiro I.M., Pacifici M. Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes. J Cell Biol 1997, 137:1149-1160.
17. Lefebvre V., Garofalo S., Zhou G., Metsaranta M., Vuorio E., De Crombrugghe B. Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice. Matrix Biol 1994, 14:329-335.
18. Wang W., Kirsch T. Annexin V/beta5 integrin interactions regulate apoptosis of growth plate chondrocytes. J Biol Chem 2006, 281:30848-30856.
19. Wang W., Xu J., Du B., Kirsch T. Role of the progressive ankylosis gene (ank) in cartilage mineralization. Mol Cell Biol 2005, 25:312-323.
20. Wang W., Kirsch T. Retinoic acid stimulates annexin-mediated growth plate chondrocyte mineralization. J Cell Biol 2002, 157:1061-1069.
21. Pucci B., Adams C.S., Fertala J., Snyder B.C., Mansfield K.D., Tafani M., et al. Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation. J Cell Physiol 2007, 210:609-615.
22. Iwamoto M., Shapiro I.M., Yagami K., Boskey A.L., Leboy P.S., Adams S.L., et al. Retinoic acid induces rapid mineralization and expression of mineralization-related genes in chondrocytes. Exp Cell Res 1993, 207:413-420.
23. Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem 1976, 22:972-976.
24. Kolettas E., Muir H.I., Barrett J.C., Hardingham T.E. Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor. Rheumatology 2001, 40:1146-1156.
25. Cecil D.L., Rose D.M., Terkeltaub R., Liu-Bryan R. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. Arthritis Rheum 2005, 52:144-154.
26. Koyama E., Golden E.B., Kirsch T., Adams S.L., Chandraratna R.A., Michaille J.J., et al. Retinoid signaling is required for chondrocyte maturation and endochondral bone formation during limb skeletogenesis. Dev Biol 1999, 208:375-391.
27. Wuthier R.E. Involvement of cellular metabolism of calcium and phosphate in calcification of avian growth plate cartilage. J Nutr 1993, 123:301-309.
28. Beck G.R., Moran E., Knecht N. Inorganic phosphate regulates multiple genes during osteoblast differentiation, including Nrf2. Exp Cell Res 2003, 288:288-300.
29. Gerber H.P., Vu T.H., Ryan A.M., Kowalski J., Werb Z., Ferrara N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999, 5:623-628.
30. Johansson N., Saarialhokere U., Airola K., Herva R., Nissinen L., Westermarck J., et al. Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development. Dev Dyn 1997, 208:387-397.
31. Tuckermann J.P., Pittois K., Partridge N.C., Merregaert J., Angel P. Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. J Bone Miner Res 2000, 15:1257-1265.
32. Zheng Q., Sebald E., Zhou G., Chen Y., Wilcox W., Lee B., et al. Dysregulation of chondrogenesis in human cleidocranial dysplasia. Am J Hum Genet 2005, 77:305-312.
33. Wang X., Manner P.A., Horner A., Shum L., Tuan R.S., Nuckolls G.H. Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage. Osteoarthritis Cartilage 2004, 12:963-973.
34. Kamekura S., Kawasaki Y., Hoshi K., Shimoaka T., Chikuda H., Maruyama Z., et al. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 2006, 54:2462-2470.
35. Takaishi H., Kimura T., Dalal S., Okada Y., D'Armiento J. Joint diseases and matrix metalloproteinases: a role for MMP-13. Curr Pharm Biotechnol 2008, 9:47-54.
36. Hirose J., Ryan L.M., Masuda I. Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease. Arthritis Rheum 2002, 46:3218-3229.
37. i excess. Osteoarthritis Cartilage 2004, 12:321-335.
38. Thouverey C., Bechkoff G., Pikula S., Buchet R. Inorganic pyrophosphate as a regulator of hydroxyapatite or calcium pyrophosphate dihydrate mineral deposition by matrix vesicles. Osteoarthritis Cartilage 2009, 17:64-72.