Amelioration of hepatic fibrosis by NK cell activation

Gut

Volumn 60, Issue 1, 2011, Pages 90-98

  Muhanna, Nidal ^a   Tair, Lina Abu ^a   Doron, Sarit ^a   Amer, Johnny ^a   Azzeh, Maysa ^b   Mahamid, Mahmud ^a   Friedman, Scott ^c   Safadi, Rifaat ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b AL QUDS UNIVERSITY   (Palestine)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; CARBON TETRACHLORIDE; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MITOGEN ACTIVATED PROTEIN KINASE 1; SMALL INTERFERING RNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; DEGRANULATION; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNOTHERAPY; LIVER FIBROSIS; LIVER INJURY; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCID MOUSE; SPLEEN CELL; STELLATE CELL;

ADOPTIVE TRANSFER; ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; GENE KNOCKDOWN TECHNIQUES; GENE THERAPY; HUMANS; KILLER CELLS, NATURAL; LIVER CIRRHOSIS; LIVER CIRRHOSIS, EXPERIMENTAL; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; MIDDLE AGED; RECEPTORS, KIR; RNA, MESSENGER; RNA, SMALL INTERFERING; SPLEEN;

EID: 78651233786     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.211136     Document Type: Article

References (26)

1. Friedman SL, Arthur MJ. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest 1989;84:1780-5.
2. Melhem A, Muhanna N, Bishara A, et al. Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J Hepatol 2006;45:60-71.
3. Radaeva S, Sun R, Jaruga B, et al. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 2006;130:435-52. (Pubitemid 43202042)
4. Muhanna N, Doron S, Wald O, et al. Activation of hepatic stellate cells following phagocytosis of lymphocytes - a novel pathway of fibrogenesis. Hepatology 2008;48:963-77.
5. Long EO. Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 1999;17:875-904. (Pubitemid 29241142)
6. Lanier LL. Natural killer cell receptor signaling. Curr Opin Immunol 2003;15:308-14.
7. Smith HR, Chuang HH, Wang LL, et al. Nonstochastic coexpression of activation receptors on murine natural killer cells. J Exp Med 2000;191:1341-54.
8. Corado J, Toro F, Rivera H, et al. Impairment of natural killer (NK) cytotoxic activity in hepatitis C virus (HCV) infection. Clin Exp Immunol 1997;9:451-7. (Pubitemid 27402312)
9. Li G, Xie Q, Shi Y, et al. Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats. J Gene Med 2006;8:889-900.
10. Xu L, Hui AY, Albanis E, et al. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 2005;54:142-51.
11. Canbay A, Taimr P, Torok N, et al. Apoptotic body engulfment by a human stellate cell line is profibrogenic. Lab Invest 2003;83:655-63.
12. Dorshkind K, Pollack SB, Bosma MJ, et al. Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid). J Immunol 1985;134:3798-801.
13. Alter G, Malenfant JM, Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods 2004;294:15-22. (Pubitemid 39626587)
14. Muhanna N, Horani A, Safadi R. Lymphocyte-hepatic stellate cell proximity suggests a direct interaction. Clin Exp Immunol 2007;148:338-47.
15. Lechner F, Wong DKH, Dunbar PR, et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000;191:1499-512. (Pubitemid 30257347)
16. Moretta A, Bottino C, Vitale M, et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 2001;19:197-223.
17. Nattermann J, Feldmann G, Sauerbruch T, et al. Surface expression and cytolytic function of NK cell receptors is altered in chronic hepatitis C. Gut 2006;55:869-77.
18. Jinushi M, Takehara T, Tatsumi T, et al. Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection. J Immunol 2004;173:6072-81.
19. Spengler U, Nattermann J. Immunopathogenesis in hepatitis C virus cirrhosis. Clin Sci 2007;112:141-55.
20. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005;115:209-18.
21. Horani A, Muhanna N, Pappo O, et al. The beneficial effect of glatiramer acetate (Copaxone®) on immune modulation of experimental hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol 2007;292:G628-38.
22. Safadi R, Zigmond E, Pappo O, et al. Amelioration of hepatic fibrosis via beta-glucoslyceramide mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution. Int Immunol 2007;19:1021-9. (Pubitemid 47386927)
23. Binyamin L, Alpaugh RK, Hughes TL, et al. Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of antilymphoma therapy. J Immunol 2008;180:6392-401.
24. Mehal WZ, Azzaroli F, Crispe IN. Immunology of the healthy liver: old questions and new insights. Gastroenterology 2001;120:250-60.
25. Lin AW, Gonzalez SA, Cunningham-Rundles S, et al. CD56(+dim) and CD56 (+bright) cell activation and apoptosis in hepatitis C virus infection. Clin Exp Immunol 2004;137:408-16.
26. Golden-Mason L, Madrigal-Estebas L, McGrath E, et al. Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. Gut 2008;57:1121-8.