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Volumn 34, Issue 10, 2010, Pages 1675-1686

Alcohol and hepatitis C virus-interactions in immune dysfunctions and liver damage

Author keywords

Antigen Presenting Cells; CD4+ T Cells; CD8+ T Cells; CYP2E1; Cytokines; Cytotoxic T Lymphocytes (CTL); Dendritic Cells (DCs); HCV; HCV Core Protein; Hepatocellular Carcinoma (HCC); Hepatocytes; Innate and Adaptive Immunity; Lieber DeCarli diet; Lipopolysaccharide (LPS); Mitochondrial Ca2+; Mitochondrial Dysfunction; Mn Superoxide Dismutase (SOD2); NS5a Protein; Proteasome; Reactive Oxygen Species (ROS); Toll Like Receptor 4 (TLR4); Transgenic Mice

Indexed keywords

ALCOHOL; LIPOPOLYSACCHARIDE; PROTEASOME; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4;

EID: 77957369677     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01255.x     Document Type: Review
Times cited : (67)

References (135)
  • 1
    • 21744438136 scopus 로고    scopus 로고
    • Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses
    • Abdalla MY, Ahmad IM, Spitz DR, Schmidt WN, Britigan BE (2005) Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. J Med Virol 76 : 489 497.
    • (2005) J Med Virol , vol.76 , pp. 489-497
    • Abdalla, M.Y.1    Ahmad, I.M.2    Spitz, D.R.3    Schmidt, W.N.4    Britigan, B.E.5
  • 3
    • 33847042376 scopus 로고    scopus 로고
    • Chronic ethanol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction
    • DOI 10.1053/j.gastro.2006.11.016, PII S0016508506024656
    • Aloman C, Gehring S, Wintermeyer P, Kuzushita N, Wands JR (2007) Chronic ethanol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction. Gastroenterology 132 : 698 708. (Pubitemid 46274653)
    • (2007) Gastroenterology , vol.132 , Issue.2 , pp. 698-708
    • Aloman, C.1    Gehring, S.2    Wintermeyer, P.3    Kuzushita, N.4    Wands, J.R.5
  • 4
    • 59149103099 scopus 로고    scopus 로고
    • Protease and polymerase inhibitors for the treatment of hepatitis C
    • Asselah T, Benhamou Y, Marcellin P (2009) Protease and polymerase inhibitors for the treatment of hepatitis C. Liver Int 29 (Suppl 1 57 67.
    • (2009) Liver Int , vol.29 , Issue.1 , pp. 57-67
    • Asselah, T.1    Benhamou, Y.2    Marcellin, P.3
  • 5
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • DOI 10.1038/32588
    • Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392 : 245 252. (Pubitemid 28155090)
    • (1998) Nature , vol.392 , Issue.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 6
    • 0033180064 scopus 로고    scopus 로고
    • Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: Ultrastructural and biochemical findings
    • DOI 10.1111/j.1572-0241.1999.01294.x, PII S0002927099003500
    • Barbaro G, Di Lorenzo G, Asti A, Ribersani M, Belloni G, Grisorio B, Filice G, Barbarini G (1999) Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings. Am J Gastroenterol 94 : 2198 2205. (Pubitemid 29374554)
    • (1999) American Journal of Gastroenterology , vol.94 , Issue.8 , pp. 2198-2205
    • Barbaro, G.1    Di Lorenzo, G.2    Asti, A.3    Ribersani, M.4    Belloni, G.5    Grisorio, B.6    Filice, G.7    Barbarini, G.8
  • 7
    • 13844298275 scopus 로고    scopus 로고
    • The effect of ethanol-induced CYP2E1 on proteasome activity: The role of 4-hydroxynonenal
    • DOI 10.1016/j.yexmp.2004.10.005
    • Bardag-Gorce F, Li J, French BA, French SW (2005) The effect of ethanol-induced cyp2e1 on proteasome activity: the role of 4-hydroxynonenal. Exp Mol Pathol 78 : 109 115. (Pubitemid 40248791)
    • (2005) Experimental and Molecular Pathology , vol.78 , Issue.2 , pp. 109-115
    • Bardag-Gorce, F.1    Li, J.2    French, B.A.3    French, S.W.4
  • 9
    • 46749149199 scopus 로고    scopus 로고
    • Hepatitis C virus infection and hepatocellular carcinoma
    • DOI 10.1016/j.cld.2008.03.007, PII S1089326108000366
    • Blonski W, Reddy KR (2008) Hepatitis C virus infection and hepatocellular carcinoma. Clin Liver Dis 12 : 661 674. (Pubitemid 351952471)
    • (2008) Clinics in Liver Disease , vol.12 , Issue.3 , pp. 661-674
    • Blonski, W.1    Reddy, K.R.2
  • 11
    • 34249799591 scopus 로고    scopus 로고
    • Stem cells in the adult pancreas and liver
    • DOI 10.1042/BJ20070167
    • Burke ZD, Thowfeequ S, Peran M, Tosh D (2007) Stem cells in the adult pancreas and liver. Biochem J 404 : 169 178. (Pubitemid 46849588)
    • (2007) Biochemical Journal , vol.404 , Issue.2 , pp. 169-178
    • Burke, Z.D.1    Thowfeequ, S.2    Peran, M.3    Tosh, D.4
  • 12
    • 0035055699 scopus 로고    scopus 로고
    • DNA oxidative damage in leukocytes correlates with the severity of HCV-related liver disease: Validation in an open population study
    • DOI 10.1016/S0168-8278(00)00098-2, PII S0168827800000982
    • Cardin R, Saccoccio G, Masutti F, Bellentani S, Farinati F, Tiribelli C (2001) DNA oxidative damage in leukocytes correlates with the severity of HCV-related liver disease: validation in an open population study. J Hepatol 34 : 587 592. (Pubitemid 32328517)
    • (2001) Journal of Hepatology , vol.34 , Issue.4 , pp. 587-592
    • Cardin, R.1    Saccoccio, G.2    Masutti, F.3    Bellentani, S.4    Farinati, F.5    Tiribelli, C.6
  • 14
    • 33745924696 scopus 로고    scopus 로고
    • Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties
    • DOI 10.1002/hep.21227
    • Chiba T, Kita K, Zheng YW, Yokosuka O, Saisho H, Iwama A, Nakauchi H, Taniguchi H (2006) Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 44 : 240 251. (Pubitemid 44049156)
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 240-251
    • Chiba, T.1    Kita, K.2    Zheng, Y.-W.3    Yokosuka, O.4    Saisho, H.5    Iwama, A.6    Nakauchi, H.7    Taniguchi, H.8
  • 15
    • 33749058955 scopus 로고    scopus 로고
    • Redox modulation of the hepatitis C virus replication complex is calcium dependent
    • DOI 10.1016/j.freeradbiomed.2006.08.008, PII S0891584906005132
    • Choi J, Forman HJ, Ou JH, Lai MM, Seronello S, Nandipati A (2006) Redox modulation of the hepatitis C virus replication complex is calcium dependent. Free Radic Biol Med 41 : 1488 1498. (Pubitemid 44466731)
    • (2006) Free Radical Biology and Medicine , vol.41 , Issue.9 , pp. 1488-1498
    • Choi, J.1    Forman, H.J.2    Ou, J.-h.3    Lai, M.M.C.4    Seronello, S.5    Nandipati, A.6
  • 16
    • 1442306648 scopus 로고    scopus 로고
    • Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells
    • DOI 10.1002/hep.20001
    • Choi J, Lee KJ, Zheng Y, Yamaga AK, Lai MM, Ou JH (2004) Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells. Hepatology 39 : 81 89. (Pubitemid 38461470)
    • (2004) Hepatology , vol.39 , Issue.1 , pp. 81-89
    • Choi, J.1    Lee, K.J.2    Zheng, Y.3    Yamaga, A.K.4    Lai, M.M.C.5    Ou, J.-H.6
  • 17
    • 0031948693 scopus 로고    scopus 로고
    • Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis
    • DOI 10.1002/hep.510270404
    • Corrao G, Aricò S (1998) Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis. Hepatology 27 : 914 919. (Pubitemid 28160474)
    • (1998) Hepatology , vol.27 , Issue.4 , pp. 914-919
    • Corrao, G.1    Arico, S.2
  • 19
    • 67649321463 scopus 로고    scopus 로고
    • Modulation of lysozyme function and degradation after nitration with peroxynitrite
    • Curry-McCoy TV, Osna NA, Donohue Jr. TM (2009) Modulation of lysozyme function and degradation after nitration with peroxynitrite. Biochim Biophys Acta 1790 : 778 786.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 778-786
    • Curry-Mccoy, T.V.1    Osna, N.A.2    Donohue, Jr.T.M.3
  • 20
    • 33644527617 scopus 로고    scopus 로고
    • Alcohol and oxidative liver injury
    • DOI 10.1002/hep.20957
    • Dey A, Cederbaum AI (2006) Alcohol and oxidative liver injury. Hepatology 43 : S63 S74. (Pubitemid 43303970)
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Dey, A.1    Cederbaum, A.I.2
  • 22
    • 33750826035 scopus 로고    scopus 로고
    • Hepatitis C Virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-α and plasmacytoid dendritic cell loss in chronic HCV infection
    • Dolganiuc A, Chang S, Kodys K, Mandrekar P, Bakis G, Szabo G (2006) Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection. J Immunol 177 (10 6758 6768. (Pubitemid 44715040)
    • (2006) Journal of Immunology , vol.177 , Issue.10 , pp. 6758-6768
    • Dolganiuc, A.1    Chang, S.2    Kodys, K.3    Mandrekar, P.4    Bakis, G.5    Cormier, M.6    Szabo, G.7
  • 23
    • 0038308837 scopus 로고    scopus 로고
    • Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction
    • Dolganiuc A, Kodys K, Kopasz A, Marshall C, Mandrekar P, Szabo G (2003) Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction. Alcohol Clin Exp Res 27 : 1023 1031. (Pubitemid 36759393)
    • (2003) Alcoholism: Clinical and Experimental Research , vol.27 , Issue.6 , pp. 1023-1031
    • Dolganiuc, A.1    Kodys, K.2    Kopasz, A.3    Marshall, C.4    Mandrekar, P.5    Szabo, G.6
  • 24
    • 7644226241 scopus 로고    scopus 로고
    • Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    • DOI 10.1053/j.gastro.2004.08.067, PII S0016508504015689
    • Dolganiuc A, Kodys K, Shin S, Finberg R, Golenbock D, Kurt-Jones E, Szabo G (2004) Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology 127 : 1513 1524. (Pubitemid 39457776)
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. 1513-1524
    • Dolganiuc, A.1    Oak, S.2    Kodys, K.3    Golenbock, D.T.4    Finberg, R.W.5    Kurt-Jones, E.6    Szabo, G.7
  • 25
    • 35649007401 scopus 로고    scopus 로고
    • Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
    • DOI 10.1053/j.gastro.2007.08.003, PII S0016508507014497
    • Dolganiuc A, Norkina O, Kodys K, Catalano D, Mandrekar P, Bakis G, Marshall C, Szabo G (2007) Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology 133 (5 1627 1636. (Pubitemid 350029734)
    • (2007) Gastroenterology , vol.133 , Issue.5 , pp. 1627-1636
    • Dolganiuc, A.1    Norkina, O.2    Kodys, K.3    Catalano, D.4    Bakis, G.5    Marshall, C.6    Mandrekar, P.7    Szabo, G.8
  • 27
    • 27544457323 scopus 로고    scopus 로고
    • Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome p450 2e1 as a model of ethanol-elicited cytotoxicity
    • Donohue TM, Osna NA, Clemens DL (2006) Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome p450 2e1 as a model of ethanol-elicited cytotoxicity. Int J Biochem Cell Biol 38 : 92 101.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 92-101
    • Donohue, T.M.1    Osna, N.A.2    Clemens, D.L.3
  • 29
    • 27644535720 scopus 로고    scopus 로고
    • Prophylactic and therapeutic vaccination with dendritic cells against hepatitis C virus infection
    • DOI 10.1111/j.1365-2249.2005.02919.x
    • Encke J, Findeklee J, Geib J, Pfaff E, Stremmel W (2005) Prophylactic and therapeutic vaccination with dendritic cells against hepatitis C virus infection. Clin Exp Immunol 142 : 362 369. (Pubitemid 41565254)
    • (2005) Clinical and Experimental Immunology , vol.142 , Issue.2 , pp. 362-369
    • Encke, J.1    Findeklee, J.2    Geib, J.3    Pfaff, E.4    Stremmel, W.5
  • 30
    • 0033854171 scopus 로고    scopus 로고
    • Ethanol inhibition: The humoral and cellular immune response to hepatitis C virus NS5 protein after genetic immunization
    • Encke J, Wands JR (2000) Ethanol inhibition: the humoral and cellular immune response to hepatitis C virus NS5 protein after genetic immunization. Alcohol Clin Exp Res 24 : 1063 1069. (Pubitemid 30604327)
    • (2000) Alcoholism: Clinical and Experimental Research , vol.24 , Issue.7 , pp. 1063-1069
    • Encke, J.1    Wands, J.R.2
  • 31
    • 0032212215 scopus 로고    scopus 로고
    • Genetic immunization generates cellular and humoral immune responses against the nonstructural proteins of the hepatitis C virus in a murine model
    • Encke J, zu Putlitz J, Geissler M, Wands JR (1998) Genetic immunization generates cellular and humoral immune responses against the nonstructural proteins of the hepatitis C virus in a murine model. J Immunol 161 : 4917 4923. (Pubitemid 28492071)
    • (1998) Journal of Immunology , vol.161 , Issue.9 , pp. 4917-4923
    • Encke, J.1    Zu Putlitz, J.2    Geissler, M.3    Wands, J.R.4
  • 32
    • 0036481121 scopus 로고    scopus 로고
    • C-type lectin receptors on dendritic cells and langerhans cells
    • Figdor CG, van Kooyk Y, Adema GJ (2002) C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol 2 : 77 84. (Pubitemid 37323231)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.2 , pp. 77-84
    • Figdor, C.G.1    Van Kooyk, Y.2    Adema, G.J.3
  • 34
  • 35
    • 0031066827 scopus 로고    scopus 로고
    • Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids
    • Geissler M, Gesien A, Tokushige K, Wands JR (1997b) Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J Immunol 158 : 1231 1237. (Pubitemid 127469946)
    • (1997) Journal of Immunology , vol.158 , Issue.3 , pp. 1231-1237
    • Geissler, M.1    Gesien, A.2    Tokushige, K.3    Wands, J.R.4
  • 36
    • 0031573081 scopus 로고    scopus 로고
    • Inhibitory Effects of Chronic Ethanol Consumption on Cellular Immune Responses to Hepatitis C Virus Core Protein Are Reversed by Genetic Immunizations Augmented with Cytokine-Expressing Plasmids
    • Geissler M, Gesien A, Wands JR (1997a) Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids. J Immunol 159 : 5107 5113. (Pubitemid 127471051)
    • (1997) Journal of Immunology , vol.159 , Issue.10 , pp. 5107-5113
    • Geissler, M.1    Gesien, A.2    Wands, J.R.3
  • 37
    • 0030874908 scopus 로고    scopus 로고
    • Chronic ethanol effects on cellular immune responses to hepatitis B virus envelope protein: An immunologic mechanism for induction of persistent viral infection in alcoholics
    • Geissler M, Gesien A, Wands JR (1997c) Chronic ethanol effects on cellular immune responses to hepatitis B virus envelope protein: an immunologic mechanism for induction of persistent viral infection in alcoholics. Hepatology 26 : 764 770. (Pubitemid 27392371)
    • (1997) Hepatology , vol.26 , Issue.3 , pp. 764-770
    • Geissler, M.1    Gesien, A.2    Wands, J.R.3
  • 38
    • 0036777957 scopus 로고    scopus 로고
    • The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides
    • DOI 10.1016/S0161-5890(02)00098-6, PII S0161589002000986
    • Goldberg AL, Cascio P, Saric T, Rock KL (2002) The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides. Mol Immunol 39 : 147 164. (Pubitemid 35013508)
    • (2002) Molecular Immunology , vol.39 , Issue.3-4 , pp. 147-164
    • Goldberg, A.L.1    Cascio, P.2    Saric, T.3    Rock, K.L.4
  • 40
    • 0032080117 scopus 로고    scopus 로고
    • Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome
    • DOI 10.1074/jbc.273.18.10857
    • Grune T, Blasig IE, Sitte N, Roloff B, Haseloff R, Davies KJ (1998) Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome. J Biol Chem 273 : 10857 10862. (Pubitemid 28204920)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.18 , pp. 10857-10862
    • Grune, T.1    Blasig, I.E.2    Sitte, N.3    Roloff, B.4    Haseloff, R.5    Davies, K.J.A.6
  • 42
    • 0036829556 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus
    • DOI 10.1053/jhep.2002.36780
    • Hassan MM, Hwang LY, Hatten CJ, Swaim M, Li D, Abbruzzese JL, Beasley P, Patt YZ (2002) Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus. Hepatology 36 : 1206 1213. (Pubitemid 35253437)
    • (2002) Hepatology , vol.36 , Issue.5 II , pp. 1206-1213
    • Hassan, M.M.1    Hwang, L.-Y.2    Hatten, C.J.3    Swaim, M.4    Li, D.5    Abbruzzese, J.L.6    Beasley, P.7    Patt, Y.Z.8
  • 43
    • 0036961904 scopus 로고    scopus 로고
    • SDF-1α/CXCR4: A mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats
    • Hatch HM, Zheng D, Jorgensen ML, Petersen BE (2002) SDF-1alphaCXCR4: a mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats. Cloning Stem Cells 4 : 339 351. (Pubitemid 36105802)
    • (2002) Cloning and Stem Cells , vol.4 , Issue.4 , pp. 339-351
    • Hatch, H.M.1    Zheng, D.2    Jorgensen, M.L.3    Petersen, B.E.4
  • 44
    • 34548558965 scopus 로고    scopus 로고
    • Ethanol consumption modifies dendritic cell antigen presentation in mice
    • DOI 10.1111/j.1530-0277.2007.00479.x
    • Heinz R, Waltenbaugh C (2007) Ethanol consumption modifies dendritic cell antigen presentation in mice. Alcohol Clin Exp Res 31 : 1759 1771. (Pubitemid 47390040)
    • (2007) Alcoholism: Clinical and Experimental Research , vol.31 , Issue.10 , pp. 1759-1771
    • Heinz, R.1    Waltenbaugh, C.2
  • 45
    • 33750621103 scopus 로고    scopus 로고
    • Significance of circulating endothelial progenitor cells in hepatocellular carcinoma
    • DOI 10.1002/hep.21353
    • Ho JW, Pang RW, Lau C, Sun CK, Yu WC, Fan ST, Poon RT (2006) Significance of circulating endothelial progenitor cells in hepatocellular carcinoma. Hepatology 44 : 836 843. (Pubitemid 46489546)
    • (2006) Hepatology , vol.44 , Issue.4 , pp. 836-843
    • Ho, J.W.Y.1    Pang, R.W.C.2    Lau, C.3    Sun, C.K.4    Wan, C.Y.5    Sheung, T.F.6    Poon, R.T.P.7
  • 46
    • 70349245146 scopus 로고    scopus 로고
    • Intracellular innate immune cascades and interferon defenses that control hepatitis C virus
    • Horner SM, Gale M Jr. (2009) Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. J Interferon Cytokine Res 29 : 489 498.
    • (2009) J Interferon Cytokine Res , vol.29 , pp. 489-498
    • Horner, S.M.1    Gale, Jr.M.2
  • 48
    • 27644500797 scopus 로고    scopus 로고
    • Influence of alcohol on the progression of hepatitis C virus infection: A meta-analysis
    • DOI 10.1016/S1542-3565(05)00407-6, PII S1542356505004076
    • Hutchinson SJ, Bird SM, Goldberg DJ (2005) Influence of alcohol on the progression of hepatitis C virus infection: a meta-analysis. Clin Gastroenterol Hepatol 3 : 1150 1159. (Pubitemid 41565383)
    • (2005) Clinical Gastroenterology and Hepatology , vol.3 , Issue.11 , pp. 1150-1159
    • Hutchinson, S.J.1    Bird, S.M.2    Goldberg, D.J.3
  • 50
    • 25644432064 scopus 로고    scopus 로고
    • The effect of cyp2e1-dependent oxidant stress on activity of proteasomes in hepg2 cells
    • Kessova IG, Cederbaum AI (2005) The effect of cyp2e1-dependent oxidant stress on activity of proteasomes in hepg2 cells. J Pharmacol Exp Ther 315 : 304 312.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 304-312
    • Kessova, I.G.1    Cederbaum, A.I.2
  • 53
    • 27844604269 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
    • DOI 10.1074/jbc.M506412200
    • Korenaga M, Wang T, Li Y, Showalter LA, Chan T, Sun J, Weinman SA (2005b) Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production. J Biol Chem 280 : 37481 37488. (Pubitemid 41642356)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.45 , pp. 37481-37488
    • Korenaga, M.1    Wang, T.2    Li, Y.3    Showalter, L.A.4    Chan, T.5    Sun, J.6    Weinman, S.A.7
  • 55
    • 60049097867 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits hepatitis C virus RNA replication through modulation of the glutathione redox system and oxidative stress
    • Kuroki M, Ariumi Y, Ikeda M, Dansako H, Wakita T, Kato N (2009) Arsenic trioxide inhibits hepatitis C virus RNA replication through modulation of the glutathione redox system and oxidative stress. J Virol 83 : 2338 2348.
    • (2009) J Virol , vol.83 , pp. 2338-2348
    • Kuroki, M.1    Ariumi, Y.2    Ikeda, M.3    Dansako, H.4    Wakita, T.5    Kato, N.6
  • 56
    • 32044443616 scopus 로고    scopus 로고
    • Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens
    • DOI 10.1053/j.gastro.2005.10.048, PII S0016508505022274
    • Kuzushita N, Gregory SH, Monti NA, Carlson R, Gehring S, Wands JR (2006) Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens. Gastroenterology 130 : 453 464. (Pubitemid 43202043)
    • (2006) Gastroenterology , vol.130 , Issue.2 , pp. 453-464
    • Kuzushita, N.1    Gregory, S.H.2    Monti, N.A.3    Carlson, R.4    Gehring, S.5    Wands, J.R.6
  • 59
    • 0032077192 scopus 로고    scopus 로고
    • Superoxide dismutase in patients with chronic hepatitis C virus infection
    • DOI 10.1016/S0891-5849(97)00437-1, PII S0891584997004371
    • Larrea E, Beloqui O, Munoz-Navas MA, Civeira MP, Prieto J (1998) Superoxide dismutase in patients with chronic hepatitis C virus infection. Free Radic Biol Med 24 : 1235 1241. (Pubitemid 28246738)
    • (1998) Free Radical Biology and Medicine , vol.24 , Issue.7-8 , pp. 1235-1241
    • Larrea, E.1    Beloqui, O.2    Munoz-Navas, M.-A.3    Civeira, M.-P.4    Prieto, J.5
  • 61
    • 34547739644 scopus 로고    scopus 로고
    • 2+ uniporter activity
    • DOI 10.1096/fj.06-7345com
    • Li Y, Boehning DF, Qian T, Popov VL, Weinman SA (2007) Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity. FASEB J 21 : 2474 2485. (Pubitemid 47230677)
    • (2007) FASEB Journal , vol.21 , Issue.10 , pp. 2474-2485
    • Li, Y.1    Boehning, D.F.2    Qian, T.3    Popov, V.L.4    Weinman, S.A.5
  • 63
    • 34249980343 scopus 로고    scopus 로고
    • Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells
    • DOI 10.1053/j.gastro.2007.04.025, PII S001650850700786X
    • Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY (2007) Identification and characterization of tumorigenic liver cancer stemprogenitor cells. Gastroenterology 132 : 2542 2556. (Pubitemid 46890873)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2542-2556
    • Ma, S.1    Chan, K.2    Hu, L.3    Lee, T.K.4    Wo, J.Y.5    Ng, I.O.6    Zheng, B.7    Guan, X.8
  • 64
    • 40749150740 scopus 로고    scopus 로고
    • + HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • DOI 10.1038/sj.onc.1210811, PII 1210811
    • Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY (2008) CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the AktPKB survival pathway. Oncogene 27 : 1749 1758. (Pubitemid 351380265)
    • (2008) Oncogene , vol.27 , Issue.12 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.-J.3    Chan, K.W.4    Guan, X.-Y.5
  • 65
    • 33745797050 scopus 로고    scopus 로고
    • Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation
    • Machida K, Cheng KT, Lai CK, Jeng KS, Sung VM, Lai MM (2006a) Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J Virol 80 : 7199 7207.
    • (2006) J Virol , vol.80 , pp. 7199-7207
    • MacHida, K.1    Cheng, K.T.2    Lai, C.K.3    Jeng, K.S.4    Sung, V.M.5    Lai, M.M.6
  • 66
    • 30344444475 scopus 로고    scopus 로고
    • Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6
    • DOI 10.1128/JVI.80.2.866-874.2006
    • Machida K, Cheng KT, Sung VM, Levine AM, Foung S, Lai MM (2006b) Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol 80 : 866 874. (Pubitemid 43062898)
    • (2006) Journal of Virology , vol.80 , Issue.2 , pp. 866-874
    • Machida, K.1    Cheng, K.T.H.2    Sung, V.M.-H.3    Levine, A.M.4    Foung, S.5    Lai, M.M.C.6
  • 69
    • 34250160595 scopus 로고    scopus 로고
    • Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma
    • Maki A, Kono H, Gupta M, Asakawa M, Suzuki T, Matsuda M, Fujii H, Rusyn I (2007) Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol 14 : 1182 1190.
    • (2007) Ann Surg Oncol , vol.14 , pp. 1182-1190
    • Maki, A.1    Kono, H.2    Gupta, M.3    Asakawa, M.4    Suzuki, T.5    Matsuda, M.6    Fujii, H.7    Rusyn, I.8
  • 70
    • 4344593751 scopus 로고    scopus 로고
    • Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production
    • Mandrekar P, Catalano D, Dolganiuc A, Kodys K, Szabo G (2004) Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production. J Immunol 173 : 3398 3407. (Pubitemid 39142050)
    • (2004) Journal of Immunology , vol.173 , Issue.5 , pp. 3398-3407
    • Mandrekar, P.1    Catalano, D.2    Dolganiuc, A.3    Kodys, K.4    Szabo, G.5
  • 71
    • 40949141493 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
    • Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM (2008) Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic Biol Med 44 : 1259 1272.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1259-1272
    • Mantena, S.K.1    King, A.L.2    Andringa, K.K.3    Eccleston, H.B.4    Bailey, S.M.5
  • 72
    • 58149474179 scopus 로고    scopus 로고
    • Manganese superoxide dismutase V16A single-nucleotide polymorphism in the mitochondrial targeting sequence is associated with reduced enzymatic activity in cryopreserved human hepatocytes
    • Martin RC, Li Y, Liu Q, Jensen NS, Barker DF, Doll MA, Hein DW (2009) Manganese superoxide dismutase V16A single-nucleotide polymorphism in the mitochondrial targeting sequence is associated with reduced enzymatic activity in cryopreserved human hepatocytes. DNA Cell Biol 28 : 3 7.
    • (2009) DNA Cell Biol , vol.28 , pp. 3-7
    • Martin, R.C.1    Li, Y.2    Liu, Q.3    Jensen, N.S.4    Barker, D.F.5    Doll, M.A.6    Hein, D.W.7
  • 73
    • 56749131192 scopus 로고    scopus 로고
    • Alcohol metabolism increases the replication of hepatitis C virus and attenuates the antiviral action of interferon
    • McCartney EM, Semendric L, Helbig KJ, Hinze S, Jones B, Weinman SA, Beard MR (2008) Alcohol metabolism increases the replication of hepatitis C virus and attenuates the antiviral action of interferon. J Infect Dis 198 : 1766 1775.
    • (2008) J Infect Dis , vol.198 , pp. 1766-1775
    • McCartney, E.M.1    Semendric, L.2    Helbig, K.J.3    Hinze, S.4    Jones, B.5    Weinman, S.A.6    Beard, M.R.7
  • 75
    • 40049085583 scopus 로고    scopus 로고
    • Evidence of oxidative stress as a cofactor in the development of insulin resistance in patients with chronic hepatitis C
    • DOI 10.1111/j.1872-034X.2007.00280.x
    • Mitsuyoshi H, Itoh Y, Sumida Y, Minami M, Yasui K, Nakashima T, Okanoue T (2008) Evidence of oxidative stress as a cofactor in the development of insulin resistance in patients with chronic hepatitis C. Hepatol Res 38 : 348 353. (Pubitemid 351321177)
    • (2008) Hepatology Research , vol.38 , Issue.4 , pp. 348-353
    • Mitsuyoshi, H.1    Itoh, Y.2    Sumida, Y.3    Minami, M.4    Yasui, K.5    Nakashima, T.6    Okanoue, T.7
  • 76
    • 56149115918 scopus 로고    scopus 로고
    • Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
    • Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA (2008) Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 48 : 1420 1429.
    • (2008) Hepatology , vol.48 , pp. 1420-1429
    • Miura, K.1    Taura, K.2    Kodama, Y.3    Schnabl, B.4    Brenner, D.A.5
  • 78
    • 54449096808 scopus 로고    scopus 로고
    • Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: A nationwide analysis
    • Nguyen GC, Sam J, Thuluvath PJ (2008) Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: a nationwide analysis. Hepatology 48 : 1336 1341.
    • (2008) Hepatology , vol.48 , pp. 1336-1341
    • Nguyen, G.C.1    Sam, J.2    Thuluvath, P.J.3
  • 80
    • 33745624260 scopus 로고    scopus 로고
    • Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis
    • DOI 10.1099/vir.0.81701-0
    • Nomura-Takigawa Y, Nagano-Fujii M, Deng L, Kitazawa S, Ishido S, Sada K, Hotta H (2006) Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J Gen Virol 87 (Pt 7 1935 1945. (Pubitemid 43985876)
    • (2006) Journal of General Virology , vol.87 , Issue.7 , pp. 1935-1945
    • Nomura-Takigawa, Y.1    Nagano-Fujii, M.2    Deng, L.3    Kitazawa, S.4    Ishido, S.5    Sada, K.6    Hotta, H.7
  • 82
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, Weinman SA (2002) Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122 : 366 375. (Pubitemid 34116988)
    • (2002) Gastroenterology , vol.122 , Issue.2 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3    Showalter, L.A.4    Scholle, F.5    Lemon, S.M.6    Weinman, S.A.7
  • 83
    • 0028030008 scopus 로고
    • Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis C
    • DOI 10.1016/0270-9139(94)90745-5
    • Oshita M, Hayashi N, Kasahara A, Hagiwara H, Mita E, Naito M, Katayama K, Fusamoto H, Kamada T (1994) Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis C. Hepatology 20 : 1115 1120. (Pubitemid 24323554)
    • (1994) Hepatology , vol.20 , Issue.5 , pp. 1115-1120
    • Oshita, M.1    Hayashi, N.2    Kasahara, A.3    Hagiwara, H.4    Mita, E.5    Naito, M.6    Katayama, K.7    Fusamoto, H.8    Kamada, T.9
  • 84
    • 0041930639 scopus 로고    scopus 로고
    • Interferon gamma enhances proteasome activity in recombinant hep g2 cells that express cytochrome p4502e1: Modulation by ethanol
    • Osna NA, Clemens DL, Donohue TM Jr. (2003) Interferon gamma enhances proteasome activity in recombinant hep g2 cells that express cytochrome p4502e1: modulation by ethanol. Biochem Pharmacol 66 : 697 710.
    • (2003) Biochem Pharmacol , vol.66 , pp. 697-710
    • Osna, N.A.1    Clemens, D.L.2    Donohue, Jr.T.M.3
  • 85
    • 34848860810 scopus 로고    scopus 로고
    • Implication of altered proteasome function in alcoholic liver injury
    • Osna NA, Donohue TM Jr. (2007) Implication of altered proteasome function in alcoholic liver injury. World J Gastroenterol 13 : 4931 4937.
    • (2007) World J Gastroenterol , vol.13 , pp. 4931-4937
    • Osna, N.A.1    Donohue, Jr.T.M.2
  • 86
    • 4544304395 scopus 로고    scopus 로고
    • Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo
    • DOI 10.1002/hep.20352
    • Osna NA, Haorah J, Krutik VM, Donohue TM Jr. (2004) Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo. Hepatology 40 : 574 582. (Pubitemid 39265578)
    • (2004) Hepatology , vol.40 , Issue.3 , pp. 574-582
    • Osna, N.A.1    Haorah, J.2    Krutik, V.M.3    Donohue Jr., T.M.4
  • 87
    • 44649095826 scopus 로고    scopus 로고
    • Proteasome Activation by Hepatitis C Core Protein Is Reversed by Ethanol-Induced Oxidative Stress
    • DOI 10.1053/j.gastro.2008.02.063, PII S0016508508003296
    • Osna NA, White RL, Krutik VM, Wang T, Weinman SA, Donohue TM Jr. (2008) Proteasome activation by hepatitis c core protein is reversed by ethanol-induced oxidative stress. Gastroenterology 134 : 2144 2152. (Pubitemid 351783253)
    • (2008) Gastroenterology , vol.134 , Issue.7 , pp. 2144-2152
    • Osna, N.A.1    White, R.L.2    Krutik, V.M.3    Wang, T.4    Weinman, S.A.5    Donohue Jr., T.M.6
  • 88
    • 65449181938 scopus 로고    scopus 로고
    • Ethanol metabolism alters major histocompatibility complex class i-restricted antigen presentation in liver cells
    • Osna NA, White RL, Thiele GM, Donohue TM Jr. (2009) Ethanol metabolism alters major histocompatibility complex class i-restricted antigen presentation in liver cells. Hepatology 49 : 1308 1315.
    • (2009) Hepatology , vol.49 , pp. 1308-1315
    • Osna, N.A.1    White, R.L.2    Thiele, G.M.3    Donohue, Jr.T.M.4
  • 89
    • 33846421564 scopus 로고    scopus 로고
    • Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells
    • DOI 10.1002/hep.21442
    • Osna NA, White RL, Todero S, McVicker BL, Thiele GM, Clemens DL, Tuma DJ, Donohue TM Jr. (2007) Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells. Hepatology 45 : 53 61. (Pubitemid 46144364)
    • (2007) Hepatology , vol.45 , Issue.1 , pp. 53-61
    • Osna, N.A.1    White, R.L.2    Todero, S.3    Mc Vicker, B.L.4    Thiele, G.M.5    Clemens, D.L.6    Tuma, D.J.7    Donohue Jr., T.M.8
  • 90
    • 11144342818 scopus 로고    scopus 로고
    • Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells
    • DOI 10.1053/j.gastro.2004.10.045, PII S001650850401995X
    • Otani K, Korenaga M, Beard MR, Li K, Qian T, Showalter LA, Singh AK, Wang T, Weinman SA (2005) Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology 128 : 96 107. (Pubitemid 40039962)
    • (2005) Gastroenterology , vol.128 , Issue.1 , pp. 96-107
    • Otani, K.1    Korenaga, M.2    Beard, M.R.3    Li, K.4    Qian, T.5    Showalter, L.A.6    Singh, A.K.7    Wang, T.8    Weinman, S.A.9
  • 91
    • 0031011220 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation by-products in chronic liver diseases
    • Paradis V, Kollinger M, Fabre M, Holstege A, Poynard T, Bedossa P (1997) In situ detection of lipid peroxidation by-products in chronic liver diseases. Hepatology 26 : 135 142. (Pubitemid 27280317)
    • (1997) Hepatology , vol.26 , Issue.1 , pp. 135-142
    • Paradis, V.1    Kollinger, M.2    Fabre, M.3    Holstege, A.4    Poynard, T.5    Bedossa, P.6
  • 92
    • 0346874205 scopus 로고    scopus 로고
    • Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model
    • DOI 10.1016/S0168-8278(03)00414-8
    • Perlemuter G, Letteron P, Carnot F, Zavala F, Pessayre D, Nalpas B, Bréchot C (2003) Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model. J Hepatol 39 : 1020 1027. (Pubitemid 37523775)
    • (2003) Journal of Hepatology , vol.39 , Issue.6 , pp. 1020-1027
    • Perlemuter, G.1    Letteron, P.2    Carnot, F.3    Zavala, F.4    Pessayre, D.5    Nalpas, B.6    Brechot, C.7
  • 95
    • 34547415672 scopus 로고    scopus 로고
    • Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress
    • DOI 10.1002/hep.21679
    • Piccoli C, Scrima R, Quarato G, D'Aprile A, Ripoli M, Lecce L, Boffoli D, Moradpour D, Capitanio N (2007) Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress. Hepatology 46 : 58 65. (Pubitemid 47171921)
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 58-65
    • Piccoli, C.1    Scrima, R.2    Quarato, G.3    D'Aprile, A.4    Ripoli, M.5    Lecce, L.6    Boffoli, D.7    Moradpour, D.8    Capitanio, N.9
  • 96
    • 1642464020 scopus 로고    scopus 로고
    • Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: Role of JNK, p38 MAPK and AP-1
    • DOI 10.1042/BJ20031587
    • Qadri I, Iwahashi M, Capasso JM, Hopken MW, Flores S, Schaack J, Simon FR (2004) Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J 378 (Pt 3 919 928. (Pubitemid 38406869)
    • (2004) Biochemical Journal , vol.378 , Issue.3 , pp. 919-928
    • Qadri, I.1    Iwahashi, M.2    Capasso, J.M.3    Hopken, M.W.4    Flores, S.5    Schaack, J.6    Simon, F.R.7
  • 97
    • 33644872508 scopus 로고    scopus 로고
    • Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control
    • Qian SB, Princiotta MF, Bennink JR, Yewdell JW (2006) Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control. J Biol Chem 281 : 392 400.
    • (2006) J Biol Chem , vol.281 , pp. 392-400
    • Qian, S.B.1    Princiotta, M.F.2    Bennink, J.R.3    Yewdell, J.W.4
  • 98
    • 57749102534 scopus 로고    scopus 로고
    • Subcellular localizations of the hepatitis C virus alternate reading frame proteins
    • Ratinier M, Boulant S, Crussard S, McLauchlan J, Lavergne JP (2009) Subcellular localizations of the hepatitis C virus alternate reading frame proteins. Virus Res 139 : 106 110.
    • (2009) Virus Res , vol.139 , pp. 106-110
    • Ratinier, M.1    Boulant, S.2    Crussard, S.3    McLauchlan, J.4    Lavergne, J.P.5
  • 99
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
    • Rehermann B (2009) Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 119 : 1745 1754.
    • (2009) J Clin Invest , vol.119 , pp. 1745-1754
    • Rehermann, B.1
  • 100
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • DOI 10.1038/nri1573
    • Rehermann B, Nascimbeni M (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5 : 215 229. (Pubitemid 40364823)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.3 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 101
    • 33745533559 scopus 로고    scopus 로고
    • Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    • DOI 10.1038/sj.onc.1209558, PII 1209558
    • Roskams T (2006) Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 25 : 3818 3822. (Pubitemid 43980477)
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3818-3822
    • Roskams, T.1
  • 103
    • 42249094350 scopus 로고    scopus 로고
    • Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice
    • DOI 10.1002/hep.22141
    • Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC (2008) Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology 47 : 1288 1297. (Pubitemid 351547915)
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1288-1297
    • Rountree, C.B.1    Senadheera, S.2    Mato, J.M.3    Crooks, G.M.4    Lu, S.C.5
  • 105
    • 3242673323 scopus 로고    scopus 로고
    • Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif
    • DOI 10.1128/JVI.78.15.7958-7968.2004
    • Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M (2004) Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol 78 : 7958 7968. (Pubitemid 38944281)
    • (2004) Journal of Virology , vol.78 , Issue.15 , pp. 7958-7968
    • Schwer, B.1    Ren, S.2    Pietschmann, T.3    Kartenbeck, J.4    Kaehlcke, K.5    Bartenschlager, R.6    Yen, T.S.B.7    Ott, M.8
  • 106
    • 42449088547 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus (HCV) core protein- induced cell growth by non-structural protein 4A (NS4A) is mediated by mitochondrial dysregulation
    • Selimovic D, Hassan M (2008) Inhibition of hepatitis C virus (HCV) core protein- induced cell growth by non-structural protein 4A (NS4A) is mediated by mitochondrial dysregulation. Bosn J Basic Med Sci 8 : 4 11.
    • (2008) Bosn J Basic Med Sci , vol.8 , pp. 4-11
    • Selimovic, D.1    Hassan, M.2
  • 110
    • 34547932626 scopus 로고    scopus 로고
    • Mechanisms of synergy between alcohol and hepatitis C virus
    • DOI 10.1097/MCG.0b013e3180381584, PII 0000483620070900000007
    • Singal AK, Anand BS (2007) Mechanisms of synergy between alcohol and hepatitis C virus. J Clin Gastroenterol 41 : 761 772. (Pubitemid 47267763)
    • (2007) Journal of Clinical Gastroenterology , vol.41 , Issue.8 , pp. 761-772
    • Singal, A.K.1    Anand, B.S.2
  • 112
  • 116
    • 21644434561 scopus 로고    scopus 로고
    • Inhibition of antigen-presenting cell functions by alcohol: Implications for hepatitis C virus infection
    • DOI 10.1016/j.alcohol.2004.07.003
    • Szabo G, Dolganiuc A, Mandrekar P, White B (2004) Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection. Alcohol 33 : 241 249. (Pubitemid 41123667)
    • (2004) Alcohol , vol.33 , Issue.3 , pp. 241-249
    • Szabo, G.1    Dolganiuc, A.2    Mandrekar, P.3    White, B.4
  • 117
    • 58849132562 scopus 로고    scopus 로고
    • A recent perspective on alcohol, immunity, and host defense
    • Szabo G, Mandrekar P (2009) A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res 33 : 220 232.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 220-232
    • Szabo, G.1    Mandrekar, P.2
  • 118
    • 16244405250 scopus 로고    scopus 로고
    • Hepatitis C virus, ER stress, and oxidative stress
    • DOI 10.1016/j.tim.2005.02.004
    • Tardif KD, Waris G, Siddiqui A (2005) Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol 13 : 159 163. (Pubitemid 40463317)
    • (2005) Trends in Microbiology , vol.13 , Issue.4 , pp. 159-163
    • Tardif, K.D.1    Waris, G.2    Siddiqui, A.3
  • 119
    • 10044270011 scopus 로고    scopus 로고
    • A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: Role of NADPH oxidase-derived oxygen radicals
    • DOI 10.1189/jlb.0704387
    • Thoren F, Romero A, Lindh M, Dahlgren C, Hellstrand K (2004) A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals. J Leukoc Biol 76 : 1180 1186. (Pubitemid 39602954)
    • (2004) Journal of Leukocyte Biology , vol.76 , Issue.6 , pp. 1180-1186
    • Thoren, F.1    Romero, A.2    Lindh, M.3    Dahlgren, C.4    Hellstrand, K.5
  • 120
    • 34748910077 scopus 로고    scopus 로고
    • Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet
    • DOI 10.1016/j.biocel.2007.06.008, PII S1357272507002063
    • Tirnitz-Parker JE, Tonkin JN, Knight B, Olynyk JK, Yeoh GC (2007) Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet. Int J Biochem Cell Biol 39 : 2226 2239. (Pubitemid 47484278)
    • (2007) International Journal of Biochemistry and Cell Biology , vol.39 , Issue.12 , pp. 2226-2239
    • Tirnitz-Parker, J.E.E.1    Tonkin, J.N.2    Knight, B.3    Olynyk, J.K.4    Yeoh, G.C.T.5
  • 121
    • 0029971032 scopus 로고    scopus 로고
    • Expression and immune response to hepatitis C virus core DNA-based vaccine constructs
    • DOI 10.1053/jhep.1996.v24.pm0008707253
    • Tokushige K, Wakita T, Pachuk C, Moradpour D, Weiner DB, Zurawski VR Jr., Wands JR (1996) Expression and immune response to hepatitis C virus core DNA-based vaccine constructs. Hepatology 24 : 14 20. (Pubitemid 26249406)
    • (1996) Hepatology , vol.24 , Issue.1 , pp. 14-20
    • Tokushige, K.1    Wakita, T.2    Pachuk, C.3    Moradpour, D.4    Weiner, D.B.5    Zurawski Jr., V.R.6    Wands, J.R.7
  • 123
    • 0141866947 scopus 로고    scopus 로고
    • Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice
    • DOI 10.1053/jhep.2003.50399
    • Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, Matsuura Y, Koike K, Miyamura T (2003) Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice. Hepatology 38 : 820 828. (Pubitemid 37221665)
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 820-828
    • Tsutsumi, T.1    Suzuki, T.2    Moriya, K.3    Shintani, Y.4    Fujie, H.5    Miyoshi, H.6    Matsuura, Y.7    Koike, K.8    Miyamura, T.9
  • 124
    • 79951945023 scopus 로고    scopus 로고
    • Hepatitis C protein expression in conjunction with reduced SOD2 causes marked sensitivity to alcohol-induced liver injury
    • Tumurbaatar B, Hao J, Weinman SA (2008) Hepatitis C protein expression in conjunction with reduced SOD2 causes marked sensitivity to alcohol-induced liver injury. Hepatology 48 : 495A.
    • (2008) Hepatology , vol.48
    • Tumurbaatar, B.1    Hao, J.2    Weinman, S.A.3
  • 125
    • 0036023302 scopus 로고    scopus 로고
    • Oxidative stress EPR measurement in human liver by radical-probe technique. Correlation with etiology, histology and cell proliferation
    • DOI 10.1080/107156021000006653
    • Valgimigli M, Valgimigli L, Trere D, Gaiani S, Pedulli GF, Gramantieri L, Bolondi L (2002) Oxidative stress EPR measurement in human liver by radical-probe technique. Correlation with etiology, histology and cell proliferation. Free Radic Res 36 : 939 948. (Pubitemid 34863641)
    • (2002) Free Radical Research , vol.36 , Issue.9 , pp. 939-948
    • Valgimigli, M.1    Valgimigli, L.2    Trere, D.3    Gaiani, S.4    Pedulli, G.F.5    Gramantieri, L.6    Bolondi, L.7
  • 127
    • 37849038662 scopus 로고    scopus 로고
    • Combination of oxidative stress and steatosis is a risk factor for fibrosis in alcohol-drinking patients with chronic hepatitis C
    • Vidali M, Occhino G, Ivaldi A, Rigamonti C, Sartori M, Albano E (2008a) Combination of oxidative stress and steatosis is a risk factor for fibrosis in alcohol-drinking patients with chronic hepatitis C. Am J Gastroenterol 103 : 147 153.
    • (2008) Am J Gastroenterol , vol.103 , pp. 147-153
    • Vidali, M.1    Occhino, G.2    Ivaldi, A.3    Rigamonti, C.4    Sartori, M.5    Albano, E.6
  • 129
    • 33747600880 scopus 로고    scopus 로고
    • Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C
    • DOI 10.1111/j.1440-1746.2006.04591.x
    • Wang T, Weinman SA (2006) Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C. J Gastroenterol Hepatol 21 (Suppl 3 S34 S37. (Pubitemid 44266547)
    • (2006) Journal of Gastroenterology and Hepatology , vol.21 , Issue.SUPPL. 3
    • Wang, T.1    Weinman, S.A.2
  • 130
    • 77957359528 scopus 로고    scopus 로고
    • Role of hepatitis C virus core protein in viral-induced mitochondrial dysfunction
    • [Epub ahead of print].
    • Wang T, Campbell RV, Yi MK, Lemon SM, Weinman SA (2009) Role of hepatitis C virus core protein in viral-induced mitochondrial dysfunction. J Viral Hepat [Epub ahead of print].
    • (2009) J Viral Hepat
    • Wang, T.1    Campbell, R.V.2    Yi, M.K.3    Lemon, S.M.4    Weinman, S.A.5
  • 131
    • 67449119450 scopus 로고    scopus 로고
    • Access of viral proteins to mitochondria via mitochondria-associated membranes
    • Williamson CD, Colberg-Poley AM (2009) Access of viral proteins to mitochondria via mitochondria-associated membranes. Rev Med Virol 19 : 147 164.
    • (2009) Rev Med Virol , vol.19 , pp. 147-164
    • Williamson, C.D.1    Colberg-Poley, A.M.2
  • 132
    • 0036790718 scopus 로고    scopus 로고
    • Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C
    • Yadav D, Hertan HI, Schweitzer P, Norkus EP, Pitchumoni CS (2002) Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C. Am J Gastroenterol 97 : 2634 2639.
    • (2002) Am J Gastroenterol , vol.97 , pp. 2634-2639
    • Yadav, D.1    Hertan, H.I.2    Schweitzer, P.3    Norkus, E.P.4    Pitchumoni, C.S.5
  • 135
    • 4143065907 scopus 로고    scopus 로고
    • Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S
    • DOI 10.1002/cncr.20427
    • Yuan JM, Govindarajan S, Arakawa K, Yu MC (2004) Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the US. Cancer 101 : 1009 1017. (Pubitemid 39100435)
    • (2004) Cancer , vol.101 , Issue.5 , pp. 1009-1017
    • Yuan, J.-M.1    Govindarajan, S.2    Arakawa, K.3    Yu, M.C.4


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