Novel anthraquinone derivatives with redox-active functional groups capable of producing free radicals by metabolism: Are free radicals essential for cytotoxicity?

European Journal of Medicinal Chemistry

Volumn 34, Issue 7-8, 1999, Pages 597-615

  Barasch, Dinorah ^a   Zipori, Omer ^a   Ringel, Israel ^a   Ginsburg, Isaac ^a   Samuni, Amram ^a   Katzhendler, Jehoshua ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Anthraquinones; Bioreduction; Cytotoxicity

Indexed keywords

ANTHRAQUINONE DERIVATIVE; FREE RADICAL; MITOXANTRONE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DERIVATIZATION; DNA CLEAVAGE; DRUG EFFICACY; DRUG METABOLISM; ELECTRON TRANSPORT; INTERCALATION COMPLEX; OXIDATION REDUCTION REACTION; RECEPTOR AFFINITY;

EID: 0032710427     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)80029-X     Document Type: Article

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