Exposure of mice to concentrated ambient particulate matter results in platelet and systemic cytokine activation

Inhalation Toxicology

Volumn 22, Issue 4, 2010, Pages 267-276

  Wilson, D W ^a   Aung, H H ^a   Lame, M W ^a   Plummer, L ^a   Pinkerton, K E ^a   Ham, W ^b   Kleeman, M ^b   Norris, J W ^a   Tablin, F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

Author keywords

Air pollution; Cytokines; Flow cytometry; Platelet activation; Platelets

Indexed keywords

COLONY STIMULATING FACTOR 1; CYTOKINE; EOTAXIN; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PADGEM PROTEIN; PLATELET DERIVED GROWTH FACTOR BB; RANTES; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; THROMBIN; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

AIR POLLUTION; AMBIENT AIR; ANIMAL EXPERIMENT; ARTICLE; BLOOD CELL; CELL COUNT; CONCENTRATION (PARAMETERS); CYTOKINE PRODUCTION; FLOW CYTOMETRY; MALE; MOUSE; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE SHAPE; UNITED STATES; UPREGULATION;

AIR POLLUTANTS; ANIMALS; BLOOD CELL COUNT; CALIFORNIA; CYTOKINES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FIBRINOGEN; FLOW CYTOMETRY; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; MALE; MICE; MICE, INBRED C57BL; PARTICLE SIZE; PARTICULATE MATTER; PLATELET ACTIVATION; POLYCYCLIC HYDROCARBONS, AROMATIC;

ANIMALIA; MUS;

EID: 77149157805     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958370903278069     Document Type: Article

References (76)

1. Amrani DL. 1990. Regulation of fibrinogen biosynthesis: Glucocorticoid and interleukin-6 control. Blood Coagul Fibrinolysis 1:443-446.
2. Baccarelli A, Zanobetti A, Martinelli I, Grillo P, Hou L, Giacomini S, Bonzini M, Lanzani G, Mannucci PM, Bertazzi PA, Schwartz J. 2007. Effects of exposure to air pollution on blood coagulation. J Thromb Haemost 5:252-260.
3. Baccarelli A, Martinelli I, Zanobetti A, Grillo P, Hou LF, Bertazzi PA, Mannucci P M, Schwartz J. 2008. Exposure to particulate air pollution and risk of deep vein thrombosis. Arch Intern Med 168:920-927.
4. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. 2008. Growth factors and cytokines in wound healing. Wound Repair Regen 16:585-601.
5. Bazzoni G, Dejana E, DelMaschio A. 1991. Platelet-neutrophil interactions Possible relevance in the pathogenesis of thrombosis and inflammation. Haematologica 76:491-499.
6. Becker S, Dailey LA, Soukup JM, GrambowSC, Develin RB, Huang YC. 2005. Seasonal variations in air pollution-induced inflammatory mediator release and oxidative stress. Environ Health Perspect 113:1032-1038.
7. Bobrowski W F, McDuffie J E, Sobocinski G, Chupka J, Olle E, Bowman A, Albassam M. 2005. Comparative methods for multiplex analysis of cytokine protein expression in plasma of lipopolysaccharide-treated mice. Cytokine 32:194-198.
8. Boehlen F, Clemetson KJ 2001 Platelet chemokines and their receptors: What is their relvance to platelet storage and transfusion practice? Transfus Med 11:403-417.
9. Boscia J, Chalupa D, Utell M, Zareba W, Konecki J A, Morrow P E. 2000. Airway and cardiovascular effects of inhaled ultrafine carbon particles in resting healthy nonsmoking adults. Am J Respir Crit Care Med 161:A239
10. Bouthillier L, Vincent R, Goegan P, Adamson I Y, Bjarnason S, Stewart M, Guenette J, Potvin M, Kumarathasan P. 1998. Acute effects of inhaled urban particles and ozone: Lung morphology macrophage activity and plasma endothelin-1. Am J Pathol 153:1873-1884.
11. Braga A L, Zanobetti A, Schwartz J. 2001. The lag structure between particulate air pollution and respiratory and cardiovascular deaths in 10 US cities. J Occup Environ Med 43:927-933.
12. Brass L. 2004. Fifty (or more) ways to leave your platelets (in a thrombus). Arterioscler Thromb Vasc Biol 24:989-991.
13. Burstein SA, Peng J, Friese P, Wolf RF, Harrison P, Downs T, HamiltonK, Comp P, Dale GL. 1996. Cytokine-induced alteration of platelet and hemostatic function. Stem Cells 14(Suppl 1):154-162.
14. Capron A, Joseph M, Ameisen JC, Capron M, Pancre V, Auriault C. 1987. Platelets as effectors in immune and hypersensitivity reactions. Int Arch Allergy Appl Immunol 82:307-312.
15. Cascio WE, Cozzi E, Hazarika S, Devlin RB, HenriksenRA, Lust RM, Van Scott MR, Wingard CJ. 2007. Cardiac and vascular changes in mice after exposure to ultrafine particulate matter. Inhal Toxicol 19(S1):67-73.
16. Cass G R, Hughes L A, Bhave P, Kleeman M J, Allen J O, Salmon L G. 2000. The chemical composition of atmospheric ultrafine particles. Phil Trans R Soc Lond A Math Phys Eng Sci 358:2581-2592.
17. Chen L C, Nadziejko C. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal Toxicol 17:217-224. (Pubitemid 40516020)
18. Chuang K J, Chan C C, Su T C, Lee C T, Tang C S. 2007. The effect of urban air pollution on inflammation oxidative stress coagulation and autonomic dysfunction in young adults. Am J Respir Crit Care Med 176:370-376.
19. Chung A, Herner J D, Kleeman M J. 2001a. Detection of alkaline ultrafine atmospheric particles at Bakersfield, California. Environ Sci Technol 35:2184-2190.
20. Clemetson KJ, Clemetson JM, Proudfoot AE, Power CA, Baggiolini M, Wells TN. 2000. Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human blood platelets. Blood 96:4046-4054.
21. Coyle AJ, Spina D, Page CP. 1990. PAF-induced bronchial hyperresponsiveness in the rabbit: Contribution of platelets and airway smooth muscle. Br J Pharmacol 101:31-38.
22. Coyle AJ, AckermanSJ, Irvin CG. 1993 Cationic proteins induce airway hyperresponsiveness dependent on charge interactions. Am Rev Respir Dis 147:896-900.
23. Cozzi E, Wingard C J, Cascio W E, Devlin R B, Miles J J, Bofferding A R, Lust R M, Van Scott M R, Henriksen R A. 2007. Effect of ambient particulate matter exposure on hemostasis. Transl Res 149:324-332.
24. Dales R, Liu L, Szyszkowicz M, Dalipaj M, Willey J, Kulka R, Ruddy TD. 2007. Particulate air pollution and vascular reactivity: The bus stop study. Int Arch Occup Environ Health 81:159-164.
25. Dockery DW, Pope DA 3rd Xu S, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE. 1993. An association between air pollution and mortality in six U.S. cities. N Engl J Med 329:1753-1759.
26. Donaldson K, Stone V, Seaton A, MacNee W. 2001 Ambient particle inhalation and the cardiovascular system: Potential mechanisms. Environ Health Perspect 109(Suppl 4):523-527.
27. Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G. 2004. Systemic effects of inhalted ultrafine particles in two compromised aged rat strains. Inhal Toxicol 16:461-471.
28. Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz S R, Stein CS, Niewswandt B, Wang Y, Davidson BL, Ratliff TL. 2003. Plateletmediated modulation of adaptive immunity: A communication link between innate and adaptive immune compartments. Immunity 19:9-19.
29. Faraday N, Goldschmidt-Clermont P, Dise K, Bray P F. 1994. Quantitation of soluble fibrinogen binding to platelets by fluorescence-activated flow cytometry. J Lab Clin Med 123:728-740.
30. Frampton M W, Utell M J, Zareba W, Oberdorster G, Cox C, Huang L S, Morrow P E, Lee F E, Chalupa D, Frasier L M, Speers D M, Stewart J. 2004. Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma. Res Rep Health Eff Inst 1-47; discussion 49-63.
31. Gallucci S, Matzinger P. 2001. Danger signals: SOS to the immune system. Curr Opin Immunol 13:114-119.
32. Ghio AJ, Kim C, Devlin RB. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Resp Crit Care Med 162:981-988.
33. Goulaouic S, Foucaud L, Bennasroune A, Laval-Gilly P, Falla J. 2008. Effect of polycyclic aromatic hydrocarbons and carbon black particles on proinflammatory cytokine secretion: Impact of PAH coating onto particles. J Immuntoxicol 5:337-345.
34. Gresele P, Falcinelli E, Momi S. 2008. Potentiation and priming of platelet activation: A potential target for antiplatelet therapy. Trends Pharmacol Sci 29:352-360.
35. Happo MS, Hirvonen M-R, Halilnen AI, Jalava PI, Pennanen AS, Sillanpaa M, Hillamo R, Salonen RO. 2008. Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples from contrasting air pollution in Europe. Inhal Toxicol 20:1215-1231.
36. Heilmann E, Hynes L A, Burstein S A, George J N, Dale G L. 1994. Fluorescein derivatization of fibrinogen for flow cytometric analysis of fibrinogen binding to platelets. Cytometry 17:287-293.
37. Herd CM, Page CP. 1994. Pulmonary immune cells in health and disease: Platelets. Eur Respir J 7:1145-1160.
38. Herner J D, Aw J, Gao O, Chang DP, Kleeman M J. 2005. Size and composition distribution of airborne particulate matter in northern California: I-Particulate mass carbon and water-soluble ions. J Air Waste Manag Assoc 55:30-51.
39. Kameyoshi Y, Dorschner A, Mallet AI, Christophers E, Schroder J-M. 1992. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 176:587-592.
40. Kang Y J, Li Y, A Zhanxiang Z, Roberts A M, Cai L, Myers S R, Wang L, Schuschke D A. 2002. Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM25) in rats with acute myocardial infarction. Cardiovasc Toxicol 2:253-262.
41. Kannel WB, Sytkowski PA. 1987. Atherosclerosis risk factors. Pharmacol Ther 32:207-235.
42. Kerr R, Sitrling D, Ludlam CA. 2001. Interleukin 6 and haemostasis. Br J Haemotol 115:3-12.
43. Klinger MHF. 1997. Platelets and inflammation. Anat Embrol 196:1-11.
44. Kim S, Jaques PA, Chang MC, Froines JR, Sioutas C. 2001a. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine fine and coarse ambient particles-Part I: Development and laboratory characterization. J Aerosol Sci 32:1281-1297. (Pubitemid 32758791)
45. Kim S, Jaques PA, Chang MC, Barone T, Xiong C, Friedlander SK, Sioutas C. 2001a. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine fine and coarse ambient particles-Part II: Field evaluation. J Aerosol Sci 32:1299-1314. (Pubitemid 32758792)
46. Kissel K, Berbers, Nockher S, Santoso S, Bein G, Hackstein H. 2006. Human platelets target dendritic cell differentiation and production of proinflammatory cytokines. Transfusion 46:818-827.
47. McIntyre TM, Prescott SM, Weyrich AS, Zimmerman GA. 2003. Cell-cell interactions: Leukocyte-endothelial interactions. Curr Opin Hematol 10:150-158.
48. Morley J, Sanjhar S, Page CP. 1984. The platelet in asthma. Lancet 2:1142-1144.
49. Mutlu GM, Green D, BellmeyerA, Baker CM, Burgess Z, Rajamannan N, Christman JW, Foiles N, Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GRS. 2007. Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J Clin Invest 117:2952-2961.
50. Nemmar A, Hoylaerts M F, Hoet P H, Dinsdale D, Smith T, Xu H, Vermylen J, Nemery B. 2002. Ultrafine particles affect experimental thrombosis in an in vivo hamster model. Am J Respir Crit Care Med 166:998-1004.
51. Nemmar A, Hoet P H, Dinsdale D, Vermylen J, Hoylaerts M F, Nemery B. 2003. Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis. Circulation 107:1202-1208.
52. Nemmar A, Hoet P H, Vandervoort P, Dinsdale D, Nemery B, Hoylaerts MF. 2007. Enhanced peripheral thrombogenicity after lung inflammation is mediated by platelet-leukocyte activation: Role of P-selectin. J Thromb Haemost 5:1217-1226.
53. Neumann FJ, OttI, Marx N, LutherT, KenngottS, Gawaz M, Kotzsch M, Schomig A. 1997. Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity. Arterioscler Thromb Vasc Biol 17:3399-3405.
54. Norris JW, Pratt SM, Auh J-H, Wilson SJ, Clutter D, Magdesian KG, Ferraro GL, Tablin F. 2006. Investigation of a novel heritable bleeding diathesis of Thoroughbred horses and development of a screening assay. J Vet Intern Med 20:1450-1456.
55. Oberdorster G. 2001. Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74:1-8.
56. Page CP. 1989. Platelets as inflammatory cells Immunopharmacology. 17:51-59.
57. Pei X-H, NakanishiY, InoueH, TakayamaK, Bai F, Hara N. 2002. Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor κB activation in A549 cell line. Cytokine 19:236-241.
58. Peretz A, Sullivan J H, Leotta D F, Trenga C A, Sands F N, Allen J, Carlsten C, Wilkinson CW, Gill E A, Kaufman J D. 2008. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ Health Perspect 116:937-942.
59. Peters A, Dockery DW, Muller JE, Mittleman MA. 2001. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103:2810-2815.
60. Pope C A, Burnett R T, Thurston G D, Thun M J M, Calle E, Krewski D, Godleski J J. 2004. Cardiovascular mortality and long term exposure to particulate air pollution. Circulation 109:71-77.
61. Ruckerl R, Phipps R P, Schneider A, Frampton M, Cyrys J, Oberdorster G, Wichmann H E, Peters A. 2007. Ultrafine particles and platelet activation in patients with coronary heart disease-Results from a prospective panel study. Part Fibre Toxicol 4:1.
62. Sallusto F, Lanzavecchia A, Mackay CR. 1998. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 19:568-574.
63. Samet JM, Dominici F, Curiero FC, Coursac I, Zeger SL. 2000. Fine particulate air pollution and mortality in 20 US cities, 1987-1994. N Engl J Med 343:1742-1749.
64. Schober A, Mankta D, von Hundelshausen P, Huo Y, Hanrath P, Sarembock IJ, Ley K, Weber C. 2002. Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation xx:xx-xx.
65. Schwartz J. 1994. What are people dying of on high air pollution days? Environ Res 64:26-35.
66. Silverstein R L, Febbraio M. 1992. Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. Blood 80:1470-1475.
67. Smith KR, Veranth JM, Kodavanti UP, Aust AE, Pinkerton KE. 2006. Acute pulmonary and systemic effects of inhaled coal fly ash in rats: Comparison to ambient environmental particles. Toxicol Sci 93:390-399.
68. Stirling D, Hannant WA, Ludlam CA. 1998. Transcriptional activation of the factor VIII gene in liver cell lines by interleukin-6. Thromb Haemost 79:74-78.
69. Stouthard JM, Levi M, Hack CE, Veenhof CH, Romijn HA, Sauerwein HP, van der Poll T. 1996. Interleukin-6 stimulates coagulation not fibrinolysis in humans. Thromb Haemost 76:738-742.
70. Sun Q, Yue P, Kirk R I, Wang A, Moatti D, Jin X, Lu B, Schecter A D, Lippmann M, Gordon T, Chen L C, Rajagopalan S. 2008. Ambient air particulate matter exposure and tissue factor expression in atherosclerosis. Inhal Toxicol 20:127-137.
71. Totlandsdal AI, Refsnes M, SkomedalT, Osnes J-B, Schwarze PE, Lag M. 2008. Particle-induced cytokine respones in cardiac cell cultures-the effect of particles versus soluble mediators released by particle-exposed lung cells. Toxicol Sci 106:233-241.
72. van Eeden S, Tan W C, Suwa T, Mukae H, Terashima T, Fujii T, Qui D, Vincent R, Hogg J C. 2001. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10)). Am J Respir Crit Care Med 164:826-830.
73. von Hundelshausen P, Weber K S, Huo Y, Proudfoot A E, Nelson P J, Ley K, Weber C. 2001. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 103:1772-1777. (Pubitemid 32291415)
74. Weyrich AS Elstad MR, McEver RP, McIntyre TM, Moore KL, Morrisey JH, Prescott SM, Zimmerman GA. 1996. Activated platelets signal chemokine synthesis in human monocytes. J Clin Invest 15:1525-1534.
75. Zani B G, Kojima K, Vacanti C A, Edelman E R. 2008. Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair. Proc Natl Acad Sci USA 105:7046-7051.
76. Zanobetti A, Schwartz J, Samoli E, Gryparis A, Touloumi G, Atkinson R, Le Tertre A, Bobros J, Celko M, Goren A, Forsberg B, Michelozzi P, Rabczenko D, Aranguez Ruiz E, Katsouyanni K. 2002. The temporal pattern of mortality responses to air pollution: A multicity assessment of mortality displacement. Epidemiology 13:87-93.