A mechanistic model for amorphous protein aggregation of immunoglobulin-like domains

Journal of the American Chemical Society

Volumn 135, Issue 17, 2013, Pages 6456-6464

  Borgia, Madeleine B ^a,c   Nickson, Adrian A ^a   Clarke, Jane ^a   Hounslow, Michael J ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION MECHANISM; AMORPHOUS AGGREGATION; ANTIBODY THERAPEUTICS; IMMUNOGLOBULIN-LIKE DOMAINS; INDUSTRIAL SETTINGS; MECHANISTIC MODELS; NANOCLUSTER FORMATION; PROTEIN AGGREGATION;

CHEMISTRY; SYNTHESIS (CHEMICAL);

PROTEINS;

CONNECTIN; DIMER; IMMUNOGLOBULIN;

ARTICLE; BETA SHEET; BIREFRINGENCE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); FIBER; HUMAN; LIGHT SCATTERING; MOLECULAR DYNAMICS; POLYMERIZATION; PROTEIN AGGREGATION; PROTEIN DOMAIN; SOLUBILITY; TIME; X RAY DIFFRACTION;

CALIBRATION; CIRCULAR DICHROISM; COMPUTER SIMULATION; HUMANS; IMMUNOGLOBULINS; KINETICS; MODELS, CHEMICAL; NEPHELOMETRY AND TURBIDIMETRY; NONLINEAR DYNAMICS; PROTEIN FOLDING; PROTEINS; SCATTERING, RADIATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84877026504     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja308852b     Document Type: Article

References (46)

1. Chiti, F.; Dobson, C. M. Annu. Rev. Biochem. 2006, 75, 333
2. Helms, L. R.; Wetzel, R. J. Mol. Biol. 1996, 257, 77
3. Roberts, C. J.; Das, T. K.; Sahin, E. Int. J. Pharm. 2011, 418, 318
4. Morris, A. M.; Watzky, M. A.; Finke, R. G. Biochem. Biophys. Acta 2009, 1794, 375
5. Ferrone, F. Methods Enzymol. 1999, 309, 256
6. Knowles, T. P. J.; Waudby, C. A.; Devlin, G. L.; Cohen, S. I. A.; Aguzzi, A.; Vendruscolo, M.; Terentjev, E. M.; Welland, M. E.; Dobson, C. M. Science 2009, 326, 1533
7. Li, Y.; Roberts, C. J. J. Phys. Chem. B 2009, 113, 7020
8. Powers, E. T.; Powers, D. L. Biophys. J. 2008, 94, 379
9. Vitalis, A.; Pappu, R. V. Biophys. Chem. 2011, 159, 14
10. Caughey, B.; Lansbury, P. T. Annu. Rev. Neurosci. 2003, 26, 267
11. Eichner, T.; Radford, S. E. FEBS J. 2011, 278, 3868
12. Lundberg, K. M.; Stenland, C. J.; Cohen, F. E.; Prusiner, S. B.; Millhauser, G. L. Chem. Biol. 1997, 4, 345
13. Walsh, D. M.; Klyubin, I.; Fadeeva, J. V.; Cullen, W. K.; Anwyl, R.; Wolfe, M. S.; Rowan, M. J.; Selkoe, D. J. Nature 2002, 416, 535
14. Eichner, T.; Radford, S. E. Mol. Cell 2011, 43, 8
15. Stranks, S. D.; Ecroyd, H.; Van Sluyter, S.; Waters, E. J.; Carver, J. A.; von Smekal, L. Phys. Rev. E 2009, 80, 051907
16. Morris, A. M.; Watzky, M. A.; Agar, J. N.; Finke, R. G. Biochemistry 2008, 47, 2413
17. Watzky, M.; Finke, R. J. Am. Chem. Soc. 1997, 119, 10382
18. Wright, C. F.; Teichmann, S. A.; Clarke, J.; Dobson, C. M. Nature 2005, 438, 878
19. Wilcken, R.; Wang, G.; Boeckler, F. M.; Fersht, A. R. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 13584
20. Cellmer, T.; Douma, R.; Huebner, A.; Prausnitz, J.; Blanch, H. Biophys. Chem. 2007, 125, 350
21. Cottingham, M. G.; Hollinshead, M. S.; Vaux, D. J. T. Biochemistry 2002, 41, 13539
22. Frieden, C.; Goddette, D. Biochemistry 1983, 22, 5836
23. Roberts, C. J. Biotechnol. Bioeng. 2007, 98, 927
24. Come, J. H.; Fraser, P. E.; Lansbury, P. T., Jr. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5959
25. Flyvbjerg, H.; Jobs, E.; Leibler, S. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 5975
26. Upadhyay, A. K.; Murmu, A.; Singh, A.; Panda, A. K. PLoS One 2012, 7, e33951
27. Xue, W. F.; Homans, S. W.; Radford, S. E. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 8926
28. Serio, T. R.; Cashikar, A. G.; Kowal, A. S.; Sawicki, G. J.; Moslehi, J. J.; Serpell, L.; Arnsdorf, M. F.; Lindquist, S. L. Science 2000, 289, 1317
29. Andrews, J. M.; Roberts, C. J. J. Phys. Chem. B 2007, 111, 7897
30. Chen, Y.; Bjornson, K.; Redick, S. D.; Erickson, H. P. Biophys. J. 2005, 88, 505
31. de Young, L. R.; Fink, A. L.; Dill, K. A. Acc. Chem. Res. 1993, 26, 614
32. Souillac, P. O.; Uversky, V. N.; Fink, A. L. Biochemistry 2003, 42, 8094
33. Levenberg, K. Quart. Appl. Math. 1944, 2, 164
34. Marquardt, D. W. J. Appl. Math. 1963, 11, 431
35. Press, W. H.; Teukolsky, S. A.; Vetterling, W. T.; Flannery, B. P. Numerical Recipes: The Art of Scientific Computing, 3 rd ed.; Cambridge University Press: New York, 2007.
36. Johnson, K. A.; Simpson, Z. B.; Blom, T. Anal. Biochem. 2009, 387, 20
37. Qin, Z.; Hu, D.; Zhu, M.; Fink, A. L. Biochemistry 2007, 46, 3521
38. Souillac, P. O.; Uversky, V. N.; Millett, I. S.; Khurana, R.; Doniach, S.; Fink, A. L. J. Biol. Chem. 2002, 277, 12666
39. Arosio, P.; Owczarz, M.; Müller-Späth, T.; Rognoni, P.; Beeg, M.; Wu, H.; Salmona, M.; Morbidelli, M. PLoS One 2012, 7, e33372
40. Wang, G.; Fersht, A. R. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 13590
41. Canet, D.; Last, A. M.; Tito, P.; Sunde, M.; Spencer, A.; Archer, D. B.; Redfield, C.; Robinson, C. V.; Dobson, C. M. Nat. Struct. Biol. 2002, 9, 308
42. Lashuel, H. A.; Lai, Z.; Kelly, J. W. Biochemistry 1998, 37, 17851
43. Watzky, M. A.; Morris, A. M.; Ross, E. D.; Finke, R. G. Biochemistry 2008, 47, 10790
44. Khurana, R.; Gillespie, J. R.; Talapatra, A.; Minert, L. J.; Ionescu-Zanetti, C.; Millett, I.; Fink, A. L. Biochem. 2001, 40, 3525
45. Qin, Z. J.; Hu, D. M.; Zhu, M.; Fink, A. L. Biochem. 2007, 46, 3521
46. Scott, K. A.; Steward, A.; Fowler, S. B.; Clarke, J. J. Mol. Biol. 2002, 315, 819